PDB ID or protein name

All proteins in OPM (3380 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
3.1.20.01. Alpha-conotoxin CnIA 1b45 Conus consors (Singed cone) Secreted 1 0 0.8 ± 0.8 80 ± 20 -2.1
2.3.06.06. Triacylglycerol lipase 3g7n Penicillium expansum Secreted 1 0 3.8 ± 1.1 81 ± 14 -9.0
3.2.05.02. Microcin J25, redesigned, version 2 2mmw Designed proteins Undefined 1 0 2.6 ± 3.5 90 ± 4 -3.7
2.3.10.01. Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 3s2u Pseudomonas aeruginosa Bact. Gram-neg inner 1 0 6.8 ± 0.9 60 ± 2 -8.3
2.3.18.01. Choline O-acetyltransferase, different conformation 1t1u Rattus norvegicus Eukaryo. plasma 1 0 2.1 ± 1.7 73 ± 15 -6.8
1.2.32.01. Cytochrome P450 2D6, conformation 2 3tda Homo sapiens Endoplasm. reticulum 1 0 8.0 ± 0.7 35 ± 7 -12.5
2.2.41.02. Anthopleurin-A 1ahl Anthopleura xanthogrammica Secreted 1 0 3.7 ± 1.2 86 ± 11 -7.3
2.3.06.16. Putative epoxide hydrolase 5bov Klebsiella pneumoniae Secreted 1 0 5.7 ± 1.4 23 ± 10 -5.1
2.1.18.01. Annexin XII 1dm5 Hydra vulgaris Eukaryo. plasma 3 0 2.7 ± 1.0 90 ± 7 -10.2
1.2.43.02. E1 envelope glycoprotein 3n41 Chikungunya virus Viral 1 0 2.5 ± 2.9 71 ± 7 -5.8
2.3.01.07. Chitinase A 1nh6 Serratia marcescens Secreted 1 0 2.7 ± 1.3 80 ± 5 -6.1
2.3.02.04. Phosphatidylinositol-specific phospholipase C1 3h4x Streptomyces antibioticus Bact. Gram-pos plas. 1 0 3.7 ± 0.4 63 ± 2 -7.3
1.2.50.01. Sticholysin-1 2ks4 Stoichactis helianthus Secreted 1 0 2.3 ± 2.2 6 ± 24 -5.7
2.2.20.01. Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 2da0 Homo sapiens Eukaryo. plasma 1 0 1.7 ± 2.5 64 ± 20 -2.5
1.2.32.01. Prostaglandin I2 synthase 3b98 Danio rerio Endoplasm. reticulum 1 0 4.4 ± 1.3 65 ± 6 -4.7
2.4.11.01. Hellethionin D 1nbl Helleborus purpurascens Secreted 1 0 2.2 ± 0.9 45 ± 9 -7.4
2.3.06.17. Phosphatidylcholine-sterol acyltransferase, structure 3 5bv7 Homo sapiens Secreted 1 0 2.8 ± 3.1 76 ± 15 -6.1
2.2.20.01. Pleckstrin 1pls Homo sapiens Eukaryo. plasma 1 0 3.6 ± 2.0 61 ± 19 -3.8
1.2.43.01. Envelope glycoprotein, Zika virus, structure 1 5lcv Zika virus Viral 1 0 6.0 ± 2.6 47 ± 9 -4.9
2.3.33.01. Endo-beta-N-acetylglucosaminidase 2vtf Arthrobacter protophormiae Secreted 1 0 4.1 ± 0.7 52 ± 2 -6.5
2.3.14.01. Alpha-tocopherol transfer protein, open state 1oiz Homo sapiens Golgi 1 0 8.1 ± 1.0 64 ± 10 -17.6
2.2.41.01. Defensin-like peptide 1 1b8w Ornithorhynchus anatinus Secreted 1 0 1.8 ± 0.6 84 ± 2 -4.4
3.1.04.03. Viral protein R, peptide 52-96, dimer, different strain 1x9v Human immunodeficiency virus type 1 Eukaryo. plasma 1 0 7.2 ± 0.7 86 ± 4 -8.6
3.2.05.02. Microcin J25, peptide 38-58 1q71 Escherichia coli Secreted 1 0 3.3 ± 3.2 75 ± 17 -5.2
2.2.22.01. Hydrophobin NC2, structure 1 4aog Neurospora crassa Secreted 1 0 3.9 ± 1.7 85 ± 7 -4.6
3.1.02.06. Band 3 anion transport protein SLC4A1, fragment 436-456 1bts Homo sapiens Eukaryo. plasma 1 0 9.2 ± 0.3 84 ± 2 -14.8
2.2.02.01. Mitochondrial serine protease HtrA2 1lcy Homo sapiens Mitochon. inner 1 0 7.4 ± 1.8 67 ± 14 -5.1
3.1.02.13. Regulatory domain of brain carnitine palmitoyltransferase 2m76 Homo sapiens Mitochon. outer 1 0 6.7 ± 1.0 88 ± 16 -6.9
2.4.42.01. Latherin 3zpm Equus caballus Secreted 1 0 6.0 ± 0.4 75 ± 1 -8.0
2.2.23.01. Lipoprotein BamB, conformation 2 3p1l Escherichia coli Bact. Gram-neg outer 1 0 3.6 ± 2.8 89 ± 10 -6.4
2.1.14.01. Peroxisome targeting signal 1 receptor PEX5 1hxi Trypanosoma brucei Peroxisome 1 0 3.7 ± 1.0 71 ± 5 -8.1
3.1.16.01. Lactococcin-G subunit alpha 2jpj Lactococcus lactis Secreted 1 0 5.8 ± 2.9 77 ± 3 -5.9
3.1.02.02. Voltage sensor of calcium-activated potassium channel 2k44 Homo sapiens Eukaryo. plasma 1 0 7.5 ± 3.0 54 ± 4 -9.8
3.4.04.01. Daptomycin, Ca-bound 1t5n Streptomyces roseosporus Secreted 1 0 8.6 ± 2.0 21 ± 24 -9.0
2.3.06.01. Butyryl cholinesterase, dimer 5dyy Homo sapiens Secreted 2 0 5.9 ± 0.5 88 ± 2 -11.5
2.2.20.02. Disabled homolog 1 1nu2 Mus musculus Eukaryo. plasma 1 0 14.8 ± 1.1 46 ± 12 -17.6
3.1.21.03. Melittin 2mlt Apis mellifera Secreted 1 0 15.0 ± 1.0 65 ± 11 -12.0
2.2.35.01. Listeriolysin O 4cdb Listeria monocytogenes Secreted 1 0 3.2 ± 0.0 30 ± 0 -6.0
3.1.03.09. Peptide (2-11) of ADP-ribosylation factor 6, in micelle 2bau Homo sapiens Eukaryo. plasma 1 0 11.2 ± 0.9 22 ± 4 -9.1
3.1.07.02. Juxtamembrane peptide (665-683) of protein gp41 1jau Human immunodeficiency virus type 1 Endosome 1 0 4.0 ± 4.2 86 ± 2 -8.0
3.1.10.01. Competence stimulating peptide 2i2h Streptococcus mutants Secreted 1 0 8.2 ± 0.5 74 ± 7 -12.5
2.1.58.01. Serine/threonine-protein kinase pelle 1ik7 Drosophila melanogaster Eukaryo. plasma 1 0 1.5 ± 3.7 86 ± 0 -6.8
2.3.06.10. Lipase 2fx5 Pseudomonas mendocina Secreted 1 0 5.5 ± 1.0 50 ± 5 -8.4
2.2.27.01. C1 domanin of SH3 and cysteine-rich domain-containing protein 3 2db6 Homo sapiens Eukaryo. plasma 1 0 2.7 ± 0.1 75 ± 0 -4.8
2.1.01.01. Snake phospholipase A2, group I, isoform 1 1tc8 Bungarus caeruleus Secreted 1 0 3.1 ± 1.4 89 ± 11 -5.0
2.2.34.02. Beta-theraphotoxin-Tp1a 2m9l Thrixopelma pruriens Secreted 1 0 5.4 ± 0.7 73 ± 3 -6.6
2.2.34.02. Mu-theraphotoxin-Hhn2b 1nix Haplopelma hainanum (Chinese bird spider) Secreted 1 0 3.6 ± 1.1 64 ± 5 -5.5
2.2.16.01. Lipoprotein lppX 2byo Mycobacterium tuberculosis Bact. Gram-pos plas. 1 0 1.9 ± 1.7 80 ± 13 -4.8
3.1.27.01. Pardaxin 2kns Pardachirus marmoratus Secreted 1 0 4.0 ± 0.7 84 ± 7 -11.1
3.1.05.01. Antimicrobial peptide RP-1 2rlg Designed proteins Undefined 1 0 5.9 ± 4.2 75 ± 4 -5.0
2.2.06.01. Prostaglandin-H2 D-isomerase 2ktd Mus musculus Endoplasm. reticulum 1 0 0.0 ± 1.4 73 ± 14 -2.2
2.2.06.01. Retinol binding protein 1rbp Homo sapiens Secreted 1 0 3.5 ± 0.8 70 ± 6 -5.8
1.3.25.01. Gamma-hemolysin prepore, hetero-octamer (A+B) 4p1y Staphylococcus aureus Secreted 8 0 1.3 ± 1.0 85 ± 2 -7.8
2.3.08.02. Cytosolic phospholipase A2 delta, structure 1 5ixc Homo sapiens Vesicle 1 0 5.5 ± 2.0 85 ± 31 -4.4
2.2.34.02. Mu-theraphotoxin-Hhn2a 2jtb Haplopelma hainanum (Chinese bird spider) Secreted 1 0 3.4 ± 1.5 74 ± 12 -4.7
2.1.16.01. Myelin basic protein 2lug Mus musculus Eukaryo. plasma 1 0 5.6 ± 1.5 79 ± 7 -10.3
2.1.30.01. Membrane-integrating protein mistic, mstX 1ygm Bacillus subtilis Bact. Gram-pos plas. 1 0 2.6 ± 1.8 31 ± 6 -5.2
2.3.22.02. NrdI protein 2xod Bacillus anthracis Undefined 1 0 4.1 ± 0.4 72 ± 3 -4.8
2.4.20.02. Arylamine N-acetyltransferase 1w4t Pseudomonas aeruginosa Bact. Gram-neg inner 1 0 2.8 ± 0.4 82 ± 1 -5.8
2.1.02.01. Seed lipoxygenase-D 2iuk Glycine max Eukaryo. plasma 1 0 3.7 ± 1.7 85 ± 8 -6.2
2.4.16.01. Alpha-like neurotoxin BmK-I 1djt Buthus martensii Secreted 2 0 3.8 ± 0.9 90 ± 15 -6.9
2.3.06.08. Pancreatic lipase, complex with colipase from Pig 1lpb Homo sapiens Secreted 2 0 9.2 ± 0.4 89 ± 2 -24.2
2.4.16.08. Theromacin 2ln8 Hirudo medicinalis Secreted 1 0 3.7 ± 0.2 72 ± 3 -6.4
2.2.11.01. Protein kinase C alpha, complex with phosphatidyl serine 1dsy Rattus norvegicus Eukaryo. plasma 1 0 0.9 ± 1.5 18 ± 16 -3.0
3.1.11.03. Obestatin 2jsi Mus musculus Secreted 1 0 2.0 ± 3.3 85 ± 13 -3.1
2.1.24.01. Saposin-like domain of plant aspartic protease 3rfi Solanum tuberosum Secreted 1 0 5.6 ± 3.2 66 ± 3 -9.1
3.2.01.09. Chignolin 5awl Designed proteins Undefined 1 0 2.6 ± 2.1 77 ± 28 -2.8
2.3.06.01. Acetylcholinesterase 4ey4 Homo sapiens Eukaryo. plasma 1 0 3.2 ± 0.5 33 ± 2 -8.4
2.3.06.06. Lipase B, open state 1lbs Candida antarctica Secreted 1 0 3.7 ± 1.0 76 ± 6 -12.7
3.2.01.10. RCB-1 peptide 2mtm Ricinus communis Secreted 1 0 10.1 ± 3.0 37 ± 37 -8.4
2.1.20.01. Coagulation factor XIV (protein C) in complex with its receptor 1lqv Homo sapiens Eukaryo. plasma 2 0 3.4 ± 3.9 53 ± 14 -5.6
3.2.08.01. Amyloid beta A4 protein, peptide 688-707 5hoy Homo sapiens Eukaryo. plasma 3 0 6.0 ± 1.0 89 ± 0 -5.7
2.4.33.02. Collagenase 2y3u Clostridium histolyticum Secreted 1 0 3.0 ± 1.0 89 ± 4 -5.4
2.2.27.01. C1 domain of protein kinase C theta 4fkd Mus musculus Eukaryo. plasma 1 0 3.6 ± 0.4 35 ± 2 -8.0
2.4.16.01. Beta-insect excitatory toxin BmK IT-AP 1t0z Mesobuthus martensii (Manchurian scorpion) Secreted 1 0 3.9 ± 1.2 79 ± 10 -7.2
1.2.03.02. Hepatitis A virus cellular receptor 1 homolog 2or8 Mus musculus Eukaryo. plasma 1 0 4.2 ± 2.4 51 ± 16 -3.9
1.2.32.01. Cytochrome P450 46A1 (cholesterol 24-hydrolase), conformation 3 4j14 Homo sapiens Endoplasm. reticulum 1 0 3.4 ± 1.4 35 ± 19 -4.0
3.1.11.03. Motilin 1lbj Homo sapiens Secreted 1 0 8.6 ± 1.6 51 ± 18 -4.9
2.1.08.02. Cytochrome c4 1m70 Pseudomonas stutzeri Bact. Gram-neg inner 1 0 5.4 ± 0.8 67 ± 14 -5.6
2.2.06.02. Muscle fatty acid binding protein 1bwy Bos taurus Eukaryo. plasma 1 0 4.8 ± 1.3 71 ± 12 -6.6
2.3.30.01. Aspartate carbamoyltransferase 5ilq Plasmodium falciparum Chloroplast outer 3 0 3.0 ± 0.4 88 ± 1 -7.2
2.1.24.01. Saposin-like protein Na-SLP-1 3s63 Necator americanus Secreted 1 0 2.2 ± 1.6 74 ± 10 -3.5
3.1.02.10. Transmembrane emp24 domain-containing protein 10, peptide 207-219 1m23 Oryctolagus cuniculus Golgi 1 0 4.9 ± 3.2 66 ± 3 -6.9
2.4.16.04. Defensin-like protein 1 1gps Triticum aestivum Secreted 1 0 3.4 ± 1.3 22 ± 9 -3.9
2.2.11.01. C2 domain of E3 ubiquitin-protein ligase NEDD4 3b7y Homo sapiens Eukaryo. plasma 1 0 2.7 ± 1.5 9 ± 6 -4.1
3.4.02.03. Nisin-Lipid II complex in DMSO solution 1wco Lactococcus lactis Secreted 1 0 8.1 ± 1.0 90 ± 5 -8.0
2.2.35.01. Pneumolysin, structure 5 5aoe Streptococcus pneumoniae Secreted 1 0 4.5 ± 2.6 36 ± 16 -5.1
2.1.32.01. Alpha-synuclein 1xq8 Homo sapiens Eukaryo. plasma 1 0 8.7 ± 1.1 87 ± 4 -15.7
2.3.18.01. Carnitine O-palmitoyltransferase 2 2h4t Rattus norvegicus Mitochon. inner 1 0 4.0 ± 1.2 67 ± 10 -9.4
2.3.06.02. Antigen 85b 1f0n Mycobacterium tuberculosis Bact. Gram-pos cell wall 1 0 3.7 ± 0.9 33 ± 7 -7.4
3.1.14.01. Neuropeptide gamma 2mce Oryctolagus cuniculus Secreted 1 0 8.4 ± 1.4 60 ± 10 -6.1
2.4.49.01. Inositol-pentakisphosphate 2-kinase, structure 2 4axd Arabidopsis thaliana Eukaryo. plasma 1 0 1.5 ± 0.1 88 ± 4 -4.0
2.1.15.02. Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) 1dvp Drosophila melanogaster Endosome 2 0 3.0 ± 0.0 89 ± 0 -6.6
2.2.33.01. Antimicrobial peptide 2 1mmc Amaranthus caudatus (Inca-wheat) Secreted 1 0 1.6 ± 1.2 46 ± 9 -3.9
