PDB ID or protein name

All proteins in OPM (3809 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
1.1.21.01. CorA magnesium transporter, structure 1 2bbj Thermotoga maritima Bact. Gram-neg inner 5 10 29.9 ± 1.0 0 ± 0 -80.8
1.1.12.01. Potassium channel KcsA, structure 2 4uuj Streptomyces lividans Bact. Gram-pos plas. 4 8 29.8 ± 0.5 0 ± 0 -90.2
1.1.28.01. Heavy metal cation tricomponent efflux pump, ZneA 4k0e Ralstonia metallidurans Bact. Gram-neg inner 3 36 28.0 ± 0.7 0 ± 0 -161.5
1.1.50.01. Particulate methane monooxygenase 4phz Methylocystis sp. Bact. Gram-neg inner 12 42 30.0 ± 0.9 0 ± 0 -200.6
1.1.12.14. Kir3.1-prokaryotic Kir channel chimera 2qks Burkholderia xenovorans Bact. Gram-neg inner 4 8 30.5 ± 1.4 0 ± 1 -88.6
1.3.16.01. Osmoporin OMPC, isoform 2 2ixw Escherichia coli Bact. Gram-neg outer 3 48 24.5 ± 1.0 0 ± 0 -121.0
1.1.13.01. Acid-sensitive ion channel 1, with snake phospholipase A2 4ntx Gallus gallus Eukaryo. plasma 3 6 29.8 ± 1.8 0 ± 1 -51.0
1.1.15.01. Glycine receptor, alpha-3, structure 2 5tin Homo sapiens Eukaryo. plasma 5 20 31.0 ± 0.6 0 ± 0 -133.9
1.1.14.01. Aquaporin-2, conformation 1 4nef Homo sapiens Eukaryo. plasma 4 24 28.6 ± 1.3 0 ± 0 -117.8
1.1.06.01. Cytochrome b6f, structure 3 4h13 Mastigocladus laminosus Thylakoid 16 26 31.6 ± 0.6 0 ± 0 -219.6
1.1.14.02. Formate transporter 3q7k Salmonella enterica Bact. Gram-neg inner 5 30 28.6 ± 0.0 0 ± 0 -148.8
1.1.32.01. Proton glutamate symport protein, outward-facing state 3 5cfy Pyrococcus horikoshii Archaebac. 3 33 29.8 ± 0.3 0 ± 0 -185.9
1.1.36.01. ClC chloride transporter 1ots Escherichia coli Bact. Gram-neg inner 2 28 29.7 ± 0.8 0 ± 0 -115.3
1.1.12.01. Potassium channel KcsA, 20 A opening conformer 3fb8 Streptomyces lividans Bact. Gram-pos plas. 4 8 29.8 ± 0.4 0 ± 0 -68.2
1.1.21.01. CorA magnesium transporter, structure 3 2iub Thermotoga maritima Bact. Gram-neg inner 5 10 28.0 ± 1.2 0 ± 0 -65.7
1.3.32.01. Type II secretion system protein GspD, E. coli K12 5wq7 Escherichia coli Bact. Gram-neg outer 15 60 23.8 ± 0.6 0 ± 0 -257.6
1.1.08.01. F0 ATP synthase 4v1f Mycobacterium phlei Bact. Gram-pos plas. 9 18 33.4 ± 1.4 0 ± 0 -58.6
1.1.12.17. TRPML1 (Mucolipin-1) channel, closed 5wj5 Homo sapiens Lysosome 4 24 29.0 ± 0.8 0 ± 0 -211.4
1.1.02.04. LH1-RC complex, C2 form, structure 1 5y5s Thermochromatium tepidum Bact. Gram-neg inner 35 45 31.0 ± 0.4 0 ± 0 -246.1
1.1.12.14. Potassium channel Kir 2.2, structure 2 5kuk Gallus gallus Eukaryo. plasma 4 8 30.8 ± 0.2 0 ± 0 -108.3
1.1.61.01. Microsomal glutathione S-transferase 1, structure 2 5i9k Rattus norvegicus Endoplasm. reticulum 3 12 25.8 ± 0.2 0 ± 0 -26.4
1.1.02.03. PSII-LHCII supercomplex 3jcu Spinacia oleracea Thylakoid 42 100 30.8 ± 0.0 0 ± 0 -385.6
1.1.12.10. Sodium channel NavMs, full-length 5hvx Magnetococcus marinus Bact. Gram-neg inner 4 24 29.0 ± 0.6 0 ± 0 -159.6
1.1.61.01. FLAP protein (5-lipoxygenase activator) 2q7r Homo sapiens Endoplasm. reticulum 3 12 30.3 ± 1.3 0 ± 1 -70.8
1.1.01.01. Bacteriorhodopsin-I 4qi1 Haloquadratum walsbyi Archaebac. 3 21 31.8 ± 1.2 0 ± 0 -129.9
1.1.12.11. Voltage-gated K+ channel 4h33 Listeria monocytogenes Bact. Gram-pos plas. 4 8 33.2 ± 1.9 0 ± 0 -115.9
1.1.12.19. Multi-ligand gated K(+) channel, TrkA, mutant 4gx0 Geobacter sulfurreducens Bact. Gram-neg inner 4 8 31.8 ± 1.3 0 ± 0 -109.5
1.1.02.05. Light-harvesting complex LH3 1ijd Rhodopseudomonas acidophila Bact. Gram-neg inner 18 18 29.8 ± 0.7 0 ± 0 -174.6
1.3.24.01. Outer membrane protein ST50 5bun Salmonella enterica Bact. Gram-neg outer 3 12 23.8 ± 0.9 0 ± 0 -55.3
1.1.10.03. Antibacterial peptide transporter McjD, inward occluded state 5ofp Escherichia coli Bact. Gram-neg inner 2 12 31.4 ± 1.2 0 ± 0 -104.5
1.3.16.01. Porin OmpU 5onu Vibrio cholerae Bact. Gram-neg outer 3 48 23.8 ± 0.4 0 ± 0 -111.0
1.3.16.01. Outer membrane protein C 1osm Klebsiella pneumoniae Bact. Gram-neg outer 3 48 24.0 ± 1.1 0 ± 0 -136.6
1.1.02.04. LH1-RC complex, P21 form 3wmo Thermochromatium tepidum Bact. Gram-neg inner 35 43 31.8 ± 0.1 0 ± 0 -234.8
1.1.01.02. Squid rhodopsin, complex with 11-cis retinal, dimer 2z73 Todarodes pacificus Eukaryo. plasma 2 14 32.9 ± 1.0 0 ± 1 -143.3
1.1.15.01. Nicotinic acetylcholine receptor, alpha-4/beta-2 5kxi Homo sapiens Eukaryo. plasma 5 20 33.2 ± 0.7 0 ± 0 -133.0
1.3.25.01. Aerolysin 5jzt Aeromonas hydrophila Secreted 7 14 22.8 ± 3.0 0 ± 0 -59.5
1.1.15.01. Glutamate-gated chloride channel GluCl, with partial agonist 3rhw Caenorhabditis elegans Eukaryo. plasma 5 20 30.2 ± 0.7 0 ± 0 -107.9
1.1.25.05. Nitrate transporter NRT1/ PTR, dimer 4oh3 Arabidopsis thaliana Eukaryo. plasma 2 24 29.0 ± 0.9 0 ± 0 -106.0
1.1.02.03. Photosystem II, Br-substituted 3a0b Thermosynechococcus vulcanus Thylakoid 34 72 31.8 ± 0.4 0 ± 0 -397.1
1.1.14.01. Aquaporin AqpM 3ne2 Archaeoglobus fulgidus Archaebac. 4 24 31.2 ± 1.3 0 ± 0 -143.5
1.1.08.01. V-type Sodium ATPase 2bl2 Enterococcus hirae Bact. Gram-pos plas. 10 40 35.6 ± 0.7 0 ± 0 -189.6
1.1.26.01. Leucine transporter LeuT, outward-facing, return state 5jae Aquifex aeolicus Bact. Gram-neg inner 2 24 29.0 ± 0.8 0 ± 0 -143.0
1.1.118.01. Protein TMHC4_R 6b85 Designed proteins Undefined 4 8 30.2 ± 1.0 0 ± 0 -75.5
1.1.01.01. Halorhodopsin, different conformation 3vvk Natronomonas pharaonis Archaebac. 3 21 33.6 ± 1.1 0 ± 0 -140.5
1.1.15.02. Proton-gated ion channel, conformation 9 5j0z Gloeobacter violaceus Bact. Gram-neg inner 5 20 32.2 ± 1.4 0 ± 0 -171.9
1.1.12.15. TRPV6 channel, structure 1 6bo8 Homo sapiens Eukaryo. plasma 4 24 31.0 ± 0.6 0 ± 0 -238.1
1.1.08.01. V-type proton ATPase, structure 2 6c6l Saccharomyces cerevisiae Vacuole 14 54 33.4 ± 0.6 0 ± 0 -220.7
1.1.01.01. Sensory rhodopsin II, tetramer, structure 2 5jje Natronomonas pharaonis Archaebac. 4 18 30.2 ± 0.8 0 ± 0 -116.8
1.3.29.01. Bacterial amyloid secretion channel CsgG, structure 2 4uv3 Escherichia coli Bact. Gram-neg outer 9 36 26.4 ± 0.9 0 ± 0 -84.6
1.1.14.02. Formate/nitrite transporter 3tdp Clostridium difficile Bact. Gram-pos plas. 5 30 28.4 ± 1.9 0 ± 0 -161.3
1.1.28.05. Hopanoid transporter HpnN, structure 2 5khs Burkholderia multivorans Bact. Gram-neg inner 2 24 28.2 ± 0.8 0 ± 0 -100.7
1.2.23.01. M2 proton channel of Influenza A, open state, ligand-free 4qkm Influenza virus Viral 4 4 28.4 ± 1.7 0 ± 0 -55.4
1.1.05.05. Succinate dehydrogenase 1nek Escherichia coli Bact. Gram-neg inner 6 18 32.0 ± 0.6 0 ± 0 -183.5
1.3.16.01. Porin 2 4d65 Providencia stuartii Bact. Gram-neg outer 3 48 24.4 ± 1.0 0 ± 0 -129.2
1.1.15.01. Glycine receptor, alpha-1, glycine-bound state 3jae Danio rerio Eukaryo. plasma 5 20 31.8 ± 0.4 0 ± 0 -191.1
1.1.08.01. F0 ATP synthase 4bem Acetobacterium woodii Bact. Gram-pos plas. 10 22 34.8 ± 1.1 0 ± 0 -102.9
1.1.17.01. Ammonium sensor/transducer 6eu6 Kuenenia stuttgartiensis Bact. Gram-neg inner 3 33 30.6 ± 0.6 0 ± 0 -152.2
1.1.14.01. Aquaporin-0 2b6o Ovis aries Eukaryo. plasma 4 32 31.8 ± 1.4 0 ± 0 -143.3
1.1.90.01. Phosphatidate cytidylyltransferase, conformation 2 4q2g Thermotoga maritima Bact. Gram-neg inner 2 18 26.8 ± 0.4 0 ± 2 -55.6
1.1.28.01. Multidrug efflux transporter AcrB with YajC subunit , symmetric 2rdd Escherichia coli Bact. Gram-neg inner 6 39 28.4 ± 0.5 0 ± 0 -156.2
1.1.16.01. Glutamate receptor 2, with noncompetitive inhibitor 5l1h Rattus norvegicus Eukaryo. plasma 4 12 36.4 ± 0.7 0 ± 0 -100.1
1.3.25.01. Necrotic enteritis toxin B, NetB 4h56 Clostridium perfringens Secreted 7 17 25.2 ± 0.8 0 ± 0 -50.7
1.3.23.01. Adhesin yadA 2lme Yersinia enterocolitica Bact. Gram-neg outer 3 15 23.4 ± 2.2 0 ± 1 -37.7
1.1.16.01. Glutamate receptor 2, with conotoxin, structure 1 4u5b Rattus norvegicus Eukaryo. plasma 4 12 31.6 ± 1.1 0 ± 0 -91.5
1.1.84.01. Bifunctional IPC transferase and DIPP synthase 4mnd Archaeoglobus fulgidus Archaebac. 2 12 30.2 ± 1.0 0 ± 0 -86.4
1.1.12.12. NaK potassium channel, different strain of Bacillus cereus 3ouf Bacillus cereus Bact. Gram-pos plas. 4 8 27.9 ± 1.3 0 ± 0 -91.0
1.1.65.01. Concentrative nucleoside transporter, inward-facing state 5l26 Neisseria wadsworthii Bact. Gram-neg inner 3 24 29.0 ± 0.4 0 ± 0 -168.2
1.1.12.01. Potassium channel KcsA, complex with Rb+ 3fb7 Streptomyces lividans Bact. Gram-pos plas. 4 8 28.6 ± 1.2 0 ± 0 -79.0
1.1.13.02. ATP-gated P2X4 ion channel, closed state 3h9v Danio rerio Eukaryo. plasma 3 6 27.6 ± 1.3 0 ± 1 -61.3
1.3.32.01. Type II secretion system protein GspD 5wq8 Vibrio cholerae Bact. Gram-neg outer 15 60 19.4 ± 0.0 0 ± 0 -231.2
1.1.12.17. TRPML1 (Mucolipin-1) channel, open 5wj9 Homo sapiens Lysosome 4 24 29.4 ± 0.4 0 ± 0 -219.8
1.2.31.01. Cytochrome c nitrite reductase complex 2j7a Desulfovibrio vulgaris Bact. Gram-neg inner 2 2 31.8 ± 3.1 0 ± 2 -42.9
1.1.12.17. Polycystin-2 channel, structure 1 5k47 Homo sapiens Eukaryo. plasma 4 24 30.8 ± 0.0 0 ± 0 -231.6
1.1.113.01. ERAD-associated E3 ubiquitin-protein ligase HRD1 5v6p Saccharomyces cerevisiae Endoplasm. reticulum 2 16 30.2 ± 2.0 0 ± 0 -48.4
1.1.07.01. Mitochondrial cytochrome c oxidase, with cytochrome c 5iy5 Bos taurus Mitochon. inner 20 56 25.8 ± 1.2 0 ± 0 -204.7
1.1.54.01. Diacylglycerol kinase (DAGK), NMR model 2kdc Escherichia coli Bact. Gram-neg inner 3 9 25.5 ± 1.8 0 ± 0 -39.9
1.1.17.01. Ammonium transporter Amt-1 2b2f Archaeoglobus fulgidus Archaebac. 3 33 28.9 ± 0.7 0 ± 0 -152.5
1.1.15.01. Gamma-aminobutyric acid receptor, GABA 4cof Homo sapiens Eukaryo. plasma 5 20 31.6 ± 0.6 0 ± 0 -158.5
1.2.11.01. Capsid protein G8P 1ifi Bacteriophage fd Secreted 15 15 36.8 ± 0.2 0 ± 0 -69.8
1.1.06.01. Cytochrome bc1, bacterial 2yiu Paracoccus denitrificans Bact. Gram-neg inner 6 20 29.8 ± 0.5 0 ± 0 -188.8
1.1.66.01. K(+)-pumping pyrophosphatase, structure 3 5lzq Thermotoga maritima Bact. Gram-neg inner 2 32 31.0 ± 0.6 0 ± 0 -185.6
1.1.12.19. Multi-ligand gated K(+) channel, TrkA 4gx5 Geobacter sulfurreducens Bact. Gram-neg inner 4 8 31.6 ± 0.7 0 ± 0 -94.6
1.1.02.05. Light-harvesting complex 1lgh Rhodospirillum molischianum Bact. Gram-neg inner 16 16 29.7 ± 0.5 0 ± 0 -163.4
