PDB ID or protein name

All proteins in OPM (3380 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
2.1.25.03. Enterocin 7A 2m5z Enterococcus faecalis Secreted 0 0 4.4 ± 0.3 57 ± 3 -5.3
2.1.63.01. Phosphatidylinositol mannoside acyltransferase PatA 5f34 Mycobacterium smegmatis Bact. Gram-pos plas. 0 0 3.9 ± 0.5 58 ± 1 -6.9
2.2.50.01. Lipoprotein TP0453, intermediate conformation 3k8j Treponema pallidum Bact. Gram-neg outer 1 0 5.4 ± 1.4 33 ± 6 -9.9
3.1.07.02. Juxtamembrane peptide (662-683) of protein gp41 2pv6 Human immunodeficiency virus type 1 Endosome 1 0 6.7 ± 0.6 82 ± 2 -13.5
3.1.21.01. Papiliocin 2la2 Papilio xuthus Secreted 1 0 7.8 ± 2.0 62 ± 4 -7.4
1.2.01.01. Receptor tyrosine-protein kinase erbB-3, extracellular domains 1m6b Homo sapiens Eukaryo. plasma 1 0 2.0 ± 1.6 45 ± 5 -3.9
2.3.06.06. Lipase 2ory Photbacterium lipolyticum Secreted 1 0 6.3 ± 1.1 62 ± 10 -12.0
1.1.47.01. Aerobic respiration control sensor protein acrB 2ksd Escherichia coli Bact. Gram-neg inner 1 2 27.9 ± 2.8 9 ± 1 -33.6
1.1.01.02. Melanocortin-4 receptor model (active state) with agonist NDP-MSH 2iqr Homo sapiens Eukaryo. plasma 1 7 33.5 ± 2.0 24 ± 0 -60.6
2.1.01.01. Snake phospholipase A2-3, group II 1gmz Bothrops pirajai Secreted 1 0 3.8 ± 1.5 88 ± 10 -6.7
3.2.02.02. Conopeptide CnVA 3zkt Conus consors (Singed cone) Secreted 1 0 7.9 ± 2.9 88 ± 27 -5.2
1.1.01.02. Type-1 angiotensin II receptor 4yay Homo sapiens Eukaryo. plasma 1 7 35.8 ± 0.4 13 ± 1 -71.0
2.2.03.01. Plasmepsin IV 1qs8 Plasmodium vivax Vacuole 1 0 9.1 ± 1.5 75 ± 5 -8.9
3.1.14.01. Neuropeptide K 2b19 Homo sapiens Secreted 1 0 5.1 ± 4.3 46 ± 8 -5.7
2.1.25.02. Carnocyclin A 2kjf Carnobacterium maltaromaticum Secreted 1 0 2.1 ± 1.1 61 ± 12 -4.6
1.1.60.01. Protease GlpG, conformation 1 2xtv Escherichia coli Bact. Gram-neg inner 1 6 28.8 ± 1.6 14 ± 1 -61.1
1.2.25.02. Na,K-ATPase regulatory protein FXYD4 2jp3 Rattus norvegicus Eukaryo. plasma 1 1 31.8 ± 3.2 18 ± 7 -20.2
1.2.32.01. Cytochrome P450 2C9, structure 2 1r9o Homo sapiens Endoplasm. reticulum 1 0 4.0 ± 1.1 59 ± 8 -10.1
2.3.06.08. Phospholipase A1 4qnn Vespa basalis Secreted 1 0 3.5 ± 0.5 64 ± 2 -11.1
3.2.05.02. Xanthomonin II 2mfv Xanthomonas gardneri Secreted 1 0 4.1 ± 0.9 38 ± 6 -4.4
2.2.11.01. Perforin-1 3nsj Mus musculus Vesicle 1 0 3.1 ± 1.0 34 ± 11 -3.3
2.2.34.02. U5-theraphotoxin-Hh1a 1qk7 Haplopelma hainanum (Chinese bird spider) Secreted 1 0 6.3 ± 0.5 47 ± 2 -5.2
1.1.01.02. Neurotensin receptor type 1, structure 1 4grv Rattus norvegicus Eukaryo. plasma 1 7 31.6 ± 1.1 4 ± 1 -75.1
2.2.34.11. Cycloviolacin-O2 2kcg Viola odorata Secreted 1 0 5.1 ± 2.9 58 ± 36 -6.8
2.3.31.01. Sorbose-specific phosphotransferase enzyme IIB component 1nrz Klebsiella pneumoniae Bact. Gram-neg inner 1 0 2.1 ± 0.7 83 ± 3 -4.5
2.1.18.01. Annexin D1 1ycn Arabidopsis thaliana Eukaryo. plasma 1 0 2.3 ± 1.1 78 ± 14 -3.4
1.2.32.01. Cholesterol 7-alpha-monooxygenase (P450 7A1) 3dax Homo sapiens Endoplasm. reticulum 1 0 1.8 ± 1.9 69 ± 8 -3.9
2.4.16.01. LQH III alpha-like toxin 1fh3 Leiurus quinquestriatus hebraeus Secreted 1 0 3.6 ± 1.5 83 ± 16 -5.2
2.1.25.04. Acidocin B 2mwr Lactobacillus acidophilus Secreted 1 0 4.9 ± 1.6 76 ± 0 -8.6
1.1.01.04. Smoothened homolog, monomer, conformation 3 5l7d Homo sapiens Eukaryo. plasma 1 7 32.0 ± 1.4 6 ± 2 -60.8
3.1.12.01. Sarafotoxin-B 1srb Atractaspis engaddensis (Israeli burrowing asp) Secreted 1 0 4.9 ± 1.9 62 ± 10 -4.1
1.1.25.05. Proton-dependent oligopeptide transporter, conformation 1 4ikv Geobacillus kaustophilus Bact. Gram-pos plas. 1 14 30.8 ± 1.5 5 ± 0 -110.9
2.3.06.06. Lipase A, closed state 3guu Candida antarctica Secreted 1 0 4.4 ± 1.0 80 ± 2 -10.9
2.3.09.01. Cytidylyltransferase, second membrane-anchoring helix 1pei Rattus norvegicus Eukaryo. plasma 1 0 4.9 ± 1.0 83 ± 11 -8.2
1.1.70.01. CaaX Protease Ste24p 4il3 Saccharomyces mikatae Endoplasm. reticulum 1 7 29.8 ± 1.4 8 ± 0 -63.3
2.2.06.01. Neutrophil gelatinase-associated lipocalin 3fw5 Homo sapiens Secreted 1 0 2.0 ± 1.2 45 ± 9 -3.1
2.3.06.12. Sulfolobus shibatae 3wj1 Sulfolobus shibatae Secreted 1 0 3.1 ± 0.7 52 ± 6 -6.3
2.1.18.01. Annexin 4mdv Schistosoma mansoni Eukaryo. plasma 1 0 3.7 ± 0.8 77 ± 9 -5.9
1.1.83.01. Bacterial translocator protein, monomer 4rym Bacillus cereus Bact. Gram-pos plas. 1 5 31.4 ± 1.4 3 ± 0 -52.8
3.1.13.01. Calcitonin 1bku Anguilla japonica (Japanese eel) Secreted 1 0 3.0 ± 0.4 77 ± 3 -8.7
2.2.20.01. RAC-gamma serine/threonine-protein kinase 2x18 Homo sapiens Eukaryo. plasma 1 0 1.5 ± 1.1 53 ± 4 -3.8
2.1.04.01. Fatty acid alpha-oxidase 4kvl Oryza sativa (Rice) Endoplasm. reticulum 1 0 5.5 ± 0.7 90 ± 1 -19.0
3.1.21.08. Moricin 1x22 Spodoptera litura Secreted 1 0 4.4 ± 1.1 70 ± 5 -9.2
2.3.06.09. Cutinase 5ajh Fusarium oxysporum Secreted 1 0 6.2 ± 0.3 25 ± 9 -7.6
1.2.12.01. Fimbrial protein, type IV pilin, monomer 2pil Neisseria gonorrhoeae Bact. Gram-neg inner 1 1 30.8 ± 5.7 21 ± 5 -24.9
2.2.20.01. Rac-alpha serine/threonine kinase 1unq Homo sapiens Eukaryo. plasma 1 0 2.7 ± 2.0 67 ± 18 -3.9
1.2.43.01. Envelope glycoprotein, Zika virus, structure 5 5lbs Zika virus Viral 1 0 2.3 ± 2.5 62 ± 5 -4.7
2.4.52.01. Spondin-2 3d34 Homo sapiens Secreted 1 0 6.3 ± 0.7 35 ± 5 -10.4
2.4.06.01. STAR-related lipid transfer protein 11, apoprotein (open state) 2e3m Homo sapiens Golgi 1 0 3.4 ± 1.1 44 ± 12 -6.1
2.4.16.05. Plectasin 3e7r Pseudoplectania nigrella (Ebony cup) Secreted 1 0 2.7 ± 2.3 53 ± 17 -4.0
2.1.41.01. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 3ml9 Homo sapiens Eukaryo. plasma 1 0 3.0 ± 0.8 83 ± 2 -6.0
3.2.05.01. Siamycin II (tricyclic peptide RP71935) 1rpb Streptomyces sp. Secreted 1 0 4.2 ± 1.3 85 ± 15 -8.3
2.4.51.01. Heme acquisition protein HasA, dimer 4y4s Yersinia pseudotuberculosis Secreted 1 0 1.8 ± 1.1 83 ± 9 -4.2
2.3.06.01. Butyryl cholinesterase 1p0i Homo sapiens Eukaryo. plasma 1 0 3.1 ± 0.8 43 ± 10 -6.4
1.1.83.01. Mitochondrial translocator protein, TSPO, model 2 2n02 Mus musculus Mitochon. outer 1 7 28.4 ± 1.6 8 ± 3 -25.3
2.3.06.07. Lipase 3auk Geobacillus sp. Secreted 1 0 5.6 ± 0.8 25 ± 2 -8.5
1.3.19.01. Histidine porin OpdC 3sy9 Pseudomonas aeruginosa Bact. Gram-neg outer 1 18 23.4 ± 0.8 5 ± 0 -63.2
2.1.14.01. Peroxisomal targeting signal 1 receptor 1fch Homo sapiens Peroxisome 1 0 6.9 ± 1.2 54 ± 3 -6.7
3.1.21.06. Stomoxyn 1zrx Stomoxys calcitrans (Stable fly) Secreted 1 0 5.7 ± 0.0 80 ± 0 -12.3
1.1.25.05. Bacterial proton:oligopeptide symporter, structure 3 4tpj Shewanella oneidensis Bact. Gram-neg inner 1 14 30.6 ± 0.9 9 ± 0 -90.0
2.4.07.01. NADPH oxidase organizer 1, PX domain 2l73 Homo sapiens Eukaryo. plasma 1 0 2.8 ± 1.9 72 ± 13 -5.1
1.2.32.01. Cytochrome P450 4B1 5t6q Oryctolagus cuniculus Endoplasm. reticulum 1 0 8.8 ± 0.6 38 ± 2 -17.0
2.2.39.01. Cytotoxin-1 1rl5 Naja naja oxiana Secreted 1 0 5.2 ± 2.0 51 ± 16 -5.7
3.1.19.01. Bergofungin A 5mas Emericellopsis donezkii Secreted 1 1 30.8 ± 1.5 35 ± 20 -13.2
2.4.03.01. Tubby protein homolog 1s31 Homo sapiens Eukaryo. plasma 1 0 6.8 ± 1.0 71 ± 2 -7.6
2.2.05.01. Plastocyanin 2plt Chlamydomonas reinhardtii Thylakoid 1 0 1.3 ± 1.5 21 ± 18 -2.0
2.2.41.01. Alpha-defensin 4 1zmm Homo sapiens Secreted 1 0 2.2 ± 1.0 76 ± 10 -5.5
3.1.19.01. Zervamicin IIb, transmembrane orientation 1r9u Emericellopsis salmosynnemata Secreted 1 1 23.2 ± 5.4 38 ± 7 -15.0
2.4.51.01. Heme acquisition protein HasA 1b2v Serratia marcescens Secreted 1 0 1.9 ± 1.6 18 ± 18 -3.3
1.3.17.02. Outer membrane protein assembly factor BamA 4k3b Neisseria gonorrhoeae Bact. Gram-neg outer 1 16 23.0 ± 1.1 9 ± 0 -52.6
1.1.20.03. Claudin-19 3x29 Mus musculus Eukaryo. plasma 1 4 31.6 ± 1.9 22 ± 1 -48.8
3.1.07.01. Probable fusion peptide (93-126, 138-160) of protein gp41 2mk3 Human immunodeficiency virus type 1 Endosome 1 2 20.8 ± 0.5 18 ± 1 -13.2
2.4.16.10. Toxin MIT1 (Black mamba intestinal toxin 1) 1imt Dendroaspis polylepis polylepis (Black mamba) Secreted 1 0 4.8 ± 0.7 70 ± 3 -9.1
2.3.05.05. RabGDI protein 3p1w Plasmodium falciparum Eukaryo. plasma 1 0 6.6 ± 1.4 47 ± 3 -6.8
2.2.34.02. Psalmotoxin-1 1lmm Psalmopoeus cambridgei (Trinidad chevron tarantula) Secreted 1 0 2.4 ± 1.6 71 ± 15 -4.4
3.2.09.01. Octreotide 1soc Designed proteins Undefined 1 0 8.9 ± 1.8 77 ± 21 -7.7
1.2.32.01. Cytochrome P450 3A4, conformation 1 1tqn Homo sapiens Endoplasm. reticulum 1 0 8.7 ± 1.0 67 ± 11 -18.5
2.1.27.01. Cry3Bb1 1ji6 Bacillus thuringiensis Secreted 1 0 3.8 ± 1.6 64 ± 6 -4.2
3.1.28.05. Peptoid analogue of maculatin 2mmj Litoria genimaculata Secreted 1 0 10.0 ± 4.6 73 ± 3 -13.1
1.3.19.02. Alginate export protein, AlgE, conformation 4 4xnk Pseudomonas aeruginosa Bact. Gram-neg outer 1 18 24.4 ± 1.0 3 ± 0 -71.7
1.2.49.01. Tumor necrosis factor receptor 12A 2kmz Homo sapiens Eukaryo. plasma 1 0 5.9 ± 1.6 66 ± 3 -6.3
2.1.29.03. Cholesteryl ester transfer inhibitor protein 1eze Papio hamadryas (Hamadryas baboon) Secreted 1 0 4.6 ± 0.2 89 ± 3 -9.9
1.1.01.02. Opioid delta receptor 4ej4 Mus musculus Eukaryo. plasma 1 7 34.4 ± 0.8 11 ± 6 -73.2
2.1.01.01. Snake phospholipase A2 homolog 1, group II 2ok9 Bothrops pirajai Secreted 1 0 3.5 ± 1.4 76 ± 7 -7.6
2.2.43.01. Hypothetical protein SpyM3_0169 1pg6 Streptococcus pyogenes Undefined 1 0 7.6 ± 1.5 57 ± 6 -7.2
1.1.09.01. Calcium ATPase, E2-Pi state, conformation 3 3b9b Oryctolagus cuniculus Endoplasm. reticulum 1 10 29.9 ± 1.6 16 ± 2 -58.1
2.2.34.01. Delta conotoxin EVIA 1g1z Conus ermineus Secreted 1 0 6.5 ± 1.9 72 ± 18 -8.7
3.2.01.01. Arenicin-1 2jsb Arenicola marina Secreted 1 0 2.4 ± 2.1 80 ± 11 -5.2
1.1.01.02. Muscarinic acetylcholine receptor M1 5cxv Homo sapiens Eukaryo. plasma 1 7 32.8 ± 0.7 4 ± 0 -78.2
2.2.34.02. Kappa-hexatoxin-Hv1c 1dl0 Hadronyche versuta (Blue mountains funnel-web spider) Secreted 1 0 1.7 ± 1.3 53 ± 17 -3.1
1.1.01.02. 5-hydroxytryptamine receptor 1B, conformation 2 4iaq Homo sapiens Eukaryo. plasma 1 7 34.4 ± 1.7 6 ± 1 -77.4
2.3.01.08. Endoglucanase H 2vi0 Clostridium thermocellum Bact. Gram-pos plas. 1 0 1.5 ± 1.3 36 ± 9 -3.8
2.2.34.11. Leaf cyclotide 1 1za8 Viola hederacea Secreted 1 0 4.9 ± 1.3 48 ± 24 -8.5
1.1.68.01. Transmembrane protein 141 2lor Homo sapiens Undefined 1 2 24.4 ± 4.0 21 ± 0 -22.2
1.2.39.01. Endoplasmic reticulum aminopeptidase 2 3se6 Homo sapiens Endoplasm. reticulum 1 0 2.5 ± 1.8 60 ± 21 -4.5
2.2.39.01. Cytotoxin 1 ( Cardiotoxin gamma) 1tgx Naja mossambica pallida Secreted 1 0 6.7 ± 1.0 59 ± 12 -10.0