1.2.01.01. Macrophage colony-stimulating factor 1 receptor 3bea Homo sapiens Eukaryo. plasma 1 0 2.9 ± 1.5 54 ± 19 -4.2
2.1.08.01. Cytochrome c6 1c6s Thermosynechococcus elongatus Thylakoid 1 0 0.4 ± 1.7 89 ± 16 -1.3
3.1.21.02. Mastoparan 2czp Vespa xanthoptera Secreted 1 0 5.2 ± 1.6 88 ± 16 -9.8
2.1.19.01. Antimicrobial peptide Tk-Amp-X2 2m6a Hordeum vulgare Secreted 1 0 1.2 ± 1.0 65 ± 7 -3.4
2.2.11.01. Protein unc-13 homolog A, C2A domain 2cjs Rattus norvegicus Eukaryo. plasma 1 0 3.5 ± 2.0 47 ± 12 -5.0
2.1.24.01. NK-lysin 1nkl Sus scrofa Secreted 1 0 2.8 ± 1.5 37 ± 12 -5.4
3.1.04.05. Lactotransferrin peptide (287-303) 2md1 Bos taurus Secreted 1 0 6.0 ± 1.0 71 ± 9 -7.3
2.1.21.03. Matrix protein p15 1mn8 Moloney murine leukemia virus Endosome 1 0 1.5 ± 1.8 65 ± 24 -3.5
2.4.16.03. Potassium channel toxin gamma-KTx 1.1 1ne5 Centruroides noxius (Mexican scorpion) Secreted 1 0 3.9 ± 1.0 62 ± 2 -5.2
1.2.52.01. Cytochrome c-type biogenesis protein CcmE 1sr3 Escherichia coli Bact. Gram-neg inner 1 0 2.8 ± 2.7 59 ± 6 -2.2
2.1.56.01. PALS1-associated tight junction protein 1vf6 Homo sapiens Eukaryo. plasma 2 0 5.8 ± 0.4 53 ± 2 -9.4
3.1.21.02. Mastoparan-L 1d7n Vespula lewisii Secreted 1 0 6.5 ± 1.7 82 ± 16 -7.5
3.1.29.02. Indolicidin, with P->A substitution 1hr1 Designed proteins Undefined 1 0 5.4 ± 4.0 84 ± 9 -8.3
1.2.32.01. Cytochrome P450 2C5 1nr6 Oryctolagus cuniculus Endoplasm. reticulum 1 0 10.6 ± 1.0 54 ± 18 -9.1
2.1.01.01. Phospholipase A2, group X 1le6 Homo sapiens Secreted 1 0 7.4 ± 0.9 78 ± 6 -13.2
3.4.02.03. Bovicin HJ50 2m8v Streptococcus equinus Secreted 1 0 2.8 ± 1.0 71 ± 8 -4.0
1.2.03.08. HLA class II histocompatibility antigen, DM alpha chain 2bc4 Homo sapiens Eukaryo. plasma 1 0 1.5 ± 0.7 21 ± 3 -4.7
2.1.29.02. Apolipoprotein A-II 2ou1 Homo sapiens Secreted 2 0 2.7 ± 1.2 87 ± 2 -17.7
2.1.34.01. Septium site-determining protein DivIVA 2wuj Bacillus subtilis Bact. Gram-pos plas. 2 0 4.0 ± 1.8 2 ± 18 -5.4
2.3.06.08. Pancreatic lipase-related protein 1 1rp1 Canis lupus familiaris Secreted 1 0 6.3 ± 1.0 79 ± 4 -7.5
2.3.24.02. Hydrolase 3n1u Legionella pneumophila Undefined 4 0 5.6 ± 0.6 90 ± 1 -10.8
2.4.07.01. PX domain of C2alpha-PI3 kinase 2ar5 Homo sapiens Eukaryo. plasma 1 0 5.6 ± 0.9 83 ± 17 -3.7
2.2.34.11. Palicourein 1r1f Palicourea condensata Secreted 1 0 4.8 ± 1.4 70 ± 19 -5.0
2.1.60.03. Cysteine-rich secretory protein 2 2cq7 Homo sapiens Secreted 1 0 0.7 ± 1.1 68 ± 5 -2.5
1.2.03.02. Hepatitis A virus cellular receptor 2 5f71 Homo sapiens Eukaryo. plasma 1 0 4.0 ± 2.0 63 ± 7 -5.3
3.1.03.07. N-terminal peptide (24-58) of Disabled homolog 2 2lsw Homo sapiens Vesicle 1 0 2.1 ± 0.6 85 ± 5 -3.8
2.2.34.02. Omega-theraphotoxin-Hh1a 1y29 Haplopelma hainanum (Chinese bird spider) Secreted 1 0 0.7 ± 1.3 83 ± 17 -2.7
2.3.26.01. Phosphate acyltransferase 1u7n Enterococcus faecalis Bact. Gram-pos plas. 2 0 6.1 ± 1.5 78 ± 13 -6.1
2.2.34.11. Varv peptide F 3e4h Viola arvensis Secreted 1 0 4.2 ± 3.0 87 ± 43 -5.6
2.4.06.04. STAR-related bacterial protein 3ggn Deinococcus radiodurans Undefined 1 0 5.2 ± 1.6 53 ± 8 -4.1
2.2.11.01. E3 ubiquitin-protein ligase SMURF2 2jqz Homo sapiens Eukaryo. plasma 1 0 4.2 ± 1.8 23 ± 17 -5.6
3.1.07.06. NS2 protease, segment 836-868 of polyprotein 2kwt Hepatitis C virus Endoplasm. reticulum 1 0 9.5 ± 3.6 81 ± 3 -15.7
3.1.21.09. Cytotoxic linear peptide IsCT 1t51 Opisthacanthus madagascariensis Secreted 1 0 4.1 ± 0.6 87 ± 11 -10.5
3.1.04.07. Peptide (70-94) of antifreeze protein Afp1 2lq1 Glaciozyma antarctica Undefined 1 0 6.2 ± 4.3 87 ± 1 -8.8
2.4.41.01. Hepatitis C virus non-structural protein NS2 (955-1026) 2hd0 Hepatitis C virus Endoplasm. reticulum 2 0 6.7 ± 0.6 85 ± 0 -11.8
2.2.41.01. Beta-defensin 1 1ijv Homo sapiens Secreted 1 0 3.5 ± 1.9 74 ± 17 -5.4
2.4.16.04. Flower-specific gamma-thionin-like protein 4uj0 Solanum lycopersicum Secreted 1 0 2.6 ± 0.9 19 ± 5 -4.8
3.1.01.02. Leader peptide of patellamide protein 2kya Prochloron didemni Secreted 1 0 5.8 ± 0.5 86 ± 4 -8.8
2.2.11.01. Extended synaptotagmin-2, two first C2 domains 4npk Homo sapiens Eukaryo. plasma 1 0 3.8 ± 2.8 56 ± 9 -4.5
3.1.25.01. Latarcin-1 (M-zodatoxin-Lt1a) 2pco Lachesana tarabaevi (Spider) Secreted 1 0 10.1 ± 0.8 77 ± 6 -9.4
3.1.05.03. Antimicrobial peptide PaDBS1R1 2n9r Designed proteins Undefined 1 0 5.6 ± 1.0 83 ± 6 -8.3
2.3.06.07. Lipase, open (active) state 1ex9 Pseudomonas aeruginosa Secreted 1 0 11.0 ± 1.0 52 ± 5 -30.0
3.1.20.01. O2-contryphan-Vc1 2n24 Conus victoriae (Queen Victoria cone) Secreted 1 0 1.6 ± 1.0 89 ± 22 -3.6
1.2.43.01. Envelope glycoprotein 4fg0 St. louis encephalitis virus Viral 3 0 6.5 ± 0.6 4 ± 2 -11.4
1.2.01.01. Fibroblast growth factor receptor 2 complex 3oj2 Homo sapiens Secreted 6 0 2.0 ± 0.4 81 ± 3 -5.4
1.2.38.03. Endo-type membrane-bound lytic murein transglycosylase A 2y8p Escherichia coli Bact. Gram-neg outer 1 0 0.0 ± 3.6 86 ± 15 -2.2
2.2.20.01. Dynamin-2 2ys1 Homo sapiens Eukaryo. plasma 1 0 2.1 ± 0.4 49 ± 3 -5.3
2.4.16.01. Alpha-toxin Cn12 1pe4 Centruroides noxius (Mexican scorpion) Secreted 1 0 2.1 ± 2.3 17 ± 13 -3.1
1.2.30.01. Potassium voltage-gated channel subfamily E member 1 2k21 Homo sapiens Eukaryo. plasma 1 0 12.1 ± 0.4 54 ± 2 -24.7
1.2.53.01. Squalene synthase, conformation 4 3wek Homo sapiens Endoplasm. reticulum 1 0 0.4 ± 2.5 87 ± 15 -3.2
3.1.19.01. Antiamoebin I 1joh Emercelliopsis sp. Secreted 1 0 8.1 ± 0.8 82 ± 5 -11.7
3.2.10.01. PawS derived peptide 21 2ndm Zinnia haageana Secreted 1 0 1.9 ± 1.2 83 ± 16 -3.7
2.2.10.01. High potential iron protein 1hpi Ectothiorhodospira vacuolata Bact. Gram-neg inner 1 0 2.7 ± 1.0 89 ± 12 -4.4
2.2.06.02. Cellular retinol-binding protein II 1kqw Danio rerio Eukaryo. plasma 1 0 3.1 ± 1.3 45 ± 13 -4.9
3.1.31.01. Dermcidin, crystal structure 2ymk Homo sapiens Secreted 1 0 4.8 ± 1.3 90 ± 0 -31.0
2.2.45.01. Outer membrane protein IcsA autotransporter 3ml3 Shigella flexneri Bact. Gram-neg outer 1 0 3.4 ± 0.5 65 ± 2 -6.2
2.4.13.01. Oxysterol-binding protein homolog 4, conformation 2 1zhy Saccharomyces cerevisiae Golgi 1 0 0.9 ± 0.4 87 ± 4 -4.7
3.1.29.01. Cathelicidin-6 2ket Bos taurus Secreted 1 0 7.1 ± 0.7 82 ± 3 -13.6
2.2.06.02. Fatty acid binding protein 6, ileal (Gastrotropin) 3elz Danio rerio Eukaryo. plasma 1 0 1.1 ± 0.9 85 ± 6 -2.4
2.1.01.01. Snake phospholipase A2, group I 1s6b Naja sagittifera Secreted 1 0 3.0 ± 1.1 81 ± 10 -7.5
2.4.34.01. Ice-structuring protein SP2(HPLC 1) 1ops Zoarces americanus Secreted 1 0 2.4 ± 1.4 60 ± 12 -4.8
2.2.20.01. Son of sevenless homolog 1 (two domains) 1dbh Homo sapiens Eukaryo. plasma 1 0 2.7 ± 2.8 28 ± 19 -4.2
2.1.01.01. Acidic phospholipase A2 5 4rfp Trimeresurus stejnegeri Secreted 1 0 2.8 ± 0.3 81 ± 3 -7.1
2.2.06.02. Intestinal fatty acid binding protein, structure 2 3akm Homo sapiens Eukaryo. plasma 1 0 3.0 ± 1.1 46 ± 8 -4.4
2.2.26.01. LM-5 FYVE domain 1z2q Leishmania major Endosome 1 0 1.5 ± 1.5 22 ± 19 -3.4
3.1.21.06. Spinigerin 1zrv Pseudacanthotermes spiniger Secreted 1 0 2.1 ± 3.4 77 ± 5 -3.9
1.2.04.01. Integrin beta-3/alpha-V complex 3ije Homo sapiens Eukaryo. plasma 2 0 6.1 ± 2.1 13 ± 14 -9.0
2.1.03.01. Phospholipase C 1p6d Bacillus cereus Secreted 1 0 2.8 ± 1.0 52 ± 6 -8.4
2.2.12.01. Ganglioside GM2 activator, apo-protein 2ag4 Homo sapiens Lysosome 1 0 3.1 ± 1.3 58 ± 12 -5.4
2.2.20.01. PH domain of docking protein 2 2d9w Homo sapiens Eukaryo. plasma 1 0 2.2 ± 1.2 13 ± 17 -3.5
2.1.01.01. Snake phospholipase A2, group II, B 1jia Agkistrodon halys pallas Secreted 1 0 3.3 ± 0.5 78 ± 4 -11.2
3.2.01.01. Alvinellacin 2llr Alvinella pompejana Secreted 1 0 1.6 ± 1.4 90 ± 5 -2.6
3.1.07.02. Juxtamembrane peptide (662-683) of protein gp160 4g6f Human immunodeficiency virus type 1 Endosome 1 0 4.9 ± 1.4 86 ± 0 -5.0
3.1.28.01. Dermaseptin-4 2dd6 Phyllomedusa sauvagei (Sauvage's leaf frog) Secreted 1 0 4.2 ± 1.6 76 ± 6 -7.0
2.4.49.01. Inositol-pentakisphosphate 2-kinase, structure 1 2xar Arabidopsis thaliana Eukaryo. plasma 1 0 2.6 ± 1.6 69 ± 7 -6.1
2.1.01.01. Phospholipase A2 BnSP-7 1pa0 Bothrops neuwiedi pauloensis Secreted 1 0 2.8 ± 1.0 78 ± 10 -6.9
3.1.05.04. Distinctin 1xkm Designed proteins Undefined 2 0 3.9 ± 0.4 87 ± 2 -4.6
2.3.16.05. ATPase Get3, complex with Get1 cytosolic domain 3sja Saccharomyces cerevisiae Endoplasm. reticulum 4 0 6.4 ± 1.6 89 ± 45 -8.1
2.3.06.08. Pancreatic lipase 1hpl Equus caballus Secreted 1 0 3.8 ± 0.3 80 ± 5 -8.1
3.4.12.03. Bacitracin 4k7t Bacillus subtilis Secreted 1 0 9.0 ± 0.9 69 ± 8 -8.4
2.2.34.01. Kappa-conotoxin PVIIA 1av3 Conus purpurascens (Purple cone) Secreted 1 0 3.4 ± 1.9 77 ± 7 -3.2
2.1.01.01. Snake phospholipase A2 crotoxin basic chain 2, group II 2qog Crotalus durissus terrificus Secreted 1 0 2.1 ± 1.1 84 ± 8 -7.2
2.3.07.01. Endoglucanase 1vho Thermotoga maritima Undefined 1 0 5.4 ± 0.2 89 ± 1 -7.0
3.1.02.03. Juxtamembrane helix of ATP synthase subunit b 2khk Escherichia coli Bact. Gram-neg inner 1 0 1.9 ± 0.1 85 ± 3 -3.9
1.2.32.01. Sterol 14-alpha-demethylase (CYP51) 3ld6 Homo sapiens Endoplasm. reticulum 1 0 8.9 ± 0.6 57 ± 2 -16.8
2.2.34.02. Robustoxin 1qdp Atrax robustus Secreted 1 0 1.8 ± 1.9 86 ± 18 -5.0
2.3.02.03. Phospholipase D 3rlh Loxosceles intermedia Secreted 1 0 3.0 ± 0.7 81 ± 6 -6.2
2.2.09.03. Surface layer protein 1l0q Methanosarcina mazei (Methanosarcina frisia) Archaebac. 1 0 3.1 ± 0.9 81 ± 7 -5.1
2.2.11.01. C2 domain of abscisic acid-related protein CAR4 5a52 Arabidopsis thaliana Eukaryo. plasma 2 0 3.9 ± 0.7 82 ± 11 -6.6
1.2.43.02. E1 envelope glycoprotein 1rer Semiliki forest virus Viral 3 0 2.6 ± 2.0 38 ± 5 -6.5
3.1.20.01. Alpha-conotoxin OmIA 2gcz Conus omaria (Omaria cone) Secreted 1 0 3.0 ± 1.5 62 ± 11 -3.7
2.4.07.01. Sorting nexin-11, conformation 2 4ikd Homo sapiens Eukaryo. plasma 1 0 3.0 ± 1.2 58 ± 4 -5.3
3.1.07.03. Hemagglutinin, fusion peptide 346-365, wild type 1ibn Influenza virus Viral 1 0 9.1 ± 1.2 67 ± 7 -8.0
3.1.14.01. Uperolein 2gfr Uperoleia rugosa (Wrinkled toadlet) Secreted 1 0 6.4 ± 1.2 88 ± 9 -8.2
2.3.06.06. Lipase 2 3o0d Yarrowia lipolytica Secreted 1 0 6.8 ± 2.4 79 ± 26 -9.4
1.2.32.01. Cytochrome P450 2B6, conformation 2 3ua5 Homo sapiens Endoplasm. reticulum 1 0 4.7 ± 1.1 55 ± 3 -12.9