1.1.28.02. Efflux pump membrane transporter CmeB, structure 2 5t0o Campylobacter jejuni Bact. Gram-neg inner 3 36 27.8 ± 0.6 0 ± 0 -183.8
1.1.36.01. ClC chloride transporter 3org Cyanidoschyzon merolae Eukaryo. plasma 2 28 28.7 ± 1.3 0 ± 2 -140.4
1.3.16.01. Anion-selective porin 2fgq Comamonas acidovorans Bact. Gram-neg outer 3 48 25.0 ± 0.9 0 ± 0 -130.8
1.1.12.02. Potassium channel Kv1.2. - Kv2.1. chimera, complex with Charybdotoxin 4jtc Rattus norvegicus Eukaryo. plasma 4 24 30.2 ± 0.4 0 ± 0 -247.3
1.1.06.01. Cytochrome bc1, mitochondrial, structure 2 2fyu Bos taurus Mitochon. inner 12 26 29.8 ± 0.5 0 ± 0 -182.9
1.1.14.01. Aquaglyceroporin 3c02 Plasmodium falciparum Eukaryo. plasma 4 32 30.4 ± 1.3 0 ± 0 -137.4
1.1.13.02. P2X purinoceptor 3, closed, apo state 5svj Homo sapiens Eukaryo. plasma 3 6 34.2 ± 0.8 0 ± 0 -58.1
1.1.73.01. Outer membrane complex of type IV secretion system (VirB7/VirB9/VirB10 complex) 3jqo Escherichia coli Bact. Gram-neg outer 14 14 22.6 ± 0.6 0 ± 0 -67.4
1.1.02.03. Photosystem II, monomeric form 3kzi Thermosynechococcus elongatus Thylakoid 16 36 31.8 ± 0.5 0 ± 0 -310.1
1.1.28.02. Efflux transporter CusA, complex with CusB 3ne5 Escherichia coli Bact. Gram-neg inner 3 36 29.0 ± 0.7 0 ± 0 -165.0
1.1.09.01. Copper efflux ATPase, CopA 3j08 Archaeoglobus fulgidus Archaebac. 2 16 27.6 ± 0.8 0 ± 0 -72.3
1.1.15.01. Glutamate-gated chloride channel GluCl, POPC-bound conformation 4tnw Caenorhabditis elegans Eukaryo. plasma 5 20 30.6 ± 0.9 0 ± 0 -125.0
1.1.28.02. Efflux transporter CusA, complex with CusB, pre-extrusion state 3t56 Escherichia coli Bact. Gram-neg inner 3 36 30.4 ± 0.6 0 ± 0 -153.7
1.1.12.15. TRPV6 channel, structure 2 6boa Homo sapiens Eukaryo. plasma 4 24 31.4 ± 0.4 0 ± 0 -231.9
1.1.104.01. TRIC cation channel, structure 1 5wud Sulfolobus acidocaldarius Archaebac. 3 21 28.2 ± 1.0 0 ± 0 -141.2
1.1.13.01. Acid-sensing ion channel 1, structure 3 6ave Gallus gallus Eukaryo. plasma 3 6 31.0 ± 0.8 0 ± 0 -56.7
1.1.12.14. Potassium channel Kirbac1.1, closed state 1p7b Burkholderia pseudomallei Bact. Gram-neg inner 4 8 33.1 ± 1.3 0 ± 0 -111.9
1.1.15.01. Glycine receptor, alpha-1, glycine/ivermectin-bound state 3jaf Danio rerio Eukaryo. plasma 5 20 33.4 ± 1.4 0 ± 0 -180.2
1.3.16.01. OmpC porin 5fvn Enterobacter cloacae Bact. Gram-neg outer 3 48 23.2 ± 0.6 0 ± 0 -124.2
1.1.17.01. Ammonium transporter MEP2 5aex Saccharomyces cerevisiae Eukaryo. plasma 3 33 29.4 ± 1.4 0 ± 0 -121.0
1.2.23.01. M2 proton channel of Influenza A, drug-bound 2muv Influenza virus Viral 4 4 32.4 ± 1.1 0 ± 0 -59.2
1.1.14.01. Aquaporin-1 1j4n Bos taurus Eukaryo. plasma 4 32 31.8 ± 1.0 0 ± 0 -129.2
1.3.24.01. Outer membrane protein TolC 1ek9 Escherichia coli Bact. Gram-neg outer 3 12 24.6 ± 1.4 0 ± 2 -56.1
1.1.15.01. Glycine receptor, alpha-1 2m6i Homo sapiens Eukaryo. plasma 5 20 26.8 ± 0.3 0 ± 0 -92.1
1.1.61.01. Microsomal prostaglandin E synthase 1, structure 3 4yl3 Homo sapiens Endoplasm. reticulum 3 12 29.8 ± 0.7 0 ± 0 -85.2
1.1.12.17. Polycystin-2 channel, structure 3 5mkf Homo sapiens Eukaryo. plasma 4 24 29.0 ± 1.2 0 ± 1 -164.0
1.1.14.01. Aquaporin-2, conformation 2 4oj2 Homo sapiens Eukaryo. plasma 4 24 29.0 ± 0.7 0 ± 0 -125.9
1.1.02.02. Photosystem I of cyanobacteria, virus-like, structure 1 4kt0 Synechocystis sp. Thylakoid 6 27 32.0 ± 0.7 0 ± 0 -235.3
1.1.12.10. Voltage-gated sodium channel Nav1.7- NavAb, with antagonist 5ek0 Arcobacter butzleri Bact. Gram-neg inner 4 24 30.2 ± 0.6 0 ± 0 -236.2
1.3.16.01. Osmoporin OMPC 3upg Salmonella typhimurium Bact. Gram-neg outer 3 48 23.4 ± 0.7 0 ± 0 -118.0
1.1.15.02. Proton-gated ion channel, inactive conformation 4 4a97 Erwinia chrysanthemi Bact. Gram-neg inner 5 40 31.8 ± 0.5 0 ± 0 -125.8
1.1.50.01. Particulate methane monooxygenase 1yew Methylococcus capsulatus Bact. Gram-neg inner 9 42 28.2 ± 0.7 0 ± 0 -188.5
1.1.10.05. ABC transporter ABCG2, structure 3 6eti Homo sapiens Eukaryo. plasma 2 12 31.4 ± 0.8 0 ± 0 -102.9
1.1.16.01. Glutamate receptor 2, with antagonist, structure 1 3kg2 Rattus norvegicus Eukaryo. plasma 4 12 31.8 ± 2.0 0 ± 0 -93.0
1.3.11.03. Amyloid secretion protein FapF, structure 1 5o65 Pseudomonas sp. Bact. Gram-neg outer 3 36 25.0 ± 0.4 0 ± 0 -126.2
1.1.39.03. Folate ECF transporter 4z7f Enterococcus faecalis Bact. Gram-pos plas. 1 6 30.6 ± 1.6 0 ± 1 -53.1
1.1.12.17. TRPML1 (Mucolipin-1) channel, closed I 5wpq Mus musculus Lysosome 4 24 31.4 ± 0.8 0 ± 0 -194.7
1.1.102.01. STRA6 receptor, with calmodulin 5sy1 Danio rerio Eukaryo. plasma 2 18 30.8 ± 0.0 0 ± 0 -141.2
1.1.26.05. Arginine/agmatine antiporter (AdiC), outward-facing conformation 3hqk Salmonella enterica Bact. Gram-neg inner 2 26 29.8 ± 1.0 0 ± 0 -124.6
1.1.20.02. Innexin-6 gap junction channel 5h1r Caenorhabditis elegans Eukaryo. plasma 8 40 30.6 ± 0.4 0 ± 0 -233.4
1.1.26.04. L-carnitine/gamma-butyrobetaine antiporter CaiT, open inward-facing conformation 2wsw Proteus mirabilis Bact. Gram-neg inner 3 42 29.8 ± 0.5 0 ± 0 -218.9
1.1.16.01. Glutamate receptor ionotropic, NMDA 1 4pe5 Rattus norvegicus Eukaryo. plasma 4 12 28.6 ± 0.8 0 ± 0 -25.4
1.1.02.03. PSII-LHCII supercomplex 5xnl Pisum sativum Thylakoid 58 0 29.0 ± 0.4 0 ± 0 -539.7
1.1.12.10. Sodium channel BacNaV, channel neck mutants 5hj8 Alkalilimnicola ehrlichei Bact. Gram-neg inner 4 8 30.6 ± 1.1 0 ± 0 -96.1
1.2.11.01. Capsid protein G8P 1ifk Bacteriophage If1 Secreted 15 15 31.8 ± 0.7 0 ± 0 -83.5
1.1.21.01. Magnesium transport protein CorA 4ev6 Methanococcus jannaschii Archaebac. 5 10 28.4 ± 1.5 0 ± 1 -92.4
1.1.12.12. NaK potassium channel, open state 3e86 Bacillus cereus Bact. Gram-pos plas. 4 8 27.6 ± 0.9 0 ± 0 -90.0
1.1.24.01. Bestrophin ion channel 4wd8 Klebsiella pneumoniae Bact. Gram-neg inner 5 20 27.4 ± 0.6 0 ± 0 -119.7
1.1.12.20. ATP-sensitive K+ channel SUR1/Kir6.2, structure 1 6baa Rattus norvegicus Eukaryo. plasma 8 76 31.4 ± 0.4 0 ± 0 -443.7
1.1.18.01. Mechanosensitive channel MscL, closed state 4y7k Methanosarcina acetivorans Archaebac. 5 10 31.8 ± 0.1 0 ± 0 -121.6
1.1.108.01. Nitrate/nitrite sensor histidine kinase NarQ, structure 1 5iji Escherichia coli Bact. Gram-neg inner 2 4 31.8 ± 2.0 0 ± 1 -57.1
1.1.13.02. ATP-gated P2X4 ion channel, open state 4dw1 Danio rerio Eukaryo. plasma 3 6 26.8 ± 0.6 0 ± 0 -56.0
1.1.26.06. Uric acid-xanthine permease 5i6c Emericella nidulans Eukaryo. plasma 2 28 29.2 ± 1.0 0 ± 0 -119.2
1.1.43.01. Saccharide transporter, EIIC (ChbC), outward-facing 5iws Bacillus cereus Bact. Gram-pos plas. 2 20 31.2 ± 1.0 0 ± 0 -161.7
1.3.16.02. Porin 2por Rhodobacter capsulatus Bact. Gram-neg outer 3 48 23.4 ± 0.6 0 ± 0 -114.8
1.1.12.14. G protein-activated inward rectifier potassium channel 2 4kfm Mus musculus Eukaryo. plasma 4 8 33.6 ± 1.2 0 ± 0 -120.7
1.1.06.01. Cytochrome bc1, mitochondrial, bovine/chicken, structure 1 1bcc Bos taurus Mitochon. inner 24 10 29.8 ± 0.6 0 ± 0 -197.0
1.1.14.01. Aquaporin-4 2d57 Rattus norvegicus Eukaryo. plasma 4 32 29.8 ± 1.1 0 ± 0 -126.2
1.1.13.02. P2X purinoceptor 3, open state 5svk Homo sapiens Eukaryo. plasma 3 6 31.6 ± 0.8 0 ± 0 -81.4
1.1.41.01. Magnesium ion transporter-E (MgtE), structure 2 4u9n Thermus thermophilus Bact. Gram-neg inner 2 10 31.8 ± 0.8 0 ± 0 -85.3
1.1.08.01. F0 ATP synthase 2xqu Arthrospira platensis Thylakoid 15 30 31.8 ± 0.8 0 ± 0 -129.7
1.1.16.01. Glutamate receptor 2, with auxiliary subunit GSG1L, structure 1 5vhy Rattus norvegicus Eukaryo. plasma 4 20 33.0 ± 0.8 0 ± 0 -176.6
1.1.10.02. Molybdate transporter ModBC, open state 2onk Archaeoglobus fulgidus Archaebac. 2 12 32.0 ± 1.7 0 ± 1 -100.7
1.1.15.01. Glutamate-gated chloride channel GluCl, apo (non-conducting state) 4tnv Caenorhabditis elegans Eukaryo. plasma 5 20 30.8 ± 1.5 0 ± 0 -106.1
1.1.08.01. F0 ATP synthase, structure 1 2x2v Bacillus pseudofirmus Bact. Gram-pos plas. 13 26 35.3 ± 1.2 0 ± 0 -137.7
1.1.29.01. YddG transporter 5i20 Starkeya novella Bact. Gram-neg inner 1 10 30.2 ± 1.3 0 ± 0 -78.1
1.1.32.01. Proton/glutamate symporter, apo 5dwy Pyrococcus kodakaraensis Archaebac. 3 24 30.8 ± 0.6 0 ± 0 -184.1
1.1.26.04. Glycine betaine transporter BetP, substrate-bound 2wit Corynebacterium glutamicum Bact. Gram-pos plas. 3 36 30.4 ± 1.2 0 ± 0 -198.6
1.1.12.15. TRPV6 channel, tetramer, structure 2 6bob Rattus norvegicus Eukaryo. plasma 4 24 30.6 ± 0.2 0 ± 0 -222.9
1.1.104.01. TRIC cation channel, structure 2 5wue Sulfolobus acidocaldarius Archaebac. 3 21 28.2 ± 0.4 0 ± 0 -121.8
1.1.35.03. Citrate-sodium symporter CitS, structure 1 5xar Klebsiella pneumoniae Bact. Gram-neg inner 2 22 30.2 ± 0.6 0 ± 0 -138.2
1.1.28.01. Multidrug efflux transporter AcrB, symmetric 3d9b Escherichia coli Bact. Gram-neg inner 3 36 28.4 ± 0.6 0 ± 0 -189.9
1.1.14.01. Aquaporin-4 3gd8 Homo sapiens Eukaryo. plasma 4 32 29.8 ± 1.1 0 ± 1 -122.9
1.1.10.05. ABC transporter ABCG2, structure 4 6ffc Homo sapiens Eukaryo. plasma 2 12 30.6 ± 0.6 0 ± 0 -101.9
1.1.17.01. Ammonium transporter MEP2, structure 1 5aez Candida albicans Eukaryo. plasma 3 33 32.4 ± 0.8 0 ± 0 -154.4
1.1.10.03. Mitochondrial ABC transporter ABCB10, conformation 1 4ayt Homo sapiens Mitochon. inner 2 12 30.4 ± 0.8 0 ± 0 -79.7
1.2.11.02. Capsid protein G8P 2mjz Bacteriophage M13 Viral 10 10 30.8 ± 0.3 0 ± 0 -20.4
1.1.14.01. Aquaporin-0 1ymg Bos taurus Eukaryo. plasma 4 32 31.3 ± 1.2 0 ± 0 -138.4
1.1.12.01. Potassium channel KcsA, open deep-inactivated conformation 5vke Streptomyces lividans Bact. Gram-pos plas. 4 8 30.2 ± 0.6 0 ± 0 -104.9
1.3.25.01. Gamma-hemolysin, complete channel, hetero-octamer (A+B) 3b07 Staphylococcus aureus Secreted 8 16 21.4 ± 1.0 0 ± 0 -32.8
1.3.24.01. Multidrug Resistance (VceC) protein 1yc9 Vibrio cholerae Bact. Gram-neg outer 3 12 24.6 ± 1.0 0 ± 0 -62.2
1.1.01.02. C-C chemokine receptor type 5 4mbs Homo sapiens Eukaryo. plasma 1 7 34.4 ± 1.5 0 ± 0 -88.8
1.1.06.01. Cytochrome bc1, mitochondrial, with cytochrome c iso-2 3cxh Saccharomyces cerevisiae Mitochon. inner 24 10 27.6 ± 1.1 0 ± 0 -167.0