2.1.44.01. Bacteriocin ASM1 2mvi Lactobacillus plantarum Secreted 1 0 5.3 ± 1.4 33 ± 5 -4.9
2.2.20.01. PH domain of phospholipase C delta 1 1mai Rattus norvegicus Eukaryo. plasma 1 0 15.0 ± 1.8 22 ± 14 -17.8
2.4.50.01. Matrix protein, Indiana virus, complex with mRNA export factor 4owr Vesicular stomatitis virus Viral 1 0 2.1 ± 0.8 65 ± 2 -7.6
3.1.11.02. Glucagon-like peptide 2 2l64 Homo sapiens Secreted 1 0 3.9 ± 0.3 90 ± 5 -10.8
1.3.20.01. Outer membrane cobalamin transporter BtuB 1nqe Escherichia coli Bact. Gram-neg outer 1 22 23.4 ± 1.0 5 ± 0 -68.8
2.2.16.01. Lipoprotein LprG 3mh9 Mycobacterium tuberculosis Bact. Gram-pos plas. 1 0 2.5 ± 2.7 47 ± 10 -3.0
3.1.13.01. Islet amyloid polypeptide, fragment 34-70, alternative structure 2l86 Homo sapiens Secreted 1 0 6.2 ± 0.8 88 ± 7 -9.6
3.2.01.09. Peptide PG-989 2n7n Designed proteins Undefined 1 0 6.1 ± 1.4 83 ± 7 -5.5
1.1.38.01. Na+/drug antiporter NorM, outward-open, structure 1 4hum Neisseria gonorrhoeae Bact. Gram-neg inner 1 12 28.6 ± 1.1 5 ± 1 -54.5
2.4.05.01. Uncharacterized protein 3bkr Aedes aegypti (Yellowfever mosquito) Eukaryo. plasma 1 0 0.4 ± 6.2 50 ± 73 -1.2
1.1.09.01. Calcium ATPase, E2 state (Ca-free), conformation 8 2zbg Oryctolagus cuniculus Endoplasm. reticulum 1 10 30.0 ± 1.7 21 ± 0 -66.5
2.3.06.06. Triacylglycerol lipase 1lgy Rhizopus niveus Secreted 1 0 1.9 ± 1.8 33 ± 16 -4.8
3.2.05.02. Chaxapeptin 1 2n5c Streptomyces leeuwenhoekii Secreted 1 0 7.2 ± 1.0 82 ± 9 -8.8
2.2.11.01. Synaptotagmin-3 3hn8 Rattus norvegicus Eukaryo. plasma 1 0 4.0 ± 3.1 74 ± 19 -4.0
1.1.01.02. C-C chemokine receptor type 9 5lwe Homo sapiens Eukaryo. plasma 1 7 33.0 ± 1.8 7 ± 0 -75.8
1.2.43.01. Envelope glycoprotein, chimeric 1k4r Dengue virus Viral 1 0 6.6 ± 2.4 21 ± 12 -4.9
2.2.12.03. Immunogenic protein MPT63 1lmi Mycobacterium tuberculosis Secreted 1 0 2.2 ± 1.9 86 ± 7 -4.3
2.2.27.01. C1 domain of protein kinase C theta 2enn Homo sapiens Eukaryo. plasma 1 0 6.2 ± 1.9 89 ± 3 -7.5
1.1.39.03. ECF transporter, S-component 5d0y Lactobacillus delbrueckii Bact. Gram-pos plas. 1 6 29.8 ± 1.8 2 ± 2 -55.7
2.4.16.01. Toxin CsEv1 1vna Centruroides sculpturatus (Bark scorpion) Secreted 1 0 4.9 ± 1.0 65 ± 10 -7.8
1.1.25.06. D-xylose-proton symporter xylE, conformation 3 4ja4 Escherichia coli Bact. Gram-neg inner 1 12 28.2 ± 1.3 0 ± 0 -82.8
1.2.04.01. Integrin beta-3, 742-788, biphosphorylated (747pY, 759pY) 2lje Homo sapiens Eukaryo. plasma 1 0 4.0 ± 0.5 74 ± 2 -7.0
3.1.21.05. Poneratoxin 1g92 Paraponera clavata Secreted 1 0 22.8 ± 8.5 29 ± 7 -12.9
2.2.34.07. Asteropsin D 2lzy Asteropus sp. Secreted 1 0 4.7 ± 1.5 49 ± 29 -3.0
2.2.05.01. Pseudoazurin 1pmy Methylobacterium extorquens Bact. Gram-neg inner 1 0 1.6 ± 1.4 45 ± 13 -4.3
2.2.06.02. Epidermal fatty acid binding protein 4lkt Homo sapiens Eukaryo. plasma 1 0 3.8 ± 1.2 39 ± 7 -6.7
2.3.06.01. Acetylcholinesterase 5x61 Anopheles gambiae (African malaria mosquito) Eukaryo. plasma 1 0 2.6 ± 1.5 37 ± 4 -4.0
1.2.40.01. Mitochondria fission 1 protein, crystal structure 1nzn Homo sapiens Mitochon. outer 1 0 6.1 ± 1.4 72 ± 8 -9.3
2.4.06.03. Class 10 plant pathogenesis-related protein 2qim Lupinus luteus Secreted 1 0 3.3 ± 1.4 41 ± 3 -3.1
2.1.07.01. Decaheme cytochrome c MtrF 3pmq Shewanella oneidensis Bact. Gram-neg outer 1 0 3.9 ± 0.9 86 ± 2 -6.2
2.4.16.04. Defensin 1ti5 Vigna radiata (Mung bean) Secreted 1 0 1.9 ± 2.4 62 ± 16 -3.0
2.1.03.01. Alpha-toxin, different sequence (PHLC2_CLOPE in Uniprot) 1kho Clostridium perfringens Secreted 1 0 3.8 ± 1.0 87 ± 4 -8.2
2.2.35.01. Pneumolysin, structure 7 4zgh Streptococcus pneumoniae Secreted 1 0 5.0 ± 2.5 24 ± 25 -4.9
2.1.18.01. Annexin IV, monomeric state 1ann Bos taurus Eukaryo. plasma 1 0 2.2 ± 1.0 77 ± 3 -6.0
2.3.06.02. MPT51/MPB51 antigen 1r88 Mycobacterium tuberculosis Bact. Gram-pos cell wall 1 0 1.8 ± 1.0 28 ± 26 -3.9
2.1.01.01. Basic phospholipase A2 homolog CTs-R6 4h0s Trimeresurus stejnegeri Secreted 1 0 6.0 ± 1.2 87 ± 4 -9.4
1.3.16.04. Porin B, low pH structure 4gf4 Pseudomonas putida Bact. Gram-neg outer 1 16 22.4 ± 1.1 5 ± 2 -54.3
3.1.02.02. S4-S5 linker peptide (532-551) of HERG K+ channel 2le7 Homo sapiens Eukaryo. plasma 1 0 2.9 ± 1.4 69 ± 9 -5.0
2.4.07.01. PX domain of NADH oxidase (p47phox), ligand-bound 1o7k Homo sapiens Endosome 1 0 15.2 ± 1.7 60 ± 15 -18.4
3.2.01.05. Polyphemusin-1 1rkk Limulus polyphemus (Atlantic horseshoe crab) Secreted 1 0 3.5 ± 3.7 63 ± 11 -4.0
1.3.14.01. Fatty Acid Transporter FadL, D348R, open channel 3pgr Escherichia coli Bact. Gram-neg outer 1 14 25.4 ± 1.4 3 ± 1 -50.8
3.1.04.03. Viral protein R, peptide 50-82 1bde Human immunodeficiency virus type 1 Eukaryo. plasma 1 0 3.8 ± 1.1 89 ± 24 -6.7
2.4.07.01. Sorting nexin-5 3hpc Rattus norvegicus Endosome 1 0 0.0 ± 2.1 90 ± 8 -2.4
3.1.21.07. Cupiennin-1a (M-ctenitoxin-Cs1a) 2k38 Cupiennius salei (Wandering spider) Secreted 1 0 8.1 ± 4.0 77 ± 9 -5.1
1.1.15.01. Nicotinic acetylcholine receptor, beta-2, in LDAO micelles 2lm2 Homo sapiens Eukaryo. plasma 1 4 29.2 ± 1.6 14 ± 2 -48.8
2.4.16.05. Micasin 2lr5 Arthroderma otae Secreted 1 0 8.3 ± 0.6 58 ± 6 -7.8
2.1.24.01. Saposin A (peptide 60-140) 2dob Homo sapiens Lysosome 1 0 2.0 ± 2.5 70 ± 29 -4.2
2.3.16.04. Dynamin-like protein 2j69 Nostoc punctiforme Bact. Gram-neg inner 1 0 4.0 ± 7.0 15 ± 10 -5.5
1.2.61.01. Mitochondrial inner membrane translocase subunit TIM50 4qqf Saccharomyces cerevisiae Mitochon. inner 1 0 5.4 ± 0.8 76 ± 1 -7.0
2.1.01.01. Snake phospholipase A2, group I 1ae7 Notechis scutatus scutatus (Mainland tiger snake) Secreted 1 0 4.7 ± 0.6 84 ± 9 -6.2
2.1.62.01. Thuricin beta 2la0 Bacillus cereus Secreted 1 0 10.0 ± 2.6 37 ± 7 -8.8
3.1.02.01. Peptide 171-197 of parathyroid hormone receptor 1bl1 Homo sapiens Eukaryo. plasma 1 1 20.8 ± 1.2 19 ± 4 -11.5
3.1.07.01. Fusion peptide (772-787) of spike glycoprotein 2rum Human SARS coronavirus Endosome 1 0 11.1 ± 1.1 57 ± 13 -10.8
3.1.01.02. Leader peptide of bacteriocin microcin B17 2mlp Escherichia coli Secreted 1 0 3.2 ± 3.6 84 ± 4 -6.6
2.1.01.04. Phospholipase A2 homolog 2wg7 Oryza sativa (Rice) Secreted 1 0 4.0 ± 1.1 77 ± 3 -10.7
3.1.05.07. Penetratin 1omq Designed proteins Undefined 1 0 3.2 ± 1.0 79 ± 7 -7.4
2.4.06.02. Phosphatidylinositol transfer protein alpha isoform 1kcm Mus musculus Eukaryo. plasma 1 0 5.3 ± 1.4 59 ± 5 -11.0
1.2.32.01. Cytochrome P450 2B4, open state 2 1po5 Oryctolagus cuniculus Endoplasm. reticulum 1 0 3.5 ± 1.4 79 ± 9 -7.2
2.2.22.01. Hydrophobin II 1r2m Hypocrea jecorina Secreted 1 0 4.1 ± 1.0 16 ± 15 -6.6
3.2.05.01. Sviceucin 2ls1 Streptomyces sviceus Secreted 1 0 2.6 ± 1.3 78 ± 5 -7.0
2.2.34.09. Psi-conotoxin PIIIE 1as5 Conus purpurascens (Purple cone) Secreted 1 0 1.9 ± 1.3 87 ± 11 -3.6
2.2.20.01. Fermitin family homolog 2 4f7h Homo sapiens Eukaryo. plasma 1 0 2.2 ± 1.4 72 ± 4 -4.2
2.3.06.12. Carboxylesterase 2hm7 Alicyclobacillus acidocaldarius Bact. Gram-pos plas. 1 0 5.8 ± 1.7 70 ± 5 -7.7
2.1.01.01. Snake phospholipase A2 homolog zhaoermiatoxin, group II 2ph4 Zhaoermia manqshanensis Secreted 1 0 4.8 ± 0.8 86 ± 5 -9.2
2.3.13.05. Putative peroxiredoxin Rv2238c/MT2298 1xvw Mycobacterium tuberculosis Undefined 1 0 4.6 ± 1.0 20 ± 5 -7.0
2.4.06.04. STAR-related bacterial protein 2d4r Thermus thermophilus Bact. Gram-neg inner 1 0 6.9 ± 2.2 28 ± 6 -7.1
2.2.34.02. Voltage sensor toxin VSTx1 1s6x Grammostola rosea (Chilean rose tarantula) Secreted 1 0 4.4 ± 1.4 79 ± 13 -6.3
2.3.06.07. Lipase I.3, open state 3a70 Pseudomonas sp. MIS 38 Secreted 1 0 9.1 ± 1.0 58 ± 1 -32.9
1.1.26.01. Sodium-dependent serotonin transporter, outward-facing state 5i6x Homo sapiens Eukaryo. plasma 1 12 31.6 ± 1.4 10 ± 0 -90.7
3.1.20.01. Alpha-conotoxin BuIA 2i28 Conus bullatus (Bubble cone) Secreted 1 0 7.4 ± 2.2 68 ± 9 -4.6
2.2.07.01. Lipocalin BcnA 5ixh Burkholderia cepacia Bact. Gram-neg inner 1 0 1.4 ± 2.6 28 ± 29 -1.7
3.1.28.05. Aurein 1.2 1vm5 Litoria aurea Secreted 1 0 9.5 ± 1.8 63 ± 14 -9.7
3.2.10.01. PawS derived peptide 11 2lwq Designed proteins Undefined 1 0 10.1 ± 1.4 55 ± 22 -9.5
2.1.02.01. Arachidonate 5-lipoxygenase 3o8y Homo sapiens Eukaryo. plasma 1 0 2.1 ± 1.0 89 ± 4 -3.8
2.2.41.01. Beta-defensin 12 1bnb Bos taurus Secreted 1 0 6.0 ± 1.6 88 ± 15 -10.8
3.1.14.01. Tachykinin-4 2moc Homo sapiens Secreted 1 0 4.6 ± 0.6 75 ± 5 -7.7
1.1.30.01. YidC-like protein 5c8j Methanococcus jannaschii Archaebac. 1 4 29.8 ± 1.4 42 ± 2 -42.1
2.1.18.01. Annexin III 1axn Homo sapiens Eukaryo. plasma 1 0 2.7 ± 0.8 77 ± 11 -5.7
3.1.07.05. Nonstructural protein 4b, segment 1716-1755 2lvg Hepatitis C virus Viral 1 0 6.4 ± 0.7 82 ± 8 -11.4
2.2.39.01. Bucandin 1f94 Bungarus candidus (Malayan krait) Secreted 1 0 5.0 ± 1.3 61 ± 6 -4.9
1.1.01.02. Neurotensin receptor type 1, structure 2 4buo Rattus norvegicus Eukaryo. plasma 1 7 31.4 ± 1.4 6 ± 2 -62.6
1.1.26.02. Sodium-hydantoin transporter Mhp1, outward-facing conformation 1 4d1b Mycobacterium liquefaciens Bact. Gram-pos plas. 1 12 29.8 ± 0.9 17 ± 0 -96.4
1.3.25.02. Hemolysin 1xez Vibrio cholerae Secreted 1 0 8.2 ± 2.3 19 ± 6 -6.0
3.1.05.03. Glycosaminoglycan-binding (KYE) peptide 2ncw Designed proteins Undefined 1 0 5.0 ± 0.4 84 ± 6 -10.1
2.2.11.01. Rabphilin-3A 2k3h Mus musculus Eukaryo. plasma 1 0 1.7 ± 2.1 78 ± 16 -4.1
1.2.57.01. Reticulon-4 2ko2 Mus musculus Endoplasm. reticulum 1 0 2.5 ± 0.3 83 ± 1 -6.2
2.3.06.08. Pancreatic lipase 1gpl Cavia porcellus Secreted 1 0 5.8 ± 1.0 86 ± 9 -7.8
2.4.16.04. Defensin-like protein 32 2mz0 Arabidopsis thaliana Secreted 1 0 2.6 ± 1.4 19 ± 8 -3.4
1.1.35.03. PH domain of fermitin family homolog 3 5l81 Mus musculus Eukaryo. plasma 1 0 3.8 ± 2.2 59 ± 7 -4.2
1.3.01.01. Outer membrane protein A from Klebsiella 2k0l Klebsiella pneumoniae Bact. Gram-neg outer 1 8 24.3 ± 2.3 18 ± 6 -26.8
2.4.03.01. Tubby protein 3c5n Homo sapiens Eukaryo. plasma 1 0 3.4 ± 0.4 75 ± 5 -7.6
1.1.37.01. Divalent metal cation transporter MntH 5m87 Eremococcus coleocola Bact. Gram-pos plas. 1 12 30.2 ± 0.6 10 ± 0 -96.6
2.4.16.01. Toxin Bmka2 2kbj Mesobuthus martensii (Manchurian scorpion) Secreted 1 0 4.1 ± 1.5 64 ± 15 -3.6
3.1.02.01. Beta-1 adrenergic receptor, peptide 345-359 1dep Meleagris gallopavo Eukaryo. plasma 1 0 4.4 ± 1.2 76 ± 16 -8.3
1.2.32.01. Lanosterol 14-alpha demethylase (CYP51), with lanosterol 5eqb Saccharomyces cerevisiae Endoplasm. reticulum 1 1 29.8 ± 0.9 39 ± 2 -34.5