2.2.41.02. Anthopleurin-B 1apf Anthopleura xanthogrammica Secreted 1 0 6.4 ± 1.3 78 ± 19 -7.1
2.3.06.17. Phosphatidylcholine-sterol acyltransferase, structure 1 4x96 Homo sapiens Secreted 1 0 4.3 ± 1.1 67 ± 4 -7.9
2.1.18.01. Annexin 24 1dk5 Capsicum annuum Eukaryo. plasma 1 0 3.5 ± 1.3 76 ± 18 -4.4
3.1.07.01. Fusion peptide (507-560) of ebolavirus glycoprotein GP2, wild type 2lcy Zaire ebolavirus Viral 1 0 3.5 ± 2.2 59 ± 9 -4.5
2.3.01.07. Chitinase B 1h0i Serratia marcescens Secreted 1 0 3.8 ± 1.4 70 ± 12 -5.2
3.1.13.01. Proadrenomedullin N-20 terminal peptide 2fly Homo sapiens Secreted 1 0 4.8 ± 4.0 88 ± 2 -7.5
2.2.20.01. Pleckstrin homology domain-containing family B member 2 2dhi Mus musculus Eukaryo. plasma 1 0 0.6 ± 1.5 86 ± 14 -2.8
1.2.32.01. Cytochrome P450 2C19 4gqs Homo sapiens Endoplasm. reticulum 1 0 6.4 ± 2.1 71 ± 5 -9.5
3.1.15.01. Leucocin A 1cw6 Leuconostoc gelidum Secreted 1 0 3.6 ± 1.1 90 ± 16 -6.2
3.1.11.06. Parathyroid hormone-related peptide, structure 1 1bzg Homo sapiens Secreted 1 0 6.4 ± 2.2 54 ± 18 -6.4
2.2.20.01. T-lymphoma invasion and metastasis-inducing protein 1, with G-protein RAC2 1foe Mus musculus Eukaryo. plasma 2 0 4.5 ± 1.1 64 ± 7 -6.7
1.2.43.01. Envelope glycoprotein, Zika virus, structure 2 5jhl Zika virus Viral 1 0 5.9 ± 2.8 31 ± 8 -5.5
2.2.13.01. Cellulosomal scaffoldin 2xbt Bacteroides cellulosolvens Secreted 1 0 4.4 ± 0.3 84 ± 14 -5.8
2.4.13.01. Oxysterol-binding protein homolog 4 (KES1), N-terminal helix removed 1zi7 Saccharomyces cerevisiae Golgi 1 0 2.5 ± 0.5 75 ± 8 -6.9
2.4.16.02. Defensin MGD-1 1fjn Mytilus galloprovincialis (Mediterranean mussel) Secreted 1 0 1.5 ± 1.4 43 ± 12 -3.0
2.1.39.01. Viral protein R, full length 1m8l Human immunodeficiency virus type 1 Eukaryo. plasma 1 0 4.7 ± 2.8 64 ± 36 -4.0
1.2.32.01. Cytochrome P450 21-hydroxylase, 21A2 4y8w Homo sapiens Endoplasm. reticulum 1 0 7.2 ± 0.7 59 ± 4 -13.4
2.1.62.02. Subtilosin A 1pxq Bacillus subtilis Secreted 1 0 7.6 ± 0.8 86 ± 3 -9.3
2.2.22.01. Hydrophobin NC2, structure 2 4bwh Neurospora crassa Secreted 1 0 2.7 ± 3.1 85 ± 29 -4.5
1.1.63.01. Type 1 signal peptidase, complex with lipopeptide inhibitor 1t7d Escherichia coli Bact. Gram-neg inner 1 0 3.9 ± 1.0 65 ± 11 -7.6
2.3.06.01. Acetylcholinesterase 1ea5 Torpedo californica Eukaryo. plasma 1 0 1.8 ± 1.1 34 ± 5 -4.7
2.4.38.01. Ups1 transporter-Mdm35 complex, structure 1 4xiz Saccharomyces cerevisiae Mitochon. inner 2 0 2.0 ± 1.7 19 ± 13 -4.1
1.2.22.02. BH3-interacting domain death agonist 2m5i Homo sapiens Mitochon. outer 1 0 6.4 ± 1.5 86 ± 0 -18.8
2.3.06.07. Organic solvent tolerant lipase 42 4fkb Bacillus sp. Secreted 1 0 5.0 ± 0.7 26 ± 3 -6.9
2.1.08.01. Quinohemoprotein alcohol dehydrogenase ADH IIB 1kv9 Pseudomonas putida Bact. Gram-neg outer 1 0 1.7 ± 1.1 77 ± 22 -5.9
1.2.54.01. Glycolate oxidase 1gox Spinacia oleracea Peroxisome 4 0 4.1 ± 0.0 90 ± 0 -18.5
3.1.16.01. Lactococcin-G subunit beta 2jpm Lactococcus lactis Secreted 1 0 6.7 ± 3.3 86 ± 0 -11.2
3.1.02.09. Peptide (659-711) of platelet endothelial cell adhesion molecule 2ky5 Homo sapiens Eukaryo. plasma 1 0 1.0 ± 3.8 89 ± 3 -3.7
2.2.06.01. Beta-lactoglobulin 3nq9 Bos taurus Secreted 1 0 0.5 ± 0.9 89 ± 4 -2.7
2.2.34.02. Beta/omega-theraphotoxin-Tp2a 5tcz Thrixopelma pruriens Secreted 1 0 3.2 ± 0.4 77 ± 5 -4.8
2.4.06.02. Phosphatidylinositol transfer protein alpha isoform 1t27 Rattus norvegicus Eukaryo. plasma 1 0 2.3 ± 1.9 12 ± 12 -4.1
3.1.28.01. Dermatistinctin K 2k9b Phyllomedusa distincta Secreted 1 0 4.6 ± 1.0 90 ± 10 -7.0
3.1.03.09. Peptide (2-11) of ADP-ribosylation factor 6, in aqueous solution 2bao Homo sapiens Eukaryo. plasma 1 0 8.0 ± 1.2 82 ± 8 -5.5
3.4.02.05. Lichenicidin VK21 A2 2kto Bacillus licheniformis Secreted 1 0 6.6 ± 4.2 75 ± 3 -6.9
1.2.03.07. Netrin receptor UNC5B 3g5b Rattus norvegicus Eukaryo. plasma 1 0 1.9 ± 2.5 90 ± 14 -8.5
3.2.05.02. Astexin-4 2n6u Asticcacaulis excentricus Secreted 1 0 2.8 ± 1.1 41 ± 21 -3.8
1.2.17.02. Vesicle-associated membrane protein 8 (VAMP8)- Syntaxin-17 complex 4wy4 Homo sapiens Lysosome 2 0 6.8 ± 1.3 16 ± 5 -6.0
2.2.06.02. Myelin P2 protein 1yiv Equus caballus Eukaryo. plasma 1 0 1.3 ± 1.7 53 ± 11 -4.8
2.1.01.01. Myotoxin 1mc2 Agkistrodon acutus Secreted 1 0 2.4 ± 0.1 80 ± 2 -9.4
3.1.20.01. Alpha4/6-conotoxin TxIC 2m3i Conus lividus Secreted 1 0 5.3 ± 1.0 77 ± 10 -4.9
2.2.26.01. FYVE domain of Vps27 protein 1vfy Saccharomyces cerevisiae Vacuole 1 0 3.7 ± 1.8 24 ± 19 -4.2
2.4.16.11. Tertiapin 1ter Apis mellifera Secreted 1 0 5.1 ± 0.3 80 ± 5 -4.6
3.1.29.01. Cathelicidin LL-37 2k6o Homo sapiens Secreted 1 0 8.1 ± 0.4 86 ± 8 -15.7
3.1.06.02. Class A amphipathic helical peptide 2fq5 Designed proteins Undefined 1 0 6.5 ± 1.4 78 ± 6 -8.8
1.2.15.02. Signal recognition particle receptor 1nrj Saccharomyces cerevisiae Endoplasm. reticulum 2 0 3.9 ± 1.4 82 ± 11 -5.5
3.4.05.01. Cyclosporin 1cwa Tolypocladium inflatum Secreted 1 0 10.2 ± 2.5 82 ± 53 -7.2
1.3.25.01. LukF prepore, hetero-octamer (C+B) 4p1x Staphylococcus aureus Secreted 8 0 4.2 ± 0.2 89 ± 1 -19.4
2.2.26.01. FYVE domain of protein 27 1x4u Homo sapiens Vesicle 1 0 4.3 ± 1.9 38 ± 19 -6.9
2.2.34.02. Kappa-theraphotoxin-Scg1a 1la4 Stromatopelma calceatum griseipes Secreted 1 0 4.6 ± 0.4 80 ± 5 -5.9
1.2.42.01. UDP-2,3-diacylglucosamine hydrolase, lpxH 5k8k Haemophilus influenzae Bact. Gram-neg inner 1 0 9.3 ± 1.8 13 ± 7 -8.7
3.1.03.05. Anchor helix of 1,2-diacylglycerol 3-glucosyltransferase 1z2t Acholeplasma laidlawii Bact. Gram-pos plas. 1 0 9.6 ± 1.6 90 ± 4 -13.7
2.4.25.01. Uncharacterized N-acetyltransferase SSO0209 2x7b Sulfolobus solfataricus Undefined 1 0 3.9 ± 1.5 49 ± 6 -7.6
2.1.08.01. Cytochrome c peroxidase 1nml Marinobacter hydrocarbonoclasticus Bact. Gram-neg inner 1 0 2.2 ± 0.4 83 ± 0 -7.9
2.1.02.01. Seed lipoxygenase-B 2iuj Glycine max Eukaryo. plasma 1 0 1.7 ± 3.0 51 ± 15 -4.8
2.4.16.01. Neurotoxin 1dq7 Buthus tamulus Secreted 1 0 5.9 ± 1.8 88 ± 18 -8.1
3.1.11.02. Glucagon 1kx6 Bos taurus Secreted 1 0 4.4 ± 2.0 70 ± 0 -6.4
3.1.07.05. Nonstructural protein 4b, segment 1751-1780 2jxf Hepatitis C virus Endoplasm. reticulum 1 0 5.6 ± 3.6 85 ± 2 -10.6
2.3.06.08. Pancreatic lipase, complex with colipase 1eth Sus scrofa Secreted 2 0 13.6 ± 0.2 90 ± 3 -13.3
2.2.41.01. Beta-defensin 106 2lwl Homo sapiens Secreted 1 0 4.0 ± 1.5 70 ± 9 -6.4
2.2.11.01. Synaptotagmin-1 1rsy Rattus norvegicus Eukaryo. plasma 1 0 2.5 ± 1.6 24 ± 17 -4.1
1.2.059.01. Serum paraoxonase/arylesterase 1 (PON1) 1v04 Homo sapiens Eukaryo. plasma 1 0 6.7 ± 0.2 61 ± 3 -9.7
1.2.43.05. Major envelope glycoprotein 3duz Autographa californica nuclear polyhedrosis virus Viral 3 0 3.2 ± 0.4 4 ± 6 -9.3
3.1.11.02. Extendin-4 1jrj Heloderma suspectum Secreted 1 0 1.7 ± 0.8 79 ± 8 -5.0
2.2.06.02. Der f 13 allergen 2a0a Dermatophagoides farinae (American house dust mite) Secreted 1 0 3.1 ± 1.3 50 ± 6 -3.5
3.1.28.06. Magainin analogue 1 5cgn Designed proteins Undefined 2 0 6.1 ± 2.7 88 ± 6 -14.0
2.3.06.13. Protein NDRG2 2qmq Mus musculus Eukaryo. plasma 1 0 8.3 ± 2.2 43 ± 14 -9.6
2.3.06.06. Triacylglycerol lipase, closed (inactive) state 3tgl Rhizomucor miehei Secreted 1 0 2.7 ± 1.1 39 ± 7 -5.8
2.2.35.01. Pneumolysin, structure 2 5cr6 Streptococcus pneumoniae Secreted 1 0 4.3 ± 1.9 24 ± 3 -6.4
2.2.06.02. Retinol-binding protein 2 1opb Rattus norvegicus Eukaryo. plasma 1 0 1.9 ± 1.4 25 ± 7 -3.6
1.2.43.07. Glycoprotein C, structure 1 5j81 Puumala virus Viral 3 0 6.0 ± 0.3 0 ± 1 -15.7
2.4.16.03. Potassium channel toxin alpha-KTx 3.1 3odv Androctonus mauretanicus mauretanicus (Scorpion) Secreted 1 0 2.6 ± 0.9 84 ± 5 -5.1
2.2.11.01. Protein kinase C beta 3pfq Rattus norvegicus Eukaryo. plasma 1 0 2.6 ± 0.9 45 ± 5 -3.4
2.4.16.01. Alpha-mammal toxin AaH2 1aho Androctonus australis (Sahara scorpion) Secreted 1 0 1.7 ± 1.0 64 ± 17 -3.4
1.2.33.02. Protoporphyrinogen oxidase 2ivd Myxococcus xanthus Bact. Gram-neg inner 1 0 3.7 ± 0.2 29 ± 2 -8.0
2.2.12.01. Lymphocyte antigen 96 2z64 Mus musculus Eukaryo. plasma 1 0 3.4 ± 1.1 66 ± 4 -7.0
3.1.14.01. Neurokinin B 1p9f Homo sapiens Secreted 1 0 5.8 ± 1.2 89 ± 18 -6.8
2.2.34.07. Asteropsin A 3q8j Asteropus sp. Secreted 1 0 2.8 ± 1.7 75 ± 15 -3.0
2.1.05.02. Farnesyl diphosphate synthase (Geranyltranstransferase) 1rqj Escherichia coli Bact. Gram-neg inner 1 0 3.3 ± 0.7 87 ± 3 -7.7
2.2.06.02. Intestinal fatty acid binding protein, structure 1 1icm Rattus norvegicus Eukaryo. plasma 1 0 3.5 ± 1.5 51 ± 18 -4.3
3.1.03.11. Toll/interleukin-1 receptor domain-containing adapter protein 5t7q Homo sapiens Eukaryo. plasma 1 0 4.6 ± 1.3 75 ± 6 -9.3
1.2.22.01. Apoptosis regulator Bcl-2 1g5m Homo sapiens Mitochon. outer 1 0 4.2 ± 1.4 33 ± 11 -6.6
2.1.24.01. Saposin-like protein Ac-SLP-1 3s64 Ancylostoma caninum Secreted 1 0 4.2 ± 2.2 53 ± 16 -4.5
1.2.17.01. SNARE complex with synaptotagmin1 2n1t Rattus norvegicus Eukaryo. plasma 5 0 2.6 ± 2.9 42 ± 16 -4.6
2.2.12.04. ADP-ribosylation factor-binding protein GGA1 1om9 Homo sapiens Golgi 2 0 6.1 ± 1.0 76 ± 21 -5.1
2.4.16.04. Defensin-like protein 1 1gpt Hordeum vulgare Secreted 1 0 3.1 ± 1.6 28 ± 18 -2.0
2.2.11.01. C2 domain of E3 ubiquitin-protein ligase NEDD4-like 2nsq Homo sapiens Eukaryo. plasma 1 0 1.8 ± 1.1 85 ± 5 -3.3
3.4.03.01. Heat-stable enterotoxin ST-IA/ST-P 1etn Escherichia coli Secreted 1 0 3.0 ± 3.7 33 ± 39 -2.1
2.2.35.01. Pneumolysin, structure 6 5aof Streptococcus pneumoniae Secreted 1 0 2.9 ± 2.4 33 ± 9 -5.7
1.2.54.01. Dihydroorotate dehydrogenase 3i65 Plasmodium falciparum Mitochon. inner 1 0 5.1 ± 1.0 47 ± 6 -13.6
2.3.06.02. Antigen 85c, conformation 1 1va5 Mycobacterium tuberculosis Bact. Gram-pos cell wall 1 0 4.2 ± 0.2 34 ± 3 -8.2
2.2.59.01. Zymogen granule membrane protein 16 3vy7 Homo sapiens Secreted 1 0 3.6 ± 2.1 54 ± 15 -4.6
2.4.49.01. Inositol-pentakisphosphate 2-kinase, structure 3 4axc Arabidopsis thaliana Eukaryo. plasma 1 0 3.2 ± 2.3 68 ± 15 -4.5
2.4.07.01. PX domain of NADH oxidase (p40phox), ligand-bound 1h6h Homo sapiens Endosome 1 0 3.9 ± 2.0 55 ± 14 -6.0
2.2.33.01. Antifungal peptide 2 1p9z Eucommia ulmoides (Hardy rubber tree) Secreted 1 0 3.5 ± 2.0 84 ± 18 -2.9
1.2.01.01. Focal adhesion kinase 1 2j0k Gallus gallus Eukaryo. plasma 1 0 5.0 ± 2.1 36 ± 2 -4.1