1.1.01.01. Sodium pumping rhodopsin, NaR, pentamer 4xto Dokdonia eikasta Bact. Gram-neg inner 5 35 29.8 ± 0.5 0 ± 0 -170.3
1.1.26.04. L-carnitine/gamma-butyrobetaine antiporter CaiT, substrate-bound 3hfx Escherichia coli Bact. Gram-neg inner 3 42 29.8 ± 0.8 0 ± 0 -203.5
1.1.12.11. Potassium channel KvAP, complex with Fab 1orq Aeropyrum pernix Archaebac. 4 12 29.3 ± 1.6 0 ± 0 -78.6
1.3.16.01. Porin OmpF 3nsg Salmonella enterica Bact. Gram-neg outer 3 48 23.6 ± 0.8 0 ± 0 -123.4
1.1.98.01. Polyisoprenyl-phosphate glycosyltransferase GtrB 5eke Synechocystis sp. Bact. Gram-neg inner 4 8 31.4 ± 1.2 0 ± 0 -82.3
1.1.12.14. G protein-activated inward rectifier potassium channel 2 (GIRK2, Kir3.2) 3sya Mus musculus Eukaryo. plasma 4 8 34.8 ± 0.7 0 ± 0 -145.5
1.1.12.05. Calcium-gated potassium channel MthK 3ldc Methanobacterium thermoautotrophicum Archaebac. 4 8 29.8 ± 0.8 0 ± 0 -72.4
1.3.20.01. Fe-regulated protein B 4aip Neisseria meningitidis Bact. Gram-neg outer 3 66 23.4 ± 0.3 0 ± 0 -144.6
1.1.32.01. Proton glutamate symport protein, outward-facing state 4 4oye Pyrococcus horikoshii Archaebac. 3 30 28.2 ± 0.6 0 ± 0 -168.8
1.3.16.01. Porin B (PorB), different strain 3wi4 Neisseria meningitidis Bact. Gram-neg outer 3 48 23.4 ± 0.6 0 ± 0 -112.6
1.1.65.01. Concentrative nucleoside transporter, outward-facing state 5l2a Neisseria wadsworthii Bact. Gram-neg inner 3 24 27.8 ± 0.6 0 ± 0 -164.7
1.1.61.01. Microsomal prostaglandin E synthase 1, structure 2 4bpm Homo sapiens Endoplasm. reticulum 3 12 31.6 ± 1.4 0 ± 3 -87.5
1.1.72.01. Dicarboxylate/sodium symporter NadC 5uld Vibrio cholerae Bact. Gram-neg inner 2 28 30.2 ± 0.6 0 ± 1 -106.9
1.1.12.19. TrkH/TrkA potassium transport complex, structure 1 4j7c Bacillus subtilis Bact. Gram-pos plas. 2 16 31.8 ± 1.0 0 ± 0 -165.6
1.1.111.01. Prokaryotic otassium channel TMEM175 5vre Chamaesiphon minutus Bact. Gram-neg inner 4 24 30.2 ± 1.4 0 ± 0 -125.4
1.1.50.01. Particulate methane monooxygenase, different structure 3rgb Methylococcus capsulatus Bact. Gram-neg inner 9 39 28.2 ± 0.6 0 ± 0 -204.9
1.3.25.04. Protective antigen 3j9c Bacillus anthracis Secreted 7 14 34.6 ± 1.2 0 ± 0 -76.8
1.1.25.06. D-xylose-proton symporter xylE, conformation 3 4ja4 Escherichia coli Bact. Gram-neg inner 1 12 28.2 ± 1.3 0 ± 0 -82.8
1.1.14.01. Aquaporin-4, different conformation of loops with lipids 2zz9 Rattus norvegicus Eukaryo. plasma 4 28 29.5 ± 0.7 0 ± 0 -115.6
1.2.43.02. E1/E2 envelope glycoprotein complex 2yew Barmah forest virus Viral 8 8 30.0 ± 0.8 0 ± 0 -53.5
1.3.11.03. Amyloid secretion protein FapF, structure 2 5o67 Pseudomonas sp. Bact. Gram-neg outer 3 36 25.0 ± 0.6 0 ± 0 -123.7
1.1.97.01. Mycobacterial Insig homolog MvINS 4xu4 Mycobacterium vanbaalenii Bact. Gram-pos plas. 3 18 30.0 ± 0.9 0 ± 0 -122.0
1.1.12.17. TRPML1 (Mucolipin-1) channel, closed II 5wpt Mus musculus Lysosome 4 24 31.0 ± 0.4 0 ± 0 -226.1
1.1.12.04. Bacterial cyclic nucleotide regulated ion channel, full structure 4chw Rhizobium loti Bact. Gram-neg inner 4 24 29.8 ± 0.6 0 ± 0 -187.8
1.1.41.01. Magnesium ion transporter-E (MgtE), structure 1 2yvx Thermus thermophilus Bact. Gram-neg inner 2 10 31.1 ± 0.9 0 ± 0 -69.2
1.1.041.01. Bacterial semiSWEET transporter 4qnd Vibrio sp. Bact. Gram-neg inner 2 6 33.0 ± 1.7 0 ± 0 -61.5
1.1.12.11. Potassium channel KvAP 2a0l Aeropyrum pernix Archaebac. 4 12 29.5 ± 1.1 0 ± 0 -100.0
1.1.15.02. Proton-gated ion channel, conformation 4 5heo Gloeobacter violaceus Bact. Gram-neg inner 5 20 32.0 ± 0.8 0 ± 0 -121.8
1.1.57.02. Intramembrane aspartate protease 4hyg Methanoculleus marisnigri Archaebac. 3 27 31.8 ± 0.3 0 ± 0 -172.7
1.3.24.01. Outer membrane protein TolC, mutant, open conformation 1 2wmz Escherichia coli Bact. Gram-neg outer 3 12 24.4 ± 0.8 0 ± 0 -52.8
1.1.15.02. Proton-gated ion channel, conformation 8 5l4h Gloeobacter violaceus Bact. Gram-neg inner 5 20 31.8 ± 1.4 0 ± 1 -175.1
1.1.01.02. Beta-2 adrenergic receptor, inactive state, dimer 2rh1 Homo sapiens Eukaryo. plasma 2 14 31.8 ± 0.9 0 ± 1 -143.2
1.1.26.04. Glycine betaine transporter BetP, outward-open 4llh Corynebacterium glutamicum Bact. Gram-pos plas. 3 36 29.8 ± 0.4 0 ± 0 -175.4
1.1.12.06. Calcium-activated cation channel 5cbg Tsukamurella paurometabola Bact. Gram-pos plas. 4 14 31.6 ± 0.8 0 ± 0 -77.0
1.3.16.02. Porin 3prn Rhodopseudomonas blastica Bact. Gram-neg outer 3 48 23.2 ± 0.5 0 ± 0 -127.6
1.1.28.01. Multidrug efflux transporter AcrB-AcrZ complex, structure 1 4c48 Escherichia coli Bact. Gram-neg inner 6 39 29.2 ± 0.8 0 ± 0 -217.3
1.1.06.01. Cytochrome bc1, mitochondrial, bovine/chicken, structure 2 3bcc Bos taurus Mitochon. inner 24 10 28.6 ± 1.0 0 ± 0 -190.1
1.1.13.02. P2X purinoceptor 3, closed, agonist-bound 5svm Homo sapiens Eukaryo. plasma 3 6 30.8 ± 0.2 0 ± 0 -54.2
1.1.14.02. Formate transporter 1, FocA 3kcu Escherichia coli Bact. Gram-neg inner 5 35 29.9 ± 0.7 0 ± 0 -160.9
1.1.02.02. Photosystem I of cyanobacteria, trimeric, structure 2 3pcq Thermosynechococcus elongatus Thylakoid 27 96 29.8 ± 0.8 0 ± 0 -429.6
1.1.15.02. Proton-gated ion channel, Glic/Elic chimera 4yeu Gloeobacter violaceus Bact. Gram-neg inner 5 20 32.6 ± 1.1 0 ± 0 -162.5
1.1.16.01. Glutamate receptor 2, with auxiliary subunit GSG1L, structure 2 5vhz Rattus norvegicus Eukaryo. plasma 6 20 33.0 ± 0.8 0 ± 0 -171.5
1.1.16.01. Glutamate receptor 2, with auxiliary subunit GSG1L, structure 4 5wel Rattus norvegicus Eukaryo. plasma 4 20 33.0 ± 1.0 0 ± 0 -157.2
1.1.12.08. Two pore calcium channel TPC1, structure 2 6c9a Mus musculus Endosome 2 24 31.0 ± 0.4 0 ± 0 -262.2
1.1.26.01. Leucine transporter LeuT, outward-facing conformation, from bicelles 4fxz Aquifex aeolicus Bact. Gram-neg inner 2 24 28.0 ± 0.6 0 ± 0 -144.3
1.1.12.17. TRPM4 channel, structure 2 6bqr Homo sapiens Eukaryo. plasma 4 24 30.6 ± 0.8 0 ± 0 -223.2
1.3.29.01. Bacterial amyloid secretion channel CsgG, structure 1 4q79 Escherichia coli Bact. Gram-neg outer 9 36 25.6 ± 0.6 0 ± 0 -82.4
1.1.26.04. Glycine betaine transporter BetP, asymmetric trimer, conformation 2 4doj Corynebacterium glutamicum Bact. Gram-pos plas. 3 36 30.0 ± 0.6 0 ± 0 -186.4
1.1.20.01. Connexin 26 gap junction channel, structure 1 2zw3 Homo sapiens Eukaryo. plasma 6 24 32.2 ± 0.5 0 ± 0 -155.9
1.1.07.01. Mitochondrial cytochrome c oxidase 2dyr Bos taurus Mitochon. inner 20 56 28.0 ± 0.6 0 ± 0 -198.1
1.3.12.01. Outer membrane phospholipase A, dimer 5dqx Salmonella enterica Bact. Gram-neg outer 2 24 23.4 ± 1.1 0 ± 0 -73.5
1.3.24.01. Drug-Discharge Outer Membrane Protein, OprM 1wp1 Pseudomonas aeruginosa Bact. Gram-neg outer 3 12 24.7 ± 1.2 0 ± 0 -64.0
1.1.01.01. Sensory rhodopsin, dimer 4tl3 Nostoc sp. Bact. Gram-neg inner 2 17 30.6 ± 1.1 0 ± 0 -116.0
1.1.72.02. Antibiotic resistance efflux pump MtrF 4r1i Neisseria gonorrhoeae Bact. Gram-neg inner 2 22 28.9 ± 1.4 0 ± 0 -118.2
1.1.01.01. Bacteriorhodopsin 1m0l Halobacterium salinarum Archaebac. 3 21 31.8 ± 1.1 0 ± 1 -121.1
1.1.06.01. Cytochrome b6f, structure 4 4pv1 Mastigocladus laminosus Thylakoid 16 26 31.8 ± 0.5 0 ± 0 -215.7
1.1.06.01. Cytochrome bc1, bacterial, structure 1 2qjy Rhodobacter sphaeroides Bact. Gram-neg inner 6 20 30.2 ± 0.6 0 ± 0 -188.6
1.1.16.01. Glutamate receptor 2, with partial agonist, structure 5 4u4f Rattus norvegicus Eukaryo. plasma 4 12 30.2 ± 1.2 0 ± 0 -54.0
1.1.119.01. Undecaprenyl-pyrophosphate phosphatase, BacA, dimer 6cb2 Escherichia coli Bact. Gram-neg inner 2 20 30.2 ± 0.6 0 ± 0 -112.3
1.3.16.01. Porin B (PorB), different strain, conformation 2 3wi5 Neisseria meningitidis Bact. Gram-neg outer 3 48 25.4 ± 0.9 0 ± 0 -117.2
1.1.28.01. AcrAB-TolC efflux pump, structure 1 5v78 Escherichia coli Bact. Gram-neg inner 3 39 27.0 ± 1.0 0 ± 0 -156.1
1.1.10.09. MacAB-TolC efflux pump 5nik Escherichia coli Bact. Gram-neg inner 2 8 34.6 ± 2.0 0 ± 0 -96.2
1.1.14.01. Aquaporin Z 1rc2 Escherichia coli Bact. Gram-neg inner 4 32 29.7 ± 1.3 0 ± 0 -118.7
1.1.12.14. Potassium channel Kir 2.2, structure 1 3jyc Gallus gallus Eukaryo. plasma 4 8 30.5 ± 1.4 0 ± 1 -119.9
1.1.115.01. MlaA protein, with OMPF (E. coli) 5nuo Klebsiella pneumoniae Bact. Gram-neg outer 6 54 23.4 ± 0.6 0 ± 0 -181.3
1.1.84.01. Phosphatidylinositolphosphate synthase, structure 1 5d92 Renibacterium salmoninarum Bact. Gram-pos plas. 2 12 31.8 ± 1.4 0 ± 1 -98.3
1.1.12.17. TRPML1 (Mucolipin-1) channel, closed III 5wpv Mus musculus Lysosome 4 24 31.0 ± 0.4 0 ± 0 -214.3
1.1.12.14. G protein-activated inward rectifier potassium channel 2, diff. conf. 3syq Mus musculus Eukaryo. plasma 4 8 31.6 ± 0.6 0 ± 0 -107.9
1.1.12.04. Bacterial cyclic nucleotide regulated ion channel, full structure, with cAMP 4chv Rhizobium loti Bact. Gram-neg inner 4 24 28.4 ± 0.5 0 ± 0 -138.2
1.1.06.01. Cytochrome bc1, mitochondrial, structure 4 5nmi Bos taurus Mitochon. inner 12 26 29.4 ± 1.0 0 ± 0 -161.4
1.1.29.02. Triose phosphate translocator 5y79 Galdieria sulphuraria Chloroplast inner 2 20 30.2 ± 1.4 0 ± 1 -132.8
1.1.12.03. High conductance calcium-activated potassium channel, structure 1 5tj6 Aplysia californica Eukaryo. plasma 4 28 31.8 ± 0.6 0 ± 0 -273.6
1.1.14.01. Aquaporin AqpM 2f2b Methanobacterium thermoautotrophicum Archaebac. 4 32 29.0 ± 0.8 0 ± 0 -129.9
1.1.02.02. Photosystem I of cyanobacteria, trimer 5oy0 Synechocystis sp. Thylakoid 24 93 31.4 ± 0.4 0 ± 0 -473.7
1.1.15.02. Proton-gated ion channel, conformation 5 5heh Gloeobacter violaceus Bact. Gram-neg inner 5 20 33.4 ± 1.0 0 ± 0 -183.3
1.1.01.01. Bacteriorhodopsin, different loop conformaton 1fbk Halobacterium salinarum Archaebac. 3 21 30.0 ± 1.2 0 ± 0 -127.8
1.3.24.01. Outer membrane protein TolC, mutant, open conformation 2 2vde Escherichia coli Bact. Gram-neg outer 3 12 24.4 ± 1.2 0 ± 0 -57.4
1.1.19.01. Mechanosensitive channel protein MscS, closed state 4hw9 Helicobacter pylori Bact. Gram-neg inner 7 14 31.6 ± 1.8 0 ± 0 -140.9
