1tqn » Cytochrome P450 3A4, structure 1
- Type: Transmembrane (3 classes)
- Class: Bitopic proteins (67 superfamilies)
- Superfamily: Cytochrome P450 (1 families) PF00067
- Family: Cytochrome P450 (122 proteins) PF00067 IPR001128 PDBsum
- Species: Homo sapiens (2659 proteins)
- Localization: Endoplasmic reticulum membrane (548 proteins)
1tqn >> Cytochrome P450 3A4, structure 1 | |
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Hydrophobic Thickness or Depth | 8.7 Å |
Tilt Angle | 67° |
ΔGtransfer | -18.5 kcal/mol |
Links to 1tqn | PDB Sum, PDB, MSD, MMDB |
Topology | cytoplasmic side |
Resolution | 2.05 |
Primary PDB represention | 1tqn |
Other PDB entries representing this structure | 1w0e (2.8), 1w0f (2.65), 1w0g (2.73), 2j0d (2.75), 3ua1 (2.15), 4d6z (1.93), 4d75 (2.25), 4i3q (2.6), 4k9t (2.5), 4k9u (2.85), 4k9v (2.6), 4k9x (2.76), 4ny4 (2.95), 5a1p (2.5), 5a1r (2.45), 5g5j (2.6), 5vcc (1.7), 5vcd (1.95), 5vce (2.2), 5vcg (2.2), 6bcz (2.23), 6bcz (2.23), 6bd5 (2.5), 6bd6 (2.5), 6bd7 (2.42), 6bd8 (2.38), 6bdi (2.57), 6bdk (2.67), 6bdm (2.6), 6da2 (2.65), 6da3 (2.37), 6da5 (2.25), 6da8 (2.8), 6daa (2.15), 6dac (2.55), 6dag (2.8), 6daj (2.45), 6dal (2.65), 6ma6 (2.18), 6ma7 (2.09), 6ma8 (1.83), 6oo9 (2.25), 6ooa (2.52), 6oob (2.2), 7ks8 (2.5), 7kvp (2.75), 8ewd (2.2), 8ewe (2.3), 8ewl (2.35), 8ewm (2.3), 8ewn (2.1), 8ewp (2.4), 8ewq (2.25), 8ewr (2.2), 8ews (2.15), 8exb (2.05) |
Number of TM secondary structures | 0 |
Membranome | ![]() |
Uniprot | CP3A4_HUMAN |
Comments: 2j0c and 2j0d have the same calculated positions in the membrane as 1tqn, although conformations of some loops in 2j0c are different.
Verification: Cytochrome P450 3A4, structure 1 | |
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Crystallization with detergent (CYMAL-6/CHAPS). This cytochrome has a tentative N-terminal TMH, consistent with the calculated orientation. |