1cx2 » Prostaglandin H2 synthase-2 (cyclooxygenase)
- Type: Monotopic/peripheral (4 classes)
- Class: All alpha monotopic/peripheral (66 superfamilies)
- Superfamily: Heme-dependent peroxidases (1 families) PF03098
- Family: Haem peroxidase (6 proteins) PF03098 IPR019791 PDBsum
- Species: Mus musculus (411 proteins)
- Localization: Endoplasmic reticulum membrane (548 proteins)
1cx2 >> Prostaglandin H2 synthase-2 (cyclooxygenase) | |
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Hydrophobic Thickness or Depth | 9.7 Å |
Tilt Angle | 89° |
ΔGtransfer | -37.4 kcal/mol |
Links to 1cx2 | PDB Sum, PDB, MSD, MMDB |
Topology | lumenal side |
Resolution | 3.0 |
Primary PDB represention | 1cx2 |
Other PDB entries representing this structure | 1cvu (2.4), 1ddx (3.0), 1pxx (2.9), 3hs5 (2.1), 3hs6 (2.4), 3hs7 (2.65), 3krk (2.4), 3ln0 (2.2), 3ln1 (2.4), 3mdl (2.2), 3mqe (2.8), 3nt1 (1.73), 3ntb (2.27), 3ntg (2.19), 3olt (2.45), 3olu (2.35), 3pgh (2.5), 3q7d (2.4), 3qh0 (2.1), 3qmo (3.0), 3rr3 (2.84), 3tzi (2.15), 4cox (2.9), 4e1g (2.1), 4fm5 (2.81), 4m10 (2.01), 4m11 (2.45), 4otj (2.11), 4oty (2.35), 4ph9 (1.81), 4rrw (2.57), 4rrx (2.78), 4rry (2.43), 4rrz (2.57), 4rs0 (2.81), 4rut (2.16), 4z0l (2.29), 5cox (3.0), 5jvy (2.36), 5jvz (2.62), 5jw1 (2.82), 5w58 (2.27), 6bl3 (2.22), 6bl4 (2.22), 6cox (2.8), 6ofy (2.2), 6v3r (2.66) |
Number of TM secondary structures | 0 |
Membranome | ![]() |
Uniprot | PGH2_MOUSE |
Comments: May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
Verification: Prostaglandin H2 synthase-2 (cyclooxygenase) | |
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Crystallization with detergent (N-OCTYL-beta-D-GLUCOPYRANOSIDE). |