2.1.08.01. Cytochrome c6 1f1f Arthrospira maxima Thylakoid 1 0 4.8 ± 1.6 80 ± 15 -3.5
2.1.29.03. Apolipoprotein C-I, peptide 27-83 1ioj Homo sapiens Secreted 1 0 0.6 ± 1.8 80 ± 16 -2.8
2.1.19.01. Kappa-buthitoxin-Tt2b 2li3 Tityus trivittatus Secreted 1 0 0.8 ± 0.7 40 ± 6 -2.7
2.3.16.03. Transducin 1got Bos taurus Eukaryo. plasma 3 0 4.9 ± 1.2 61 ± 8 -7.0
2.1.25.01. Bacteriocin AS-48 1o82 Enterococcus faecalis Secreted 1 0 4.4 ± 1.1 81 ± 13 -7.0
2.4.51.01. Heme acquisition protein HasA, alternative position of heme 3mol Pseudomonas aeruginosa Secreted 1 0 2.9 ± 0.6 40 ± 5 -5.8
2.1.21.05. Matrix protein p15 1hek Equine infectious anemia virus Endosome 1 0 1.0 ± 2.8 76 ± 21 -2.6
2.4.16.09. S-locus pollen protein 1ugl Brassica campestris (Field mustard) Secreted 1 0 1.3 ± 0.6 51 ± 5 -3.4
2.3.16.07. Ras-related protein Rab-9A 1wms Homo sapiens Eukaryo. plasma 1 0 1.9 ± 0.8 48 ± 7 -5.0
2.3.19.01. Toxin B 2bvl Clostridium difficile Secreted 1 0 2.0 ± 1.1 24 ± 14 -4.2
2.2.34.11. Kalata B1, all-D analogue 2jue Designed proteins Undefined 1 0 3.7 ± 1.0 82 ± 17 -5.5
1.2.32.01. Cytochrome P450 2B4, closed state 1 1suo Oryctolagus cuniculus Endoplasm. reticulum 1 0 4.6 ± 1.3 57 ± 4 -14.2
2.1.01.02. Phospholipase A2 1poc Apis mellifera Secreted 1 0 4.0 ± 1.6 60 ± 6 -9.5
3.4.08.02. Somatostatin 2mi1 Homo sapiens Secreted 1 0 5.6 ± 1.5 43 ± 15 -6.2
1.2.51.01. Bis(5-adenosyl)-triphosphatase ENPP4 4lqy Homo sapiens Eukaryo. plasma 1 0 2.9 ± 1.7 81 ± 12 -5.5
2.2.03.01. Saccharopepsin 1fq5 Saccharomyces cerevisiae Vacuole 1 0 3.8 ± 0.8 84 ± 6 -8.1
2.1.29.02. Apolipoprotein A-II, different conformation 1l6l Homo sapiens Secreted 2 0 3.9 ± 1.2 65 ± 8 -10.6
2.2.35.01. Intermedilysin 1s3r Streptococcus intermedius Secreted 1 0 5.3 ± 2.0 61 ± 16 -5.6
2.3.24.01. Phosphatase YidA 1rkq Escherichia coli Undefined 1 0 2.5 ± 1.3 79 ± 9 -4.1
2.2.34.06. Gurmarin 1c4e Gymnema sylvestre Secreted 1 0 3.9 ± 2.6 75 ± 16 -4.8
2.2.34.02. U1-theraphotoxin-Cj1a 2aap Chilobrachys guangxiensis (Chinese earth tiger tarantula) Secreted 1 0 3.6 ± 0.7 82 ± 5 -4.9
3.1.02.01. Fourth intracellular loop of CB1 cannabinoid receptor 2mz2 Designed proteins Eukaryo. plasma 1 0 6.3 ± 1.2 80 ± 6 -7.4
2.1.18.01. Annexin A2 4x9p Bos taurus Vesicle 1 0 2.7 ± 2.4 81 ± 12 -3.5
2.2.34.02. Omega-hexatoxin-Hv2a 1g9p Hadronyche versuta (Blue mountains funnel-web spider) Secreted 1 0 3.0 ± 1.4 78 ± 5 -4.0
1.2.06.01. Spore surface protein Bcla 1wck Bacillus anthracis Bact. Gram-pos plas. 3 0 3.3 ± 0.2 8 ± 5 -8.9
2.2.34.11. Kalata-B5 2kux Oldenlandia affinis Secreted 1 0 4.1 ± 1.0 61 ± 25 -6.6
2.4.06.04. STAR-related bacterial protein 1t17 Caulobacter crescentus Undefined 1 0 3.4 ± 0.7 63 ± 2 -8.1
2.2.11.01. Protein unc-13 homolog A, C2C domain 3kwu Rattus norvegicus Eukaryo. plasma 1 0 3.3 ± 1.9 67 ± 16 -3.6
3.1.08.01. Antifreeze protein A 1wfb Pseudopleuronectes americanus Secreted 1 0 2.8 ± 1.0 88 ± 1 -10.1
3.1.04.07. Peptide (119-148) of antifreeze protein Afp1 2lq2 Glaciozyma antarctica Undefined 1 0 1.7 ± 2.4 84 ± 6 -8.6
2.2.54.01. Non-structural protein 5A 3fqm Hepatitis C virus Endoplasm. reticulum 1 0 4.9 ± 1.1 77 ± 7 -7.5
2.2.41.01. Beta-defensin 3 1kj6 Homo sapiens Secreted 1 0 2.7 ± 1.3 18 ± 18 -5.1
2.2.41.01. Paneth cell-specific alpha-defensin 1 2mxq Equus caballus Secreted 1 0 3.1 ± 0.6 75 ± 5 -7.2
2.2.14.01. Retinoschisin 3jd6 Homo sapiens Eukaryo. plasma 8 0 1.4 ± 0.1 90 ± 0 -19.5
2.2.34.02. Kappa-theraphotoxin-Pg1a 2wh9 Chilobrachys guangxiensis (Chinese earth tiger tarantula) Secreted 1 0 6.4 ± 1.0 57 ± 6 -9.2
3.2.10.01. PawS derived peptide 22 2ndl Designed proteins Undefined 1 0 8.6 ± 2.1 64 ± 9 -5.3
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 3 3ksw Trypanosoma cruzi Endoplasm. reticulum 1 0 8.0 ± 6.7 61 ± 6 -9.1
2.3.06.07. Lipase 1cvl Chromobacterium viscosum Secreted 1 0 9.9 ± 1.0 53 ± 9 -8.7
2.2.34.01. Conotoxin muOxi-GVIIJ 2n8h Conus geographus (Geography cone) Secreted 1 0 4.0 ± 1.0 43 ± 5 -4.1
1.2.43.01. Envelope glycoprotein, Dengue virus type 2, structure 3 4ut6 Dengue virus Viral 1 0 6.2 ± 3.0 19 ± 15 -5.4
2.1.60.03. Cysteine-rich venom protein 1rc9 Trimeresurus stejnegeri Secreted 1 0 3.9 ± 0.7 73 ± 5 -5.1
2.2.20.01. Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1 4a6f Saccharomyces cerevisiae Eukaryo. plasma 1 0 1.9 ± 1.6 62 ± 4 -6.1
2.4.16.01. Beta-insect depressant toxin LqhIT2 2i61 Leiurus quinquestriatus hebraeus Secreted 1 0 4.3 ± 1.6 80 ± 21 -3.7
2.2.06.02. Prostaglandin-H2 D-isomerase, apo form 4ors Homo sapiens Endoplasm. reticulum 1 0 2.6 ± 0.8 71 ± 7 -3.7
3.1.20.01. alpha-conotoxin PNI1 1pen Conus pennaceus Secreted 1 0 5.2 ± 1.7 27 ± 19 -3.8
2.2.35.01. Intermedilysin - CD59 receptor complex 5imt Streptococcus intermedius Secreted 4 0 8.3 ± 0.9 10 ± 26 -9.7
2.2.06.02. Cellular retinol-binding protein III 1ggl Homo sapiens Eukaryo. plasma 1 0 3.3 ± 1.9 53 ± 16 -4.9
2.3.02.02. Phosphatidylinositol-specific phospholipase C 4f2t Staphylococcus aureus Secreted 1 0 4.3 ± 0.5 65 ± 5 -7.8
2.2.45.01. Pertactin, complex with phage tail protein 2iou Bordetella bronchiseptica Bact. Gram-neg outer 4 0 3.9 ± 1.2 82 ± 2 -8.2
2.4.13.01. Oxysterol-binding protein homolog 4, conformation 3 4jch Saccharomyces cerevisiae Golgi 1 0 1.2 ± 0.2 88 ± 1 -6.0
3.1.28.04. Phylloseptin-2 2jpy Phyllomedusa hypochondrialis (Orange-legged leaf frog) Secreted 1 0 5.8 ± 1.3 86 ± 4 -15.2
3.1.04.02. Major prion protein, peptide 110-136 2lbg Homo sapiens Eukaryo. plasma 1 0 5.0 ± 7.0 86 ± 1 -9.3
2.3.06.11. Monoglyceride lipase 4zwn Saccharomyces cerevisiae Endoplasm. reticulum 1 0 4.3 ± 1.7 11 ± 17 -7.5
2.1.01.01. Snake phospholipase A2, group I, acidic 1 1gp7 Ophiophagus hannah Secreted 1 0 4.6 ± 1.0 84 ± 12 -5.8
2.4.34.01. Ice-structuring protein RD1 1ucs Lycodichthys dearborni Secreted 1 0 2.2 ± 1.0 67 ± 9 -5.5
2.2.27.01. Kinase supressor of Ras, Ksr 1kbf Mus musculus Eukaryo. plasma 1 0 1.8 ± 1.0 63 ± 11 -5.4
2.3.21.01. Protein-tyrosine phosphatase, mitochondrial 1 3rgq Mus musculus Mitochon. inner 1 0 1.7 ± 0.7 54 ± 7 -4.9
2.2.41.01. Neutrophil defensin 3 1dfn Homo sapiens Secreted 2 0 1.4 ± 1.3 87 ± 15 -3.9
2.1.20.01. Osteocalcin 4mzz Bos taurus Secreted 1 0 1.8 ± 1.1 43 ± 8 -3.0
2.2.06.02. Intestinal fatty acid binding protein, structure 3 2mji Homo sapiens Eukaryo. plasma 1 0 3.3 ± 1.0 57 ± 14 -4.1
2.4.07.01. PX domain of sorting nexin-17 (SNX17) 3fog Homo sapiens Endosome 1 0 3.4 ± 1.0 69 ± 12 -4.9
2.2.41.01. Pelovaterin 2jr3 Pelodiscus sinensis (Chinese softshell turtle) Secreted 1 0 3.2 ± 2.3 58 ± 5 -3.5
2.2.20.01. Ras-specific guanine nucleotide-releasing factor 2dtc Mus musculus Eukaryo. plasma 1 0 2.7 ± 0.4 64 ± 9 -6.3
1.2.32.01. Cytochrome P450 120a1, different conformation 2ve3 Synechocystis sp. Thylakoid 1 0 5.2 ± 1.5 52 ± 15 -6.8
2.3.02.02. Phosphatidylinositol-specific phospholipase C 1t6m Bacillus thuringiensis Secreted 1 0 3.8 ± 1.4 89 ± 13 -4.9
2.1.24.01. Saposin C (peptide 311-391) 1sn6 Homo sapiens Lysosome 1 0 4.8 ± 1.1 82 ± 7 -7.1
2.2.20.01. Oxysterol binding protein-related protein 11 2d9x Homo sapiens Eukaryo. plasma 1 0 1.4 ± 1.7 55 ± 18 -3.1
2.1.01.01. Snake phospholipase A2, group II, neutral 1bjj Agkistrodon halys pallas Secreted 1 0 2.6 ± 0.7 86 ± 5 -8.4
3.2.01.06. Symmetrical θ-defensin, BTD-2 2lye Macaca mulatta Secreted 1 0 0.4 ± 2.9 80 ± 22 -1.5
3.1.07.02. Juxtamembrane peptide (651-677) of protein gp160 2me2 Human immunodeficiency virus type 1 Endosome 1 0 7.0 ± 1.1 82 ± 7 -13.1
3.1.21.01. Cecropin A (1-8) - magainin (1-12) hybrid 1d9j Hyalophora cecropia (Cecropia moth) Secreted 1 0 2.3 ± 0.9 90 ± 10 -6.4
1.1.26.07. STAS domain of anion permease 3oiz Rhodobacter sphaeroides Bact. Gram-neg inner 1 0 3.9 ± 0.4 18 ± 5 -5.4
1.2.37.01. ADP-ribosyl cyclase 1 3f6y Homo sapiens Eukaryo. plasma 1 0 2.5 ± 2.4 51 ± 9 -6.3
2.1.01.01. Phospholipase A2 bothropstoxin-2 2oqd Bothrops jararacussu Secreted 1 0 6.0 ± 0.6 85 ± 4 -7.8
3.1.28.05. Aurein 1.2 analogue 2f3a Designed proteins Undefined 1 0 3.0 ± 1.6 88 ± 24 -11.7
1.2.32.01. Cytochrome P450 2D6, conformation 4 4xry Homo sapiens Endoplasm. reticulum 1 0 8.8 ± 3.0 41 ± 2 -15.5
2.1.03.01. Alpha-toxin 1olp Clostridium absonum Secreted 1 0 2.8 ± 1.8 62 ± 11 -6.1
3.2.05.03. Bicyclic peptide BI-32169 3njw Streptomyces sp. Secreted 1 0 6.1 ± 0.3 86 ± 3 -9.9
2.2.34.01. Omega-conotoxin MVIIA 1mvi Conus magus Secreted 1 0 4.7 ± 1.9 68 ± 14 -4.0
2.3.06.05. Copper inducible hydrolase YahD 3og9 Lactococcus lactis Bact. Gram-pos plas. 1 0 1.4 ± 1.1 33 ± 10 -4.0
2.1.01.01. Snake phospholipase A2, ammodytoxin C, group II 3g8h Vipera ammodytes ammodytes Secreted 1 0 4.1 ± 1.1 81 ± 8 -9.7
2.4.27.01. Gamma-glutamylaminecyclotransferase 1vkb Mus musculus Undefined 1 0 2.3 ± 0.7 72 ± 4 -4.8
1.2.32.01. Sterol 14-alpha-demethylase (CYP51) 3g1q Trypanosoma brucei Endoplasm. reticulum 1 0 8.1 ± 1.5 62 ± 12 -10.8
2.2.34.02. Huwentoxin-1 1qk6 Haplopelma hainanum (Chinese bird spider) Secreted 1 0 2.7 ± 1.5 88 ± 11 -5.1
2.3.06.06. Lipase 3zpx Ustilago maydis Secreted 1 0 5.8 ± 0.8 88 ± 1 -14.0
2.3.12.01. Myotubularin-related protein 1 5c16 Homo sapiens Eukaryo. plasma 1 0 4.8 ± 0.7 70 ± 16 -5.3
1.2.43.01. Envelope glycoprotein 1urz Tick-borne encephalitis virus Viral 3 0 5.9 ± 0.9 1 ± 8 -10.3
3.1.20.01. Alpha-conotoxin S1 1qmw Conus striatus Secreted 1 0 2.8 ± 2.6 43 ± 17 -2.5
3.1.07.03. Hemagglutinin, fusion peptide 346-365, G1S 1xop Influenza virus Viral 1 0 6.3 ± 0.5 70 ± 13 -11.0
3.1.13.01. Islet amyloid polypeptide, peptide 38-74 2kj7 Rattus norvegicus Secreted 1 0 3.9 ± 4.3 90 ± 4 -4.2
2.3.06.19. PHB depolymerase PhaZ7, structure 1 2x5x Pseudomonas lemoignei Secreted 1 0 4.1 ± 3.0 54 ± 41 -5.6
3.1.05.03. Peptide F 1pef Designed proteins Undefined 1 0 6.6 ± 1.3 85 ± 10 -7.8
2.3.09.01. Cytidylyltransferase 3hl4 Rattus norvegicus Eukaryo. plasma 2 0 2.7 ± 4.0 74 ± 8 -3.2
3.1.07.08. Peptide of outer capsid glycoprotein VP7 (266-326) 2lm7 Rotavirus A Endoplasm. reticulum 1 0 10.2 ± 1.5 76 ± 0 -13.6
2.2.40.01. Neurotoxin III 1ans Anemonia sulcata Secreted 1 0 3.3 ± 1.4 50 ± 15 -4.7
2.3.06.06. Lipase 4l3w Rhizopus chinensis Secreted 1 0 3.2 ± 0.7 31 ± 2 -6.5
2.1.18.01. Annexin GH1 1n00 Gossypium hirsutum Eukaryo. plasma 1 0 1.5 ± 2.0 70 ± 17 -3.7