3.1.20.01. alpha-conotoxin auIB 1dg2 Conus aulicus Secreted 1 0 5.1 ± 1.7 89 ± 16 -4.9
3.1.18.02. Phenol-soluble modulin beta-2 5kgz Staphylococcus aureus Secreted 1 0 6.2 ± 2.5 55 ± 7 -6.2
2.2.06.02. Fatty acid-binding protein Sm14 1vyf Schistosoma mansoni Eukaryo. plasma 1 0 5.1 ± 1.2 42 ± 18 -5.2
1.2.54.01. Dihydroorotate dehydrogenase 1d3h Homo sapiens Mitochon. inner 1 0 3.4 ± 0.8 55 ± 6 -10.1
2.4.06.01. Steroidogenic acute regulatory protein, mitochondrial 3p0l Homo sapiens Mitochon. outer 1 0 3.0 ± 1.3 76 ± 10 -4.7
3.1.11.02. Glucagon analog, lipidated 2m5p Homo sapiens Secreted 1 0 5.2 ± 0.6 85 ± 4 -6.0
1.3.01.02. Attachment invasion locus protein, complex with the heparin analogue 3qrc Yersinia pestis Bact. Gram-neg outer 1 8 24.6 ± 1.2 7 ± 5 -31.6
2.4.25.01. N-alpha-acetyltransferase 60, structure 1 5hgz Homo sapiens Golgi 1 0 5.7 ± 1.1 41 ± 7 -8.5
3.1.24.01. Penaeidin-4d 1xv3 Litopenaeus setiferus (Atlantic white shrimp) Secreted 1 0 3.4 ± 2.7 76 ± 17 -7.8
3.1.04.01. Protein STE5, peptide 44-67 2kgn Saccharomyces cerevisiae Eukaryo. plasma 1 0 6.4 ± 0.9 84 ± 7 -9.8
2.3.06.06. Lipase 1, closed (inactive) state 1trh Candida rugosa Secreted 1 0 4.9 ± 1.3 85 ± 7 -7.4
3.1.21.01. Cecropin-P1 2n92 Ascaris suum Secreted 1 0 1.6 ± 3.4 90 ± 0 -4.1
2.2.27.01. Diacylglycerol kinase delta 1r79 Homo sapiens Eukaryo. plasma 1 0 3.3 ± 1.6 34 ± 19 -4.9
2.3.13.04. Phospholipid hydroperoxide glutathione peroxidase 5l71 Mus musculus Mitochon. inner 1 0 7.1 ± 1.8 83 ± 14 -5.1
3.2.09.03. Tyrocidine A 4m6e Bacillus brevis Secreted 1 0 6.8 ± 0.9 56 ± 8 -9.0
1.3.27.01. Capsule assembly protein Wzi 2ynk Escherichia coli Bact. Gram-neg outer 1 18 23.8 ± 1.3 6 ± 1 -58.2
3.1.07.02. Juxtamembrane peptide (684-719) of protein gp41 2kzq Hepatitis C virus Endosome 1 0 4.3 ± 3.3 88 ± 0 -9.9
2.1.43.01. Acanthaporin 2lrd Acanthamoeba culbertsoni Secreted 1 0 4.8 ± 3.0 56 ± 26 -4.9
1.2.01.01. Receptor tyrosine-protein kinase erbB-2 1n8y Rattus norvegicus Eukaryo. plasma 1 0 3.4 ± 3.0 53 ± 5 -4.2
2.3.06.07. Lipase I.3, closed state 2z8x Pseudomonas sp. MIS 38 Secreted 1 0 6.8 ± 1.7 74 ± 6 -8.2
2.2.06.02. Cellular retinoic acid-binding protein 2 1cbs Homo sapiens Nuclear outer 1 0 7.1 ± 1.9 41 ± 13 -5.9
1.1.47.01. Sensor protein qseC 2kse Escherichia coli Bact. Gram-neg inner 1 2 31.3 ± 2.5 19 ± 0 -35.7
1.1.01.02. Melanocortin-4 receptor model (inactive state) with antagonist AGRP 2iqv Homo sapiens Eukaryo. plasma 1 7 31.9 ± 1.1 19 ± 0 -49.1
2.1.01.01. Snake phospholipase A2, group I 1ozy Micropechis ikaheka Secreted 1 0 2.6 ± 1.0 85 ± 5 -9.0
3.2.04.01. Cyclic trypsin inhibitor STFI-1 1jbl Helianthus annuus Secreted 1 0 7.2 ± 0.8 72 ± 8 -6.1
3.1.01.05. Proteinase inhibitor, vacuolar targeting peptide (372-397) 1vtp Nicotiana alata (Winged tobacco) Vacuole 1 0 3.5 ± 1.1 87 ± 4 -4.2
3.1.11.02. Vasoactive intestinal peptide 2rrh Homo sapiens Secreted 1 0 4.1 ± 0.3 79 ± 9 -5.7
1.1.38.01. Multidrug transporter MatE 4z3n Escherichia coli Bact. Gram-neg inner 1 12 29.6 ± 1.1 7 ± 1 -93.1
1.2.33.02. Alpha-glycerophosphate oxidase (GlpO) 2rgh Streptomyces sp. Bact. Gram-pos plas. 1 0 3.9 ± 1.4 71 ± 12 -6.2
2.4.20.01. Cysteine protease 3ois Xylella fastidiosa Undefined 1 0 3.2 ± 0.2 80 ± 4 -6.4
1.1.28.03. SecDF protein-export membrane protein 3aqp Thermus thermophilus Bact. Gram-neg inner 1 12 29.8 ± 0.9 5 ± 1 -93.8
1.2.32.01. Cytochrome P450 2C5, different conformation 1dt6 Oryctolagus cuniculus Endoplasm. reticulum 1 0 7.3 ± 1.0 13 ± 7 -8.8
3.1.28.07. Hylin-A1 2n0o Hypsiboas albopunctatus Secreted 1 0 11.4 ± 0.8 62 ± 4 -15.4
2.2.39.01. Cytotoxin 4 4om5 Naja atra Secreted 1 0 3.8 ± 0.6 75 ± 3 -11.1
1.1.59.01. Membrane protease specific for a stomatin homolog, monomer 3bpp Pyrococcus horikoshii Archaebac. 1 0 4.0 ± 0.4 82 ± 5 -6.3
2.2.11.01. Synaptotagmin-like protein 4 3fdw Homo sapiens Vesicle 1 0 3.0 ± 2.0 71 ± 17 -3.6
2.2.34.02. Mu-theraphotoxin-Hhn1b 1niy Haplopelma hainanum (Chinese bird spider) Secreted 1 0 2.2 ± 0.7 71 ± 6 -4.6
1.1.01.02. C-X-C chemokine receptor type 1 2lnl Homo sapiens Eukaryo. plasma 1 7 30.2 ± 0.9 19 ± 6 -54.4
2.1.47.01. Group 2 truncated hemoglobin glbO 2qrw Mycobacterium tuberculosis Bact. Gram-pos plas. 1 0 4.5 ± 1.0 52 ± 3 -5.5
2.2.34.11. Kalata-B7 2jwm Oldenlandia affinis Secreted 1 0 2.7 ± 2.2 86 ± 28 -4.8
2.2.25.01. Superoxide dismutase [Cu-Zn] 1oal Photobacterium leiognathi Bact. Gram-neg inner 1 0 2.4 ± 0.9 77 ± 2 -6.8
2.1.18.01. Annexin IV 2zhj Rattus norvegicus Eukaryo. plasma 1 0 4.1 ± 1.0 80 ± 1 -7.6
1.2.32.01. Cytochrome P450 1B1 3pm0 Homo sapiens Endoplasm. reticulum 1 0 3.8 ± 0.7 79 ± 1 -7.0
2.4.16.03. Charybdotoxin 2crd Leiurus quinquestriatus hebraeus Secreted 1 0 1.1 ± 1.5 86 ± 15 -3.2
1.1.38.01. H+-driven MATE exporter, outward-open, different conformation 4mlb Pyrococcus furiosus Archaebac. 1 12 30.2 ± 1.2 5 ± 0 -88.1
1.1.01.02. Rhodopsin, inactive, complex with inverse agonist, 11-cis retinal 1gzm Bos taurus Eukaryo. plasma 1 7 32.2 ± 1.5 11 ± 1 -75.6
1.1.01.04. Smoothened homolog, monomer, conformation 4 5l7i Homo sapiens Eukaryo. plasma 1 7 32.4 ± 1.4 10 ± 1 -58.7
3.1.07.01. Fusion peptide (524-539) of ebolavirus glycoprotein GP2 2rlj Zaire ebolavirus Viral 1 0 5.8 ± 1.8 84 ± 6 -6.8
3.1.11.01. Pancreatic hormone 1v1d Bos taurus Secreted 1 0 1.2 ± 3.0 79 ± 32 -1.9
1.1.01.02. C-C chemokine receptor type 5 4mbs Homo sapiens Eukaryo. plasma 1 7 34.4 ± 1.5 0 ± 0 -88.8
1.1.25.05. Proton-dependent oligopeptide transporter, conformation 2 4iky Geobacillus kaustophilus Bact. Gram-pos plas. 1 14 31.8 ± 1.3 4 ± 0 -115.6
2.3.06.07. Tentative lipase 2zyr Archaeoglobus fulgidus Secreted 1 0 3.0 ± 1.0 57 ± 8 -7.5
3.1.05.03. VG16KRKP peptide, structure 1 2mxh Designed proteins Undefined 1 0 2.5 ± 2.4 82 ± 11 -3.2
2.1.04.01. Alpha-dioxygenase 1 4hhr Arabidopsis thaliana Endoplasm. reticulum 1 0 10.8 ± 0.1 68 ± 2 -31.4
2.3.08.01. Patatin 1oxw Solanum cardiophyllum Secreted 1 0 3.9 ± 2.0 28 ± 11 -6.5
2.3.06.12. Carboxylesterase 3wj2 Thermoplasma acidophilum Secreted 1 0 2.9 ± 1.9 81 ± 9 -5.1
2.1.10.01. Glycolipid transfer protein, structure 1 1tfj Bos taurus Eukaryo. plasma 1 0 3.9 ± 1.0 90 ± 5 -8.3
1.1.01.02. Cannabinoid receptor 1, structure 1 5tgz Homo sapiens Eukaryo. plasma 1 7 34.4 ± 1.2 12 ± 0 -71.6
1.3.20.01. Ferric hydroxamate uptake receptor FhuA, complex with TonB 2grx Escherichia coli Bact. Gram-neg outer 1 22 24.6 ± 1.1 3 ± 0 -77.2
2.1.60.02. Potassium channel blocking domain of matrix metalloproteinase-23 2k72 Rattus norvegicus Eukaryo. plasma 1 0 2.1 ± 2.3 77 ± 22 -4.4
3.1.28.02. Alyteserin-1C 2l5r Alytes obstetricans Secreted 1 0 8.7 ± 4.1 81 ± 0 -14.1
1.1.60.01. Protease GlpG, complex with inhibitor, conformation 3 3ubb Escherichia coli Bact. Gram-neg inner 1 6 29.8 ± 1.3 21 ± 1 -65.3
2.2.20.01. Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1 3nsu Saccharomyces cerevisiae Eukaryo. plasma 1 0 0.8 ± 1.5 57 ± 12 -4.0
3.1.14.01. Kassinin 1myu Kassina senegalensis Secreted 1 0 3.4 ± 1.5 59 ± 16 -4.5
2.3.06.06. Mono- and diacylglycerol lipase 5ch8 Penicillium cyclopium Secreted 1 0 2.7 ± 0.3 9 ± 7 -4.2
2.2.20.01. Rac-beta serine/threonine protein kinase 1p6s Homo sapiens Eukaryo. plasma 1 0 3.8 ± 1.8 83 ± 11 -5.7
1.2.43.01. Envelope glycoprotein, Zika virus, structure 6 5gzn Zika virus Viral 1 0 5.1 ± 2.6 41 ± 11 -4.9
2.1.57.01. Adhesin FadA 3etw Fusobacterium nucleatum Secreted 1 0 5.0 ± 3.8 47 ± 5 -6.7
1.3.11.01. Hemoglobin-binding protease Hbp autotransporter 3aeh Escherichia coli Bact. Gram-neg outer 1 12 25.2 ± 1.1 4 ± 0 -41.9
1.2.30.01. Potassium voltage-gated channel subfamily E member 2 2m0q Homo sapiens Eukaryo. plasma 1 1 31.8 ± 3.9 34 ± 5 -31.8
2.3.16.06. ADP-ribosylation factor 1 (ARF1) 2k5u Saccharomyces cerevisiae Golgi 1 0 2.9 ± 1.6 24 ± 18 -5.5
2.4.16.02. Defensin heliomicin 1i2u Heliothis virescens (Tobacco budworm moth) Secreted 1 0 3.4 ± 0.4 59 ± 1 -7.6
1.2.28.01. Transmembrane regulatory peptide MgtR 2mc7 Salmonella enterica Bact. Gram-neg inner 1 1 31.8 ± 2.2 13 ± 4 -26.8
2.1.41.01. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform 1e7u Sus scrofa Eukaryo. plasma 1 0 2.5 ± 0.9 85 ± 3 -4.7
3.2.09.02. Gramicidin S 1tk2 Bacillus brevis Secreted 1 0 8.5 ± 1.7 86 ± 21 -8.6
2.3.06.06. Triacylglycerol lipase, closed state 2 5ap9 Humicola lanuginosa Secreted 1 0 5.7 ± 0.4 79 ± 5 -6.1
2.3.05.02. Sulfide-quinone reductase 3sx6 Acidithiobacillus ferrooxidans Bact. Gram-neg inner 1 0 10.6 ± 0.6 70 ± 8 -7.3
2.1.37.01. Erythrocyte membrane protein 1 2xu0 Plasmodium falciparum Eukaryo. plasma 1 0 3.3 ± 6.0 75 ± 45 -3.2
1.2.33.02. Protoporphyrinogen oxidase 1sez Nicotiana tabacum Mitochon. inner 1 0 2.2 ± 1.0 50 ± 3 -7.0
1.2.22.01. Bcl-2-like protein 2 1o0l Homo sapiens Mitochon. outer 1 0 1.7 ± 2.3 86 ± 14 -3.7
2.3.06.07. Thermostable lipase 4fdm Bacillus sp. Secreted 1 0 5.2 ± 0.6 28 ± 2 -8.5
1.3.19.01. Glycine-glutamate dipeptide porin OpdP 3syb Pseudomonas aeruginosa Bact. Gram-neg outer 1 18 23.6 ± 0.9 8 ± 0 -62.0
2.4.16.07. Diapause-specific peptide 2e2f Gastrophysa atrocyanea (Leaf beetle) Secreted 1 0 1.3 ± 1.0 30 ± 10 -4.2
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), structure 1 5tz1 Candida albicans Endoplasm. reticulum 1 0 8.7 ± 0.9 67 ± 4 -16.2
2.2.39.01. alpha-Cobratoxin 1ctx Naja kaouthia Secreted 1 0 2.8 ± 1.7 29 ± 18 -4.6
3.1.28.08. Ocellatin-K1 5u9x Leptodactylus knudseni Secreted 1 0 7.4 ± 0.2 77 ± 4 -11.8
1.1.44.01. DsbB - DsbA complex, conformation 2 2zup Escherichia coli Bact. Gram-neg inner 1 4 24.2 ± 2.9 3 ± 8 -18.3
1.1.60.01. Protease GlpG, complex with peptide-based inhibitor 4qo2 Escherichia coli Bact. Gram-neg inner 1 6 28.6 ± 1.2 18 ± 0 -58.3
2.2.05.01. Plastocyanin 1bxv Synechocystis sp. Thylakoid 1 0 2.0 ± 1.6 36 ± 19 -2.6
2.2.41.01. Alpha-defensin 5 1zmp Homo sapiens Secreted 1 0 4.2 ± 1.6 84 ± 14 -2.8
2.2.12.01. Ganglioside GM2 activator 1tjj Homo sapiens Lysosome 1 0 4.2 ± 0.3 57 ± 4 -8.3
2.2.20.01. PH domain of muscle M-line assembly protein unc-89 1fho Caenorhabditis elegans Eukaryo. plasma 1 0 2.3 ± 1.2 25 ± 14 -4.3
2.3.06.01. Bile-salt activated lipase, structure 2 1jmy Homo sapiens Secreted 1 0 5.0 ± 1.4 85 ± 9 -5.3
2.4.51.01. Heme acquisition protein HasA, different strain 3wah Pseudomonas aeruginosa Secreted 1 0 3.4 ± 0.6 14 ± 3 -5.1
