1cx2 >> Prostaglandin H2 synthase-2 (cyclooxygenase)
Hydrophobic Thickness or Depth9.7 Å
Tilt Angle89°
ΔGtransfer-37.4 kcal/mol
Links to 1cx2PDB Sum, PDB, MSD, MMDB
Topologylumenal side
Resolution3.0
Primary PDB represention1cx2
Other PDB entries representing this structure1cvu (2.4), 1ddx (3.0), 1pxx (2.9), 3hs5 (2.1), 3hs6 (2.4), 3hs7 (2.65), 3krk (2.4), 3ln0 (2.2), 3ln1 (2.4), 3mdl (2.2), 3mqe (2.8), 3nt1 (1.73), 3ntb (2.27), 3ntg (2.19), 3olt (2.45), 3olu (2.35), 3pgh (2.5), 3q7d (2.4), 3qh0 (2.1), 3qmo (3.0), 3rr3 (2.84), 3tzi (2.15), 4cox (2.9), 4e1g (2.1), 4fm5 (2.81), 4m10 (2.01), 4m11 (2.45), 4otj (2.11), 4oty (2.35), 4ph9 (1.81), 4rrw (2.57), 4rrx (2.78), 4rry (2.43), 4rrz (2.57), 4rs0 (2.81), 4rut (2.16), 4z0l (2.29), 5cox (3.0), 5jvy (2.36), 5jvz (2.62), 5jw1 (2.82), 5w58 (2.27), 6bl3 (2.22), 6bl4 (2.22), 6cox (2.8), 6ofy (2.2), 6v3r (2.66)
Number of TM secondary structures0
Membranome
UniprotPGH2_MOUSE
Topology in Endoplasmic reticulum membrane
lumenal side
cytoplasmic side
3D view in GLMol | LiteMol | Jmol | iCn3D

Comments: May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.

Verification: Prostaglandin H2 synthase-2 (cyclooxygenase)
Crystallization with detergent (N-OCTYL-beta-D-GLUCOPYRANOSIDE).