1.1.12.02. Potassium channel Kv1.2 - Kv2.1. chimera, in membrane-like environment 2r9r Rattus norvegicus Eukaryo. plasma 4 28 30.8 ± 0.6 0 ± 0 -252.0
1.1.12.10. Voltage-gated sodium channel 4bgn Caldalkalibacillus thermarum Bact. Gram-pos plas. 4 24 27.0 ± 0.3 0 ± 0 -201.5
1.1.12.14. Potassium channel Kir 2.2, complex with inositol lipid 3spg Gallus gallus Eukaryo. plasma 4 8 30.8 ± 1.2 0 ± 0 -109.1
1.1.01.02. C-X-C chemokine receptor type 4, inactive, dimer, complex with antagonist 3odu Homo sapiens Eukaryo. plasma 2 14 31.2 ± 1.1 0 ± 0 -129.5
1.3.16.01. Porin 1, structure 2 5nxn Providencia stuartii Bact. Gram-neg outer 3 48 24.2 ± 1.2 0 ± 0 -129.8
1.3.18.01. Maltoporin 1af6 Escherichia coli Bact. Gram-neg outer 3 54 25.1 ± 0.7 0 ± 0 -117.9
1.1.12.16. Ryanodine receptor 1, closed structure 2 3j8h Oryctolagus cuniculus Endoplasm. reticulum 4 24 30.8 ± 0.0 0 ± 0 -190.3
1.1.13.02. P2X purinoceptor 3, closed, ATP-bound 5svl Homo sapiens Eukaryo. plasma 3 6 30.8 ± 0.2 0 ± 1 -61.9
1.3.16.01. Osmoporin OMPC 2j1n Escherichia coli Bact. Gram-neg outer 3 48 25.1 ± 1.2 0 ± 2 -126.2
1.1.17.02. Urea transporter 3k3f Desulfovibrio vulgaris Bact. Gram-neg inner 3 30 29.4 ± 0.8 0 ± 0 -124.4
1.1.12.03. Na-activated potassium channel Slo2.2, open 5u70 Gallus gallus Eukaryo. plasma 4 24 31.4 ± 0.2 0 ± 0 -248.5
1.1.32.01. Excitatory amino acid transporter 1, structure 1 5llu Homo sapiens Eukaryo. plasma 3 36 31.4 ± 0.6 0 ± 0 -228.3
1.1.32.01. Proton glutamate symport protein, outward-facing state 1 2nwl Pyrococcus horikoshii Archaebac. 3 39 29.8 ± 1.3 0 ± 0 -202.1
1.1.12.12. NaK potassium channel 2ahy Bacillus cereus Bact. Gram-pos plas. 4 8 29.5 ± 0.7 0 ± 1 -105.7
1.1.16.01. Glutamate receptor 2-Cacng-2 subunit chimera, structure 3 5weo Rattus norvegicus Eukaryo. plasma 4 28 32.2 ± 1.2 0 ± 0 -236.7
1.1.12.10. Voltage-gated sodium channel NavAb, structure 4 (closed) 5vb2 Arcobacter butzleri Bact. Gram-neg inner 4 24 31.0 ± 0.8 0 ± 0 -228.1
1.1.66.01. K(+)-pumping pyrophosphatase, structure 1 4av3 Thermotoga maritima Bact. Gram-neg inner 2 32 29.8 ± 0.7 0 ± 0 -182.5
1.1.12.17. TRPM4 channel, structure 3 6bqv Homo sapiens Eukaryo. plasma 4 24 30.6 ± 0.4 0 ± 0 -217.5
1.1.12.17. Channel PKD2L1 5z1w Mus musculus Eukaryo. plasma 4 24 31.4 ± 0.4 0 ± 0 -232.1
1.1.06.01. Cytochrome bc1, mitochondrial, structure 1 1l0l Bos taurus Mitochon. inner 12 26 30.0 ± 0.6 0 ± 0 -186.6
1.1.74.01. Calcium release-activated calcium channel protein 1 4hkr Drosophila melanogaster Eukaryo. plasma 6 24 30.0 ± 1.6 0 ± 0 -105.2
1.1.15.02. Proton-gated ion channel, conformation 2 4lmj Gloeobacter violaceus Bact. Gram-neg inner 5 20 32.4 ± 0.7 0 ± 0 -177.4
1.1.16.01. Glutamate receptor 2-Cacng-2 subunit chimera, structure 2 5kbu Rattus norvegicus Eukaryo. plasma 4 20 33.6 ± 1.4 0 ± 0 -109.5
1.1.01.02. Rhodopsin, constitutively active mutant (metarhodopsin II), dimer 2x72 Bos taurus Eukaryo. plasma 2 14 30.0 ± 0.6 0 ± 0 -132.0
1.1.01.01. Sodium pumping rhodopsin, NaR, dimer 3x3b Dokdonia eikasta Bact. Gram-neg inner 2 14 29.8 ± 0.9 0 ± 0 -87.5
1.2.25.01. Phospholamban, pentamer 1zll Homo sapiens Endoplasm. reticulum 5 5 30.5 ± 1.4 0 ± 2 -76.0
1.1.12.14. Potassium channel Kirbac1.1, closed state, refined 2wll Burkholderia pseudomallei Bact. Gram-neg inner 4 8 33.4 ± 2.4 0 ± 0 -109.1
1.1.01.01. Sensory rhodopsin II, tetramer, structure 1 1h2s Natronomonas pharaonis Archaebac. 4 18 30.5 ± 1.1 0 ± 0 -123.4
1.1.02.03. Photosystem II 3wu2 Thermosynechococcus vulcanus Thylakoid 32 70 32.4 ± 0.5 0 ± 0 -409.1
1.1.61.01. Leukotriene C4 synthase 2uuh Homo sapiens Endoplasm. reticulum 3 12 29.4 ± 1.1 0 ± 0 -55.2
1.1.28.01. AcrAB-TolC efflux pump, structure 2 5v5s Escherichia coli Bact. Gram-neg inner 3 36 28.6 ± 1.0 0 ± 0 -180.0
1.1.12.20. ATP-sensitive K+ channel SUR1/Kir6.2, quatrefoil form 6c3o Mus musculus Eukaryo. plasma 8 76 31.4 ± 0.4 0 ± 0 -398.2
1.1.14.01. Glycerol uptake facilitator 1ldf Escherichia coli Bact. Gram-neg inner 4 32 30.1 ± 0.9 0 ± 0 -147.9
1.1.115.01. MlaA protein, with OMPF 5nup Klebsiella pneumoniae Bact. Gram-neg outer 6 54 23.0 ± 0.6 0 ± 0 -190.1
1.3.25.02. Cytolysin and hemolysin HlyA Pore-forming toxin 3o44 Vibrio cholerae Secreted 7 14 24.6 ± 0.0 0 ± 0 -33.1
1.1.12.17. TRPML3 (mucolipin 3) channel, closed 5w3s Callithrix jacchus Lysosome 4 24 31.0 ± 0.8 0 ± 0 -213.0
1.1.14.01. Aquaporin Sopip2, closed state 2 3cll Spinacia oleracea Eukaryo. plasma 4 27 29.8 ± 0.7 0 ± 0 -127.8
1.1.67.01. Transmembrane protein 14C 2los Homo sapiens Mitochon. inner 1 3 26.8 ± 0.4 0 ± 2 -18.5
1.1.10.03. Lipid flippase MsbA, open state 3b60 Salmonella enterica Bact. Gram-neg inner 2 12 31.8 ± 0.9 0 ± 0 -98.5
1.1.15.02. Proton-gated ion channel, pore blocker-bound conformation 4twd Erwinia chrysanthemi Bact. Gram-neg inner 5 20 32.0 ± 0.6 0 ± 0 -127.8
1.1.06.01. Cytochrome bc1, mitochondrial 5xte Homo sapiens Mitochon. inner 12 26 29.0 ± 0.8 0 ± 0 -204.1
1.1.36.01. ClC chloride transporter 3nd0 Synechocystis sp. Bact. Gram-neg inner 2 28 29.8 ± 0.7 0 ± 1 -120.9
1.1.15.02. Proton-gated ion channel, conformation 6 5heg Gloeobacter violaceus Bact. Gram-neg inner 5 20 32.0 ± 0.8 0 ± 0 -186.8
1.3.24.01. Outer membrane protein TolC, mutant, open conformation 3 2vdd Escherichia coli Bact. Gram-neg outer 3 12 24.4 ± 1.2 0 ± 0 -57.7
1.1.01.01. Channelrhodopsin 2, structure 1 6eid Chlamydomonas reinhardtii Eukaryo. plasma 2 14 31.4 ± 0.8 0 ± 0 -106.6
1.1.08.01. V-type proton ATPase, vacuolar, state 2 3j9u Saccharomyces cerevisiae Vacuole 10 40 40.4 ± 1.1 0 ± 0 -180.4
1.1.108.01. Nitrate/nitrite sensor histidine kinase NarQ, structure 4 5jgp Escherichia coli Bact. Gram-neg inner 2 4 31.4 ± 1.2 0 ± 0 -56.7
1.3.32.01. Type II secretion system protein XcpQ 5wln Pseudomonas aeruginosa Bact. Gram-neg inner 15 60 21.0 ± 1.2 0 ± 0 -254.1
1.1.80.01. Phospho-N-acetylmuramoyl-pentapeptide-transferase, structure 1 4j72 Aquifex aeolicus Bact. Gram-neg inner 2 20 31.4 ± 1.2 0 ± 0 -141.4
1.3.18.01. Maltoporin 2mpr Salmonella enterica Bact. Gram-neg outer 3 54 24.5 ± 1.0 0 ± 0 -109.7
1.1.12.16. Ryanodine receptor 1, closed structure 3 5gkz Oryctolagus cuniculus Endoplasm. reticulum 4 24 30.8 ± 0.0 0 ± 0 -188.8
1.1.15.02. Proton-gated ion channel, open state 3eam Gloeobacter violaceus Bact. Gram-neg inner 5 20 32.7 ± 0.9 0 ± 1 -183.4
1.1.13.02. P2X purinoceptor 3, closed, antagonist-bound 5svr Homo sapiens Eukaryo. plasma 3 6 30.8 ± 1.1 0 ± 2 -32.4
1.2.26.01. Outer membrane lipoprotein Wza 2j58 Escherichia coli Bact. Gram-neg outer 8 8 31.1 ± 0.8 0 ± 0 -123.8
1.1.041.01. Bacterial semiSWEET transporter, inward-open conformation 4x5m Escherichia coli Bact. Gram-neg inner 2 6 31.6 ± 1.9 0 ± 3 -66.6
1.1.12.03. Na-activated potassium channel Slo2.2, closed 5u76 Gallus gallus Eukaryo. plasma 4 24 31.0 ± 0.4 0 ± 0 -216.3
1.1.32.01. Excitatory amino acid transporter 1, structure 2 5mju Homo sapiens Eukaryo. plasma 3 36 29.8 ± 0.6 0 ± 0 -227.0
1.1.01.01. Bacteriorhodopsin, from cubic phase 1ap9 Halobacterium salinarum Archaebac. 3 21 30.6 ± 1.2 0 ± 0 -97.8
1.1.16.01. Glutamate receptor 2, with antagonist, structure 2 4uqj Rattus norvegicus Eukaryo. plasma 4 12 33.6 ± 1.6 0 ± 0 -87.3
1.1.12.10. Voltage-gated sodium channel NavAb, structure 5 (open) 5vb8 Arcobacter butzleri Bact. Gram-neg inner 4 24 31.4 ± 0.8 0 ± 0 -229.5
1.1.19.01. Mechanosensitive channel protein MscS 3t9n Thermoanaerobacter tengcongensis Bact. Gram-pos plas. 7 7 28.0 ± 0.7 0 ± 0 -131.5
1.2.23.01. M2 proton channel of Influenza A, complex with amantadine 2kqt Influenza virus Viral 4 4 30.2 ± 1.3 0 ± 4 -59.6
1.1.17.01. Rhesus Glycoprotein RhCG 3hd6 Homo sapiens Eukaryo. plasma 3 36 31.8 ± 0.7 0 ± 0 -174.1
1.1.06.01. Cytochrome bc1, mitochondrial, with cytochrome c iso-1 3cx5 Saccharomyces cerevisiae Mitochon. inner 10 24 27.2 ± 0.6 0 ± 0 -173.9
1.1.20.01. Connexin 26 gap junction channel, structure 2 5er7 Homo sapiens Eukaryo. plasma 6 24 31.4 ± 0.7 0 ± 0 -174.7
1.1.15.02. Proton-gated ion channel, conformation 3 4lml Gloeobacter violaceus Bact. Gram-neg inner 5 20 31.8 ± 0.7 0 ± 0 -178.8
1.1.10.03. Mitochondrial ABC transporter ABCB10, conformation 2 4ayw Homo sapiens Mitochon. inner 2 12 29.0 ± 0.8 0 ± 0 -65.8
1.1.08.01. F1F0 ATP synthase 5fl7 Yarrowia lipolytica Mitochon. inner 10 20 38.0 ± 0.6 0 ± 0 -92.3
1.1.28.01. Multidrug exporter MexB 2v50 Pseudomonas aeruginosa Bact. Gram-neg inner 3 36 28.6 ± 1.0 0 ± 1 -167.3
1.1.02.06. Light-Harvesting Complex II 1rwt Spinacia oleracea Thylakoid 3 9 30.0 ± 0.7 0 ± 0 -154.0
1.1.12.14. Potassium channel Kirbac3.1, closed conformation 2wlk Magnetospirillum magnetotacticum Bact. Gram-neg inner 4 8 29.8 ± 2.4 0 ± 0 -78.7
1.1.01.01. Halorhodopsin 1e12 Halobacterium salinarum Archaebac. 3 21 31.8 ± 1.4 0 ± 1 -126.7
1.1.02.03. Photosystem II 4pj0 Thermosynechococcus elongatus Thylakoid 34 72 30.8 ± 0.6 0 ± 0 -471.8
1.1.35.02. Na+/H+ antiporter, outward-open conformation 5bz3 Thermus thermophilus Bact. Gram-neg inner 2 26 29.2 ± 0.8 0 ± 0 -108.2
1.3.25.03. Hemolytic lectin CEL-III 3w9t Cucumaria echinata (Sea cucumber) Secreted 7 14 33.8 ± 0.8 0 ± 0 -82.6
1.1.01.01. Chimaera of channelrhodopsins 1 and 2 3ug9 Chlamydomonas reinhardtii Eukaryo. plasma 2 14 31.0 ± 1.2 0 ± 0 -100.3
1.1.35.02. Na+/H+ antiporter 1, outward-open conformation 4d0a Methanococcus jannaschii Archaebac. 2 26 28.4 ± 1.0 0 ± 0 -155.0
1.1.14.02. Nitrite transporter NirC 4fc4 Salmonella typhimurium Bact. Gram-neg inner 5 35 33.8 ± 0.0 0 ± 0 -112.5
1.1.12.20. ATP-sensitive K+ channel SUR1/Kir6.2, propeller form 6c3p Homo sapiens Eukaryo. plasma 8 76 31.4 ± 0.2 0 ± 0 -609.0
1.1.17.01. Ammonia Channel 1u7g Escherichia coli Bact. Gram-neg inner 3 33 29.8 ± 1.3 0 ± 0 -148.7
1.1.041.01. Bacterial semiSWEET transporter, structure 3 5uhs Leptospira biflexa Bact. Gram-neg inner 2 6 31.4 ± 1.4 0 ± 1 -68.5
1.1.12.07. Potassium channel subfamily K member 1 3ukm Homo sapiens Eukaryo. plasma 2 8 31.8 ± 1.0 0 ± 0 -108.7
1.1.01.01. Proteorhodopsin 4jq6 Gamma-proteobacterium Bact. Gram-neg inner 6 42 28.4 ± 1.3 0 ± 0 -188.5