1.3.17.02. Translocation and assembly module TamA 4c00 Escherichia coli Bact. Gram-neg outer 1 16 23.4 ± 1.3 7 ± 1 -52.2
2.4.04.01. Inositol polyphosphate 5-phosphatase OCRL-1 4cmn Homo sapiens Endosome 1 0 6.7 ± 1.6 83 ± 2 -9.2
2.2.34.02. M-theraphotoxin-Gr1a 1lu8 Grammostola rosea (Chilean rose tarantula) Secreted 1 0 2.8 ± 0.9 69 ± 7 -7.2
2.3.10.07. Lipopolysaccharide biosynthesis protein RfaG, 103-131 2n58 Escherichia coli Bact. Gram-neg inner 1 0 4.5 ± 1.1 64 ± 7 -6.3
2.4.31.01. Ficolin-1 2wnp Homo sapiens Eukaryo. plasma 1 0 3.0 ± 0.8 65 ± 2 -5.3
2.2.41.02. Toxin APETx1 1wqk Anthopleura elegantissima (Sea anemone) Secreted 1 0 4.0 ± 1.4 32 ± 18 -7.3
1.3.01.01. Transmembrane beta-barrel platform protein 2jmm Designed proteins Undefined 1 8 23.9 ± 1.3 4 ± 4 -32.3
1.1.09.01. Plasma membrane ATPase 2, E1-ATP state 5ksd Arabidopsis thaliana Eukaryo. plasma 1 10 30.8 ± 1.2 4 ± 1 -59.3
1.2.32.01. Cytochrome P450 2A6 1z10 Homo sapiens Endoplasm. reticulum 1 0 5.0 ± 1.7 44 ± 18 -9.5
2.1.27.01. Cry2Aa 1i5p Bacillus thuringiensis Secreted 1 0 3.4 ± 1.2 16 ± 12 -7.0
3.4.08.03. Oxytocin 1xy2 Bos taurus Secreted 1 0 2.1 ± 2.6 86 ± 12 -3.2
1.3.19.02. Alginate export protein, AlgE, conformation 5 4xnl Pseudomonas aeruginosa Bact. Gram-neg outer 1 18 25.2 ± 1.1 3 ± 0 -73.6
1.1.25.06. Glucose transporter GLUT3/SLC2A3, outward-occluded 4zw9 Homo sapiens Eukaryo. plasma 1 12 32.8 ± 1.4 6 ± 1 -95.1
1.1.71.01. SidF, inhibitor of growth family, member 3 4fyg Legionella pneumophila Vacuole 1 0 8.1 ± 3.3 81 ± 10 -3.9
2.1.29.03. Apolipoprotein C-I, peptide 61-79 1alf Homo sapiens Secreted 1 0 4.1 ± 0.5 86 ± 3 -9.4
3.1.04.04. Peptide of huntigtin, 1-17 2ld2 Homo sapiens Eukaryo. plasma 1 0 4.2 ± 0.6 90 ± 4 -9.3
2.1.01.01. Phospholipase A2, group IB 3elo Homo sapiens Secreted 1 0 0.4 ± 1.5 52 ± 16 -3.5
2.3.10.01. Glycosyltransferase GtfA 1pn3 Amycolatopsis orientalis (Nocardia orientalis) Undefined 1 0 7.2 ± 1.0 80 ± 5 -7.7
1.1.44.01. DsbB-DsbA complex, conformation 3 2leg Escherichia coli Bact. Gram-neg inner 1 4 30.6 ± 1.7 34 ± 2 -36.3
1.2.32.01. Cytochrome P450 2E1 3e6i Homo sapiens Endoplasm. reticulum 1 0 8.3 ± 2.0 49 ± 8 -14.2
2.2.34.01. Omega conotoxin TxVII 1f3k Conus textile Secreted 1 0 2.8 ± 1.4 57 ± 18 -4.5
3.2.03.01. Hepcidin, structure 1 3h0t Homo sapiens Secreted 1 0 4.7 ± 0.6 82 ± 9 -7.0
1.3.20.01. Hemophore receptor HasR, structure 2 5c58 Serratia marcescens Bact. Gram-neg outer 1 22 24.8 ± 1.2 2 ± 0 -68.0
1.1.01.02. Orexin receptor type 1 4zjc Homo sapiens Eukaryo. plasma 1 7 31.6 ± 1.5 4 ± 1 -67.5
2.2.11.01. C2A domain of synaptotagmin-5 5h4y Homo sapiens Vesicle 1 0 2.3 ± 2.3 29 ± 11 -4.5
2.2.34.10. Imperatoxin-A 1ie6 Pandinus imperator (Emperor scorpion) Secreted 1 0 2.6 ± 0.8 55 ± 13 -3.1
1.1.01.02. Rhodopsin, inactive, structure 3 1u19 Bos taurus Eukaryo. plasma 1 7 31.2 ± 1.5 12 ± 1 -71.9
2.3.04.01. Tyrosine-protein phosphatase CpsB 2wje Streptococcus pneumoniae Bact. Gram-pos plas. 1 0 4.2 ± 2.8 76 ± 26 -4.6
2.2.34.11. Tricyclon-A 1yp8 Viola arvensis Secreted 1 0 4.4 ± 1.7 71 ± 19 -4.7
3.2.01.09. Peptidomimetic TWLKKRRWKKAK-D-Pro-P 2m7j Designed proteins Undefined 1 0 1.0 ± 1.7 75 ± 37 -2.7
2.2.07.01. Acidic stress response factor 3hpe Helicobacter pylori Bact. Gram-neg inner 1 0 3.0 ± 0.7 34 ± 8 -6.1
1.1.01.02. Beta-1 adrenergic receptor, inactive, complex with agonist 2y02 Meleagris gallopavo Eukaryo. plasma 1 7 31.4 ± 1.3 2 ± 0 -76.9
1.2.32.01. Steroid 17-alpha-hydroxylase/17,20 lyase (P450 17A1) 3swz Homo sapiens Endoplasm. reticulum 1 0 4.2 ± 1.6 56 ± 3 -8.4
2.1.42.01. Mundticin KS immunity protein 2zrr Enterococcus mundtii Secreted 1 0 1.6 ± 1.5 72 ± 9 -3.2
2.4.06.05. Thermoacidophile-specific fatty acid carrier 3w9k Sulfolobus tokodaii Archaebac. 1 0 2.7 ± 1.4 47 ± 4 -7.1
2.2.27.01. C1 domain of protein kinase C delta 1ptr Mus musculus Eukaryo. plasma 1 0 6.6 ± 1.5 19 ± 8 -5.9
3.1.11.02. Glucagon analog 1bh0 Homo sapiens Secreted 1 0 4.9 ± 4.2 78 ± 2 -6.1
1.3.20.01. Pyoverdine Outer Membrane Receptor FpvA 2iah Pseudomonas aeruginosa Bact. Gram-neg outer 1 22 24.0 ± 0.5 8 ± 0 -79.7
1.2.17.01. Syntaxin 1A, pre-fusion structure in micelles 2m8r Rattus norvegicus Eukaryo. plasma 1 2 20.8 ± 0.5 8 ± 5 -20.5
3.4.02.03. Lantibiotic 107891 2mh5 Microbispora sp. Bact. Gram-pos plas. 1 0 7.3 ± 3.0 72 ± 38 -4.0
3.1.13.01. Islet amyloid polypeptide, fragment 34-70 2kb8 Homo sapiens Secreted 1 0 3.9 ± 4.2 90 ± 1 -10.2
3.1.05.03. VG16KRKP peptide, structure 2 2n63 Designed proteins Undefined 1 0 2.5 ± 0.3 57 ± 4 -4.0
2.4.05.01. Sterol carrier protein 2-like 2 2qzt Aedes aegypti (Yellowfever mosquito) Eukaryo. plasma 1 0 1.0 ± 2.0 45 ± 12 -3.0
1.1.09.01. Calcium ATPase, E2-Pi state, conformation 4 3b9r Oryctolagus cuniculus Endoplasm. reticulum 1 10 26.8 ± 0.0 25 ± 0 -44.1
2.3.06.06. Lipase 1, open (active) state 1lpp Candida rugosa Secreted 1 0 10.0 ± 0.4 83 ± 1 -28.0
3.1.29.01. Crotalicidin 2mwt Crotalus durissus terrificus Secreted 1 0 5.2 ± 2.4 86 ± 1 -8.6
2.2.11.01. Synaptotagmin-4 1ugk Homo sapiens Eukaryo. plasma 1 0 2.5 ± 1.7 34 ± 11 -3.5
1.2.43.01. Envelope glycoprotein, Dengue virus type 3 1uzg Dengue virus Viral 1 0 5.7 ± 2.7 18 ± 7 -5.4
2.2.15.01. Gamma-crystallin F 1m8u Bos taurus Secreted 1 0 0.7 ± 1.2 85 ± 4 -4.9
1.3.19.01. Outer membrane porin OprD 2odj Pseudomonas aeruginosa Bact. Gram-neg outer 1 18 23.0 ± 0.8 8 ± 0 -63.1
2.2.27.01. RAS guanyl-releasing protein 1 4l9m Homo sapiens Eukaryo. plasma 1 0 5.3 ± 1.3 24 ± 3 -7.8
2.4.16.01. Alpha-insect toxin LqhaIT 2yeo Leiurus quinquestriatus hebraeus Secreted 1 0 3.5 ± 0.8 43 ± 13 -5.9
1.2.04.01. Integrin beta-3, 742-788, 747pY, in water 2ljf Homo sapiens Eukaryo. plasma 1 0 0.6 ± 1.6 62 ± 14 -1.8
3.1.12.01. Endothelin-1 1edn Homo sapiens Secreted 1 0 4.3 ± 1.2 71 ± 25 -5.4
2.2.34.07. Asteropsin E 2m3j Asteropus sp. Secreted 1 0 4.5 ± 1.1 65 ± 7 -3.6
2.2.05.01. Azurin I 1rkr Alcaligenes xylosoxidans Bact. Gram-neg inner 1 0 1.0 ± 1.0 43 ± 7 -4.3
2.2.06.02. Adipocyte lipid-binding protein 1a18 Mus musculus Eukaryo. plasma 1 0 3.7 ± 0.8 47 ± 7 -7.4
2.1.64.01. Envelope glycoprotein, ligand-binding domain 1 5e7x Talaromyces marneffei Eukaryo. plasma 1 0 2.7 ± 2.2 55 ± 13 -4.4
2.4.42.01. Cholesteryl ester transfer protein 2obd Homo sapiens Secreted 1 0 7.4 ± 2.9 26 ± 6 -7.0
1.3.21.01. Outer membrane usher protein FimD 3ohn Escherichia coli Bact. Gram-neg outer 1 24 21.2 ± 1.1 5 ± 0 -45.4
1.2.39.03. Disintegrin and metalloproteinase domain-containing protein 10 2ao7 Bos taurus Golgi 1 0 3.1 ± 1.4 81 ± 6 -5.7
2.4.16.04. Floral defensin-like protein 1 1n4n Petunia hybrida Secreted 1 0 1.8 ± 0.8 6 ± 9 -3.8
2.4.15.01. Protein Nef (HIV HV1LW) 2nef Human immunodeficiency virus type 1 Eukaryo. plasma 1 0 6.3 ± 1.4 73 ± 3 -7.9
1.1.09.01. Calcium ATPase, E1 state, with macrolide BLS 4ycm Oryctolagus cuniculus Endoplasm. reticulum 1 10 3.2 ± 1.8 21 ± 1 -66.3
2.1.03.01. Alpha-toxin (PHLC1_CLOPE), closed state (inactive) 1gyg Clostridium perfringens Secreted 1 0 6.1 ± 2.0 75 ± 6 -5.9
2.2.39.02. Mambalgin-1 5dz5 Dendroaspis polylepis polylepis (Black mamba) Secreted 1 0 6.2 ± 0.1 69 ± 1 -5.6
2.4.06.01. StAR-related lipid transfer protein 13 2pso Homo sapiens Eukaryo. plasma 1 0 3.1 ± 4.0 77 ± 27 -4.6
2.3.18.01. Carnitine O-acetyltransferase 1ndb Mus musculus Mitochon. inner 1 0 3.0 ± 0.9 85 ± 6 -7.6
3.1.05.03. Peptide YW12 2o0s Designed proteins Bact. Gram-pos cell wall 1 0 3.4 ± 1.3 82 ± 5 -5.5
2.1.01.01. MTX-II chain A 4k06 Bothrops brazili Secreted 1 0 5.0 ± 1.3 60 ± 11 -7.1
1.2.44.01. Amyloid beta A4 protein (peptide 672-711), in water 2lfm Homo sapiens Eukaryo. plasma 1 0 5.3 ± 0.5 87 ± 4 -8.6
2.4.07.01. PX domain of NADH oxidase (p47phox), ligand-free, longer chain 1kq6 Homo sapiens Endosome 1 0 2.4 ± 1.6 88 ± 12 -4.6
3.2.03.01. Maurocalcine 1s6w Scorpio maurus Secreted 1 0 1.8 ± 1.6 89 ± 21 -2.3
1.3.14.01. Fatty Acid Transporter FadL, F3E, open channel 3pgu Escherichia coli Bact. Gram-neg outer 1 14 25.2 ± 1.5 1 ± 1 -51.5
3.1.07.10. Structural peptide 1 of bursal disease virus 2imu Avian infectious bursal disease virus Eukaryo. plasma 1 0 11.6 ± 4.0 76 ± 5 -17.5
2.4.07.01. Sorting nexin-23 (Kinesin-like protein KIF16B) 2v14 Homo sapiens Endosome 1 0 3.3 ± 3.0 72 ± 14 -5.4
3.1.15.04. Bacteriocin plantaricin K (PlnK) 2keg Lactobacillus plantarum Secreted 1 0 3.3 ± 1.1 83 ± 11 -8.4
1.1.30.01. Membrane protein insertase YidC, structure 1 3wvf Escherichia coli Bact. Gram-neg inner 1 5 26.8 ± 1.3 10 ± 2 -46.7
2.3.06.08. Pancreatic lipase-related protein 2 1w52 Equus caballus Secreted 1 0 4.8 ± 0.2 83 ± 0 -12.7
2.3.01.10. Galactocerebrosidase 3zr5 Mus musculus Lysosome 1 0 5.2 ± 0.6 87 ± 1 -15.3
2.2.11.01. Rabphilin-3A, C2A domain 2chd Rattus norvegicus Eukaryo. plasma 1 0 2.9 ± 1.6 57 ± 19 -2.7
2.1.01.01. Snake phospholipase A2, group II, RVV-VD 1vip Vipera russelli Secreted 1 0 4.4 ± 0.8 85 ± 11 -9.5
2.1.62.01. Thuricin 17 2lbz Bacillus cereus Secreted 1 0 3.4 ± 2.6 88 ± 0 -7.7
3.1.02.01. Third extracellular loop of cholecystokinin A receptor 1hzn Homo sapiens Eukaryo. plasma 1 0 3.4 ± 0.9 81 ± 2 -10.3
3.1.07.01. Fusion peptide (1185-1201) of spike glycoprotein 2run Human SARS coronavirus Endosome 1 0 6.8 ± 4.0 74 ± 7 -10.7
2.2.33.01. Hevein 1q9b Hevea brasiliensis (Para rubber tree) Secreted 1 0 1.0 ± 1.0 90 ± 11 -1.8
1.1.38.01. Na+/drug antiporter NorM, outward-open, structure 2 5c6p Neisseria gonorrhoeae Bact. Gram-neg inner 1 12 28.6 ± 1.1 13 ± 0 -45.3
1.2.03.04. Leukocyte immunoglobulin-like receptor subfamily B member 4 3p2t Homo sapiens Eukaryo. plasma 1 0 1.7 ± 0.4 84 ± 5 -5.9
2.4.01.01. Cholesterol oxidase 1coy Brevibacterium sterolicum Bact. Gram-pos plas. 1 0 4.4 ± 1.1 43 ± 10 -6.8
2.1.01.01. Phospholipase A2 homolog, ammodytin L 3dih Vipera ammodytes ammodytes Secreted 1 0 5.0 ± 0.4 82 ± 5 -14.4
3.1.05.08. MSI-594 derived peptide MSI-594-F5A 2l36 Designed proteins Undefined 1 0 6.9 ± 7.0 79 ± 3 -8.3
3.1.03.03. Membrane-bound helix of phosphotransferase IIA component 1o53 Escherichia coli Bact. Gram-neg inner 1 0 3.3 ± 1.3 86 ± 15 -7.8
1.2.11.02. Capsid protein G8P, monomer 2xkm Bacteriophage Pf1 Secreted 1 1 29.2 ± 4.6 34 ± 1 -23.0
3.2.05.02. Caulosegnin I 2lx6 Caulobacter segnis Secreted 1 0 2.9 ± 0.8 15 ± 5 -6.0
1.3.19.02. Alginate export protein, AlgE, conformation 6 5d5d Pseudomonas aeruginosa Bact. Gram-neg outer 1 18 23.4 ± 1.2 4 ± 1 -67.1