1.2.60.01. Dysferlin, dysferlin domain 4cah Homo sapiens Eukaryo. plasma 1 0 5.5 ± 1.4 23 ± 5 -6.0
3.1.07.01. Fusion peptide (507-560) of ebolavirus glycoprotein GP2, mutant 1 2mb1 Zaire ebolavirus Viral 1 0 3.8 ± 1.8 53 ± 34 -4.5
2.3.01.04. Hyaluronidase 1fcq Apis mellifera Secreted 1 0 1.9 ± 2.7 36 ± 13 -3.7
3.1.13.01. Calcitonin 2jxz Homo sapiens Secreted 1 0 5.5 ± 1.1 72 ± 6 -11.5
2.2.20.01. Pleckstrin homology domain-containing family A member 5 (PLEKHA5) 2dkp Homo sapiens Eukaryo. plasma 1 0 3.0 ± 0.9 64 ± 6 -3.9
2.2.20.01. PH domain of oxysterol-binding protein homolog 3, fused with lysozyme 4iap Saccharomyces cerevisiae Endoplasm. reticulum 1 0 2.5 ± 2.3 81 ± 3 -3.6
3.1.15.01. Sakacin P 1ohm Lactobacillus sake Secreted 1 0 1.8 ± 1.1 90 ± 11 -4.4
3.1.11.06. Parathyroid hormone-related peptide, structure 2 3ffd Homo sapiens Secreted 1 0 2.2 ± 1.5 89 ± 3 -5.1
2.2.20.01. Dual adaptor of phosphotyrosine and 3-phosphoinositides 1fao Homo sapiens Eukaryo. plasma 1 0 2.4 ± 2.0 59 ± 19 -3.9
1.2.43.01. Envelope glycoprotein, Zika virus, structure 3 5jhm Zika virus Viral 1 0 6.6 ± 2.4 11 ± 8 -4.9
1.2.55.01. Neutral ceramidase, structure 1 2zws Pseudomonas aeruginosa Secreted 1 0 3.1 ± 2.4 77 ± 3 -8.1
2.3.14.01. Phosphatidylinositol transfer protein sec14p 1aua Saccharomyces cerevisiae Golgi 1 0 8.8 ± 1.1 75 ± 10 -14.3
2.4.16.02. Defensin 2nz3 Anopheles gambiae (African malaria mosquito) Secreted 1 0 6.7 ± 1.3 84 ± 10 -7.4
3.2.06.01. Plasmatocyte-spreading peptide PSP1 1b5n Pseudoplusia includens Secreted 1 0 3.1 ± 1.2 87 ± 16 -3.7
2.4.51.01. Heme acquisition protein HasA, apoprotein, structure 2 5iqw Pseudomonas aeruginosa Secreted 1 0 1.5 ± 0.2 24 ± 5 -4.8
1.1.63.01. Type 1 signal peptidase, complex with inhibitor 1b12 Escherichia coli Bact. Gram-neg inner 1 0 5.4 ± 1.8 88 ± 7 -5.1
2.3.06.01. Acetylcholinesterase 1n5m Mus musculus Eukaryo. plasma 1 0 3.7 ± 1.3 28 ± 6 -6.1
1.2.54.01. Dihydroorotate dehydrogenase 1uum Rattus norvegicus Mitochon. inner 1 0 6.9 ± 0.4 50 ± 6 -6.3
2.2.46.01. Low molecular mass 30 kDa lipoprotein 19G1 4iy8 Bombyx mori Secreted 1 0 4.3 ± 1.2 31 ± 8 -4.2
2.2.21.04. Cytolethal distending toxin complex 1sr4 Haemophilus ducreyi Bact. Gram-neg outer 3 0 1.8 ± 1.5 34 ± 7 -5.0
2.1.14.01. Peroxisomal targeting signal 1 receptor, complex with sterol carrier protein 2 2c0l Homo sapiens Peroxisome 2 0 3.1 ± 2.5 85 ± 35 -5.5
2.2.34.05. Tachystatin-B2 2dcw Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 3.4 ± 0.8 2 ± 6 -10.1
1.2.03.03. Myelin protein P0 3oai Homo sapiens Eukaryo. plasma 1 0 2.2 ± 1.2 72 ± 6 -5.8
2.2.06.01. Apolipoprotein D 2hzq Homo sapiens Secreted 1 0 4.5 ± 0.9 69 ± 5 -7.8
3.1.29.01. KR-12 from cathelicidin LL-37 2na3 Homo sapiens Secreted 1 0 3.7 ± 0.7 84 ± 8 -8.3
2.4.06.02. Phosphatidylinositol transfer protein alpha isoform 1uw5 Homo sapiens Eukaryo. plasma 1 0 4.3 ± 1.5 18 ± 16 -5.4
3.1.07.04. Juxtamembrane peptide of hepatis C virus E1 glycoprotein (314-342) 2knu Hepatitis C virus Endosome 1 0 5.3 ± 0.9 82 ± 6 -5.9
3.4.02.05. Lichenicidin VK21 A1 2ktn Bacillus licheniformis Secreted 1 0 7.0 ± 1.5 77 ± 13 -5.9
2.1.51.01. Protein farnesyltransferase/geranylgeranyltransferase 1jcr Rattus norvegicus Eukaryo. plasma 2 0 3.2 ± 2.3 56 ± 5 -5.6
2.1.01.01. Phospholipase A2 homolog, taipoxin beta chain 3vbz Oxyuranus scutellatus scutellatus Secreted 1 0 2.8 ± 0.7 87 ± 2 -7.7
2.3.06.17. Group XV phospholipase A2 4x90 Homo sapiens Lysosome 1 0 1.9 ± 0.5 56 ± 1 -7.3
2.4.06.02. Phosphatidylinositol transfer protein beta isoform 2a1l Rattus norvegicus Eukaryo. plasma 1 0 4.7 ± 1.7 36 ± 17 -4.3
2.1.01.01. Snake phospholipase A2, group II, hypotensive 1umv Bothrops jararacussu Secreted 1 0 5.1 ± 0.7 87 ± 4 -8.6
3.1.20.01. Conotoxin Ar1446 2m61 Conus araneosus Secreted 1 0 1.8 ± 0.8 82 ± 6 -4.0
2.1.14.03. Vesicular transport protein sec17 1qqe Saccharomyces cerevisiae Vacuole 1 0 5.2 ± 6.1 17 ± 15 -6.2
3.4.04.02. Surfactin 2npv Bacillus subtilis Secreted 1 0 11.3 ± 2.1 55 ± 13 -11.3
2.1.02.01. 9R-lipoxygenase 5ek8 Synechococcus sp. Bact. Gram-neg inner 1 0 4.0 ± 0.7 78 ± 6 -12.2
3.2.01.08. Lactoferricin B, peptide 38-49 1y58 Bos taurus Secreted 1 0 2.9 ± 1.4 86 ± 18 -3.7
3.1.06.01. Apolipoprotein A-I, peptide 190-209 1odq Homo sapiens Undefined 1 0 3.3 ± 0.7 87 ± 4 -7.1
2.3.14.01. Neurofibromin 2d4q Homo sapiens Eukaryo. plasma 1 0 1.6 ± 2.0 34 ± 19 -3.3
1.2.32.01. Cytochrome P450 2D6, conformation 1 2f9q Homo sapiens Endoplasm. reticulum 1 0 7.0 ± 1.8 29 ± 10 -12.0
2.2.24.01. Vitelline membrane outer protein-I 1vmo Gallus gallus Secreted 1 0 3.0 ± 2.0 51 ± 12 -5.3
2.2.12.01. Niemann-Pick type C2 protein 3web Camponotus japonicus Secreted 1 0 5.4 ± 0.3 73 ± 4 -7.6
2.2.26.01. FYVE domain of protein 19 1wfk Mus musculus Vesicle 1 0 4.3 ± 1.8 17 ± 16 -5.5
2.2.34.02. Kappa-sparatoxin-Hv1b 1emx Heteropoda venatoria (Brown huntsman spider) Secreted 1 0 3.4 ± 0.9 57 ± 8 -4.8
1.1.56.01. Inner membrane protein YejM, strain LT2 5i5f Salmonella typhimurium Bact. Gram-neg inner 1 0 3.7 ± 2.4 62 ± 11 -4.9
2.2.04.01. Retinoid isomerohydrolase, conformation 2 4f2z Bos taurus Eukaryo. plasma 1 0 3.7 ± 0.9 56 ± 2 -9.2
1.2.32.01. Fatty-acid peroxygenase 1izo Bacillus subtilis Bact. Gram-pos plas. 1 0 1.2 ± 0.3 76 ± 1 -5.5
2.1.26.01. Colicin-E1 2i88 Escherichia coli Secreted 1 0 1.1 ± 3.3 58 ± 37 -1.7
2.4.35.01. Catalase-related protein 3e4w Mycobacterium paratuberculosis Undefined 2 0 9.6 ± 1.3 49 ± 6 -13.4
1.1.49.01. ATP-dependent zinc metalloprotease FtsH 1lv7 Escherichia coli Bact. Gram-neg inner 1 0 2.1 ± 1.0 80 ± 11 -4.3
2.1.18.01. Annexin IV 2zoc Homo sapiens Eukaryo. plasma 1 0 3.4 ± 1.1 82 ± 7 -7.6
2.4.06.01. Acyl-coenzyme A thioesterase 11 3fo5 Homo sapiens Endoplasm. reticulum 1 0 2.3 ± 1.4 57 ± 7 -3.9
2.4.16.01. Toxin VII 1npi Tityus serrulatus Secreted 1 0 4.6 ± 1.5 52 ± 16 -6.7
2.2.34.06. Ginsentide 2ml7 Panax ginseng Secreted 1 0 7.6 ± 1.1 54 ± 8 -7.7
3.1.09.01. ICP47 protein, active domain (1-34) 1qlo Human herpesvirus Endoplasm. reticulum 1 0 8.6 ± 0.8 58 ± 8 -10.2
2.2.30.01. Elafin, complex with elastase from Pig 1fle Homo sapiens Secreted 2 0 4.4 ± 2.0 52 ± 11 -6.3
2.4.34.01. Type III antifreeze protein nfeAFP11 2lx2 Zoarces elongatus Secreted 1 0 5.3 ± 1.0 53 ± 5 -7.0
2.2.11.01. Synaptotagmin-1, C2A domain (Calcium bound) 1byn Rattus norvegicus Eukaryo. plasma 1 0 3.8 ± 1.6 32 ± 19 -4.7
2.4.50.01. Matrix protein, Indiana virus 1lg7 Vesicular stomatitis virus Viral 1 0 2.7 ± 0.4 82 ± 2 -7.3
3.1.11.02. Extendin-4, with extracellular domain of glucagon-like peptide-1 GPCR 3c59 Heloderma suspectum Secreted 2 0 1.9 ± 0.2 64 ± 0 -6.5
2.2.06.01. Allergen Bos d 2 1bj7 Bos taurus Secreted 1 0 3.1 ± 1.3 50 ± 6 -3.5
3.1.28.06. Magainin analogue 2 5cgo Designed proteins Undefined 2 0 3.8 ± 0.9 89 ± 2 -10.8
2.3.06.13. Protein Ndr1 2xmr Homo sapiens Eukaryo. plasma 1 0 8.2 ± 2.6 50 ± 10 -8.8
2.3.06.06. Triacylglycerol lipase, open (active) state 4tgl Rhizomucor miehei Secreted 1 0 8.8 ± 0.9 64 ± 11 -18.2
2.2.35.01. Pneumolysin, structure 3 5cr8 Streptococcus pneumoniae Secreted 1 0 4.7 ± 1.2 37 ± 6 -9.3
2.2.12.02. Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2 1ds6 Homo sapiens Eukaryo. plasma 2 0 2.8 ± 1.0 82 ± 6 -5.5
1.2.43.07. Glycoprotein C, structure 2 5j9h Puumala virus Viral 3 0 4.8 ± 0.3 2 ± 4 -12.9
2.4.29.01. Enterotoxin type A 1dyq Staphylococcus aureus Secreted 1 0 3.9 ± 0.5 82 ± 6 -6.8
2.2.27.01. Ras association domain-containing protein 5, C1 domain 1rfh Mus musculus Eukaryo. plasma 1 0 1.4 ± 0.9 16 ± 6 -3.7
2.4.16.01. Alpha-insect toxin Lqq3 1lqq Leiurus quinquestriatus quinquestriatus Secreted 1 0 0.8 ± 1.0 80 ± 6 -3.3
1.2.04.01. Integrin beta-3, 742-788, in micelles 1s4x Homo sapiens Eukaryo. plasma 1 0 6.9 ± 1.0 18 ± 10 -5.8
3.4.08.01. Neurotensin 2oyv Homo sapiens Secreted 1 0 7.3 ± 2.6 67 ± 17 -5.3
2.2.34.06. Inhibitor cystine knot peptide MCh-1 2m2q Momordica charantia Secreted 1 0 6.9 ± 0.7 74 ± 7 -6.3
2.2.05.01. Amicyanin 1sfd Paracoccus denitrificans Bact. Gram-neg inner 1 0 3.5 ± 0.8 49 ± 10 -4.0
2.2.06.02. Intestinal fatty acid binding protein, structure 1 1kzw Homo sapiens Eukaryo. plasma 1 0 2.9 ± 1.3 61 ± 12 -4.1
2.1.64.01. Envelope glycoprotein, ligand-binding domain 2 5fb7 Talaromyces marneffei Eukaryo. plasma 1 0 3.2 ± 2.5 64 ± 10 -2.9
1.2.33.02. Monoamine oxidase B, monomer 1s3e Homo sapiens Mitochon. outer 2 0 7.3 ± 0.6 37 ± 1 -14.2
2.4.04.01. Beta-hemolysin 3i48 Staphylococcus aureus Secreted 1 0 2.8 ± 0.8 57 ± 5 -5.1
2.1.15.02. ADP-ribosylation factor-binding protein GGA2 1mhq Homo sapiens Golgi 1 0 4.2 ± 1.2 74 ± 5 -4.1
2.4.16.04. Defensin NaD1 1mr4 Nicotiana tabacum Secreted 1 0 4.2 ± 1.8 59 ± 11 -3.0
2.3.16.06. ADP-ribosylation factor-like protein 1 2x77 Leishmania major Eukaryo. plasma 1 0 1.6 ± 1.4 80 ± 5 -3.6
3.4.04.01. Tsushimycin 1w3m Streptomyces pseudogriseolus Secreted 1 0 9.5 ± 2.1 54 ± 24 -8.6
2.4.16.04. Defensin NsD7 5kk4 Nicotiana tabacum Secreted 2 0 3.5 ± 0.7 80 ± 4 -5.6
2.4.05.01. Sterol carrier protein 2 2cx7 Thermus thermophilus Bact. Gram-neg inner 1 0 4.7 ± 1.3 73 ± 13 -6.9
2.2.11.01. Phosphatidylinositide 3-kinase C2 alpha 2b3r Mus musculus Eukaryo. plasma 2 0 1.4 ± 1.5 88 ± 16 -4.4
2.3.05.01. Flavoprotein-ubiquinone oxydoreductase 2gmh Sus scrofa Mitochon. inner 1 0 7.2 ± 0.8 38 ± 4 -18.5
2.3.06.02. Antigen 85a 1sfr Mycobacterium tuberculosis Bact. Gram-pos cell wall 1 0 2.8 ± 0.8 27 ± 9 -7.5
2.2.11.01. Perforin 3w57 Psetta maxima Secreted 1 0 3.8 ± 1.2 38 ± 5 -7.8
3.1.02.01. C-terminal helix of MCP-1 receptor 2mlo Homo sapiens Eukaryo. plasma 1 0 6.0 ± 1.6 86 ± 8 -10.1
2.2.26.01. Early endosome antigen 1 (EEA1), monomer 1hyi Homo sapiens Endosome 1 0 3.0 ± 2.0 24 ± 17 -3.5
3.2.01.03. Androctonin 1cz6 Androctonus australis (Sahara scorpion) Secreted 1 0 1.5 ± 2.8 89 ± 16 -3.2
2.3.10.07. Lipopolysaccharide biosynthesis protein RfaG 2iw1 Escherichia coli Bact. Gram-neg inner 1 0 3.7 ± 3.1 85 ± 8 -6.0
2.2.03.01. Beta-secretase 1 2wf1 Homo sapiens Eukaryo. plasma 1 0 1.7 ± 1.2 61 ± 6 -4.9
2.1.08.01. Cytochrome c6 1ls9 Cladophora glomerata Thylakoid 1 0 4.1 ± 1.0 70 ± 14 -2.9
2.2.41.01. Beta-defensin 2 1fd3 Homo sapiens Secreted 1 0 5.2 ± 1.2 80 ± 12 -9.1