1.1.12.02. Potassium channel Kv1.2. - Kv2.1. chimera 3lnm Rattus norvegicus Eukaryo. plasma 4 28 31.1 ± 0.9 0 ± 0 -260.7
1.1.13.02. Invertebrate P2X receptor 5f1c Amblyomma maculatum Eukaryo. plasma 3 6 31.0 ± 1.4 0 ± 0 -69.4
1.1.12.19. TrkH/TrkA potassium transport complex, structure 2 5but Bacillus subtilis Bact. Gram-pos plas. 2 16 32.0 ± 0.7 0 ± 0 -143.8
1.1.10.03. Mitochondrial ABC transporter ABCB10, conformation 3 4ayx Homo sapiens Mitochon. inner 2 12 30.0 ± 0.6 0 ± 0 -76.8
1.1.02.06. Light-Harvesting Complex II 2bhw Pisum sativum Thylakoid 3 9 29.4 ± 1.0 0 ± 0 -123.2
1.3.22.01. VDAC-1 channel, dimer 5xdo Homo sapiens Mitochon. outer 2 38 23.0 ± 0.4 0 ± 0 -95.1
1.1.26.03. Sodium/sugar symporter vSGLT, substrate-free 2xq2 Vibrio parahaemolyticus Bact. Gram-neg inner 2 30 30.4 ± 0.6 0 ± 0 -162.7
1.1.80.01. Phospho-N-acetylmuramoyl-pentapeptide-transferase, structure 2 5ckr Aquifex aeolicus Bact. Gram-neg inner 2 20 30.4 ± 1.1 0 ± 0 -149.3
1.1.10.08. Cystic fibrosis transmembrane conductance regulator, dephosphorylated 5uar Danio rerio Endosome 1 12 30.6 ± 0.8 0 ± 0 -81.7
1.3.24.01. Outer membrane protein TolC, mutant, open conformation 4 2xmn Escherichia coli Bact. Gram-neg outer 3 12 23.6 ± 1.4 0 ± 0 -50.5
1.1.12.01. Potassium channel KcsA, open inactivated state 3f5w Streptomyces lividans Bact. Gram-pos plas. 4 8 29.2 ± 0.7 0 ± 0 -83.5
1.1.22.01. Pore-forming haemolysin E (ClyA) 2wcd Escherichia coli Secreted 12 36 30.8 ± 0.7 0 ± 0 -148.3
1.1.104.01. TRIC cation channel 5h36 Rhodobacter sphaeroides Bact. Gram-neg inner 3 21 31.0 ± 1.0 0 ± 0 -124.3
1.1.65.01. Concentrative nucleoside transporter 3tij Vibrio cholerae Bact. Gram-neg inner 3 27 27.0 ± 0.5 0 ± 0 -155.2
1.1.01.01. Channelrhodopsin 2, structure 2 6eig Chlamydomonas reinhardtii Eukaryo. plasma 2 14 31.4 ± 0.8 0 ± 0 -107.3
1.1.08.01. V-type proton ATPase, vacuolar, state 3 3j9v Saccharomyces cerevisiae Vacuole 10 40 40.0 ± 1.2 0 ± 0 -178.0
3.1.07.02. Paramyxovirus sv5 fusion protein core 1svf Simian virus 5 Viral 6 0 8.4 ± 0.9 0 ± 11 -10.7
1.1.116.01. Glycerol-3-phosphate acyltransferase, structure 5 5xj9 Aquifex aeolicus Bact. Gram-neg inner 1 7 0.0 ± 0.0 0 ± 0 0.0
1.1.14.01. Aquaporin-0, alternative packing with lipids 3m9i Ovis aries Eukaryo. plasma 4 24 27.6 ± 1.4 0 ± 0 -139.0
1.1.35.02. Na+/H+ antiporter 4bwz Thermus thermophilus Bact. Gram-neg inner 2 26 29.6 ± 0.6 0 ± 0 -120.8
1.1.14.01. Aquaporin-0, open state 2b6p Bos taurus Eukaryo. plasma 4 32 31.1 ± 1.5 0 ± 1 -130.0
1.3.18.01. Sucrose-specific porin 1a0s Salmonella enterica Bact. Gram-neg outer 3 54 23.8 ± 1.1 0 ± 0 -103.5
1.1.14.01. Aquaporin-0, complex with calmodulin 3j41 Ovis aries Eukaryo. plasma 4 24 29.6 ± 0.9 0 ± 0 -129.7
1.1.12.16. Ryanodine receptor 1, various structures 5gl0 Oryctolagus cuniculus Endoplasm. reticulum 4 24 30.8 ± 0.0 0 ± 0 -202.9
1.1.12.19. TrkH/TrkA potassium transport complex 4j9u Vibrio parahaemolyticus Bact. Gram-neg inner 2 20 29.4 ± 0.7 0 ± 0 -151.9
1.3.16.03. Porin OprP 2o4v Pseudomonas aeruginosa Bact. Gram-neg outer 3 48 23.9 ± 1.1 0 ± 0 -129.6
1.3.22.01. VDAC-1 channel, structure 1 2jk4 Homo sapiens Mitochon. outer 1 19 23.4 ± 2.3 0 ± 1 -40.0
1.1.17.01. Ammonia channel, complex with inhibitory GlnK 2ns1 Escherichia coli Bact. Gram-neg inner 3 33 29.1 ± 0.7 0 ± 0 -148.7
1.1.12.04. Nucleotide-gated channel 1, HCN1, structure 1 5u6o Homo sapiens Eukaryo. plasma 4 24 33.0 ± 0.8 0 ± 0 -238.4
1.1.01.01. Archaerhodopsin-2, trimeric 2ei4 Halobacterium sp. Archaebac. 3 21 30.5 ± 1.2 0 ± 1 -143.9
1.1.23.01. Chloride channel TMEM16A, structure 2 5oyg Mus musculus Eukaryo. plasma 2 20 31.4 ± 0.6 0 ± 0 -172.5
1.1.19.01. Mechanosensitive channel protein MscS, slightly different conf. 3udc Thermoanaerobacter tengcongensis Bact. Gram-pos plas. 7 7 32.2 ± 0.7 0 ± 0 -121.8
1.1.26.06. Uracil permease, occluded state 5xls Escherichia coli Bact. Gram-neg inner 2 28 30.2 ± 0.8 0 ± 0 -143.6
1.1.26.01. Leucine transporter LeuT, outward-facing substrate-free conformation 3tt1 Aquifex aeolicus Bact. Gram-neg inner 2 24 28.2 ± 1.2 0 ± 0 -160.8
3.1.07.02. Envelope glycoprotein gp41 2x7r Human immunodeficiency virus type 1 Viral 3 0 5.5 ± 1.1 0 ± 10 -10.9
1.1.08.01. F-type Sodium ATPase 1yce Ilyobacter tartaricus Bact. Gram-neg inner 11 22 37.0 ± 0.5 0 ± 0 -104.0
1.1.66.01. K(+)-pumping pyrophosphatase, structure 2 4av6 Thermotoga maritima Bact. Gram-neg inner 2 32 29.8 ± 0.8 0 ± 0 -173.1
1.1.27.01. Zinc transporter YiiP, structure 2 5vrf Shewanella oneidensis Bact. Gram-neg inner 2 12 28.6 ± 1.4 0 ± 0 -84.2
1.2.44.01. Amyloid beta A4 protein, 699-726, dimer, structure 2 2lz3 Homo sapiens Eukaryo. plasma 2 2 37.2 ± 1.8 0 ± 1 -26.9
1.3.25.05. Lysenin, structure 1 5gaq Eisenia fetida Secreted 9 18 23.6 ± 0.8 0 ± 0 -68.7
1.1.28.01. Drug efflux protein MtrD 4mt1 Neisseria gonorrhoeae Bact. Gram-neg inner 3 36 29.0 ± 0.3 0 ± 0 -214.1
1.2.23.01. M2 proton channel of Influenza A, inward-open state 5um1 Influenza virus Viral 4 4 28.6 ± 1.6 0 ± 0 -55.1
1.1.16.01. Glutamate receptor ionotropic, kainate 2 5kuf Rattus norvegicus Eukaryo. plasma 4 12 31.4 ± 0.6 0 ± 0 -81.8
1.1.06.01. Cytochrome b6f 1q90 Chlamydomonas reinhardtii Thylakoid 16 26 31.8 ± 1.0 0 ± 1 -226.4
1.1.72.02. YdaH transporter 4r0c Alcanivorax borkumensis Bact. Gram-neg inner 2 22 29.8 ± 0.5 0 ± 0 -155.5
1.1.31.01. Tellurite resistance protein tehA homolog 3m73 Haemophilus influenzae Bact. Gram-neg inner 3 30 29.1 ± 1.4 0 ± 0 -157.4
1.1.12.10. Voltage-gated sodium channel Nav1.7- NavAb, structure 1 3rvy Arcobacter butzleri Bact. Gram-neg inner 4 24 29.6 ± 0.4 0 ± 0 -216.9
1.1.10.05. ABC transporter ABCG2, structure 1 5nj3 Homo sapiens Eukaryo. plasma 2 12 31.0 ± 1.0 0 ± 0 -106.7
1.1.06.01. Cytochrome bc1, bacterial, structure 3 5kli Rhodobacter sphaeroides Bact. Gram-neg inner 6 20 29.8 ± 1.6 0 ± 0 -180.0
1.1.66.01. Proton-translocating pyrophosphatase, structure 1 4a01 Vigna radiata (Mung bean) Vacuole 2 32 32.0 ± 0.8 0 ± 0 -189.3
1.1.17.02. Urea transporter 1 4ezc Bos taurus Eukaryo. plasma 3 30 31.2 ± 0.6 0 ± 0 -138.8
1.3.20.01. Bacterial Zn-transporter ZnuD, structure 2 4rdt Neisseria meningitidis Bact. Gram-neg outer 1 22 23.4 ± 0.8 0 ± 0 -72.6
1.2.08.01. TYRO protein tyrosine kinase-binding protein, homotetramer 4wo1 Homo sapiens Eukaryo. plasma 4 4 41.8 ± 3.7 0 ± 2 -63.1
1.1.64.01. Ca2+/H+ antiporter YfkE, different conformation 4kjs Bacillus subtilis Bact. Gram-pos plas. 3 33 31.2 ± 0.8 0 ± 0 -201.6
1.1.12.17. TRPML3 (Mucolipin-3) channel, structure 1 6aye Homo sapiens Lysosome 4 24 30.6 ± 0.4 0 ± 0 -209.7
1.3.12.01. Outer membrane phospholipase A, dimer 1qd6 Escherichia coli Bact. Gram-neg outer 2 24 23.9 ± 1.0 0 ± 0 -77.2
1.1.01.04. Smoothened homolog, dimer, structure 1 4jkv Homo sapiens Eukaryo. plasma 2 14 31.9 ± 1.2 0 ± 0 -98.5
1.1.12.04. Bacterial cyclic nucleotide regulated ion channel, structure 1 3beh Rhizobium loti Bact. Gram-neg inner 4 24 30.6 ± 0.8 0 ± 0 -205.7
1.1.12.02. Potassium channel Kv1.2. 2a79 Rattus norvegicus Eukaryo. plasma 4 28 29.8 ± 1.5 0 ± 0 -147.0
1.1.12.15. TRPV1 ion channel 3j5p Rattus norvegicus Eukaryo. plasma 4 24 28.4 ± 0.7 0 ± 0 -213.2
1.1.42.01. Nicotinamide riboside transporter PnuC 4qtn Neisseria mucosa Bact. Gram-neg inner 3 24 26.8 ± 0.7 0 ± 0 -112.0
1.1.12.03. High conductance calcium-activated potassium channel, structure 2 5tji Aplysia californica Eukaryo. plasma 4 28 31.4 ± 0.6 0 ± 0 -294.2
1.1.06.01. Cytochrome b6f, structure 1 2e74 Mastigocladus laminosus Thylakoid 16 26 31.2 ± 0.8 0 ± 0 -222.1
1.1.16.01. Glutamate receptor 2, with TARP channel, structure 3 5vou Rattus norvegicus Eukaryo. plasma 8 20 32.2 ± 0.8 0 ± 0 -232.0
1.1.32.01. Proton glutamate symport protein, outward-facing state 2 2nww Pyrococcus horikoshii Archaebac. 3 36 30.6 ± 0.6 0 ± 0 -200.2
1.1.16.01. Glutamate receptor 2, with partial agonist, structure 6 4u4g Rattus norvegicus Eukaryo. plasma 4 12 33.0 ± 1.6 0 ± 0 -79.1
1.1.12.01. Potassium channel KscA, complex with charibdotoxin 2a9h Streptomyces lividans Bact. Gram-pos plas. 4 8 31.8 ± 1.4 0 ± 1 -105.1
1.1.12.17. TRPM4 channel, structure 1 5wp6 Homo sapiens Eukaryo. plasma 4 24 30.2 ± 0.4 0 ± 0 -256.0
1.1.12.08. Two pore calcium channel TPC1 5dqq Arabidopsis thaliana Vacuole 2 24 29.8 ± 0.5 0 ± 0 -188.0
1.1.12.15. TRPV4 channel 6bbj Xenopus tropicalis Eukaryo. plasma 4 24 29.8 ± 1.0 0 ± 0 -159.0
1.1.61.01. Leukotriene C4 synthase 4ntf Mus musculus Endoplasm. reticulum 3 12 29.8 ± 1.8 0 ± 2 -72.6
1.1.06.01. Cytochrome bc1, mitochondrial 3h1j Gallus gallus Mitochon. inner 10 24 28.2 ± 0.6 0 ± 0 -184.8
1.1.12.14. Potassium channel Kir 2.2, complex with pyrophosphate lipid 3spc Gallus gallus Eukaryo. plasma 4 8 30.6 ± 1.2 0 ± 0 -120.3
1.1.12.15. TRPV1 with DkTx and RTX, in lipid nanodisc 5irx Rattus norvegicus Eukaryo. plasma 4 24 29.6 ± 0.5 0 ± 0 -190.8
1.1.88.01. NAD(P) transhydrogenase, structure 1 4o9p Thermus thermophilus Bact. Gram-neg inner 4 24 29.8 ± 0.9 0 ± 0 -162.0
1.1.26.03. Sodium/sugar symporter vSGLT, substrate-bound 3dh4 Vibrio parahaemolyticus Bact. Gram-neg inner 2 30 30.0 ± 0.7 0 ± 0 -184.0
1.1.12.16. Ryanodine receptor 2, closed state 5go9 Sus scrofa Eukaryo. plasma 4 24 30.8 ± 0.3 0 ± 0 -188.1
1.1.06.01. Cytochrome bc1, bacterial 1zrt Rhodobacter capsulatus Bact. Gram-neg inner 6 20 29.9 ± 0.9 0 ± 0 -178.6
1.1.12.04. Nucleotide-gated channel 1, HCN1, structure 2 5u6p Homo sapiens Eukaryo. plasma 4 26 31.8 ± 0.8 0 ± 0 -237.0
1.1.16.01. Glutamate receptor 2, with partial agonist, structure 1 4u1x Rattus norvegicus Eukaryo. plasma 4 12 29.8 ± 0.8 0 ± 0 -79.3
1.1.01.01. Cruxrhodopsin-3 4jr8 Haloarcula vallismortis Archaebac. 3 21 31.8 ± 1.2 0 ± 0 -130.4
1.1.10.01. ABC transporter BtuCD, nucleotide-bound state 4fi3 Escherichia coli Bact. Gram-neg inner 2 20 29.0 ± 1.0 0 ± 0 -118.3
1.1.12.15. TRPV5 channel 6b5v Oryctolagus cuniculus Eukaryo. plasma 4 24 30.2 ± 0.2 0 ± 0 -162.1