1.1.25.06. Glucose transporter GLUT5, inward-open 4yb9 Bos taurus Eukaryo. plasma 1 12 31.8 ± 1.0 6 ± 0 -89.9
2.2.34.01. Omega-conotoxin SVIB 1mvj Conus striatus Secreted 1 0 1.1 ± 2.1 20 ± 24 -2.1
1.1.01.01. Chloride pumping rhodopsin 5b2n Nonlabens marinus Bact. Gram-neg inner 1 7 32.0 ± 1.0 12 ± 0 -63.1
1.2.44.01. Amyloid beta A4 protein, peptide 686-726 2llm Homo sapiens Eukaryo. plasma 1 1 32.8 ± 2.2 30 ± 0 -30.8
2.3.06.12. Esterase LipW 3qh4 Mycobacterium marinum Bact. Gram-pos plas. 1 0 2.4 ± 1.2 76 ± 32 -5.0
2.1.01.01. Snake phospholipase A2 natratoxin, group I 2osh Naja atra Secreted 1 0 2.6 ± 1.6 83 ± 11 -6.1
2.3.02.01. Phospholipase C-beta isoform 2 2zkm Homo sapiens Eukaryo. plasma 1 0 2.2 ± 2.9 38 ± 12 -3.6
1.1.09.01. Calcium ATPase, E2 state (Ca-free), conformation 7 3ar9 Oryctolagus cuniculus Endoplasm. reticulum 1 10 29.0 ± 0.9 20 ± 0 -73.8
2.2.34.03. Toxin Ado1 1lmr Agriosphodrus dohrni Secreted 1 0 3.1 ± 1.6 60 ± 19 -4.7
3.2.01.07. Protegrin-2 2muh Sus scrofa Secreted 1 0 2.1 ± 3.3 88 ± 2 -3.2
3.1.20.01. Alpha-conotoxin PIA 1zlc Conus purpurascens (Purple cone) Secreted 1 0 2.6 ± 1.3 59 ± 16 -4.3
1.3.01.01. Outer membrane protein A (OMPA), disordered loops 1qjp Escherichia coli Bact. Gram-neg outer 1 8 25.4 ± 1.5 11 ± 1 -29.5
1.1.01.03. Corticotropin-releasing factor receptor 1, structure 1 4k5y Homo sapiens Eukaryo. plasma 1 7 31.8 ± 1.1 16 ± 3 -71.4
3.1.29.03. Prophenin-1 2i1d Sus scrofa Secreted 1 0 4.8 ± 1.9 70 ± 35 -5.9
3.2.10.01. PawS derived peptide 4 2lws Designed proteins Undefined 1 0 7.5 ± 1.3 37 ± 13 -5.8
1.2.07.01. Protein spitz 3ca7 Drosophila melanogaster Endoplasm. reticulum 1 0 3.3 ± 2.8 87 ± 3 -4.3
2.2.41.01. Spheniscin-2 (bird defensin) 1ut3 Aptenodytes patagonicus Secreted 1 0 3.6 ± 1.6 44 ± 17 -6.2
3.1.34.01. Conantokin-R1-B 2mzm Conus rolani Secreted 1 0 1.9 ± 0.7 81 ± 8 -2.9
1.1.01.01. Bacteriorhodopsin-I 4wav Haloquadratum walsbyi Archaebac. 1 7 30.0 ± 2.1 9 ± 3 -63.0
3.1.07.02. Membrane proximal external helix of HIV-1 gp41 (656-683) 2m8o Human immunodeficiency virus type 1 Viral 1 0 6.0 ± 5.2 90 ± 4 -5.0
2.2.39.01. Muscarinic m1-toxin1 2vlw Dendroaspis angusticeps (Eastern green mamba) Secreted 1 0 3.4 ± 0.9 82 ± 9 -4.9
1.2.04.01. Integrin alpha-L, transmembrane helix (1082-1128) 2m3e Homo sapiens Eukaryo. plasma 1 1 29.8 ± 5.6 30 ± 17 -25.9
3.1.05.03. WYHRLSHLHSRLQD 5mxt Designed proteins Undefined 1 0 5.0 ± 0.8 77 ± 10 -6.3
1.1.25.02. Lactose permease LacY, structure 3 1pv6 Escherichia coli Bact. Gram-neg inner 1 12 31.8 ± 1.2 5 ± 0 -89.1
2.4.07.01. Bud emergence protein 1 2v6v Saccharomyces cerevisiae Eukaryo. plasma 1 0 2.1 ± 1.2 75 ± 6 -5.1
1.2.53.01. Squalene synthase, conformation 1 3v66 Homo sapiens Endoplasm. reticulum 1 0 3.1 ± 0.8 83 ± 6 -5.1
2.3.06.08. Pancreatic lipase 1bu8 Rattus norvegicus Secreted 1 0 3.5 ± 1.3 87 ± 10 -6.1
1.1.01.01. Sensory rhodopsin, monomer 1xio Nostoc sp. Bact. Gram-neg inner 1 7 31.9 ± 1.5 13 ± 4 -63.1
1.1.01.01. Proton-pumping rhodopsin-2 from algae 3am6 Acetabularia acetabulum Eukaryo. plasma 1 7 31.2 ± 1.6 10 ± 1 -65.4
1.1.01.02. 5-hydroxytryptamine receptor 2B, structure 2, with LSD 5tvn Homo sapiens Eukaryo. plasma 1 7 33.0 ± 2.0 18 ± 2 -68.3
2.2.57.01. Levansucrase 1w18 Gluconacetobacter diazotrophicus (Acetobacter diazotrophicus) Secreted 1 0 3.4 ± 1.6 57 ± 3 -7.2
1.3.20.01. Hemophore receptor HasR, structure 1 3csl Serratia marcescens Bact. Gram-neg outer 1 22 25.4 ± 1.3 4 ± 5 -72.2
1.1.106.01. Phosphatidylglycerol phosphate phosphatase 5jki Bacillus subtilis Bact. Gram-pos plas. 1 6 28.6 ± 1.4 38 ± 0 -56.7
2.1.42.01. Putative carnobacteriocin-B2 immunity protein 1tdp Carnobacterium maltaromaticum Secreted 1 0 4.4 ± 0.5 90 ± 9 -4.3
1.1.25.03. Transporter YajR 3wdo Escherichia coli Bact. Gram-neg inner 1 12 31.0 ± 1.4 2 ± 0 -81.8
3.1.02.02. Potassium voltage-gated channel protein Shaker, peptide 378-397 1ho2 Drosophila melanogaster Eukaryo. plasma 1 0 3.9 ± 1.2 88 ± 16 -7.5
1.1.79.01. P7 protein (747-809), structure 2 2mts Hepatitis C virus Endoplasm. reticulum 1 2 28.6 ± 2.1 8 ± 2 -26.1
3.1.26.01. Pleurocidin 1z64 Pseudopleuronectes americanus Secreted 1 0 5.4 ± 1.3 87 ± 18 -12.8
3.1.18.02. Phenol-soluble modulin alpha-1 5khb Staphylococcus aureus Secreted 1 0 9.4 ± 0.8 71 ± 4 -12.7
1.2.22.01. Activator of apoptosis harakiri, cytosolic helix 2l58 Homo sapiens Mitochon. outer 1 0 2.4 ± 4.0 88 ± 0 -8.5
2.1.60.01. Potassium channel toxin Bgk 1bgk Bunodosoma granulifera Secreted 1 0 1.8 ± 1.7 19 ± 27 -2.9
2.2.07.02. Factor H binding protein 1ys5 Neisseria meningitidis Bact. Gram-neg outer 1 0 3.5 ± 2.6 84 ± 5 -5.6
2.2.20.01. Rho guanine nucleotide exchange factor 9, conformation 1 4mt7 Rattus norvegicus Eukaryo. plasma 1 0 1.9 ± 2.6 52 ± 14 -3.9
2.4.25.01. N-alpha-acetyltransferase 60, structure 2 5hh0 Homo sapiens Golgi 1 0 5.2 ± 0.0 46 ± 1 -10.7
2.4.16.06. Mytilin-B 2eem Mytilus edulis (Blue mussel) Secreted 1 0 3.6 ± 1.4 76 ± 8 -3.2
3.1.02.01. Second intracellular loop (118-149) of alpha-2A adrenergic receptor 1hod Homo sapiens Eukaryo. plasma 1 0 3.9 ± 4.1 75 ± 3 -7.2
3.1.21.02. Decoralin 2n9a Oreumenes decoratus Secreted 1 0 6.7 ± 1.7 86 ± 11 -8.9
1.1.44.01. Disulfide bond formation protein B, conformation 1 2k74 Escherichia coli Bact. Gram-neg inner 1 4 29.7 ± 2.4 26 ± 1 -50.2
2.3.17.02. Folic acid synthesis protein FOL1 2bmb Saccharomyces cerevisiae Mitochon. inner 1 0 2.0 ± 0.6 31 ± 2 -5.8
2.2.41.03. Big defensin, segment 43-72 2rq2 Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 1 25.6 ± 4.4 18 ± 2 -13.5
2.1.29.03. Apolipoprotein C-I, peptide 1-38 1opp Homo sapiens Secreted 1 0 3.6 ± 0.2 87 ± 2 -10.9
1.1.44.01. Disulfide bond formation protein B, conformation 3 2zuq Escherichia coli Bact. Gram-neg inner 1 4 27.9 ± 3.1 27 ± 1 -36.6
1.2.32.01. Cytochrome P450 11B2, mitochondrial 4dvq Homo sapiens Mitochon. inner 1 0 4.8 ± 0.6 48 ± 4 -9.1
1.2.16.01. Pulmonary surfactant-associated protein C 1spf Sus scrofa Secreted 1 1 31.7 ± 3.3 21 ± 0 -32.0
1.3.10.01. Oligogalacturonate-specific porin KdgM 4fqe Dickeya dadantii Bact. Gram-neg outer 1 12 22.2 ± 1.5 2 ± 1 -42.1
2.3.16.07. Ras-related protein Rab-5C 4kyi Homo sapiens Eukaryo. plasma 1 0 4.3 ± 1.4 73 ± 1 -6.0
2.1.29.06. Perilipin-3 1szi Mus musculus Endosome 1 0 2.4 ± 2.3 61 ± 6 -4.1
2.2.33.01. Antimicrobial Peptide AMP-1.1a 2kus Stellaria media Secreted 1 0 1.5 ± 0.9 18 ± 27 -2.7
2.2.22.01. Hydrophobin I 2gvm Hypocrea jecorina Secreted 1 0 5.3 ± 1.1 27 ± 18 -8.7
2.3.14.01. Yeast Sec14 Homolog Sfh1 (YKL091C) 3b7n Saccharomyces cerevisiae Nuclear outer 1 0 2.9 ± 1.5 65 ± 18 -5.8
2.1.01.01. Myotoxin II 1xxs Bothrops moojeni Secreted 1 0 4.5 ± 1.2 76 ± 10 -5.3
3.2.04.02. Bowman-Birk type proteinase inhibitor peptide 1gm2 Macrotyloma axillare Secreted 1 0 2.0 ± 1.9 59 ± 14 -3.5
1.3.17.01. Filamentous hemagglutinin transporter FhaC, structure 2 4ql0 Bordetella pertussis Bact. Gram-neg outer 1 16 23.2 ± 0.9 10 ± 0 -62.7
3.1.04.08. Truncated superoxide dismutase 1 2mp3 Homo sapiens Eukaryo. plasma 1 0 2.1 ± 2.3 83 ± 0 -6.3
2.4.07.01. PX domain of vacuolar morphogenesis protein VAM7 1kmd Saccharomyces cerevisiae Vacuole 1 0 3.4 ± 1.2 76 ± 8 -7.8
3.1.15.03. Bacteriocin peptide plantaricin E (PlnE) 2jui Lactobacillus plantarum Secreted 1 0 4.3 ± 4.2 79 ± 4 -5.0
1.2.38.01. Penicillin-binding protein 2 2olv Staphylococcus aureus Bact. Gram-pos plas. 1 0 3.7 ± 2.0 58 ± 8 -7.3
2.2.11.01. Synaptotagmin-1, C2A domain (Calcium free) 3f00 Homo sapiens Eukaryo. plasma 1 0 1.4 ± 1.5 29 ± 18 -3.3
2.2.35.01. Perfringolysin 1pfo Clostridium perfringens Secreted 1 0 4.4 ± 2.0 38 ± 12 -6.7
2.1.60.03. Pseudechetoxin 2dda Pseudechis australis Secreted 1 0 4.5 ± 2.8 89 ± 7 -4.3
1.3.17.02. BamACDE subcomplex, structure 2 5d0q Escherichia coli Bact. Gram-neg outer 1 16 22.8 ± 1.1 10 ± 0 -44.9
2.2.11.01. Synaptotagmin-7 2d8k Homo sapiens Vesicle 1 0 2.8 ± 1.3 27 ± 16 -6.6
2.2.34.02. Mu-agatoxin-Aa1a 1eit Agelenopsis aperta Secreted 1 0 1.3 ± 1.5 59 ± 10 -3.1
1.2.42.01. UDP-2,3-diacylglucosamine hydrolase 5b49 Pseudomonas aeruginosa Bact. Gram-neg inner 1 0 9.9 ± 1.9 42 ± 16 -4.9
2.3.06.09. Mycobacterial lipase 3aja Mycobacterium smegmatis Secreted 1 0 6.0 ± 1.0 28 ± 10 -6.7
2.2.09.01. Kelch-like protein 7 3ii7 Homo sapiens Undefined 1 0 2.6 ± 1.8 90 ± 16 -6.5
2.3.32.01. UDP-N-acetylmuramate--L-alanine ligase 1p31 Haemophilus influenzae Bact. Gram-neg inner 1 0 4.4 ± 1.8 29 ± 14 -4.6
1.1.01.02. Dopamine D3 receptor 3pbl Homo sapiens Eukaryo. plasma 1 7 33.0 ± 1.8 8 ± 1 -56.6
1.2.32.01. Cytochrome P450 2A13 2p85 Homo sapiens Endoplasm. reticulum 1 0 4.9 ± 0.4 47 ± 2 -10.0
2.4.16.03. Toxin I5a 1sis Buthus eupeus Secreted 1 0 3.1 ± 1.4 74 ± 16 -4.4
3.4.08.04. Met-enkephalin 1plw Homo sapiens Secreted 1 0 4.9 ± 0.8 85 ± 17 -3.8
3.1.01.03. N-terminal helix of prion-like protein doppel 1z65 Mus musculus Eukaryo. plasma 1 1 21.0 ± 6.2 8 ± 4 -13.2
1.2.03.05. Cytokine receptor common subunit beta (432-473) 2na8 Homo sapiens Eukaryo. plasma 1 1 34.0 ± 2.8 22 ± 2 -32.9
3.1.07.03. Hemagglutinin, fusion peptide 346-365, G13A 2l4g Influenza virus Viral 1 0 11.1 ± 0.4 73 ± 4 -10.4
3.1.11.01. Neuropeptide Y 1ron Homo sapiens Secreted 1 0 7.9 ± 1.6 74 ± 10 -8.6
1.1.25.05. Proton-dependent oligopeptide transporter, conformation 3 4ikx Geobacillus kaustophilus Bact. Gram-pos plas. 1 14 31.0 ± 1.0 10 ± 0 -115.9
3.4.07.01. VG16KRKP peptide 2mwl Designed proteins Undefined 1 0 4.4 ± 1.3 79 ± 12 -3.6
1.2.32.01. Cytochrome P450 1A1 4i8v Homo sapiens Endoplasm. reticulum 1 0 7.1 ± 1.0 64 ± 3 -15.1
2.3.06.01. Bile-salt activated lipase, conformation 1 1aql Bos taurus Secreted 1 0 5.7 ± 1.1 78 ± 7 -9.6
2.3.06.18. Tle1 effector of type VI lipase 4o5p Pseudomonas aeruginosa Secreted 1 0 3.1 ± 2.5 85 ± 8 -5.8
1.3.20.01. Outer membrane cobalamin transporter BtuB, complex with TonB 2gsk Escherichia coli Bact. Gram-neg outer 1 22 23.4 ± 0.7 5 ± 0 -77.5
2.2.14.01. C2 domain of coagulation factor VIII 4mo3 Sus scrofa Eukaryo. plasma 1 0 3.7 ± 0.6 19 ± 4 -9.7
3.1.28.03. Bombinin-H5 2ap8 Bombina variegata (Yellow-bellied toad) Secreted 1 0 8.6 ± 4.2 77 ± 3 -10.6
1.1.60.01. Protease GlpG, conformation 2 2nrf Escherichia coli Bact. Gram-neg inner 1 6 27.6 ± 1.5 13 ± 2 -45.9
2.2.20.01. Rho GTPase-activating protein 27 3pp2 Homo sapiens Eukaryo. plasma 1 0 2.5 ± 2.2 72 ± 14 -3.4
1.1.79.01. P7 protein (747-809), structure 1 3zd0 Hepatitis C virus Endoplasm. reticulum 1 2 29.2 ± 4.2 12 ± 5 -15.3