2.1.19.01. Ribosome-inactivating protein luffin P1 2l37 Luffa aegyptiaca Secreted 1 0 1.3 ± 0.9 80 ± 7 -3.3
2.3.05.02. Sulfide-quinone reductase 3h28 Aquifex aeolicus Bact. Gram-neg inner 3 0 2.4 ± 0.1 90 ± 0 -19.4
2.1.09.01. Major allergen I 1puo Felis catus Secreted 1 0 3.7 ± 0.8 58 ± 6 -7.8
2.4.51.01. Heme acquisition protein HasA 3ell Pseudomonas aeruginosa Secreted 1 0 3.3 ± 0.4 18 ± 8 -5.5
3.1.07.01. Fusion peptide (84-101) from E1 envelope glycoprotein 2rsw Chikungunya virus Endosome 1 0 8.3 ± 0.6 57 ± 7 -6.9
3.1.29.01. Ovispirin-1 1hu5 Ovis aries Secreted 1 0 5.7 ± 0.5 81 ± 1 -9.2
2.3.16.07. GTP-binding protein Rheb 1xtq Homo sapiens Eukaryo. plasma 1 0 2.6 ± 0.6 76 ± 20 -5.1
2.3.19.01. Cytotoxin L 2vkh Clostridium sordellii Secreted 1 0 1.4 ± 2.0 51 ± 17 -4.5
3.4.07.02. Compstatin 1a1p Designed proteins Undefined 1 0 3.4 ± 1.9 72 ± 18 -5.6
1.2.32.01. Cytochrome P450 2C8 1pq2 Homo sapiens Endoplasm. reticulum 1 0 3.8 ± 1.8 65 ± 9 -8.6
2.1.01.03. Prokaryotic phospholipase A2 1kp4 Streptomyces violaceoruber Secreted 1 0 2.4 ± 1.3 42 ± 13 -5.6
2.1.44.01. Sublancin-168 2mij Bacillus subtilis Secreted 1 0 4.0 ± 5.0 83 ± 0 -4.2
1.2.04.01. Integrin alpha-L, cytoplasmic domain (1113-1170) 2k8o Homo sapiens Eukaryo. plasma 1 0 2.2 ± 0.7 65 ± 3 -3.7
2.2.03.01. Plasmepsin-2 1lf2 Plasmodium falciparum Vacuole 1 0 6.2 ± 0.4 76 ± 3 -11.0
2.1.29.04. Apolipoprotein C-II 1i5j Homo sapiens Secreted 1 0 4.4 ± 2.3 42 ± 3 -9.9
2.2.35.01. Anthrolysin O 3cqf Bacillus anthracis Secreted 1 0 2.8 ± 1.0 75 ± 1 -5.8
2.3.24.01. Phosphonoacetaldehyde hydrolase 1rdf Bacillus cereus Undefined 1 0 4.3 ± 0.9 68 ± 4 -5.1
1.2.32.01. Cytochrome P450 1A2 2hi4 Homo sapiens Endoplasm. reticulum 1 0 6.9 ± 1.0 66 ± 9 -16.2
2.2.34.08. Agouti-related protein 1mr0 Homo sapiens Secreted 1 0 3.1 ± 2.0 37 ± 18 -5.6
2.2.34.02. S64 4b2v Sicarius dolichocephalus Secreted 1 0 2.5 ± 0.5 71 ± 2 -4.3
2.3.01.05. 1,3-beta-glucanosyltransferase, structure 3 5fih Saccharomyces cerevisiae Eukaryo. plasma 1 0 2.5 ± 0.6 89 ± 1 -5.3
3.1.03.10. Lipid droplet anchoring peptide of CGI-58 5a4h Mus musculus Vesicle 1 0 3.9 ± 1.2 37 ± 7 -7.5
2.2.34.02. Beta-hexatoxin-Mg1a 2gx1 Macrothele gigas (Spider) Secreted 1 0 5.6 ± 2.6 51 ± 9 -4.6
2.2.47.01. Glycoside hydrolase family 9 protein 1wzx Clostridium thermocellum Bact. Gram-pos plas. 1 0 7.4 ± 2.0 77 ± 6 -4.1
2.2.34.11. Violacin 1 2fqa Viola odorata Secreted 1 0 2.4 ± 3.4 70 ± 46 -4.0
1.1.55.01. Bacterial polysaccharide co-polymerase FepE 3b8n Escherichia coli Bact. Gram-neg inner 9 0 1.6 ± 0.1 1 ± 0 -20.3
2.2.11.01. Rabphilin-3A, C2B domain 2cm5 Rattus norvegicus Eukaryo. plasma 1 0 2.5 ± 2.0 56 ± 14 -4.1
3.2.01.06. Theta-defensin 1 (RTD-1) 1hvz Macaca mulatta Secreted 1 0 0.8 ± 1.0 89 ± 4 -2.9
2.2.34.11. Melanocortin agonist based on kalata-B1 2lur Designed proteins Undefined 1 0 6.5 ± 1.0 74 ± 21 -6.7
2.3.06.11. Monoglyceride lipase MGLL, open ligand-free conformation 3jw8 Homo sapiens Eukaryo. plasma 1 0 8.1 ± 1.3 11 ± 9 -11.3
1.2.32.01. Steroid 21-hydroxylase (P450 C21) 3qz1 Bos taurus Endoplasm. reticulum 1 0 5.9 ± 1.6 72 ± 3 -10.4
2.2.41.01. Beta-defensin 7 1e4t Mus musculus Secreted 1 0 3.6 ± 1.4 13 ± 19 -5.2
3.4.10.01. Methanobactin 4oz7 Methylosinus sporium Secreted 1 0 2.5 ± 1.4 86 ± 15 -4.5
2.1.11.01. Spectrin alpha chain 2spc Drosophila melanogaster Eukaryo. plasma 2 0 4.3 ± 0.8 87 ± 11 -6.2
3.1.07.03. Hemagglutinin, fusion peptide 346-365, H1 subtype 2kxa Influenza virus Viral 1 0 10.3 ± 1.9 84 ± 13 -14.5
2.2.39.01. Beta-cardiotoxin 3plc Ophiophagus hannah Secreted 1 0 4.6 ± 1.1 73 ± 4 -6.7
3.1.11.02. Gastric inhibitory polypeptide, complex with N-terminal domain of GPCR 2qkh Homo sapiens Secreted 2 0 6.3 ± 3.2 64 ± 23 -5.9
3.1.05.03. Lavracin 2n8d Designed proteins Undefined 1 0 5.1 ± 1.2 89 ± 13 -5.7
2.2.06.02. Fatty acid-binding protein 2k62 Gallus gallus Eukaryo. plasma 1 0 0.0 ± 2.9 82 ± 13 -2.0
1.2.32.01. Cytochrome P450 2B4, closed state 2 2q6n Oryctolagus cuniculus Endoplasm. reticulum 1 0 5.5 ± 0.4 55 ± 2 -13.0
2.3.06.07. Lipase L1 1ku0 Bacillus stearothermophilus Secreted 1 0 4.0 ± 0.6 23 ± 9 -8.9
2.1.25.05. Aureocin A53 2n8o Staphylococcus aureus Secreted 1 0 0.8 ± 0.4 78 ± 6 -2.6
2.4.35.01. 8R-Lipoxygenase, N-terminal domain 1u5u Plexaura homomalla Eukaryo. plasma 1 0 3.1 ± 0.3 72 ± 3 -10.4
1.2.43.01. Envelope glycoprotein, Dengue virus type 2, structure 4 4ut9 Dengue virus Viral 1 0 5.5 ± 2.8 31 ± 8 -5.1
2.4.53.01. Resistin 1rfx Mus musculus Secreted 3 0 3.4 ± 1.2 10 ± 6 -8.7
2.4.16.04. Defensin-like protein 195 1jxc Arabidopsis thaliana Secreted 1 0 4.0 ± 1.5 21 ± 20 -3.9
2.2.06.02. Prostaglandin-H2 D-isomerase, apo form, mutant 4os0 Homo sapiens Endoplasm. reticulum 1 0 2.4 ± 1.0 77 ± 4 -3.1
3.1.20.01. alpha-conotoxin PNIB 1akg Conus pennaceus Secreted 1 0 4.2 ± 1.4 42 ± 19 -5.9
2.2.35.01. Intermedilysin - CD59 receptor complex, trapped toxin 5imy Streptococcus intermedius Secreted 2 0 4.1 ± 1.6 63 ± 7 -7.5
2.2.06.02. Retinoid-binding protein 7 1lpj Homo sapiens Eukaryo. plasma 1 0 2.6 ± 1.1 44 ± 13 -6.0
2.2.45.01. Pertactin autotransporter 1dab Bordetella pertussis Bact. Gram-neg outer 1 0 2.6 ± 1.1 73 ± 6 -5.9
2.4.13.01. Oxysterol-binding protein homolog 4, conformation 4 3spw Saccharomyces cerevisiae Golgi 1 0 7.3 ± 1.1 60 ± 9 -4.5
3.1.28.04. Gaegurin-4 2g9l Glandirana rugosa (Japanese wrinkled frog) Secreted 1 0 8.9 ± 4.0 71 ± 3 -9.6
3.1.04.02. Major prion protein, peptide 173-195 2iv5 Homo sapiens Eukaryo. plasma 1 0 5.3 ± 4.1 83 ± 17 -3.5
2.3.06.06. Triacylglycerol lipase, closed (inactive) state 1dt5 Humicola lanuginosa Secreted 1 0 5.1 ± 0.9 79 ± 13 -5.9
2.4.34.01. Ice-structuring protein 4ur4 Zoarces viviparus Secreted 1 0 3.2 ± 4.1 68 ± 2 -5.8
2.2.27.01. RAF-1 proto-oncogene serine/threonine-protein kinase 1faq Homo sapiens Eukaryo. plasma 1 0 4.8 ± 1.1 30 ± 14 -7.3
2.2.34.11. Circulin A 1bh4 Chassalia parviflora Secreted 1 0 3.9 ± 1.2 60 ± 18 -6.6
2.1.20.01. Coagulation factor X, GLA domain 1iod Bos taurus Secreted 1 0 3.3 ± 0.9 25 ± 15 -5.2
2.2.12.01. Lymphocyte antigen 96, structure 2 4g8a Homo sapiens Eukaryo. plasma 1 0 2.7 ± 1.3 67 ± 6 -3.8
3.1.07.05. Nonstructural protein, membrane-bound domain 1fw5 Semiliki forest virus Endosome 1 0 7.9 ± 1.5 73 ± 17 -10.2
3.1.28.04. Ranatuerin-2csa 2k10 Rana temporaria Secreted 1 0 10.4 ± 1.2 74 ± 5 -14.3
3.1.02.16. Peptide 211-263 of YscU protein 2ml9 Yersinia pseudotuberculosis Bact. Gram-neg inner 1 0 2.9 ± 1.8 82 ± 5 -6.6
2.2.20.01. Rho guanine nucleotide exchange factor 9 complex 2dfk Rattus norvegicus Eukaryo. plasma 2 0 2.8 ± 2.7 69 ± 3 -5.0
3.4.02.04. Cinnamycin 2dde Streptoverticillium griseoverticillatum Secreted 1 0 3.6 ± 1.9 30 ± 24 -5.4
2.3.01.01. Glucosylceramidase 2vt0 Pan troglodytes Lysosome 1 0 2.3 ± 1.0 86 ± 5 -7.3
2.3.20.01. Hydrophilic domain of respiratory complex I 3i9v Thermus thermophilus Bact. Gram-neg inner 8 0 5.1 ± 1.4 34 ± 10 -11.6
2.3.16.06. ADP-ribosylation factor-like protein 2, complex with human PDEdelta 1ksg Mus musculus Eukaryo. plasma 1 0 6.9 ± 1.7 77 ± 15 -5.7
2.1.01.01. Snake phospholipase A2, group II 1vap Agkistridon piscivorus Secreted 1 0 5.1 ± 0.6 88 ± 5 -10.3
2.2.34.11. Kalata-B12 2kvx Oldenlandia affinis Secreted 1 0 4.4 ± 1.2 68 ± 27 -5.6
3.1.07.02. Juxtamembrane peptide (636-662) of protein gp160 2me3 Human immunodeficiency virus type 1 Endosome 1 0 6.1 ± 0.4 81 ± 7 -12.4
3.1.21.01. Cecropin B analogue 2igr Hyalophora cecropia (Cecropia moth) Secreted 1 0 5.1 ± 3.6 87 ± 0 -11.3
1.1.26.07. STAS domain of sulfate permease 4dgh Vibrio cholerae Bact. Gram-neg inner 1 0 4.6 ± 0.6 33 ± 2 -6.2
2.2.53.01. Fas apoptotic inhibitory molecule 1 3mx7 Homo sapiens Eukaryo. plasma 1 0 4.2 ± 1.4 16 ± 13 -7.1
2.3.06.08. Pancreatic lipase-related protein 1 2ppl Homo sapiens Secreted 1 0 7.1 ± 0.9 79 ± 6 -10.2
3.1.05.05. Anticoccidial peptide PW2 2jq2 Designed proteins Undefined 1 0 6.2 ± 2.3 67 ± 36 -4.5
1.2.39.01. Endoplasmic reticulum aminopeptidase 1, different conformation 2yd0 Homo sapiens Endoplasm. reticulum 1 0 4.1 ± 2.2 59 ± 8 -4.6
1.2.50.01. Equinatoxin II 1iaz Actinia equina Secreted 1 0 3.0 ± 1.2 44 ± 9 -5.1
3.2.05.02. Astexin-1, structure 1 2lti Asticcacaulis excentricus Secreted 1 0 2.4 ± 1.0 85 ± 9 -3.6
2.2.34.01. Omega-conotoxin GVIA 2cco Conus geographus (Geography cone) Secreted 1 0 4.4 ± 0.9 62 ± 7 -3.1
2.3.06.05. Carboxylesterase 2h1i Bacillus cereus Bact. Gram-pos plas. 1 0 2.3 ± 1.8 32 ± 31 -3.6
2.1.01.01. Myotoxin II 1y4l Bothrops asper Secreted 1 0 2.8 ± 0.8 76 ± 7 -10.3
2.2.05.02. Mavicyanin 1ws8 Cucurbita pepo Undefined 1 0 3.7 ± 0.5 31 ± 8 -6.5
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 1 2wuz Trypanosoma cruzi Endoplasm. reticulum 1 0 4.0 ± 1.1 75 ± 11 -9.9
2.2.34.02. Phrixotoxin 1 1v7f Paraphysa scrofa Secreted 1 0 4.1 ± 1.2 90 ± 16 -6.8
2.3.06.07. Lipase 4gw3 Proteus mirabilis Secreted 1 0 3.7 ± 0.9 43 ± 7 -5.1
1.1.59.01. Membrane protease specific for a stomatin homolog, dimer 3viv Pyrococcus horikoshii Archaebac. 2 0 4.5 ± 0.4 88 ± 9 -9.5
1.3.32.01. Type III secretion injectisome secretin InvG 5tcq Salmonella enterica Bact. Gram-neg outer 15 0 17.0 ± 0.4 90 ± 0 -145.8
3.1.20.01. Alpha-conotoxin EI 1k64 Conus ermineus Secreted 1 0 3.6 ± 1.4 78 ± 19 -3.3
3.1.12.01. Sarafotoxin-M 2ldf Atractaspis microlepidota microlepidota Secreted 1 0 2.3 ± 1.5 30 ± 35 -2.1
1.2.39.01. Glutamyl aminopeptidase 4kxd Homo sapiens Eukaryo. plasma 1 0 3.3 ± 0.8 77 ± 2 -4.2
2.3.06.14. Esterase LipA 3h2g Xanthomonas oryzae Secreted 1 0 5.1 ± 1.7 87 ± 8 -4.9
3.1.21.01. Cecropin (1-7)-melittin (2-9) hybrid 2jmy Designed proteins Undefined 1 0 6.5 ± 3.3 77 ± 7 -6.1
2.3.09.01. Cytidylyltransferase, first membrane-anchoring helix 1peh Rattus norvegicus Eukaryo. plasma 1 0 3.2 ± 0.6 90 ± 2 -5.0
2.2.31.01. Collagen-binding type II domain of seminal plasma protein PDC-109 1h8p Bos taurus Secreted 2 0 10.5 ± 0.9 87 ± 7 -16.6
2.3.06.16. Putative hydrolase RPA1511 4psu Rhodopseudomonas palustris Secreted 1 0 7.0 ± 1.2 47 ± 4 -13.0
2.1.02.01. Arachidonate 15-lipoxygenase 2p0m Oryctolagus cuniculus Eukaryo. plasma 1 0 8.6 ± 0.1 87 ± 5 -14.3