1.1.12.04. Bacterial cyclic nucleotide regulated ion channel, structure 2 2zd9 Rhizobium loti Bact. Gram-neg inner 4 24 31.6 ± 1.2 0 ± 0 -192.8
1.2.23.01. M2 proton channel of Influenza A, S31N, crystal structure 5c02 Influenza virus Viral 4 4 28.6 ± 1.9 0 ± 0 -53.5
1.1.29.03. GDP-mannose transporter 1 5oge Saccharomyces cerevisiae Golgi 2 20 25.8 ± 0.2 0 ± 0 -122.5
1.1.01.01. Bacteriorhodopsin, K state, with lipids 1iw6 Halobacterium salinarum Archaebac. 3 21 30.0 ± 0.6 0 ± 0 -112.6
1.1.02.02. Photosystem I of plants 4xk8 Arabidopsis thaliana Thylakoid 13 45 29.8 ± 0.5 0 ± 0 -319.6
1.1.10.05. ABC transporter ABCG2, structure 2 5njg Homo sapiens Eukaryo. plasma 2 12 31.0 ± 1.0 0 ± 0 -105.6
1.1.15.01. Gamma-aminobutyric acid receptor, GABA, chimaeric beta3-alpha5 5ojm Homo sapiens Eukaryo. plasma 5 20 31.0 ± 0.8 0 ± 0 -136.5
1.1.10.01. Hemin transport system permease, HmuU 4g1u Yersinia pestis Bact. Gram-neg inner 2 20 29.8 ± 0.5 0 ± 0 -114.3
1.1.64.01. Ca2+/H+ antiporter YfkE 4kjr Bacillus subtilis Bact. Gram-pos plas. 3 33 29.8 ± 0.4 0 ± 0 -181.6
1.1.28.02. Efflux pump membrane transporter CmeB, structure 1 5lq3 Campylobacter jejuni Bact. Gram-neg inner 36 3 28.2 ± 0.6 0 ± 0 -186.7
1.1.08.01. F0 ATP synthase 3zk1 Fusobacterium nucleatum Bact. Gram-neg inner 11 22 36.6 ± 2.3 0 ± 0 -84.3
1.1.12.02. Potassium channel Kv1.2., full-length 3lut Rattus norvegicus Eukaryo. plasma 4 24 25.1 ± 0.5 0 ± 0 -153.1
1.2.43.01. Capsid envelop protein complex, Dengue 3j2p Dengue virus Viral 4 8 22.8 ± 0.4 0 ± 0 -62.7
1.3.32.01. Type II secretion system protein GspD, pathogenic E. coli 5w68 Escherichia coli Bact. Gram-neg outer 15 60 19.4 ± 0.2 0 ± 0 -147.2
1.1.12.15. TRPV2 channel 5hi9 Rattus norvegicus Eukaryo. plasma 4 24 30.2 ± 1.0 0 ± 0 -187.5
1.1.12.17. TRPML3 (Mucolipin-3) channel, structure 2 6ayf Homo sapiens Lysosome 4 24 31.4 ± 0.6 0 ± 0 -192.9
1.1.08.01. F0 ATP synthase 4f4s Saccharomyces cerevisiae Mitochon. inner 10 20 38.4 ± 1.3 0 ± 0 -89.9
1.1.15.02. Proton-gated ion channel, inactive conformation 1 2vl0 Erwinia chrysanthemi Bact. Gram-neg inner 5 20 31.8 ± 1.3 0 ± 0 -107.6
1.1.14.01. Aquaporin-1, structure 1 1h6i Homo sapiens Eukaryo. plasma 4 32 30.8 ± 1.1 0 ± 0 -135.6
1.1.26.08. Boron transporter 1 5l25 Arabidopsis thaliana Eukaryo. plasma 2 28 30.8 ± 0.5 0 ± 0 -109.6
1.1.12.15. TRPV1 ion channel, complex with DkTx and RTX toxins 3j5q Rattus norvegicus Eukaryo. plasma 4 24 30.0 ± 0.5 0 ± 0 -203.0
1.1.17.01. Rh-like protein 3b9y Nitrosomonas europaea Bact. Gram-neg inner 3 33 29.8 ± 1.3 0 ± 0 -150.1
1.1.36.01. CLC-K chloride channel, structure 1 5tqq Bos taurus Eukaryo. plasma 2 28 31.4 ± 0.4 0 ± 0 -126.9
1.1.06.01. Cytochrome b6f 2zt9 Nostoc sp. Thylakoid 16 26 31.2 ± 1.0 0 ± 1 -214.2
1.3.26.01. Porin MspA 1uun Mycobacterium smegmatis Bact. Gram-pos cell wall 8 16 40.7 ± 2.1 0 ± 0 -71.0
1.2.01.01. Vascular endothelial growth factor receptor 2 (759-795), homodimer 2 2meu Homo sapiens Eukaryo. plasma 2 2 32.0 ± 1.7 0 ± 2 -24.7
1.1.18.01. Mechanosensitive channel MscL, closed state 2oar Mycobacterium tuberculosis Bact. Gram-pos plas. 5 10 36.1 ± 2.2 0 ± 0 -142.7
1.1.15.02. Proton-gated ion channel, conformation 7 5hcm Gloeobacter violaceus Bact. Gram-neg inner 5 20 32.0 ± 1.4 0 ± 0 -184.3
1.1.16.01. Glutamate receptor 2, with TARP channel, structure 4 5vov Rattus norvegicus Eukaryo. plasma 8 20 31.4 ± 0.4 0 ± 0 -232.0
1.1.24.01. Bestrophin-1 4rdq Gallus gallus Eukaryo. plasma 4 16 30.8 ± 1.0 0 ± 0 -124.8
1.1.12.01. Potassium channel KcsA, 17A opening conformer 3f7y Streptomyces lividans Bact. Gram-pos plas. 4 8 31.3 ± 1.3 0 ± 0 -82.3
1.1.21.01. CorA magnesium transporter, complete loops, structure 3 5jrw Thermotoga maritima Bact. Gram-neg inner 5 10 31.0 ± 0.6 0 ± 0 -80.2
1.1.12.17. TRPM4 channel, apo form 6bcl Mus musculus Eukaryo. plasma 4 24 30.6 ± 0.2 0 ± 0 -237.1
1.1.14.01. Aquaporin TIP2-1 5i32 Arabidopsis thaliana Vacuole 4 24 30.0 ± 0.8 0 ± 0 -154.0
1.3.24.01. MtrE protein 4mt0 Neisseria gonorrhoeae Bact. Gram-neg outer 3 12 25.0 ± 0.7 0 ± 0 -57.4
1.1.21.01. CorA magnesium transporter, complete loops, structure 1 4i0u Thermotoga maritima Bact. Gram-neg inner 5 10 30.4 ± 1.1 0 ± 0 -83.4
1.2.01.01. Receptor tyrosine kinase EphA1, at pH 4.3 2k1k Homo sapiens Eukaryo. plasma 2 2 30.2 ± 1.5 0 ± 5 -43.3
1.2.43.01. Envelope glycoprotein, Dengue virus type 2, structure 1 1ok8 Dengue virus Viral 3 0 5.2 ± 0.9 0 ± 6 -9.5
1.1.05.02. Formate dehydrogenase 1kqf Escherichia coli Bact. Gram-neg inner 6 15 33.7 ± 1.1 0 ± 0 -141.9
1.1.12.15. TRPV2 channel 5an8 Oryctolagus cuniculus Eukaryo. plasma 4 24 31.8 ± 0.4 0 ± 0 -220.1
1.1.12.10. Voltage-gated sodium channel NavAb, structure 6 5yua Arcobacter butzleri Bact. Gram-neg inner 4 26 29.4 ± 0.8 0 ± 0 -229.8
1.1.12.10. Sodium channel NavMs, open state 2 3zjz Magnetococcus marinus Bact. Gram-neg inner 4 8 29.8 ± 1.8 0 ± 1 -61.1
1.1.12.15. TRPV1, in lipid nanodisc 5irz Rattus norvegicus Eukaryo. plasma 4 24 30.4 ± 0.7 0 ± 0 -208.9
1.1.104.01. Trimeric intracellular cation channel, structure 1 5eik Caenorhabditis elegans Endoplasm. reticulum 3 21 26.8 ± 0.3 0 ± 0 -45.3
1.1.10.03. Antibacterial peptide transporter McjD, outward occluded state 4pl0 Escherichia coli Bact. Gram-neg inner 2 12 32.4 ± 0.8 0 ± 0 -107.2
1.1.12.16. Ryanodine receptor 2, open state 5goa Sus scrofa Eukaryo. plasma 4 24 30.8 ± 0.1 0 ± 0 -194.3
1.1.12.20. ATP-sensitive K+ channel SUR1/Kir6.2 5wua Mus musculus Eukaryo. plasma 8 76 31.0 ± 0.6 0 ± 0 -286.4
1.1.10.03. ATP-binding cassette, sub-family B, member 1 3wme Cyanidoschyzon merolae Eukaryo. plasma 2 12 35.0 ± 1.6 0 ± 0 -83.5
1.1.08.01. ATP synthase of chloroplast 3v3c Pisum sativum Thylakoid 14 28 32.0 ± 1.0 0 ± 0 -111.5
1.3.25.01. Alpha-hemolysin 7ahl Staphylococcus aureus Secreted 7 14 23.5 ± 0.9 0 ± 1 -49.3
1.3.16.01. Porin B (PorB) 4aui Neisseria gonorrhoeae Bact. Gram-neg outer 3 48 24.2 ± 0.8 0 ± 0 -89.7
1.1.12.02. Potassium channel Kv1.2 - Kv2.1. chimera, inactivated state 5wie Rattus norvegicus Eukaryo. plasma 4 24 30.6 ± 0.4 0 ± 0 -245.0
1.1.12.04. Cyclic nucleotide-gated ion Channel 5v4s Leptospira licerasiae Bact. Gram-neg inner 4 24 31.0 ± 0.2 0 ± 0 -223.4
1.1.12.15. Transient receptor potential cation channel A1, TRPA1 3j9p Homo sapiens Eukaryo. plasma 4 24 26.8 ± 0.3 0 ± 0 -121.0
1.1.26.04. Glycine betaine transporter BetP, asymmetric trimer, conformation 1 4ain Corynebacterium glutamicum Bact. Gram-pos plas. 3 36 29.8 ± 0.6 0 ± 0 -198.8
1.1.12.10. Voltage-gated sodium channel NavAb, structure 2 4ekw Arcobacter butzleri Bact. Gram-neg inner 4 24 29.4 ± 0.5 0 ± 0 -201.0
1.1.12.13. K+ channel Eag1 (Kcnh1), with calmodulin 5k7l Rattus norvegicus Eukaryo. plasma 4 24 33.8 ± 0.6 0 ± 0 -272.0
1.3.20.01. SusD-SusC complex, BT_2263, a dimer 5fq6 Bacteroides thetaiotaomicron Bact. Gram-neg outer 2 44 26.6 ± 2.2 0 ± 0 -142.4
1.2.01.01. Epidermal growth factor receptor, erbB-1, homodimer (642-697) 2m20 Homo sapiens Eukaryo. plasma 2 2 34.0 ± 3.0 0 ± 3 -52.5
1.1.12.14. Potassium channel Kirbac3.1, open conformation 2 4lp8 Magnetospirillum magnetotacticum Bact. Gram-neg inner 4 8 29.2 ± 0.8 0 ± 0 -89.2
3.1.07.02. Transmembrane domain of HIV-1 gp41 (677-716), trimer 5jyn Human immunodeficiency virus type 1 Viral 3 3 36.0 ± 1.6 0 ± 2 -22.0
1.1.15.02. Proton-gated ion channel, inactive conformation 3 3rqw Erwinia chrysanthemi Bact. Gram-neg inner 5 20 29.8 ± 0.4 0 ± 0 -118.8
1.3.16.01. Phosphoporin (PhoE) 1pho Escherichia coli Bact. Gram-neg outer 3 48 24.1 ± 1.2 0 ± 0 -134.1
1.1.26.05. Arginine/agmatine antiporter (AdiC), outward-facing structure 1 3h5m Escherichia coli Bact. Gram-neg inner 2 26 29.0 ± 0.8 0 ± 0 -128.9
1.1.01.01. Bacteriorhodopsin, trimer, complex with annular lipids 2zzl Halobacterium salinarum Archaebac. 3 21 29.8 ± 0.6 0 ± 0 -119.0
1.1.02.06. Photoprotective protein PsbS 4ri2 Spinacia oleracea Thylakoid 2 8 29.8 ± 0.9 0 ± 0 -82.2
1.1.12.01. Potassium channel KcsA, full-length, closed 3eff Streptomyces lividans Bact. Gram-pos plas. 4 8 31.8 ± 1.3 0 ± 0 -107.3
1.1.15.01. GLIC-GABAAR alpha1 chimera, structure 1 5osa Mus musculus Eukaryo. plasma 5 20 31.0 ± 0.6 0 ± 1 -121.7
1.1.14.01. Aquaporin-1, structure 2 4csk Homo sapiens Eukaryo. plasma 4 24 31.6 ± 0.8 0 ± 0 -152.1
1.1.76.01. Acid-activated urea channel 3ux4 Helicobacter pylori Bact. Gram-neg inner 6 36 30.0 ± 0.5 0 ± 0 -190.2
1.1.10.01. ABC transporter BtuCD, symmetric structure 1l7v Escherichia coli Bact. Gram-neg inner 2 22 30.7 ± 1.1 0 ± 1 -121.0
1.3.16.03. Porin OprO 4rjw Pseudomonas aeruginosa Bact. Gram-neg outer 3 48 25.4 ± 0.7 0 ± 0 -129.0
1.2.11.01. Capsid protein G8P 1ifl Bacteriophage IKe Secreted 10 10 30.8 ± 0.8 0 ± 0 -93.6
1.1.104.01. TRIC cation channel 5wuf Colwellia psychrerythraea Bact. Gram-neg inner 3 21 30.2 ± 0.8 0 ± 0 -112.5
1.1.40.01. Glutamate-dependent intramembrane protease Rce1 4cad Saccharomyces cerevisiae Endoplasm. reticulum 1 8 30.8 ± 1.3 0 ± 1 -86.1
1.2.50.01. Fragaceatoxin C, transmembrane octamer 4tsy Actinia fragacea (Strawberry anemone) Secreted 8 8 29.8 ± 1.3 0 ± 0 -79.7
1.1.10.09. Macrolide export permease MacB 5gko Acinetobacter baumannii Bact. Gram-neg inner 2 8 30.2 ± 1.0 0 ± 0 -64.1
1.1.13.01. Acid-sensitive ion channel 1, at low pH 4nyk Gallus gallus Eukaryo. plasma 3 6 28.2 ± 1.1 0 ± 1 -38.3
1.1.08.01. F1F0 ATP synthase, structure 1 2xok Saccharomyces cerevisiae Mitochon. inner 10 20 35.3 ± 1.3 0 ± 0 -58.9
1.2.23.01. M2 proton channel of Influenza A, closed state, S31N, with drug 2ly0 Influenza virus Viral 4 4 34.0 ± 1.6 0 ± 0 -67.5
1.1.28.02. Efflux transporter CusA, apo-protein 3k07 Escherichia coli Bact. Gram-neg inner 3 33 27.4 ± 1.2 0 ± 0 -166.7
1.3.16.01. Chitoporin, structure 1 5mdr Vibrio harveyi Bact. Gram-neg outer 3 48 23.8 ± 0.6 0 ± 0 -117.8
1.1.17.01. Ammonium transporter MEP2, structure 2 5ah3 Candida albicans Eukaryo. plasma 3 33 31.8 ± 0.7 0 ± 0 -157.0