3.1.14.01. Eledoisin 1mxq Eledone cirrhosa (Curled octopus) Secreted 1 0 2.9 ± 1.7 59 ± 19 -5.0
2.1.08.01. Cytochrome c552 1a8c Nitrosomonas europaea Bact. Gram-neg inner 1 0 2.7 ± 1.0 80 ± 11 -4.7
2.2.20.01. SET binding factor 1 1v5u Mus musculus Eukaryo. plasma 1 0 4.2 ± 1.5 59 ± 10 -5.3
2.2.06.02. Retinol-binding protein 1 5h9a Homo sapiens Eukaryo. plasma 1 0 3.3 ± 0.9 59 ± 4 -5.7
3.1.07.02. Membrane proximal peptide of gp41 (95-121) 2ncs Human immunodeficiency virus type 1 Viral 1 0 20.8 ± 2.0 28 ± 3 -14.6
2.2.51.01. 25 kDa protein elicitor 3gnz Pythium aphanidermatum Secreted 1 0 5.7 ± 2.5 77 ± 13 -5.1
1.1.10.03. ATP-binding cassette, sub-family B, member 1, mutant 3wmg Cyanidoschyzon merolae Eukaryo. plasma 1 6 36.8 ± 0.3 10 ± 3 -65.5
2.4.07.01. PX domain of Phosphoinositide-3-kinase, class 2, gamma polypeptide 2wwe Homo sapiens Golgi 1 0 2.5 ± 1.3 56 ± 16 -4.8
2.2.41.01. Oral alpha defensin 1 2k1i Macaca mulatta Secreted 1 0 0.9 ± 3.2 70 ± 15 -2.2
2.3.13.04. Glutathione peroxidase 8 3kij Homo sapiens Endoplasm. reticulum 1 0 3.4 ± 2.7 56 ± 16 -6.1
3.4.02.01. Actagardine, structure in acetonitrile solution 1aj1 Actinoplanes liguriae Secreted 1 0 3.0 ± 1.1 90 ± 11 -5.7
1.2.39.02. Matrilysin, structure 1 2mze Homo sapiens Secreted 1 0 3.3 ± 0.9 68 ± 2 -8.0
3.1.02.11. Methyl-accepting chemotaxis protein II 2l9g Escherichia coli Bact. Gram-neg inner 1 0 8.1 ± 4.2 75 ± 0 -11.7
2.1.37.01. Erythrocyte membrane protein 1 variant 3c64 Plasmodium falciparum Eukaryo. plasma 1 0 5.3 ± 2.5 52 ± 3 -9.6
1.2.40.01. Mitochondria fission 1 protein 1y8m Saccharomyces cerevisiae Mitochon. outer 1 0 5.2 ± 0.6 88 ± 1 -5.2
2.3.06.07. Lipase 46 kDa form 2hih Staphylococcus hyicus Secreted 1 0 4.6 ± 0.3 83 ± 1 -16.0
1.3.19.01. Porin OpdF 3szd Pseudomonas aeruginosa Bact. Gram-neg outer 1 18 22.0 ± 1.6 3 ± 0 -60.3
1.2.41.01. Acyl-CoA-binding protein 2cb8 Homo sapiens Peroxisome 1 0 2.7 ± 2.0 74 ± 29 -5.2
2.4.16.02. Termicin 1mm0 Pseudacanthotermes spiniger Secreted 1 0 4.2 ± 0.5 81 ± 3 -3.3
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), structure 2 5fsa Candida albicans Endoplasm. reticulum 1 0 9.0 ± 0.8 61 ± 2 -18.0
3.1.30.01. Lactoferricin peptide (36-59) 5id5 Sus scrofa Secreted 1 0 7.4 ± 1.0 87 ± 9 -6.2
2.2.05.01. Plastocyanin 1b3i Prochlorothrix hollandica Thylakoid 1 0 2.8 ± 1.4 43 ± 18 -4.4
2.2.41.01. Alpha-defensin 6 1zmq Homo sapiens Secreted 1 0 3.7 ± 1.6 76 ± 18 -3.6
2.2.12.01. Ganglioside GM2 activator 2agc Mus musculus Lysosome 1 0 3.2 ± 1.0 54 ± 12 -5.3
2.3.10.02. Beta-1,2-glucuronosyltrnansferase GumK 2q6v Xanthomonas campestris Bact. Gram-neg inner 1 0 5.2 ± 1.0 61 ± 8 -9.5
2.1.03.01. Alpha-toxin (PHLC1_CLOPE), open state 1ca1 Clostridium perfringens Secreted 1 0 2.9 ± 1.0 89 ± 4 -9.3
2.4.51.01. Heme acquisition protein HasA 4jet Yersinia pestis Secreted 1 0 4.8 ± 0.9 29 ± 2 -7.0
2.4.43.01. Cell wall anchor protein of the T6SS system 4b62 Pseudomonas aeruginosa Bact. Gram-neg outer 1 0 2.8 ± 2.5 46 ± 36 -4.6
1.1.01.02. C-X-C chemokine receptor type 4, complex with peptide 4rws Homo sapiens Eukaryo. plasma 1 7 33.8 ± 1.5 9 ± 1 -76.9
1.2.46.01. Agnoprotein (17-52) 2mj2 JC polyomavirus Endosome 1 1 22.0 ± 2.0 25 ± 3 -15.0
3.4.09.01. Granin, cyclic analogue 1n2y Bos taurus Secreted 1 0 1.9 ± 2.1 71 ± 16 -3.4
1.2.44.01. Amyloid beta A4 protein (peptide 688-704), in water 2mj1 Homo sapiens Eukaryo. plasma 1 0 9.4 ± 3.4 38 ± 11 -7.4
2.2.41.02. Toxin APETx2 1wxn Anthopleura elegantissima (Sea anemone) Secreted 1 0 4.9 ± 1.7 33 ± 18 -5.5
3.1.06.02. Amphipathic alpha-helix of apolipoprotein 2irg Designed proteins Undefined 1 0 6.4 ± 1.7 83 ± 15 -12.1
1.1.60.01. Protease GlpG, complex with inhibitor, conformation 1 2xow Escherichia coli Bact. Gram-neg inner 1 6 29.0 ± 1.7 15 ± 2 -59.0
2.2.06.02. Prostaglandin-H2 D-isomerase, ligand-bound 3o22 Homo sapiens Endoplasm. reticulum 1 0 0.7 ± 1.2 78 ± 13 -2.4
3.1.27.01. Pardaxin, different conformation 1xc0 Pardachirus marmoratus Secreted 1 1 20.8 ± 5.4 42 ± 2 -9.6
3.4.12.01. Actinomycin D 1a7y Streptomyces antibioticus Secreted 1 0 11.5 ± 0.9 89 ± 11 -12.2
1.3.15.02. CymA protein, conformation 1 4d51 Klebsiella oxytoca Bact. Gram-neg outer 1 14 25.0 ± 1.7 2 ± 1 -44.8
1.1.01.02. Rhodopsin, complex with arrestin 4zwj Homo sapiens Eukaryo. plasma 1 7 31.8 ± 1.1 9 ± 1 -78.7
2.1.29.01. Apolipoprotein E 2l7b Homo sapiens Secreted 1 0 2.5 ± 1.0 73 ± 8 -4.9
1.1.39.01. Riboflavin transporter RibU 3p5n Staphylococcus aureus Bact. Gram-pos plas. 1 6 30.6 ± 1.4 6 ± 4 -53.5
2.1.01.01. Snake phospholipase A2 homolog 2, group II 2q2j Bothrops pirajai Secreted 1 0 1.9 ± 1.2 89 ± 9 -5.6
2.3.28.01. Aldo-keto reductase family 1 member C1 1qwk Caenorhabditis elegans Undefined 1 0 2.8 ± 1.0 66 ± 3 -6.3
1.1.01.01. Green-light absorbing proteorhodopsin 2l6x Gamma-proteobacterium Bact. Gram-neg inner 1 7 27.8 ± 1.3 18 ± 1 -55.2
2.4.06.01. StAR-related lipid transfer protein 5 2r55 Homo sapiens Eukaryo. plasma 1 0 1.7 ± 1.2 47 ± 19 -4.8
1.2.32.01. Cytochrome P450 2R1 3czh Homo sapiens Endoplasm. reticulum 1 0 8.3 ± 1.5 48 ± 13 -13.2
2.2.34.01. Delta conotoxin TxVIA 1fu3 Conus textile Secreted 1 0 6.5 ± 1.8 25 ± 18 -8.3
3.2.06.01. Growth-blocking peptide 2dj9 Mamestra brassicae Secreted 1 0 2.2 ± 0.7 31 ± 4 -6.2
2.2.34.02. Toxin GsMTx2 1lup Grammostola rosea (Chilean rose tarantula) Secreted 1 0 3.8 ± 1.1 90 ± 8 -4.8
3.1.01.01. Kalata-B3/B6 propeptide 1wn8 Oldenlandia affinis Secreted 1 0 3.6 ± 1.2 81 ± 22 -8.4
3.1.05.11. ALPS-23 peptide 2m0w Designed proteins Undefined 1 0 5.7 ± 0.5 72 ± 6 -9.4
2.2.07.01. Protein yceI 1y0g Escherichia coli Bact. Gram-neg inner 1 0 4.2 ± 1.5 24 ± 16 -2.1
1.1.01.02. Rhodopsin, inactive, structure 2 (with beta-ionone) 3oax Bos taurus Eukaryo. plasma 1 7 30.9 ± 1.4 11 ± 0 -73.6
2.3.06.15. Polyneuridine-aldehyde esterase 2wfm Rauvolfia serpentina (Serpentwood) Endoplasm. reticulum 1 0 2.5 ± 1.7 88 ± 3 -4.6
2.2.39.01. Cardiotoxin VI 1ug4 Naja atra Secreted 1 0 6.4 ± 0.9 62 ± 4 -12.2
2.2.35.01. Suilysin 3hvn Streptococcus suis Secreted 1 0 5.6 ± 1.1 5 ± 4 -6.4
1.1.01.02. Endothelin B receptor, with endothelin 5glh Homo sapiens Eukaryo. plasma 1 7 34.8 ± 1.0 6 ± 1 -81.5
3.1.01.03. Viral core-E1 signal peptide 2lif Hepatitis C virus Viral 1 1 29.6 ± 5.0 19 ± 10 -16.6
3.2.06.01. Paralytic peptide 1 1hrl Manduca sexta Secreted 1 0 6.5 ± 0.6 51 ± 6 -6.2
1.1.01.02. Muscarinic acetylcholine receptor M2, active 4mqs Homo sapiens Eukaryo. plasma 1 7 32.2 ± 2.1 8 ± 3 -70.0
2.2.12.01. Mite group 2 allergen Der p 2 1ktj Dermatophagoides pteronyssinussearch Secreted 1 0 1.4 ± 1.3 65 ± 9 -3.2
3.2.10.01. PawS derived peptide 10 2nb6 Designed proteins Undefined 1 0 9.9 ± 2.0 48 ± 30 -9.1
1.1.60.01. Protease GlpG, complex with inhibitor, conformation 2 3zeb Escherichia coli Bact. Gram-neg inner 1 6 28.4 ± 1.3 12 ± 0 -64.0
2.4.05.01. Sterol carrier protein 2 1pz4 Aedes aegypti (Yellowfever mosquito) Eukaryo. plasma 1 0 0.8 ± 5.0 37 ± 49 -1.3
1.1.09.01. Calcium ATPase, E2-Pi state, conformation 5 3fpb Oryctolagus cuniculus Endoplasm. reticulum 1 10 27.0 ± 2.3 23 ± 0 -64.9
2.3.06.06. Lipase 2 1gz7 Candida rugosa Secreted 1 0 4.8 ± 1.3 87 ± 10 -8.5
3.1.35.01. Cn-AMP1 peptide 2n0v Cocos nucifera Secreted 1 0 2.9 ± 1.3 73 ± 18 -2.3
2.2.11.01. Protein kinase C beta, C2 domain 1a25 Rattus norvegicus Eukaryo. plasma 1 0 3.1 ± 1.0 44 ± 18 -2.8
1.1.01.02. C-C chemokine receptor type 2 5t1a Homo sapiens Eukaryo. plasma 1 7 32.6 ± 1.4 3 ± 2 -80.2
1.2.43.01. Envelope glycoprotein, West Nile virus, structure 2 2i69 West Nile virus Viral 1 0 6.7 ± 2.8 5 ± 12 -5.0
2.2.21.03. Interleukin-36 receptor antagonist protein 1md6 Mus musculus Secreted 1 0 3.8 ± 0.4 40 ± 3 -6.5
1.3.11.01. Serine protease EspP, post-cleavage structure 2qom Escherichia coli Bact. Gram-neg outer 1 12 25.1 ± 1.6 6 ± 7 -55.9
2.2.27.01. Rac GTPase-activating protein 1 4b6d Homo sapiens Eukaryo. plasma 1 0 3.5 ± 0.9 55 ± 4 -5.9
2.4.16.01. Beta-toxin Cn5 2kja Centruroides noxius (Mexican scorpion) Secreted 1 0 4.1 ± 1.1 73 ± 6 -7.0
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 6 4coh Trypanosoma cruzi Endoplasm. reticulum 1 0 6.3 ± 1.3 56 ± 6 -7.3
3.1.19.01. Zervamicin IIb 1ih9 Emericellopsis salmosynnemata Secreted 1 0 11.5 ± 2.0 74 ± 10 -12.3
2.2.34.06. Peptide jS1 2n5q Jasminum sambac Secreted 1 0 3.8 ± 1.2 71 ± 15 -6.1
2.2.05.01. Azurin iso-2 1cuo Methylomonas sp. Bact. Gram-neg inner 1 0 1.4 ± 1.6 69 ± 15 -4.3
2.2.06.02. Adipocyte lipid-binding protein 1tow Homo sapiens Eukaryo. plasma 1 0 2.5 ± 1.7 51 ± 18 -4.5
1.1.01.06. Adiponectin receptor 1, open 5lxg Homo sapiens Eukaryo. plasma 1 7 31.8 ± 1.0 21 ± 0 -68.3
2.1.01.01. Ammodytin L1 isoform 3ux7 Vipera ammodytes meridionalis Secreted 1 0 2.7 ± 0.3 82 ± 1 -13.2
1.3.21.01. Outer membrane usher protein FimD, complex with FimC-FimH 3rfz Escherichia coli Bact. Gram-neg outer 1 24 23.8 ± 0.8 5 ± 0 -65.1
1.1.01.05. Metabotropic glutamate receptor 5 4oo9 Homo sapiens Eukaryo. plasma 1 7 32.4 ± 1.2 2 ± 1 -66.3
2.3.05.06. Endothelin-converting enzyme 2 2pxx Homo sapiens Golgi 1 0 7.1 ± 1.3 37 ± 8 -8.4
2.4.16.04. Defensin 2 (PDF1) 2gl1 Vigna radiata (Mung bean) Secreted 1 0 2.8 ± 0.6 6 ± 4 -5.7
1.1.25.08. Na+/melibiose symporter 4m64 Salmonella typhimurium Bact. Gram-neg inner 1 12 30.4 ± 1.3 11 ± 0 -64.9
2.4.15.01. Protein Nef, N-terminal helix (HIV HV1B1) 1zec Human immunodeficiency virus type 1 Eukaryo. plasma 1 0 3.6 ± 4.1 89 ± 2 -6.8
2.3.06.01. Bile-salt activated lipase, conformation 3 2bce Bos taurus Secreted 1 0 5.3 ± 0.8 74 ± 6 -7.0
2.2.39.02. Mambalgin-2 2mfa Dendroaspis polylepis polylepis (Black mamba) Secreted 1 0 2.7 ± 2.5 76 ± 5 -6.4
2.1.10.01. Glycolipid transfer protein, conformation 2 1swx Homo sapiens Eukaryo. plasma 1 0 4.6 ± 1.0 87 ± 8 -7.1
2.3.18.01. Carnitine O-octanoyltransferase 1nm8 Homo sapiens Mitochon. inner 1 0 1.7 ± 3.0 67 ± 15 -5.3
2.3.18.02. Phthiocerol/phthiodiolone dimycocerosyl transferase 1q9j Mycobacterium tuberculosis Bact. Gram-pos cell wall 1 0 6.7 ± 2.2 25 ± 6 -5.2
2.1.01.03. Phospholipase A2 group XIII 4aup Tuber borchii Secreted 1 0 3.7 ± 0.7 63 ± 6 -7.7
1.2.44.01. Amyloid beta A4 protein (peptide 672-699) 1amb Homo sapiens Eukaryo. plasma 1 0 2.1 ± 2.3 87 ± 0 -3.2
3.2.01.05. Tachyplesin-1 2rtv Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 4.2 ± 0.4 88 ± 3 -6.8