3.1.07.01. Fusion peptide (507-560) of ebolavirus glycoprotein GP2, mutant 2 2m5f Zaire ebolavirus Viral 1 0 5.7 ± 1.7 29 ± 30 -5.2
2.3.01.06. Endoglycoceramidase II 2osx Rhodococcus sp. Secreted 1 0 7.9 ± 0.4 68 ± 1 -13.4
3.1.13.01. Calcitonin-1 2glg Oncorhynchus keta (Chum salmon) Secreted 1 0 6.1 ± 0.8 84 ± 4 -11.7
2.2.20.01. Rho guanine nucleotide exchange factor 4 2dx1 Homo sapiens Eukaryo. plasma 1 0 2.2 ± 2.2 80 ± 10 -3.6
2.4.13.01. Oxysterol-binding protein homolog 3 4ic4 Saccharomyces cerevisiae Endoplasm. reticulum 1 0 4.3 ± 0.9 86 ± 29 -5.9
3.1.21.08. Moricin 1kv4 Bombyx mori Secreted 1 0 6.1 ± 0.6 77 ± 14 -10.3
2.1.25.02. Enterocin NKR-5-3B 2mp8 Enterococcus faecium Secreted 1 0 4.9 ± 1.9 68 ± 29 -6.4
2.2.20.01. PH domain of TAPP1 1eaz Homo sapiens Eukaryo. plasma 1 0 1.7 ± 1.6 87 ± 14 -3.0
1.2.43.01. Envelope glycoprotein, Zika virus, structure 4 5lbv Zika virus Viral 1 0 5.7 ± 2.9 31 ± 6 -5.2
2.4.32.01. Vanadium chloroperoxidase 3bb0 Curvularia inaequalis Secreted 1 0 3.8 ± 0.8 52 ± 6 -5.3
3.1.07.09. Membrane fusion protein p15 2mns Baboon orthoreovirus Eukaryo. plasma 1 0 9.3 ± 7.0 86 ± 4 -9.4
2.4.06.01. STAR-related lipid transfer protein 11, complexes with lipids 2e3q Homo sapiens Golgi 1 0 4.3 ± 2.0 41 ± 17 -3.7
2.4.16.02. Defensin 2b68 Crassostrea gigas (Pacific oyster) Secreted 1 0 5.8 ± 1.7 28 ± 20 -4.0
2.1.40.01. Protein unc-13 homolog A, MHD domain 3swh Rattus norvegicus Eukaryo. plasma 1 0 6.6 ± 3.0 27 ± 12 -6.8
3.2.06.01. Paralytic peptide 1irr Bombyx mori Secreted 1 0 2.2 ± 1.9 74 ± 19 -3.3
2.4.51.01. Heme acquisition protein HasA 4xzd Yersinia pseudotuberculosis Secreted 1 0 3.5 ± 0.4 25 ± 2 -5.9
1.1.63.01. Type 1 signal peptidase, apo-enzyme 1kn9 Escherichia coli Bact. Gram-neg inner 1 0 3.4 ± 1.4 80 ± 6 -7.8
2.3.06.01. Acetylcholinesterase, complex with fasciculin-2 4bdt Homo sapiens Eukaryo. plasma 2 0 10.7 ± 0.8 56 ± 3 -11.6
2.1.01.01. Basic phospholipase A2 PA-11 3v9m Pseudechis australis Secreted 1 0 4.0 ± 0.5 83 ± 2 -10.1
2.4.05.01. Sterol carrier protein 2 like domain of multifunctional enzyme type 2 1ikt Homo sapiens Peroxisome 1 0 3.5 ± 1.2 75 ± 17 -4.0
2.2.34.05. Tachystatin-B1 2dcv Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 1.8 ± 1.1 5 ± 9 -5.9
1.2.03.03. Myelin protein P0 1neu Rattus norvegicus Eukaryo. plasma 1 0 5.4 ± 1.8 70 ± 8 -6.6
2.2.39.01. Cardiotoxin-A1 (cytotoxin 1) 2cdx Naja atra Secreted 1 0 2.6 ± 1.4 85 ± 17 -6.9
3.2.05.02. LP2006 5jpl Nocardiopsis alba Secreted 1 0 3.6 ± 1.7 59 ± 12 -4.2
2.2.50.01. Lipoprotein TP0453, closed conformation 3k8g Treponema pallidum Bact. Gram-neg outer 1 0 6.9 ± 2.8 46 ± 7 -8.5
1.2.39.01. Leucyl-cystinyl aminopeptidase 5c97 Homo sapiens Eukaryo. plasma 1 0 3.8 ± 1.0 76 ± 3 -7.6
3.1.07.01. Fusion peptide (510-532) of protein gp41 2pjv Human immunodeficiency virus type 1 Endosome 1 0 8.7 ± 3.8 64 ± 4 -10.9
3.1.21.04. Oxyopinin-4a 2l3i Oxyopes takobius (Lynx spider) Secreted 1 0 6.2 ± 1.2 71 ± 10 -6.8
2.1.51.01. Protein farnesyltransferase/geranylgeranyltransferase 2h6f Homo sapiens Eukaryo. plasma 2 0 4.5 ± 1.5 87 ± 6 -6.5
1.2.32.01. Cytochrome P450 120a1 2ve4 Synechocystis sp. Thylakoid 1 0 6.3 ± 0.9 47 ± 8 -8.6
2.3.06.10. Platelet-activating factor acetylhydrolase 3d59 Homo sapiens Secreted 1 0 5.5 ± 1.2 87 ± 10 -13.6
2.1.02.01. 12S-Lipoxygenase 3d3l Homo sapiens Eukaryo. plasma 1 0 5.0 ± 0.6 51 ± 3 -9.0
2.1.01.01. Myotoxin 1god Bothrops godmani Secreted 1 0 3.0 ± 0.8 80 ± 8 -7.4
3.2.02.02. Chi-conotoxin Ar1248 2m62 Conus araneosus Secreted 1 0 1.9 ± 1.0 78 ± 12 -3.0
2.2.06.02. Intestinal fatty acid binding protein, structure 4 2mo5 Homo sapiens Eukaryo. plasma 1 0 1.9 ± 1.3 59 ± 6 -3.4
2.2.03.01. Phytepsin 1qdm Hordeum vulgare Vacuole 1 0 9.9 ± 1.1 88 ± 10 -10.4
2.2.39.01. Erabutoxin b 3ebx Laticauda semifasciata (Black-banded sea krait) Secreted 1 0 1.9 ± 1.4 47 ± 11 -4.3
1.2.29.01. Septation ring formation regulator EzrA 4uy3 Staphylococcus aureus Bact. Gram-pos plas. 1 0 1.2 ± 2.8 44 ± 4 -3.0
3.1.29.02. Indolicidin analogue (cathelicidin-4) 1qx9 Bos taurus Secreted 1 0 6.6 ± 1.9 46 ± 15 -7.7
3.1.06.01. Apolipoprotein E, peptide 281-304 1oef Homo sapiens Undefined 1 0 4.8 ± 0.9 88 ± 19 -5.5
2.2.42.01. Matrix protein 2vqp Human respiratory syncytial virus Eukaryo. plasma 1 0 2.9 ± 1.1 86 ± 10 -6.1
1.2.32.01. Cytochrome P450 2B4, open state 1 2bdm Oryctolagus cuniculus Endoplasm. reticulum 1 0 10.6 ± 1.0 48 ± 15 -16.2
2.4.16.12. Actinomycesin 2ru0 Actinomyces sp. Secreted 1 0 3.5 ± 0.7 83 ± 7 -4.1
2.1.35.01. Protein kinase C and casein kinase substrate 3lll Mus musculus Vesicle 2 0 1.9 ± 0.4 88 ± 1 -5.4
2.2.34.02. Beta-theraphotoxin-Cj1a 2i1t Chilobrachys guangxiensis (Chinese earth tiger tarantula) Secreted 1 0 3.2 ± 0.7 58 ± 6 -5.8
1.1.56.01. Inner membrane protein YejM, strain K12 5i5h Salmonella typhimurium Bact. Gram-neg inner 1 0 1.1 ± 1.6 65 ± 2 -3.6
2.2.04.01. Retinoid isomerohydrolase, conformation 3 4f30 Bos taurus Eukaryo. plasma 1 0 3.4 ± 1.4 61 ± 7 -10.9
2.4.20.02. Arylamine N-acetyltransferase 1w5r Mycobacterium smegmatis Bact. Gram-pos plas. 1 0 2.6 ± 0.5 82 ± 6 -6.2
2.2.34.11. Cycloviolacin-O14 2gj0 Viola odorata Secreted 1 0 3.6 ± 1.5 85 ± 16 -5.4
2.4.23.01. Methyl-accepting chemotaxis protein 3eee Thermoanaerobacter tengcongensis Undefined 1 0 3.2 ± 0.9 81 ± 4 -5.9
2.3.16.09. GTP-binding protein YjiA 1nij Escherichia coli Bact. Gram-neg inner 1 0 3.4 ± 0.1 41 ± 1 -6.7
2.1.18.01. Annexin VI 1avc Bos taurus Eukaryo. plasma 1 0 4.4 ± 1.0 83 ± 1 -8.1
1.2.32.01. Cytochrome P450 2B6, conformation 1 3ibd Homo sapiens Endoplasm. reticulum 1 0 4.7 ± 1.0 57 ± 3 -10.8
2.4.16.01. Tx10 alpha-like toxin 1kv0 Buthus martensii Secreted 1 0 1.9 ± 1.1 83 ± 11 -4.6
3.1.13.01. Adrenomedullin 2l7s Homo sapiens Secreted 1 0 2.6 ± 0.7 90 ± 5 -6.7
2.2.26.01. Rabphilin-3A 1zbd Rattus norvegicus Eukaryo. plasma 2 0 3.8 ± 1.8 68 ± 15 -4.0
2.1.17.01. Small hydrophilic endoplasmic reticulum-associated protein (Sherp) 2x43 Leishmania major Endoplasm. reticulum 1 0 4.1 ± 0.3 82 ± 2 -9.0
2.2.30.01. Nawaprin 1udk Naja nigricollis Secreted 1 0 6.3 ± 1.0 81 ± 8 -7.3
2.4.16.13 Copsin 2mn5 Coprinopsis cinerea Secreted 1 0 3.0 ± 1.5 59 ± 9 -5.9
2.2.11.01. Synaptotagmin-1, C2B domain (Calcium bound) 1uov Rattus norvegicus Eukaryo. plasma 1 0 1.7 ± 1.8 36 ± 13 -3.7
2.4.50.01. Matrix protein, New Jersey virus 2w2r Vesicular stomatitis virus Viral 1 0 4.1 ± 0.1 57 ± 1 -10.4
3.1.11.02. Glucagon-like peptide 1, with extracellular GPCR domain 3iol Homo sapiens Secreted 2 0 2.8 ± 4.0 70 ± 1 -6.7
2.3.05.02. FAD-dependent pyridine nucleotide-disulfide oxidoreductase 4nwz Caldalkalibacillus thermarum Bact. Gram-pos plas. 2 0 6.2 ± 1.0 90 ± 2 -13.7
2.2.06.01. Extracellular fatty acid-binding protein 2kt4 Coturnix coturnix japonica (Japanese quail) Secreted 1 0 3.9 ± 2.9 61 ± 8 -3.4
3.2.01.09. Peptide PG-990 2n7o Designed proteins Undefined 1 0 7.9 ± 1.6 68 ± 21 -5.6
2.1.10.01. Glycolipid transfer protein Het-c2 3kv0 Podospora anserina Eukaryo. plasma 1 0 8.3 ± 1.3 83 ± 5 -13.6
2.3.06.06. Triacylglycerol lipase, open (active) state 1ein Humicola lanuginosa Secreted 1 0 8.1 ± 0.8 63 ± 4 -14.5
3.1.28.02. Neuromedin-C 2n0h Homo sapiens Secreted 1 0 4.1 ± 1.6 82 ± 18 -3.1
2.2.11.01. Protein kinase C epsilon 1gmi Rattus rattus Eukaryo. plasma 1 0 2.9 ± 1.2 46 ± 15 -5.9
1.2.43.01. Envelope glycoprotein, Dengue virus type 4 3uaj Dengue virus Viral 1 0 5.6 ± 2.6 17 ± 7 -5.4
2.3.01.09. Arabinogalactan endo-1,4-beta-galactosidase 1hjq Humicola insolens (Soft-rot fungus) Secreted 1 0 1.8 ± 1.4 86 ± 7 -3.7
2.2.27.01. C1 domain of protein kinase C alpha 2eli Homo sapiens Eukaryo. plasma 1 0 2.1 ± 0.4 23 ± 4 -7.4
2.1.63.01. Phosphatidylinositol mannoside acyltransferase PatA 5f34 Mycobacterium smegmatis Bact. Gram-pos plas. 0 0 3.9 ± 0.5 58 ± 1 -6.9
2.4.16.01. Beta-toxin CsEI 1b3c Centruroides sculpturatus (Bark scorpion) Secreted 1 0 2.9 ± 1.2 70 ± 7 -3.9
1.2.04.01. Integrin beta-3, 742-788, 747pY, in micelles 2ljd Homo sapiens Eukaryo. plasma 1 0 8.1 ± 0.6 44 ± 4 -7.6
3.1.11.04. Orexin-A 1wso Homo sapiens Secreted 1 0 6.4 ± 1.7 72 ± 14 -5.5
2.2.34.07. Asteropsin B 2lzx Asteropus sp. Secreted 1 0 2.2 ± 1.7 90 ± 21 -3.3
2.2.05.01. Amicyanin 1id2 Paracoccus versutus Bact. Gram-neg inner 1 0 4.2 ± 1.3 52 ± 8 -4.9
2.2.06.02. Brain fatty acid binding protein 1fdq Homo sapiens Eukaryo. plasma 1 0 3.1 ± 1.4 51 ± 15 -4.9
2.2.14.01. Lactadherin 3bn6 Bos taurus Secreted 1 0 2.8 ± 0.5 11 ± 4 -7.2
2.3.10.05. 3-Deoxy-D-manno-octulosonic-acid transferase, WaaA 2xci Aquifex aeolicus Bact. Gram-neg outer 1 0 8.3 ± 1.5 72 ± 1 -20.3
2.3.19.02. Histo-blood group ABO system transferase 2rj6 Homo sapiens Golgi 1 0 2.1 ± 1.3 77 ± 3 -7.1
2.4.16.04. Defensin 3psm Pachyrhizus erosus Secreted 1 0 4.1 ± 1.8 32 ± 8 -5.4
2.3.16.06. ADP-ribosylation factor-like protein 5A 1z6y Homo sapiens Eukaryo. plasma 1 0 1.5 ± 1.9 66 ± 15 -4.0
3.4.04.01. Daptomycin, Ca-free, different conformation 1t5m Streptomyces roseosporus Secreted 1 0 2.3 ± 1.3 33 ± 6 -7.9
3.1.21.04. Spiderine-1a 2n85 Oxyopes takobius (Lynx spider) Secreted 1 0 3.2 ± 4.2 88 ± 0 -7.8
1.2.32.01. Cytochrome P450 24a1 (1,25-dihydroxyvitamin D(3) 24-hydroxylase) 3k9v Rattus norvegicus Mitochon. inner 1 0 6.6 ± 1.0 49 ± 6 -9.6
2.1.38.01. Anion-specific porin B 2vql Corynebacterium glutamicum Bact. Gram-pos cell wall 1 0 6.2 ± 0.3 83 ± 2 -12.7
2.2.35.01. Streptolysin O 4hsc Streptococcus pyogenes Secreted 1 0 2.8 ± 3.5 15 ± 27 -5.1
3.1.04.06. Amyloidogenic peptide (248-286) of prostatic acid phosphatase 2l3h Homo sapiens Eukaryo. plasma 1 0 4.5 ± 2.7 86 ± 0 -4.2
2.3.12.01. Myotubularin-related protein 2, monomer 1zvr Homo sapiens Endosome 1 0 3.1 ± 0.4 89 ± 8 -5.0
3.2.01.04. Gomesin 1kfp Acanthoscurria gomesiana (Tarantula spider) Secreted 1 0 0.5 ± 1.0 75 ± 6 -2.7
2.3.12.01. Myotubularin-related protein 2, dimer 1m7r Homo sapiens Eukaryo. plasma 2 0 1.4 ± 0.3 89 ± 0 -6.4
2.2.05.01. Plastocyanin 9pcy Phaseolus vulgaris Thylakoid 1 0 1.8 ± 1.6 18 ± 19 -1.9
2.2.41.01. Alpha-defensin cryptdin-4 1tv0 Mus musculus Secreted 1 0 2.9 ± 1.4 67 ± 13 -4.5
2.1.24.01. Saposin B (peptide 195-273), structure 1 1n69 Homo sapiens Lysosome 2 0 1.2 ± 1.0 58 ± 6 -2.4