1.1.12.17. TRPML3 (Mucolipin-3) channel, structure 3 6ayg Homo sapiens Lysosome 4 24 31.0 ± 0.8 0 ± 0 -132.3
1.1.10.03. ABC transporter related protein 4mrs Novosphingobium aromaticivorans Bact. Gram-neg inner 2 12 32.0 ± 1.0 0 ± 0 -92.5
1.1.50.01. Particulate methane monooxygenase 3chx Methylosinus trichosporium Bact. Gram-neg inner 10 30 29.8 ± 0.4 0 ± 0 -152.0
1.1.14.01. Aquaporin Sopip2, closed state 1z98 Spinacia oleracea Eukaryo. plasma 4 32 28.1 ± 2.2 0 ± 0 -117.2
1.1.27.01. Ferrous-iron efflux pump fieF 3h90 Escherichia coli Bact. Gram-neg inner 2 12 29.6 ± 0.8 0 ± 2 -83.9
1.1.13.02. P2X purinoceptor, structure 1 5u1x Ailuropoda melanoleuca Eukaryo. plasma 3 6 30.2 ± 2.2 0 ± 1 -39.0
1.1.08.01. ATP synthase of chloroplast 2w5j Spinacia oleracea Thylakoid 14 28 32.8 ± 0.7 0 ± 0 -116.3
1.3.19.03. MOMP porin 5ldv Campylobacter jejuni Bact. Gram-neg outer 3 54 25.4 ± 0.6 0 ± 0 -125.2
1.1.12.01. Potassium channel KcsA 1r3j Streptomyces lividans Bact. Gram-pos plas. 4 8 34.8 ± 1.2 0 ± 0 -111.0
1.1.12.01. Potassium channel KcsA, 23A opening conformer 3f7v Streptomyces lividans Bact. Gram-pos plas. 4 8 30.1 ± 1.1 0 ± 0 -95.2
1.1.15.02. Proton-gated ion channel, inactive conformation 2 3uq7 Erwinia chrysanthemi Bact. Gram-neg inner 5 20 32.0 ± 1.6 0 ± 1 -92.6
1.1.12.17. TRPM4 channel, ATP-bound 6bcq Mus musculus Eukaryo. plasma 4 24 30.6 ± 0.2 0 ± 0 -243.8
1.1.66.01. Proton-translocating pyrophosphatase, structure 2 5gpj Vigna radiata (Mung bean) Vacuole 2 32 31.0 ± 0.4 0 ± 0 -176.0
1.1.32.01. Proton/glutamate symporter, substrate-bound 5e9s Pyrococcus kodakaraensis Archaebac. 3 24 31.4 ± 0.6 0 ± 0 -197.9
1.1.05.01. Polysulfide reductase, substrate-bound state 2vpx Thermus thermophilus Bact. Gram-neg inner 2 16 27.1 ± 1.1 0 ± 1 -103.3
1.1.14.01. Aquaporin-5 3d9s Homo sapiens Eukaryo. plasma 4 32 30.3 ± 0.9 0 ± 0 -133.3
1.1.05.03. Respiratory Nitrate Reductase 1q16 Escherichia coli Bact. Gram-neg inner 2 10 30.1 ± 0.9 0 ± 0 -126.9
1.1.26.01. Leucine transporter LeuT, outward-facing substrate-bound conformation 2a65 Aquifex aeolicus Bact. Gram-neg inner 2 28 29.8 ± 0.5 0 ± 0 -157.9
1.3.24.01. Multidrug efflux protein OprN 5azp Pseudomonas aeruginosa Bact. Gram-neg outer 3 12 24.2 ± 0.9 0 ± 0 -59.5
1.1.12.04. Bacterial cyclic nucleotide regulated ion channel, structure 3 6eo1 Rhizobium loti Bact. Gram-neg inner 4 24 30.6 ± 0.4 0 ± 0 -217.6
1.1.26.04. L-carnitine/gamma-butyrobetaine antiporter 4m8j Proteus mirabilis Bact. Gram-neg inner 3 36 29.8 ± 0.8 0 ± 0 -220.2
1.1.01.02. Opsin, active, retinal-free state, dimer 3cap Bos taurus Eukaryo. plasma 2 14 30.8 ± 1.1 0 ± 0 -130.1
1.1.12.15. TRPV6 channel, tetramer, structure 1 5iwk Rattus norvegicus Eukaryo. plasma 4 24 30.4 ± 0.6 0 ± 0 -244.6
1.1.89.01. Inner membrane protein YgaP 2mpn Escherichia coli Bact. Gram-neg inner 2 4 30.0 ± 1.5 0 ± 1 -29.6
1.1.34.01. Mitochondrial ADP-ATP carrier, dimer, conformation 1 4c9h Saccharomyces cerevisiae Mitochon. inner 2 12 30.4 ± 0.7 0 ± 0 -121.4
1.3.16.01. Osmoporin OMPC, isoform 1 2ixx Escherichia coli Bact. Gram-neg outer 3 48 26.2 ± 1.3 0 ± 1 -142.5
1.1.13.01. Acid-sensitive ion channel 1, with psalmotoxin 4fz1 Gallus gallus Eukaryo. plasma 3 6 31.8 ± 0.9 0 ± 0 -32.3
1.1.15.02. Proton-gated ion channel - human GLRA1 channel chimera 4x5t Gloeobacter violaceus Bact. Gram-neg inner 5 20 35.8 ± 0.1 0 ± 0 -107.4
1.1.14.01. Aquaporin Z2 3llq Agrobacterium tumefaciens Bact. Gram-neg inner 4 32 29.8 ± 0.6 0 ± 0 -134.5
1.1.12.20. ATP-sensitive K+ channel SUR1/Kir6.2, structure 2 5twv Rattus norvegicus Eukaryo. plasma 8 76 31.8 ± 0.4 0 ± 0 -311.7
1.1.06.01. Cytochrome b6f, structure 2 2d2c Mastigocladus laminosus Thylakoid 16 26 28.6 ± 0.6 0 ± 0 -156.9
1.1.32.01. Proton glutamate symport protein, inward-facing state 1 3kbc Pyrococcus horikoshii Archaebac. 3 30 28.1 ± 0.9 0 ± 1 -158.8
1.1.12.12. NaK potassium channel, open state, mutant with DMA 4r7c Bacillus cereus Bact. Gram-pos plas. 4 8 27.8 ± 0.9 0 ± 0 -41.0
1.1.26.05. Arginine/agmatine antiporter (AdiC), outward-facing structure 2 5j4i Escherichia coli Bact. Gram-neg inner 2 24 32.8 ± 0.9 0 ± 0 -155.1
1.1.32.01. Proton glutamate symport protein, inward-facing state 2 4p19 Pyrococcus horikoshii Archaebac. 3 30 30.6 ± 1.0 0 ± 0 -172.9
1.1.23.01. Chloride channel TMEM16A, structure 4 6bgj Mus musculus Eukaryo. plasma 2 20 27.4 ± 1.4 0 ± 0 -70.6
1.1.01.01. Bacteriorhodopsin 6eyu Candidatus nanosalina Archaebac. 3 21 29.8 ± 1.0 0 ± 0 -101.2
1.1.12.01. Potassium channel KcsA, 16 A opening conformer 3fb6 Streptomyces lividans Bact. Gram-pos plas. 4 8 30.2 ± 1.0 0 ± 0 -86.1
1.1.15.02. Proton-gated ion channel, conformation 1 3tlw Gloeobacter violaceus Bact. Gram-neg inner 5 20 34.0 ± 1.6 0 ± 0 -190.3
1.1.14.01. Aquaporin AQY1 2w2e Pichia pastoris Eukaryo. plasma 4 32 30.2 ± 0.8 0 ± 0 -131.7
1.1.10.03. Lipid flippase MsbA, closed state 3b5x Vibrio cholerae Bact. Gram-neg inner 2 12 30.2 ± 1.0 0 ± 0 -58.7
1.1.10.02. ABC-type polar amino acid transporter 4ymu Caldanaerobacter subterraneus Bact. Gram-pos plas. 2 10 29.8 ± 0.8 0 ± 0 -71.5
1.1.01.02. Beta-1 adrenergic receptor, inactive, dimer 4gpo Meleagris gallopavo Eukaryo. plasma 2 14 30.8 ± 1.2 0 ± 0 -144.8
1.2.43.07. Glycoprotein C, structure 1 5j81 Puumala virus Viral 3 0 6.0 ± 0.3 0 ± 1 -15.7
1.1.02.03. Photosystem II 4yuu Cyanidium caldarium Thylakoid 34 70 32.2 ± 0.8 0 ± 0 -411.9
1.1.21.01. CorA magnesium transporter, complete loops, structure 2 3jcf Thermotoga maritima Bact. Gram-neg inner 5 10 31.6 ± 0.7 0 ± 0 -78.0
1.1.61.01. Microsomal glutathione S-transferase 1, structure 1 2h8a Rattus norvegicus Endoplasm. reticulum 3 12 29.7 ± 0.7 0 ± 1 -47.7
1.1.12.21. KCNQ1 channel, with calmodulin 5vms Xenopus laevis Eukaryo. plasma 4 24 31.4 ± 0.4 0 ± 0 -259.2
1.1.10.01. Heme importer BhuUV, with BhuT protein 5b58 Burkholderia cepacia Bact. Gram-neg inner 2 20 29.0 ± 1.0 0 ± 0 -81.6
1.1.15.02. Proton-gated ion channel, inactive conformation 5 5lg3 Erwinia chrysanthemi Bact. Gram-neg inner 5 20 33.8 ± 1.1 0 ± 0 -108.7
1.1.02.05. Light-harvesting complex LH2 1nkz Rhodopseudomonas acidophila Bact. Gram-neg inner 18 18 31.8 ± 0.6 0 ± 0 -193.5
1.1.28.02. Efflux transporter CusA, Cu(i) complex 3kss Escherichia coli Bact. Gram-neg inner 3 33 28.8 ± 0.5 0 ± 0 -147.7
1.3.16.01. Chitoporin, structure 2 5mdq Vibrio harveyi Bact. Gram-neg outer 3 48 24.2 ± 0.6 0 ± 0 -122.4
1.3.16.01. Porin OmpF 3pox Escherichia coli Bact. Gram-neg outer 3 48 24.0 ± 0.8 0 ± 0 -136.2
3.1.02.07. Na(+)/H(+) antiporter, TMH IV, fusion construct 2m7w Saccharomyces cerevisiae Eukaryo. plasma 3 3 26.8 ± 0.1 0 ± 2 -5.7
1.1.01.02. Rhodopsin, active (metarhodopsin II), without transducin peptide 3pxo Bos taurus Eukaryo. plasma 2 14 31.8 ± 1.2 0 ± 0 -125.4
1.1.08.01. F1F0 ATP synthase, structure 2 4b2q Saccharomyces cerevisiae Mitochon. inner 10 20 38.4 ± 0.9 0 ± 0 -115.7
1.1.19.01. Mechanosensitive channel protein MscS, open state 5aji Escherichia coli Bact. Gram-neg inner 7 21 29.8 ± 1.7 0 ± 0 -127.8
1.3.23.01. Autotransporter Hia, 992-1098 2gr7 Haemophilus influenzae Bact. Gram-neg outer 3 12 22.7 ± 2.0 0 ± 1 -43.5
1.1.13.02. 5u1x » P2X purinoceptor, structure 2 5u2h Ailuropoda melanoleuca Eukaryo. plasma 3 6 25.8 ± 0.2 0 ± 1 -14.8
1.3.16.01. Porin B (PorB) 3a2s Neisseria meningitidis Bact. Gram-neg outer 3 48 24.4 ± 1.0 0 ± 0 -102.1
1.1.15.01. 5-hydroxytryptamine receptor 3A, structure 1 4pir Mus musculus Eukaryo. plasma 5 20 30.8 ± 1.0 0 ± 0 -153.9
1.1.12.01. Potassium channel KcsA 1s5h Streptomyces coelicolor Bact. Gram-pos plas. 4 8 33.7 ± 1.3 0 ± 1 -111.9
1.1.12.14. Potassium channel Kirbac3.1, open conformation 3zrs Magnetospirillum magnetotacticum Bact. Gram-neg inner 4 8 30.0 ± 1.1 0 ± 0 -85.9
1.1.01.01. Deltarhodopsin 4fbz Haloterrigena thermotolerans Archaebac. 3 21 31.6 ± 0.8 0 ± 0 -110.6
1.1.12.01. Potassium channel KcsA, 14.5 A opening conformer 3fb5 Streptomyces lividans Bact. Gram-pos plas. 4 8 33.7 ± 0.9 0 ± 0 -115.9
1.1.12.12. NaK-NavSulP chimera channel 3vou Sulfitobacter sp. Bact. Gram-neg inner 4 8 30.4 ± 0.8 0 ± 0 -100.1
1.1.12.17. TRPM8 channel 6bpq Ficedula albicollis Eukaryo. plasma 4 24 30.2 ± 1.0 0 ± 1 -158.2
1.1.104.01. TRIC cation channel 5h35 Sulfolobus solfataricus Archaebac. 3 21 27.4 ± 0.8 0 ± 0 -112.8
1.3.24.01. Outer membrane channel CmeC 4mt4 Campylobacter jejuni Bact. Gram-neg outer 3 12 26.8 ± 0.4 0 ± 0 -67.1
1.1.28.05. Hopanoid transporter HpnN, structure 1 5khn Burkholderia multivorans Bact. Gram-neg inner 2 24 27.8 ± 1.0 0 ± 0 -111.2
1.1.26.08. Electrogenic sodium bicarbonate cotransporter 1, SLC4A4 6caa Homo sapiens Eukaryo. plasma 2 28 30.6 ± 0.6 0 ± 0 -181.6
1.3.16.01. Porin 1, structure 1 5nxr Providencia stuartii Bact. Gram-neg outer 3 48 25.0 ± 1.4 0 ± 0 -131.8
1.1.15.01. Glycine receptor, alpha-1, strychnine-bound state 3jad Danio rerio Eukaryo. plasma 5 20 30.8 ± 1.0 0 ± 0 -92.4
1.3.24.01. Outer membrane protein OprJ 5azs Pseudomonas aeruginosa Bact. Gram-neg outer 3 12 23.4 ± 0.8 1 ± 1 -55.3
1.1.10.02. Molybdate transporter ModBC, open state 3d31 Methanosarcina acetivorans Archaebac. 2 12 29.8 ± 1.5 1 ± 0 -91.6
1.1.01.01. Halorhodopsin 3a7k Natronomonas pharaonis Archaebac. 3 21 33.8 ± 1.4 1 ± 0 -141.3
1.1.01.02. Muscarinic acetylcholine receptor M3, structure 2 4u15 Rattus norvegicus Eukaryo. plasma 1 7 31.8 ± 1.5 1 ± 1 -70.6
1.2.03.05. Growth hormone receptor (254-293), structure 2 5ohd Homo sapiens Eukaryo. plasma 2 2 35.6 ± 3.2 1 ± 2 -64.7
1.1.55.01. Bacterial polysaccharide co-polymerase FepE 3b8n Escherichia coli Bact. Gram-neg inner 9 0 1.6 ± 0.1 1 ± 0 -20.3
1.1.36.01. CLC-K chloride channel, structure 2 5tr1 Bos taurus Eukaryo. plasma 2 28 31.4 ± 1.0 1 ± 0 -135.2
1.1.13.01. Acid-sensing ion channel 1, structure 2 5wku Gallus gallus Eukaryo. plasma 3 6 29.0 ± 1.8 1 ± 0 -61.7
1.2.23.01. M2 proton channel, influenza A and B hydrid 2ljb Influenza virus Viral 4 4 31.6 ± 1.6 1 ± 1 -51.3