1.3.14.01. Fatty Acid Transporter FadL, delS3, open channel 2r88 Escherichia coli Bact. Gram-neg outer 1 14 24.0 ± 1.4 6 ± 2 -53.8
3.1.02.15. Glutamate receptor ionotropic, NMDA 1, TMH 2 2nr1 Homo sapiens Eukaryo. plasma 1 0 7.0 ± 3.7 84 ± 0 -12.5
2.4.07.01. Nischarin 3p0c Homo sapiens Endosome 1 0 4.1 ± 0.5 82 ± 13 -7.0
2.4.16.02. Nasonin 2koz Nasonia vitripennis (Parasitic wasp) Secreted 1 0 2.9 ± 0.9 68 ± 7 -4.6
1.2.03.02. Cytotoxic T-lymphocyte protein 4 1dqt Mus musculus Eukaryo. plasma 1 0 3.4 ± 1.6 64 ± 4 -5.3
2.2.04.01. 9-cis-epoxycarotenoid dioxygenase 1, chloroplastic 3npe Zea mays Thylakoid 1 0 6.0 ± 0.1 30 ± 5 -11.1
2.1.01.01. Snake phospholipase A2, group II (ecarpholin S) 2qhd Echis carinatus Secreted 1 0 8.1 ± 0.6 79 ± 5 -12.5
2.4.20.01. Cathepsin F 1m6d Homo sapiens Lysosome 1 0 4.3 ± 0.8 80 ± 3 -11.7
2.2.11.01. Protein kinase C delta 1yrk Homo sapiens Eukaryo. plasma 1 0 2.0 ± 1.6 52 ± 19 -1.8
2.1.01.01. Snake phospholipase A2, group II 1jlt Vipera ammodytes meridionalis Secreted 1 0 2.8 ± 1.0 89 ± 7 -8.7
3.1.20.01. Conotoxin pc16a 2ler Conus pictus Secreted 1 0 4.0 ± 1.0 64 ± 7 -4.1
1.2.04.01. Integrin alpha-X, cytoplasmic helix (peptide 1129-1163) 2luv Homo sapiens Eukaryo. plasma 1 0 4.0 ± 0.5 80 ± 7 -5.8
3.1.07.01. Fusion peptide (983-887) of spike glycoprotein 2ruo Human SARS coronavirus Endosome 1 0 9.9 ± 4.0 72 ± 6 -9.0
2.4.16.04. Defensin-like protein 1brz Pentadiplandra brazzeana Secreted 1 0 1.2 ± 1.2 83 ± 10 -3.6
1.2.38.02. Lysozyme 3hde Enterobacteria phage p21 Secreted 1 0 1.8 ± 1.4 55 ± 10 -4.7
3.1.05.09. Histidine-rich peptide LAH4 2kjn Designed proteins Undefined 1 0 10.5 ± 6.3 89 ± 2 -10.2
2.3.06.05. Carboxylesterase 2 1auo Pseudomonas fluorescens Bact. Gram-neg inner 1 0 1.7 ± 3.0 33 ± 21 -3.4
1.1.01.02. TM1-TM2 fragment of fungal STE2 receptor 2k9p Saccharomyces cerevisiae Eukaryo. plasma 1 2 29.8 ± 3.1 21 ± 4 -10.5
2.2.02.01. Exfoliative toxin B 1qtf Staphylococcus aureus Secreted 1 0 2.8 ± 1.9 81 ± 11 -5.8
3.2.05.02. Lassomycin 2mai Lentzea kentuckyensis Secreted 1 0 3.1 ± 1.0 72 ± 9 -4.7
1.3.17.02. BamACDE subcomplex, structure 1 5ekq Escherichia coli Bact. Gram-neg outer 1 16 23.4 ± 0.7 18 ± 0 -61.9
1.1.25.06. Glucose transporter GLUT5, outward-open 4ybq Rattus norvegicus Eukaryo. plasma 1 12 32.4 ± 3.0 5 ± 0 -110.6
2.1.18.01. Annexin I 1hm6 Sus scrofa Vesicle 1 0 2.1 ± 0.9 88 ± 7 -5.6
2.2.34.01. Conotoxin mr3e 2efz Conus marmoreus Secreted 1 0 1.0 ± 1.3 83 ± 25 -3.2
2.1.01.01. Snake phospholipase A2, acidic, group I 2wq5 Naja naja Secreted 1 0 3.4 ± 0.3 89 ± 6 -6.2
2.1.07.01. Nonaheme cytochrome c 1duw Desulfovibrio desulfuricans Bact. Gram-neg inner 1 0 5.1 ± 0.4 87 ± 10 -4.9
2.3.06.01. Acetylcholinesterase 1qon Drosophila melanogaster Eukaryo. plasma 1 0 5.5 ± 1.6 4 ± 13 -5.0
1.2.32.01. Cytochrome P450 46A1 (cholesterol 24-hydrolase), conformation 2 3mdm Homo sapiens Endoplasm. reticulum 1 0 3.8 ± 1.3 51 ± 8 -5.9
2.2.34.04. Leginsulin 1ju8 Glycine max Secreted 1 0 11.3 ± 1.6 21 ± 17 -8.6
2.2.35.01. Intermedilysin - CD59 receptor complex, disulfide-locked mutant 4bik Streptococcus intermedius Secreted 1 0 5.9 ± 3.1 28 ± 43 -6.4
2.1.02.01. Arachidonate 15-lipoxygenase 3rde Sus scrofa Eukaryo. plasma 1 0 6.9 ± 0.4 83 ± 1 -8.7
3.1.20.01. Alpha-conotoxin Vc1A 2h8s Conus victoriae (Queen Victoria cone) Secreted 1 0 2.4 ± 0.8 59 ± 6 -2.5
1.3.01.02. Outer membrane protein X (OMPX) 1qj8 Escherichia coli Bact. Gram-neg outer 1 8 23.6 ± 2.8 12 ± 5 -30.7
1.1.01.03. Glucagon receptor, structure 1 4l6r Homo sapiens Eukaryo. plasma 1 7 28.8 ± 1.8 20 ± 0 -46.7
3.1.29.03. Prophenin-1 analogues 2i1e Sus scrofa Secreted 1 0 5.2 ± 1.0 53 ± 7 -7.5
3.2.10.01. PawS derived peptide 5 2lwt Designed proteins Undefined 1 0 8.1 ± 2.2 55 ± 21 -5.2
2.3.14.01. Retinaldehyde-binding protein 1, closed state 3hx3 Homo sapiens Eukaryo. plasma 1 0 1.2 ± 2.9 77 ± 32 -4.8
1.2.32.01. Cytochrome P450 2D6, conformation 3 3qm4 Homo sapiens Endoplasm. reticulum 1 0 9.0 ± 1.4 35 ± 11 -9.3
2.2.41.01. Alpha-defensin corticostatin-related peptide RK-1 1ews Oryctolagus cuniculus Secreted 1 0 4.7 ± 1.1 18 ± 17 -4.4
2.2.35.01. Pneumolysin, structure 1 4qqq Streptococcus pneumoniae Secreted 1 0 4.6 ± 3.7 27 ± 7 -6.8
1.1.64.01. Sodium/calcium exchanger, structure 3 5hwy Methanococcus jannaschii Archaebac. 1 10 29.0 ± 1.7 2 ± 2 -63.7
2.1.18.01. Annexin V 1hvf Homo sapiens Eukaryo. plasma 1 0 2.3 ± 1.5 79 ± 10 -5.4
1.2.45.01. Envelope small membrane protein 2mm4 Human SARS coronavirus Viral 1 1 29.6 ± 4.1 53 ± 1 -32.2
2.2.39.01. Muscarinic m1-toxin1, sequence version 3neq Dendroaspis angusticeps (Eastern green mamba) Secreted 1 0 4.0 ± 0.8 65 ± 5 -7.0
1.3.04.03. Lipid A acylase PagP 3gp6 Escherichia coli Bact. Gram-neg outer 1 8 24.7 ± 1.5 40 ± 1 -32.5
1.1.100.01. Voltage-sensor domain of phosphatase, conformation 1 4g80 Ciona intestinalis Eukaryo. plasma 1 4 29.4 ± 1.4 14 ± 1 -44.6
2.3.10.06. Alpha-(1-2)-phosphatidylinositol mannosyltransferase, structure 1 2gek Mycobacterium smegmatis Bact. Gram-pos plas. 1 0 3.4 ± 2.6 85 ± 5 -5.7
1.3.25.01. Gamma-hemolysin, component B 3lkf Staphylococcus aureus Secreted 1 0 1.7 ± 2.5 51 ± 11 -4.5
3.1.05.03. GLFDIVKKVVGALG 5mxl Designed proteins Undefined 1 0 5.0 ± 0.4 86 ± 6 -7.8
1.1.25.02. Lactose permease LacY, structure 4 2y5y Escherichia coli Bact. Gram-neg inner 1 12 31.8 ± 1.3 4 ± 1 -89.0
2.2.20.01. Cytohesin-2 1u27 Mus musculus Eukaryo. plasma 1 0 0.5 ± 2.4 53 ± 9 -2.4
1.2.53.01. Squalene synthase, conformation 2 3wcf Homo sapiens Endoplasm. reticulum 1 0 2.8 ± 0.8 87 ± 3 -7.0
2.3.06.09. Cutinase 1 1oxm Fusarium solani Secreted 1 0 6.8 ± 1.1 36 ± 15 -9.1
3.1.28.04. Esculentin-1A 2n6m Pelophylax esculentus Secreted 1 0 7.9 ± 0.4 67 ± 5 -7.9
2.2.06.02. Fatty acid-binding protein 2flj Locusta migratoria (Migratory locust) Eukaryo. plasma 1 0 1.2 ± 1.5 62 ± 10 -3.6
1.1.01.02. Adenosine receptor A2a, with triazole-carboximidamide antagonist 5uig Homo sapiens Eukaryo. plasma 1 7 30.6 ± 1.4 13 ± 4 -62.6
2.2.34.02. Neurotoxin Hm-3 2mqu Heriaeus melloteei Secreted 1 0 2.4 ± 0.6 75 ± 11 -7.4
1.3.09.01. Lipid A deacylase LpxR 3fid Salmonella enterica Bact. Gram-neg outer 1 12 25.6 ± 2.0 24 ± 0 -58.6
2.4.13.01. Oxysterol-binding protein homolog 4, conformation 1 1zhx Saccharomyces cerevisiae Golgi 1 0 1.2 ± 0.9 90 ± 7 -5.0
2.1.42.01. Immunity protein for enterocin A (Entl) 2bl7 Enterococcus faecium Secreted 1 0 3.3 ± 1.0 89 ± 3 -4.5
1.2.24.01. Protein Vpu, cytoplasmic domain, in DPC micelles 2k7y Human immunodeficiency virus type 1 Eukaryo. plasma 1 0 4.5 ± 1.4 54 ± 17 -5.4
3.2.01.08. Lactoferricin B, peptide 36-60 1lfc Bos taurus Secreted 1 0 4.6 ± 0.5 90 ± 6 -5.3
2.2.41.01. Gallinacin-7 5lcs Gallus gallus Secreted 1 0 2.5 ± 1.4 85 ± 5 -5.6
2.3.10.01. Peptidoglycan biosynthesis glycosyltransferase MurG, conformation 2 1f0k Escherichia coli Bact. Gram-neg inner 1 0 5.3 ± 1.2 55 ± 7 -8.6
1.1.01.02. Beta-2 adrenergic receptor, active state, complex with G-protein 3sn6 Homo sapiens Eukaryo. plasma 1 7 31.0 ± 1.6 8 ± 1 -68.2
2.3.18.01. Carnitine O-palmitoyltransferase 1, liver isoform, N-terminal domain 2le3 Homo sapiens Mitochon. outer 1 0 3.9 ± 3.7 80 ± 3 -9.3
2.1.60.01. Potassium channel toxin ShK 1roo Stoichactis helianthus Secreted 1 0 1.2 ± 1.2 46 ± 8 -3.7
1.3.20.01. Enantio-pyochelin receptor FetA 3qlb Pseudomonas fluorescens Bact. Gram-neg outer 1 22 23.4 ± 0.8 7 ± 0 -75.3
2.2.20.01. Rho guanine nucleotide exchange factor 9, conformation 2 4mt6 Rattus norvegicus Eukaryo. plasma 1 0 3.0 ± 1.9 68 ± 4 -5.1
2.3.06.12. Gibberellin receptor GID1 3ebl Oryza sativa (Rice) Nuclear inner 1 0 5.2 ± 1.5 59 ± 14 -9.1
2.4.12.01. Liver-expressed antimicrobial peptide 2 2l1q Homo sapiens Secreted 1 0 5.3 ± 1.4 56 ± 11 -2.7
1.1.75.03. Sec-independent protein translocase protein TatB 2mi2 Escherichia coli Bact. Gram-neg inner 1 1 27.6 ± 2.5 22 ± 0 -18.5
1.2.44.01. Amyloid beta A4 protein (peptide 672-711) 1ba4 Homo sapiens Eukaryo. plasma 1 0 6.0 ± 0.3 85 ± 5 -10.9
2.1.42.01. Lactococcin-A immunity protein 5lfi Lactococcus lactis Secreted 1 0 2.7 ± 1.4 40 ± 9 -4.8
2.3.05.04. Reticulon-4-interacting protein 1 2vn8 Homo sapiens Mitochon. inner 1 0 4.0 ± 0.0 82 ± 0 -10.2
2.2.41.03. Big defensin 2rng Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 6.5 ± 2.3 21 ± 4 -7.5
2.2.39.01. Muscarinic m1-toxin1, chimeric sequence 3fev Dendroaspis angusticeps (Eastern green mamba) Secreted 1 0 5.5 ± 1.5 76 ± 8 -6.3
2.3.05.03. Glycerol-3-phosphate dehydrogenase (GlpD) 2qcu Escherichia coli Bact. Gram-neg inner 1 0 4.5 ± 1.5 74 ± 11 -8.4
2.4.03.01. Tubby protein, ligand-bound 1i7e Mus musculus Eukaryo. plasma 1 0 3.8 ± 1.9 75 ± 13 -4.7
3.1.19.01. Chrysospermin C 1ee7 Apiocrea chrysosperma Secreted 1 0 9.8 ± 2.3 82 ± 12 -12.2
1.3.06.02. Carbapenem-associated resistance porin CarO3 4fuv Acinetobacter baumannii Bact. Gram-neg outer 1 8 25.0 ± 2.3 3 ± 1 -38.5
1.2.03.05. Erythropoietin receptor (236-284) 2mv6 Homo sapiens Eukaryo. plasma 1 1 31.4 ± 3.3 34 ± 6 -36.3
2.2.29.01. Multivesicular body subunit 12B 3tow Homo sapiens Endosome 1 0 4.5 ± 2.3 33 ± 22 -5.8
2.1.44.01. Bacteriocin glycocin F 2kuy Lactobacillus plantarum Secreted 1 0 5.4 ± 1.2 65 ± 6 -6.2
2.1.49.01. cGMP-specific 3',5'-cyclic phosphodiesterase 1rkp Homo sapiens Eukaryo. plasma 1 0 5.0 ± 1.6 61 ± 11 -5.2
1.1.09.01. Calcium ATPase, E2 state (Ca-free), conformation 1 2agv Oryctolagus cuniculus Endoplasm. reticulum 1 10 29.7 ± 2.2 20 ± 2 -61.5
2.1.01.01. Snake phospholipase A2, group II, VRV-PL-VIIIa 1zwp Daboia russelli pulchella Secreted 1 0 4.9 ± 1.0 76 ± 7 -12.5
3.2.04.03. Peptide leucine arginine 2m3n Lithobates pipiens Secreted 1 0 4.7 ± 0.6 83 ± 5 -5.7
1.3.02.01. Opacity protein opA60, structure 1 2maf Neisseria gonorrhoeae Bact. Gram-neg outer 1 8 23.8 ± 1.0 20 ± 1 -34.2
2.1.33.01. DrrA protein, PtdIns(4) binding domain, from different strain 3l0m Legionella pneumophila Vacuole 1 0 3.7 ± 4.2 44 ± 7 -4.8
3.1.15.03. Bacteriocin peptide plantaricin F (PlnF) 2rlw Lactobacillus plantarum Secreted 1 0 8.7 ± 4.4 79 ± 5 -11.7
1.1.01.02. Sphingosine 1-phosphate receptor 1 3v2y Homo sapiens Eukaryo. plasma 1 7 32.2 ± 1.4 10 ± 0 -65.9
1.2.38.01. Glycosyltransferase MtgA 3hzs Staphylococcus aureus Bact. Gram-pos plas. 1 0 7.0 ± 1.1 54 ± 9 -14.6
2.4.29.01. Superantigen-like protein 3r2t Staphylococcus aureus Undefined 1 0 4.2 ± 0.0 79 ± 1 -6.2