1.1.49.01. ATP-dependent zinc metalloprotease FtsH 3kds Thermotoga maritima Bact. Gram-neg inner 6 0 2.2 ± 0.4 90 ± 0 -12.8
3.2.01.01. Arenicin-2 2jni Arenicola marina Secreted 1 0 2.1 ± 1.1 82 ± 15 -5.2
2.4.51.01. Heme acquisition protein HasA, apoprotein 1ybj Serratia marcescens Secreted 1 0 2.8 ± 2.4 33 ± 9 -3.9
3.1.07.02. Juxtamembrane peptide (657-683) of protein gp160 2me1 Human immunodeficiency virus type 1 Endosome 1 0 7.7 ± 3.8 82 ± 1 -15.0
2.2.34.03. Toxin Ptu1 1i26 Peirates turpis (Assassin bug) Secreted 1 0 2.5 ± 0.9 52 ± 7 -3.6
2.3.16.07. Ras-related C3 botulinum toxin substrate 1 2p2l Homo sapiens Eukaryo. plasma 1 0 3.2 ± 0.8 58 ± 2 -5.2
2.4.16.01. Beta-insect excitatory toxin BmKIT1 1wwn Mesobuthus martensii (Manchurian scorpion) Secreted 1 0 4.2 ± 1.1 72 ± 6 -4.4
3.1.05.06. Transportan 1smz Designed proteins Undefined 1 0 9.1 ± 0.8 87 ± 7 -8.9
1.2.32.01. Cytochrome P450 2C9, structure 1 1og5 Homo sapiens Endoplasm. reticulum 1 0 7.6 ± 1.0 79 ± 6 -13.7
2.1.26.01. Colicin A channel-forming domain 1col Escherichia coli Secreted 1 0 1.8 ± 1.0 43 ± 11 -3.2
3.1.15.05. LsbB 2mlu Lactococcus lactis Secreted 1 0 4.4 ± 4.1 89 ± 2 -6.0
1.2.04.01. Integrin alpha-M, cytoplasmic helix (1129-1152) 2lke Homo sapiens Eukaryo. plasma 1 0 4.1 ± 1.8 73 ± 12 -3.6
2.1.29.01. Apolipoprotein A-I, alternative structure of C-terminal domain 3r2p Homo sapiens Secreted 2 0 1.7 ± 1.6 87 ± 3 -4.1
2.1.02.01. Arachidonate 5-lipoxygenase, complex with arachidonic acid 3v99 Homo sapiens Eukaryo. plasma 1 0 3.0 ± 2.3 88 ± 9 -2.5
2.1.01.01. Snake phospholipase A2, group I, isoform 3 3jql Naja sagittifera Secreted 1 0 6.2 ± 1.0 85 ± 5 -7.0
2.3.17.01. Phospho-2-dehydro-3-deoxyheptonate aldolase 1of8 Saccharomyces cerevisiae Undefined 2 0 7.2 ± 0.4 80 ± 6 -9.3
1.2.32.01. Prostacyclin synthase (cytochrome P450 8A1) 3b6h Homo sapiens Endoplasm. reticulum 1 0 5.0 ± 1.6 64 ± 18 -6.3
2.2.34.01. Omega conotoxin SO3 1fyg Conus striatus Secreted 1 0 2.9 ± 1.1 76 ± 18 -3.5
2.2.34.02. U2-agatoxin-Aop1a 2e2s Allagelena opulenta Secreted 1 0 3.5 ± 0.7 45 ± 14 -5.7
2.3.08.02. Cytosolic phospholipase A2 delta, structure 2 5iz5 Homo sapiens Vesicle 1 0 1.0 ± 0.0 77 ± 0 -4.1
2.2.34.02. Hybrid atracotoxin 2h1z Hadronyche versuta (Blue mountains funnel-web spider) Secreted 1 0 0.6 ± 2.0 82 ± 20 -1.9
1.2.05.02. Internalin C 1xeu Listeria monocytogenes Bact. Gram-pos plas. 1 0 2.9 ± 1.3 81 ± 0 -4.1
2.2.34.11. Leaf cyclotide 2 2kuk Viola hederacea Secreted 1 0 3.4 ± 1.2 83 ± 20 -5.9
3.1.05.10. WALP19 - Pro8 peptide 2lco Designed proteins Undefined 1 0 9.0 ± 0.4 85 ± 4 -15.0
1.1.62.01. Diguanylate cyclase/phosphodiesterase 3pjv Pseudomonas fluorescens Bact. Gram-neg inner 5 0 4.6 ± 1.5 79 ± 4 -6.6
3.2.01.06. Retrocyclin-2 (HTD-2) 2atg Macaca mulatta Secreted 1 0 2.4 ± 0.6 87 ± 9 -5.6
3.2.10.01. PawS derived peptide 6 2lwv Designed proteins Undefined 1 0 6.8 ± 1.1 69 ± 16 -7.3
2.3.06.11. Monoglyceride lipase MGLL, closed ligand-bound conformation 3pe6 Homo sapiens Eukaryo. plasma 1 0 0.9 ± 3.0 54 ± 28 -2.7
2.3.16.08. Interferon-inducible GTPase 1 1tpz Mus musculus Endoplasm. reticulum 1 0 2.5 ± 2.0 37 ± 7 -5.0
2.2.41.01. Beta-defensin 8 1e4r Mus musculus Secreted 1 0 2.8 ± 1.1 74 ± 19 -5.5
3.4.10.01. Methanobactin 2xjh Methylosinus trichosporium Secreted 1 0 0.7 ± 0.7 67 ± 7 -2.9
2.1.18.01. Annexin II 1w7b Homo sapiens Eukaryo. plasma 1 0 2.4 ± 1.2 87 ± 18 -3.8
2.1.20.01. Osteocalcin 1q8h Sus scrofa Secreted 1 0 2.3 ± 1.7 81 ± 17 -4.4
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 5 4by0 Trypanosoma cruzi Eukaryo. plasma 1 0 4.8 ± 2.6 88 ± 7 -1.6
3.1.29.01. Retro KR-12 2nal Designed proteins Undefined 1 0 3.7 ± 0.5 83 ± 5 -6.1
2.2.06.02. Fatty acid-binding protein 2 2ftb Ambystoma mexicanum (Axolotl) Eukaryo. plasma 1 0 0.6 ± 2.0 77 ± 20 -1.7
1.2.32.01. Cytochrome P450 2B4, closed state 3 3g5n Oryctolagus cuniculus Endoplasm. reticulum 1 0 5.7 ± 1.8 65 ± 3 -12.1
2.3.06.07. Lipase L1, isoform 1 1ji3 Bacillus stearothermophilus Secreted 1 0 3.5 ± 1.7 22 ± 10 -8.0
2.1.25.05. Lacticin Q 2n8p Lactococcus lactis Secreted 1 0 3.5 ± 0.8 80 ± 6 -4.0
2.2.21.01. Hisactophilin-1 1hce Dictyostelium discoideum Eukaryo. plasma 1 0 3.5 ± 1.1 60 ± 15 -1.6
1.2.43.01. Envelope glycoprotein, Dengue virus type 2, structure 5 4utc Dengue virus Viral 1 0 6.3 ± 2.4 13 ± 7 -4.2
2.4.53.01. Resistin, different conformation 1rgx Mus musculus Secreted 3 0 8.2 ± 1.2 12 ± 6 -12.1
2.4.16.01. Toxin BmKaIT1 1omy Mesobuthus martensii (Manchurian scorpion) Secreted 1 0 4.0 ± 1.3 83 ± 10 -3.8
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 8 4c0c Trypanosoma cruzi Endoplasm. reticulum 1 0 9.4 ± 1.9 64 ± 7 -10.9
3.1.20.01. alpha-conotoxin MII 1mii Conus magus Secreted 1 0 2.7 ± 1.8 45 ± 19 -4.2
3.1.18.02. Phenol-soluble modulin alpha 3 peptide 5kgy Staphylococcus aureus Secreted 1 0 9.4 ± 1.0 73 ± 7 -17.3
2.3.15.01. Electron transfer flavoprotein 1efp Paracoccus denitrificans Bact. Gram-neg inner 2 0 4.3 ± 1.1 90 ± 13 -4.8
2.2.06.02. Myelin P2 protein 1pmp Bos taurus Eukaryo. plasma 1 0 2.7 ± 1.3 61 ± 13 -6.1
1.3.25.01. Necrotic enteritis toxin B 4i0n Clostridium perfringens Secreted 1 0 1.6 ± 2.4 38 ± 7 -4.3
2.1.41.01. Phosphatidylinositol 4-kinase type 2-alpha, structure 2 4pla Homo sapiens Golgi 1 0 1.0 ± 1.7 49 ± 3 -2.8
3.1.24.01. Penaeidin-3a 1ueo Litopenaeus vannamei (Whiteleg shrimp) Secreted 1 0 1.3 ± 3.5 89 ± 2 -5.5
3.1.03.01. Myc box-dependent-interacting protein 1, membrane anchor helix (peptide 1-33) 2rnd Homo sapiens Eukaryo. plasma 1 0 4.0 ± 0.4 85 ± 2 -8.4
1.2.32.01. Cytochrome P450 2B4, closed state, mutant 5iut Oryctolagus cuniculus Endoplasm. reticulum 1 0 5.3 ± 0.5 56 ± 2 -13.0
2.3.06.01. Bile-salt activated lipase, conformation 2 1akn Bos taurus Secreted 1 0 3.8 ± 1.5 77 ± 15 -6.7
2.2.17.01. 6.5 kDa glycine-rich antifreeze protein 2pne Hypogastrura harveyi Secreted 1 0 1.7 ± 0.2 89 ± 5 -7.7
2.2.27.01. C1 domain of protein kinase C gamma 1tbn Rattus rattus Eukaryo. plasma 1 0 4.8 ± 1.6 42 ± 19 -3.7
2.3.11.01. Ferrochelatase, mitochondrial 1lbq Saccharomyces cerevisiae Mitochon. inner 2 0 5.3 ± 0.5 90 ± 3 -6.9
2.4.16.02. Drosomycin 1myn Drosophila melanogaster Secreted 1 0 4.6 ± 1.2 10 ± 17 -6.0
2.1.20.01. Coagulation factor IX, GLA domain 1nl0 Homo sapiens Secreted 1 0 4.1 ± 0.9 38 ± 13 -4.4
2.2.26.01. RUN and FYVE domain-containing protein 1 2yw8 Homo sapiens Endosome 1 0 0.7 ± 3.4 48 ± 38 -2.8
2.4.16.08. Hydramacin-1 2k35 Hydra vulgaris Secreted 1 0 2.0 ± 0.2 87 ± 2 -4.3
2.2.03.02. Retropepsin 2q63 Human immunodeficiency virus type 1 Eukaryo. plasma 2 0 4.5 ± 0.4 89 ± 4 -10.4
2.1.29.01. Apolipoprotein A-I 2a01 Homo sapiens Secreted 1 0 4.8 ± 1.2 63 ± 11 -6.5
2.3.06.04. Palmitoyl-protein thioesterase 1 3gro Homo sapiens Lysosome 1 0 3.6 ± 0.1 55 ± 3 -6.8
1.1.01.03. Ectodomain of G-protein coupled receptor Mth 1fjr Drosophila melanogaster Eukaryo. plasma 1 0 1.8 ± 1.5 56 ± 13 -4.3
2.1.01.01. Myotoxin 1s8i Agkistrodon contortrix laticinctus Secreted 1 0 4.9 ± 0.7 83 ± 5 -10.6
2.1.62.01. Thuricin alpha 2l9x Bacillus cereus Secreted 1 0 7.1 ± 3.2 84 ± 7 -7.8
2.1.61.01. Muramidase Tse3 4m5e Pseudomonas aeruginosa Bact. Gram-neg outer 1 0 5.2 ± 2.0 65 ± 10 -8.0
3.1.07.02. Juxtamembrane peptide (671-697) of protein gp160 2me4 Human immunodeficiency virus type 1 Endosome 1 0 7.9 ± 2.9 81 ± 4 -14.0
3.1.15.04. Bacteriocin plantaricin J (PlnJ) 2khg Lactobacillus plantarum Secreted 1 0 5.4 ± 4.0 72 ± 2 -9.0
1.1.26.07. STAS domain of sulfate permease 4dgf Wolinella succinogenes Bact. Gram-neg inner 1 0 2.6 ± 0.5 51 ± 2 -7.0
1.2.03.07. Cell adhesion molecule complex 3n1f Homo sapiens Eukaryo. plasma 2 0 5.2 ± 0.9 59 ± 4 -5.7
2.3.06.07. Triacylglycerol lipase 2w22 Geobacillus thermocatenulatus Secreted 1 0 5.6 ± 0.0 86 ± 0 -22.4
3.1.28.06. Magainin analogue, MSI-594 2k98 Designed proteins Undefined 1 0 3.2 ± 0.2 86 ± 2 -8.9
2.3.14.01. SEC14-like protein 2 (supernatant factor protein) 1o6u Homo sapiens Eukaryo. plasma 1 0 3.6 ± 1.4 62 ± 14 -4.9
1.2.39.01. Endoplasmic reticulum aminopeptidase 1 3mdj Homo sapiens Endoplasm. reticulum 1 0 1.9 ± 3.6 63 ± 10 -4.6
1.2.50.01. Sticholysin II 1gwy Stoichactis helianthus Secreted 1 0 3.4 ± 1.9 35 ± 15 -5.0
3.2.05.02. Astexin-1, structure 2 2m37 Asticcacaulis excentricus Secreted 1 0 3.2 ± 1.1 83 ± 13 -5.1
1.1.26.07. STAS domain of prestin 3llo Rattus norvegicus Eukaryo. plasma 1 0 5.4 ± 0.6 68 ± 4 -5.3
2.2.34.09. Psi-conotoxin PIIIF 1jlp Conus purpurascens (Purple cone) Secreted 1 0 2.1 ± 1.1 72 ± 30 -3.1
3.1.02.08. High affinity copper uptake protein 1, peptide 156-179 2ls4 Homo sapiens Eukaryo. plasma 1 0 4.9 ± 0.7 82 ± 10 -6.5
2.3.06.12. Heroin esterase 1lzk Rhodococcus sp. Bact. Gram-pos plas. 1 0 1.5 ± 1.5 69 ± 9 -4.0
2.1.01.01. Myotoxin II 2aoz Atropoides nummifer Secreted 1 0 3.4 ± 0.7 80 ± 3 -11.8
2.4.24.01. Mandelate racemase/muconate lactonizing enzyme 1wue Enterococcus faecalis Undefined 2 0 4.0 ± 0.3 86 ± 10 -5.5
1.2.32.01. Cytochrome P450 1n97 Thermus thermophilus Bact. Gram-neg inner 1 0 5.2 ± 0.3 43 ± 5 -9.9
1.2.32.01. Sterol 14-alpha-demethylase (CYP51) 3l4d Leishmania infantum Endoplasm. reticulum 1 0 8.4 ± 1.8 66 ± 9 -12.6
2.2.34.02. Hanatoxin 1 1d1h Grammostola rosea (Chilean rose tarantula) Secreted 1 0 3.4 ± 1.7 68 ± 15 -4.2
2.3.06.07. Lipase L1, isoform 2 4fmp Bacillus stearothermophilus Secreted 1 0 5.0 ± 1.6 25 ± 12 -8.9
3.1.20.01. Alpha-conotoxin-like EpI 1a0m Conus episcopatus (Bishop's cone) Secreted 1 0 3.3 ± 1.2 58 ± 9 -3.2
2.2.07.01. Lipocalin BcnB 5ixg Burkholderia cepacia Bact. Gram-neg inner 1 0 2.0 ± 1.0 36 ± 5 -3.9
3.1.12.01. Sarafotoxin-B 1srb Atractaspis engaddensis (Israeli burrowing asp) Secreted 1 0 4.9 ± 1.9 62 ± 10 -4.1
2.3.06.06. Lipase A, closed state 3guu Candida antarctica Secreted 1 0 4.4 ± 1.0 80 ± 2 -10.9
2.3.09.01. Cytidylyltransferase, second membrane-anchoring helix 1pei Rattus norvegicus Eukaryo. plasma 1 0 4.9 ± 1.0 83 ± 11 -8.2
2.2.06.01. Neutrophil gelatinase-associated lipocalin 3fw5 Homo sapiens Secreted 1 0 2.0 ± 1.2 45 ± 9 -3.1
2.3.06.12. Sulfolobus shibatae 3wj1 Sulfolobus shibatae Secreted 1 0 3.1 ± 0.7 52 ± 6 -6.3
2.2.02.01. Serine protease HTRA1 3nzi Homo sapiens Secreted 6 0 4.2 ± 0.7 90 ± 0 -11.8
2.1.18.01. Annexin 4mdv Schistosoma mansoni