1.1.01.01. Bacteriorhodopsin 5jsi Candidatus Actinomarina minuta Bact. Gram-pos plas. 2 14 25.8 ± 0.6 1 ± 1 -71.9
1.1.12.17. Polycystin-2 channel, structure 2 5mke Homo sapiens Eukaryo. plasma 4 24 25.8 ± 0.0 1 ± 0 -168.9
1.1.25.06. D-xylose-proton symporter xylE, conformation 1 4gc0 Escherichia coli Bact. Gram-neg inner 1 12 30.2 ± 0.9 1 ± 0 -90.2
1.1.10.03. ABC-type bacteriocin transporter 4ry2 Clostridium thermocellum Bact. Gram-pos plas. 2 12 33.8 ± 0.2 1 ± 0 -109.4
1.2.26.01. Outer membrane lipoprotein Wza, water-soluble part 2w8h Escherichia coli Bact. Gram-neg outer 8 0 1.6 ± 0.2 1 ± 0 -22.1
1.1.02.03. PSII-LHCII supercomplex 5mdx Arabidopsis thaliana Thylakoid 48 122 29.4 ± 0.4 1 ± 0 -609.5
1.3.14.01. Fatty Acid Transporter FadL, F3E, open channel 3pgu Escherichia coli Bact. Gram-neg outer 1 14 25.2 ± 1.5 1 ± 1 -51.5
1.1.13.02. P2X purinoceptor 5xw6 Gallus gallus Eukaryo. plasma 3 6 31.0 ± 0.6 1 ± 0 -79.8
1.1.28.01. AcrABZ-TolC multidrug efflux pump 5o66 Escherichia coli Bact. Gram-neg inner 6 39 28.6 ± 0.4 1 ± 0 -203.4
1.1.10.02. Methionine importer MetNI, conformation 3 3dhw Escherichia coli Bact. Gram-neg inner 2 10 29.2 ± 1.0 1 ± 0 -82.5
1.1.16.01. Glutamate receptor 2, with conotoxin, structure 2 4u5c Rattus norvegicus Eukaryo. plasma 4 12 31.4 ± 1.1 1 ± 1 -95.7
1.1.15.02. Proton-gated ion channel, resting state 4npq Gloeobacter violaceus Bact. Gram-neg inner 5 20 33.8 ± 2.1 1 ± 0 -185.4
1.1.10.01. ABC transporter permease HI1471 2nq2 Haemophilus influenzae Bact. Gram-neg inner 2 20 31.9 ± 0.9 1 ± 1 -124.2
1.1.35.01. Sodium/proton antiporter 1 (NhaA), dimer, different conformation 4atv Escherichia coli Bact. Gram-neg inner 2 24 28.6 ± 1.3 1 ± 0 -154.7
1.1.01.02. Histamine H1 receptor 3rze Homo sapiens Eukaryo. plasma 1 7 32.0 ± 1.4 1 ± 1 -72.4
1.1.14.02. Formate transporter 1, FocA 3kly Vibrio cholerae Bact. Gram-neg inner 5 35 31.4 ± 0.5 1 ± 0 -188.2
1.1.16.01. Glutamate receptor 2, with auxiliary subunit GSG1L, structure 3 5wek Rattus norvegicus Eukaryo. plasma 4 20 33.0 ± 1.4 1 ± 0 -162.4
1.1.12.08. Two pore calcium channel TPC1, structure 1 6c96 Mus musculus Endosome 2 24 31.0 ± 0.4 1 ± 0 -256.4
1.1.103.01. ExbB/ExbD complex, structure 1 5sv0 Escherichia coli Bact. Gram-neg inner 5 15 31.8 ± 0.8 1 ± 1 -102.1
1.1.19.01. Mechanosensitive channel protein MscS, expanded state 2oau Escherichia coli Bact. Gram-neg inner 7 14 31.8 ± 0.8 1 ± 1 -171.3
1.1.69.01. HIG1 domain family member 1A 2lom Homo sapiens Mitochon. inner 1 2 22.0 ± 5.0 1 ± 1 -27.3
1.1.02.06. Light-Harvesting Complex II-CP24 complex 5xno Pisum sativum Thylakoid 4 12 27.0 ± 1.4 1 ± 0 -127.8
1.2.01.01. Receptor tyrosine kinase erbB-2, dimer, structure 3 5ob4 Homo sapiens Eukaryo. plasma 2 2 27.3 ± 3.0 1 ± 1 -28.6
1.1.12.16. Ryanodine receptor 1, closed structure 1 5gky Oryctolagus cuniculus Endoplasm. reticulum 4 24 30.8 ± 0.0 1 ± 0 -174.0
1.1.26.04. Glycine betaine transporter BetP, alternative inward-facing open conformation 3p03 Corynebacterium glutamicum Bact. Gram-pos plas. 3 36 29.8 ± 0.7 1 ± 0 -160.9
1.1.05.01. Polysulfide reductase, inactive state 2vpz Thermus thermophilus Bact. Gram-neg inner 2 16 29.8 ± 1.5 1 ± 0 -105.2
1.2.23.01. M2 proton channel of Influenza A, S31N, NMR structure 2n70 Influenza virus Viral 4 4 29.8 ± 1.7 1 ± 0 -65.3
1.1.06.01. Cytochrome bc1, mitochondrial 1ezv Saccharomyces cerevisiae Mitochon. inner 24 10 27.5 ± 0.6 1 ± 0 -170.6
1.1.105.01. CD81 antigen 5tcx Homo sapiens Eukaryo. plasma 1 4 34.2 ± 2.4 1 ± 1 -55.9
1.3.14.01. Toluene transporter TbuX 3bry Ralstonia pickettii Bact. Gram-neg outer 1 14 25.4 ± 1.5 1 ± 2 -57.7
1.1.90.01. Phosphatidate cytidylyltransferase, conformation 1 4q2e Thermotoga maritima Bact. Gram-neg inner 2 18 29.8 ± 0.6 1 ± 0 -77.7
1.1.27.01. Ferrous-iron efflux pump fieF, different conformation 2qfi Escherichia coli Bact. Gram-neg inner 2 12 25.0 ± 1.3 1 ± 2 -32.4
1.3.19.01. Pyroglutamate porin OpdO 2y0k Pseudomonas aeruginosa Bact. Gram-neg outer 1 18 23.8 ± 1.2 1 ± 0 -55.8
1.1.12.15. Mechanotransduction channel NOMPC 5vkq Drosophila melanogaster Eukaryo. plasma 4 24 30.6 ± 0.6 1 ± 0 165.5
1.1.08.01. V-type proton ATPase, vacuolar, state 1 3j9t Saccharomyces cerevisiae Vacuole 10 40 39.6 ± 1.3 1 ± 0 -169.3
1.1.01.05. Metabotropic glutamate receptor 1 4or2 Homo sapiens Eukaryo. plasma 2 14 31.4 ± 0.9 1 ± 0 -117.3
1.1.83.01. TspO protein, structure 1 4uc1 Rhodobacter sphaeroides Bact. Gram-neg outer 2 10 29.6 ± 1.3 1 ± 1 -70.6
1.2.49.01. Tumor necrosis factor receptor 6 2na7 Homo sapiens Eukaryo. plasma 3 3 26.8 ± 0.6 1 ± 1 -33.2
1.1.35.02. Na+/H+ antiporter 1, inward-open conformation 4czb Methanococcus jannaschii Archaebac. 26 26 27.2 ± 0.5 1 ± 0 -128.3
1.1.21.01. CorA magnesium transporter, structure 2 4eeb Thermotoga maritima Bact. Gram-neg inner 5 10 30.0 ± 1.0 1 ± 1 -81.6
1.1.81.01. P7 viral protein 2m6x Hepatitis C virus Endoplasm. reticulum 6 12 26.8 ± 0.1 1 ± 0 -35.4
1.1.01.01. Blue-light absorbing proteorhodopsin 4knf Gamma-proteobacterium Bact. Gram-neg inner 5 35 28.4 ± 1.5 1 ± 1 -159.6
1.1.11.01. Protein translocase Sec61, with signal peptide 3jc2 Canis lupus familiaris Endoplasm. reticulum 13 4 28.8 ± 1.3 1 ± 0 -73.0
1.3.21.01. Outer membrane usher protein FimD, complex with FimC-FimF-FimG-FimH 4j3o Escherichia coli Bact. Gram-neg outer 1 24 23.8 ± 1.4 1 ± 1 -52.9
1.3.20.01. Ferric enterobactin receptor PirA 5fr8 Acinetobacter baumannii Bact. Gram-neg outer 1 22 23.4 ± 0.8 1 ± 0 -65.3
1.1.10.03. Mitochondrial ABC transporter ABCB10, conformation 4 3zdq Homo sapiens Mitochon. inner 2 12 30.8 ± 0.5 1 ± 0 -71.8
1.3.22.01. VDAC-1 channel, structure 2 (NMR) 2k4t Homo sapiens Mitochon. outer 1 19 22.0 ± 1.5 1 ± 1 -34.8
1.1.43.01. Saccharide transporter, EIIC (ChbC), inward-facing 3qnq Bacillus cereus Bact. Gram-pos plas. 2 20 29.6 ± 1.0 1 ± 0 -140.6
1.1.23.01. Chloride channel TMEM16A, structure 1 5oyb Mus musculus Eukaryo. plasma 2 20 31.8 ± 0.8 1 ± 0 -178.1
1.1.83.01. TspO protein, structure 2 4uc2 Rhodobacter sphaeroides Bact. Gram-neg outer 2 10 30.4 ± 0.9 1 ± 0 -79.2
1.2.43.01. Envelope glycoprotein, Dengue virus type 1 3g7t Dengue virus Viral 3 0 5.9 ± 0.9 1 ± 3 -12.2
1.1.01.02. Thrombin (proteinase-activated) receptor 1, PAR1 3vw7 Homo sapiens Eukaryo. plasma 1 7 33.4 ± 1.9 1 ± 0 -72.2
1.1.28.01. Multidrug efflux transporter AcrB, asymmetric 2gif Escherichia coli Bact. Gram-neg inner 3 36 29.0 ± 0.2 1 ± 0 -187.5
1.1.16.01. Glutamate receptor 2, with TARP channel, structure 1 5kk2 Rattus norvegicus Eukaryo. plasma 8 32 34.0 ± 0.4 1 ± 0 -123.2
1.1.01.02. Adenosine receptor A1 5uen Homo sapiens Eukaryo. plasma 2 14 32.2 ± 1.0 1 ± 0 -145.8
1.1.08.01. F0 ATP synthase, structure 2 3zo6 Bacillus pseudofirmus Bact. Gram-pos plas. 12 24 39.6 ± 1.1 1 ± 0 -130.6
1.2.44.01. Amyloid beta A4 protein, 686-726, dimer, structure 1 2loh Homo sapiens Eukaryo. plasma 2 2 32.8 ± 1.6 1 ± 1 -34.1
1.1.115.01. MlaA protein, with OMPF (E. coli) 5nuq Serratia marcescens Bact. Gram-neg outer 4 50 23.8 ± 0.2 1 ± 0 -148.6
1.1.28.01. Multidrug efflux transporter AcrB, asymmetric, complex with ankyrin repeat 1 4dx5 Escherichia coli Bact. Gram-neg inner 3 36 27.4 ± 0.7 1 ± 0 -181.0
1.3.19.01. BenF-like porin 3jty Pseudomonas fluorescens Bact. Gram-neg outer 1 18 24.2 ± 1.2 1 ± 0 -59.8
1.1.10.03. Oligosaccharide flippase PglK, inward-open, structure 2 5c76 Campylobacter jejuni Bact. Gram-neg inner 2 12 32.0 ± 0.8 1 ± 0 -120.5
1.1.16.01. GluN1/GluN2A/GluN2B NMDA receptor, structure 2 5up2 Xenopus laevis Eukaryo. plasma 4 12 31.0 ± 0.6 1 ± 0 -111.8
1.1.02.02. Photosystem I-light harvesting supercomplex, structure 2 6fos Cyanidoschyzon merolae Thylakoid 12 44 30.2 ± 0.2 1 ± 0 -301.5
1.1.16.01. Glutamate receptor 2, with TARP channel, structure 2 5vot Rattus norvegicus Eukaryo. plasma 8 20 31.4 ± 1.2 1 ± 0 -222.9
1.1.80.01. DPAGT1, dimer, structure 1 5o5e Homo sapiens Endoplasm. reticulum 2 20 31.0 ± 0.8 1 ± 1 -127.3
1.1.15.02. Proton-gated ion channel, inactive conformation 6 5sxv Erwinia chrysanthemi Bact. Gram-neg inner 5 20 30.6 ± 0.6 1 ± 0 -100.4
1.1.06.02. Ascorbate-dependent oxidoreductase 4o6y Arabidopsis thaliana Eukaryo. plasma 2 12 31.0 ± 1.3 1 ± 0 -97.6
1.1.041.01. Bacterial semiSWEET transporter, outward-open conformation 4x5n Escherichia coli Bact. Gram-neg inner 2 6 36.8 ± 1.1 1 ± 3 -70.5
1.2.43.03. Envelope glycoprotein B 3nw8 Human herpesvirus Viral 3 0 4.6 ± 0.0 1 ± 1 -11.7
1.1.02.04. Reaction center-LH1-PufX dimer complex, unit 1 4jcb Rhodobacter sphaeroides Bact. Gram-neg inner 32 40 28.0 ± 0.5 1 ± 0 -127.0
1.1.24.01. Bestrophin-1 5x87 Klebsiella pneumoniae Bact. Gram-neg inner 5 20 31.0 ± 2.4 1 ± 0 -120.3
1.1.01.04. Smoothened homolog, dimer, structure 2 4qin Homo sapiens Eukaryo. plasma 2 14 31.6 ± 1.3 1 ± 1 -94.0
1.1.15.02. Proton-gated ion channel, inactive conformation 7 5sxu Erwinia chrysanthemi Bact. Gram-neg inner 5 20 30.2 ± 0.8 1 ± 0 -100.5
1.1.26.04. Glycine betaine transporter BetP, inward-facing conformation 4c7r Corynebacterium glutamicum Bact. Gram-pos plas. 3 39 30.0 ± 0.7 1 ± 0 -186.7
1.1.34.01. Mitochondrial ADP-ATP carrier, conformation 1 4c9g Saccharomyces cerevisiae Mitochon. inner 1 6 31.4 ± 1.5 1 ± 1 -54.6
1.1.88.01. NAD(P) transhydrogenase, structure 2 4o9u Thermus thermophilus Bact. Gram-neg inner 4 24 30.6 ± 1.1 1 ± 0 -150.7
1.3.24.01. Cation efflux system protein CusC 3pik Escherichia coli Bact. Gram-neg outer 3 12 24.3 ± 1.2 1 ± 0 -33.8
1.1.02.02. Photosystem I of plants 4rku Pisum sativum Thylakoid 13 45 31.8 ± 1.0 1 ± 0 -346.8
1.1.12.01. Potassium channel KcsA, full length, open 3pjs Streptomyces lividans Bact. Gram-pos plas. 4 8 31.6 ± 1.2 1 ± 1 -87.3
1.1.23.01. TMEM16 lipid scramblase 4wis Nectria haematococca Eukaryo. plasma 2 20 29.8 ± 0.9 1 ± 1 -99.7
1.1.28.01. Multidrug efflux transporter AcrB-AcrZ complex, structure 2 5nc5 Escherichia coli Bact. Gram-neg inner 6 39 29.8 ± 0.6 1 ± 0 -215.8
1.3.20.01. SusD-SusC complex, a dimer 5t4y Bacteroides thetaiotaomicron