2.2.11.01. E3 ubiquitin-protein ligase Itchy homolog 2nq3 Homo sapiens Eukaryo. plasma 1 0 3.4 ± 1.9 25 ± 17 -6.7
2.2.34.11. Kalata B2, segment 71-98 (repeat 1) 1pt4 Oldenlandia affinis Secreted 1 0 4.6 ± 1.2 83 ± 14 -9.2
2.1.60.03. Pseudecin, conformation 1 2ddb Pseudechis porphyriacus Secreted 1 0 4.8 ± 0.7 90 ± 3 -5.4
1.3.17.02. BamABCDE complex, structure 1 5ayw Escherichia coli Bact. Gram-neg outer 1 16 22.8 ± 1.2 7 ± 0 -57.5
2.2.11.01. C2 domain of otoferlin 3l9b Rattus norvegicus Vesicle 1 0 2.4 ± 5.2 16 ± 33 -3.4
2.2.34.02. Delta-amaurobitoxin-Pl1a 1v90 Pireneitega luctuosa (Tangled nest spider) Secreted 1 0 2.9 ± 0.7 26 ± 14 -4.0
1.2.18.01. Sortase B 1rz2 Bacillus anthracis Bact. Gram-pos plas. 1 0 3.0 ± 0.6 82 ± 6 -5.8
2.3.06.09. Cutinase 1 3gbs Aspergillus oryzae Secreted 1 0 11.2 ± 0.5 55 ± 5 -12.6
2.1.50.01. Phosphate transport system protein phoU homolog 2 1sum Thermotoga maritima Bact. Gram-neg inner 1 0 4.9 ± 2.1 68 ± 4 -4.3
2.2.11.01. Synaptotagmin-13 1wfm Homo sapiens Eukaryo. plasma 1 0 2.2 ± 1.9 88 ± 15 -4.5
1.2.32.01. Cytochrome P450 2B4, open state 3 3r1b Oryctolagus cuniculus Endoplasm. reticulum 1 0 5.7 ± 0.0 43 ± 5 -9.8
2.4.16.02. Defensin ARD1 1ozz Archaeoprepona demophon Secreted 1 0 4.9 ± 1.7 31 ± 17 -7.1
3.1.21.01. Aedesin 2mmm Aedes aegypti (Yellowfever mosquito) Secreted 1 1 20.8 ± 0.8 11 ± 3 -12.3
1.1.52.01. Transmembrane oligosaccharyl transferase 3wak Archaeoglobus fulgidus Archaebac. 1 13 29.8 ± 0.6 12 ± 0 -100.8
3.1.07.03. Hemagglutinin, peptide 330-349, F9A 2jrd Influenza virus Viral 1 0 8.1 ± 4.0 71 ± 5 -6.8
3.1.11.01. Peptide YY 2dez Homo sapiens Secreted 1 0 4.0 ± 0.2 84 ± 2 -5.9
2.2.14.01. Coagulation factor VIII, light chain 3j2s Homo sapiens Eukaryo. plasma 1 0 4.8 ± 1.0 34 ± 15 -6.1
1.1.01.01. Proteorhodopsin 4hyj Exiguobacterium sibiricum Bact. Gram-pos plas. 1 7 30.0 ± 1.6 15 ± 7 -56.8
2.1.01.01. Phospholipase A2 2not Notechis scutatus scutatus (Mainland tiger snake) Secreted 1 0 2.6 ± 1.5 73 ± 8 -3.9
3.1.11.02. Glucagon-like peptide-1 receptor agonists 2n08 Designed proteins Undefined 1 0 6.3 ± 1.3 45 ± 10 -5.4
2.3.06.01. Neuroligin-2 3bl8 Mus musculus Eukaryo. plasma 1 0 1.7 ± 1.6 32 ± 5 -4.1
2.3.14.01. Phosphatidylinositol transfer protein PDR16 4fmm Saccharomyces cerevisiae Endoplasm. reticulum 1 0 9.9 ± 2.6 78 ± 19 -13.9
2.3.06.01. Bile-salt activated lipase, structure 1 1f6w Homo sapiens Secreted 1 0 1.8 ± 0.5 81 ± 10 -5.1
2.3.06.01. Carboxylic ester hydrolase, open state 4be9 Ophiostoma piceae Secreted 1 0 8.7 ± 0.4 88 ± 2 -30.9
2.1.10.01. Glycolipid transfer protein, structure 2 1wbe Bos taurus Eukaryo. plasma 1 0 1.1 ± 2.4 89 ± 8 -9.4
1.1.105.01. CD81 antigen 5tcx Homo sapiens Eukaryo. plasma 1 4 34.2 ± 2.4 1 ± 1 -55.9
1.2.23.01. M2 proton channel of Influenza A, monomer 4rwb Influenza virus Viral 1 1 31.6 ± 4.5 46 ± 6 -25.4
1.3.15.01. Outer membrane protein G (OMPG), open state 1 2iwv Escherichia coli Bact. Gram-neg outer 1 14 25.3 ± 1.4 3 ± 5 -61.3
2.1.10.01. Accelerated-cell-death 11 apo-protein 4nt1 Arabidopsis thaliana Eukaryo. plasma 1 0 2.6 ± 2.0 85 ± 7 -5.4
2.1.24.01. Saposin D (peptide 405-486) 2rb3 Homo sapiens Secreted 1 0 2.2 ± 1.7 88 ± 10 -3.4
1.1.60.01. Protease GlpG, conformation 3 2irv Escherichia coli Bact. Gram-neg inner 1 6 28.2 ± 1.3 23 ± 5 -48.1
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 4 3zg2 Trypanosoma cruzi Endoplasm. reticulum 1 0 5.8 ± 1.0 62 ± 4 -9.0
3.1.14.01. Neurokinin A 1n6t Gallus gallus Secreted 1 0 6.8 ± 1.2 60 ± 17 -4.9
3.1.11.02. Exendin-4-conotoxin chimera 2naw Designed proteins Secreted 1 0 4.3 ± 1.4 69 ± 8 -2.7
2.1.08.01. Cytochrome c2 1co6 Rhodopseudomonas viridis Bact. Gram-neg inner 1 0 1.4 ± 0.7 78 ± 10 -3.3
2.2.20.01. Triple functional domain protein 1nty Homo sapiens Eukaryo. plasma 1 0 3.2 ± 2.0 59 ± 16 -3.9
1.1.10.08. Multidrug resistance protein 1 (MRP1), structure 1 5uj9 Homo sapiens Eukaryo. plasma 1 17 31.0 ± 0.2 7 ± 0 -110.7
1.2.45.02. Small hydrophobic protein, peptide 39-49 2nb8 Human respiratory syncytial virus Viral 1 0 8.5 ± 1.2 57 ± 13 -5.9
2.4.51.01. Heme acquisition protein HasA, apoprotein, structure 1 3mok Pseudomonas aeruginosa Secreted 1 0 4.5 ± 0.7 37 ± 7 -6.7
1.1.73.01. TrbI protein 2bhv Helicobacter pylori Bact. Gram-neg outer 1 0 3.1 ± 1.3 42 ± 11 -6.4
1.1.01.02. P2Y purinoceptor 12, structure 2 4pxz Homo sapiens Eukaryo. plasma 1 7 36.0 ± 1.9 4 ± 3 -79.5
2.3.16.06. ADP-ribosylation factor 1 (ARF1), different conformation 2ksq Saccharomyces cerevisiae Golgi 1 0 4.7 ± 0.1 62 ± 0 -10.4
2.1.41.01. Phosphatidylinositol 3-kinase catalytic subunit type 3 3ls8 Homo sapiens Eukaryo. plasma 1 0 2.7 ± 2.2 75 ± 9 -4.7
1.1.95.02. Ceramide fatty acid hydroxylase SCS7 4zr1 Saccharomyces cerevisiae Endoplasm. reticulum 1 4 28.2 ± 1.6 34 ± 0 -50.6
1.2.39.02. Matrilysin, structure 2 2mzi Homo sapiens Secreted 1 0 3.5 ± 0.5 71 ± 4 -7.7
1.1.25.03. Multidrug transporter EmrD 2gfp Escherichia coli Bact. Gram-neg inner 1 12 31.6 ± 1.5 9 ± 0 -58.0
2.4.05.01. Sterol carrier protein 2 1c44 Oryctolagus cuniculus Eukaryo. plasma 1 0 3.7 ± 1.2 74 ± 17 -4.8
1.2.40.01. Mitochondria fission 1 protein, NMR 1pc2 Homo sapiens Mitochon. outer 1 0 8.5 ± 2.5 48 ± 23 -8.0
2.2.34.11. Kalata-B8 2b38 Oldenlandia affinis Secreted 1 0 5.5 ± 1.0 88 ± 12 -5.6
1.3.19.01. Porin OpdQ 3t24 Pseudomonas aeruginosa Bact. Gram-neg outer 1 18 23.0 ± 1.3 2 ± 0 -56.5
2.4.07.01. PX domain of sorting nexin-14 4bgj Homo sapiens Eukaryo. plasma 1 0 2.7 ± 2.2 72 ± 22 -4.3
1.2.41.01. Acyl-CoA-binding domain-containing protein 4 2wh5 Homo sapiens Peroxisome 1 0 7.2 ± 2.4 77 ± 26 -5.7
2.2.34.06. Antimicrobial peptide 1 1dkc Phytolacca americana (American pokeweed) Secreted 1 0 3.5 ± 1.2 84 ± 10 -4.1
1.1.46.01. MerF bacterial mercury uptake transporter, structure 3 2moz Morganella morganii Bact. Gram-neg inner 1 2 27.8 ± 1.9 16 ± 2 -33.5
1.2.17.01. Vesicle-associated membrane protein 2 2kog Rattus norvegicus Eukaryo. plasma 1 1 34.8 ± 1.7 27 ± 1 -33.7
1.1.02.06. Light-harvesting complex CP29 3pl9 Spinacia oleracea Thylakoid 1 3 29.8 ± 1.6 2 ± 2 -66.6
2.4.11.01. Alpha-1-purothionin 2plh Triticum aestivum Secreted 1 0 2.4 ± 2.0 53 ± 17 -4.6
3.1.20.01. O2-contryphan-Vc2 5l34 Conus victoriae (Queen Victoria cone) Secreted 1 0 2.4 ± 0.4 85 ± 8 -4.2
1.2.47.01. Nickel-cobalt-cadmium resistance protein NccX 4clv Alcaligenes xylosoxidans Bact. Gram-neg inner 1 0 3.1 ± 0.9 83 ± 0 -6.7
1.2.39.02. Stromelysin-1 1c3i Homo sapiens Eukaryo. plasma 1 0 3.6 ± 1.7 85 ± 17 -4.4
2.2.05.01. Plantacyanin 1f56 Spinacia oleracea Thylakoid 1 0 1.4 ± 1.5 11 ± 15 -2.0
2.2.08.01. Osmotin-like protein 1aun Nicotiana tabacum Secreted 1 0 5.8 ± 1.0 85 ± 11 -6.7
2.3.01.01. Glucosylceramidase 1ogs Homo sapiens Lysosome 1 0 4.2 ± 1.1 89 ± 4 -9.0
2.3.10.03. Heptosyltransferase WaaC 2h1h Escherichia coli Bact. Gram-neg inner 1 0 5.0 ± 1.1 67 ± 5 -9.1
1.2.54.01. Dihydroorotate dehydrogenase, structure 2 4cq8 Plasmodium falciparum Mitochon. inner 1 0 4.9 ± 0.4 52 ± 1 -12.0
2.1.01.01. Snake phospholipase A2, group I 1poa Naja atra Secreted 1 0 4.8 ± 1.0 89 ± 7 -10.7
2.4.51.01. Heme acquisition protein HasA, apoprotein 4jes Yersinia pestis Secreted 1 0 5.2 ± 0.3 40 ± 2 -9.6
2.2.11.01. Synaptotagmin-1, C2B domain (Calcium-bound) 4v11 Homo sapiens Eukaryo. plasma 1 0 1.6 ± 2.3 40 ± 7 -3.2
3.4.09.01. Granin 1lv4 Homo sapiens Secreted 1 0 1.8 ± 0.4 81 ± 3 -6.8
2.2.34.02. Huwentoxin-4 1mb6 Haplopelma hainanum (Chinese bird spider) Secreted 1 0 4.4 ± 0.8 70 ± 12 -5.8
1.1.38.01. Na+/drug antiporter NorM, outward-open 3mkt Vibrio cholerae Bact. Gram-neg inner 1 12 29.8 ± 1.1 9 ± 0 -74.0
1.2.32.01. Sterol 14-alpha-demethylase (CYP51), conformation 2 2wx2 Trypanosoma cruzi Endoplasm. reticulum 1 0 5.9 ± 5.9 63 ± 2 -6.2
2.1.28.01. Heat-stable enterotoxin II 1ehs Escherichia coli Secreted 1 0 1.4 ± 1.1 64 ± 11 -6.0
3.4.12.01. Actinomycin Z3 1a7z Streptomyces antibioticus Secreted 1 0 10.0 ± 1.3 76 ± 24 -9.6
1.3.15.02. CymA protein, conformation 2 4d5b Klebsiella oxytoca Bact. Gram-neg outer 1 14 23.4 ± 1.0 3 ± 1 -48.7
1.1.01.02. Neurotensin receptor type 1, structure 3 4xes Rattus norvegicus Eukaryo. plasma 1 7 31.8 ± 1.4 5 ± 1 -68.3
1.1.64.01. Vacuolar calcium ion transporter 4k1c Saccharomyces cerevisiae Vacuole 1 11 29.8 ± 1.0 3 ± 0 -87.5
2.1.29.03. Apolipoprotein C-I, peptide 33-50 1ale Homo sapiens Secreted 1 0 4.9 ± 1.0 72 ± 4 -7.8
1.1.69.01. HIG1 domain family member 1A 2lom Homo sapiens Eukaryo. plasma 1 2 22.0 ± 5.0 1 ± 1 -27.3
1.2.27.01. Fst toxin 2kv5 Enterococcus faecalis Bact. Gram-pos plas. 1 1 26.0 ± 2.9 35 ± 8 -18.9
2.1.01.01. Snake phospholipase A2, acidic 2, group I 1p7o Micropechis ikaheka Secreted 1 0 2.6 ± 0.5 90 ± 2 -9.4
2.3.28.01. Aldo-keto reductase family 1 member C21 3fjn Mus musculus Undefined 1 0 2.8 ± 1.0 56 ± 3 -5.2
1.1.48.01. Putative sulfate permease CysZ 3tx3 Idiomarina loihiensis Bact. Gram-neg inner 1 6 29.8 ± 0.6 17 ± 4 -49.5
1.2.32.01. Cytochrome P450 46A1 (cholesterol 24-hydrolase), conformation 1 2q9f Homo sapiens Endoplasm. reticulum 1 0 2.8 ± 1.0 86 ± 7 -5.8
2.2.34.01. Mu-O conotoxin MrVIB 1rmk Conus marmoreus Secreted 1 0 10.1 ± 1.3 62 ± 19 -10.7
3.2.01.08. Lactoferricin B, peptide 10-19 1y5c Bos taurus Secreted 1 0 2.2 ± 1.2 54 ± 11 -3.4
2.3.06.12. Carboxylesterase (EstA) 1jji Archaeoglobus fulgidus Archaebac. 1 0 2.8 ± 1.0 56 ± 22 -4.8
1.3.20.01. Ferredoxin receptor FusA 4zgv Pectobacterium atrosepticum Bact. Gram-neg outer 1 22 23.6 ± 0.7 7 ± 0 -65.8
3.1.20.01. Alpha-conotoxin PIVA 1p1p Conus purpurascens (Purple cone) Secreted 1 0 2.4 ± 1.0 30 ± 11 -3.8
1.1.38.02. Lipid II flippase MurJ, inward-facing conformation 5t77 Thermosipho africanus Bact. Gram-neg inner 1 14 30.6 ± 1.4 3 ± 0 -124.8
1.1.07.01. Nitric oxide reductase 3ayf Bacillus stearothermophilus Bact. Gram-pos plas. 1 14 31.6 ± 0.8 8 ± 0 -109.3
3.1.01.01. Varv peptide A/Kalata-B1 propeptide 1wn4 Viola odorata Secreted 1 0 6.4 ± 1.1 81 ± 14 -7.2
2.4.11.01. Crambin, enantiomer 3ue7 Designed proteins Undefined 1 0 3.4 ± 1.7 89 ± 13 -4.6
1.1.01.02. Beta-2 adrenergic receptor, active state, complex with antibody 3p0g Homo sapiens Eukaryo. plasma 1 7 30.1 ± 1.4 9 ± 1 -62.9
2.2.39.01. Cardiotoxin II (cytotoxin II) 1ffj Naja naja oxiana Secreted 1 0 7.9 ± 0.8 56 ± 5 -13.7
1.1.01.02. Endothelin B receptor 5gli Homo sapiens Eukaryo. plasma 1