PDB ID or protein name

Alpha-helical transmembrane superfamilies

1.1.01. Rhodopsin-like proteins (2 families)
1.1.02. Photosynthetic reaction centers and photosystems (3 families) 3.E.2 (TCDB)
1.1.03. Light-harvesting complexes (2 families)
1.1.04. Transmembrane cytochrome b like (5 families)
1.1.05. Cytochrome c oxidases (1 family) 3.D.4 (TCDB)
1.1.06. Proton or Sodium translocating F-type, V-type and A-type ATPases (1 family) 3.A.2 (TCDB)
1.1.07. Methane monooxygenase (1 family)
1.1.08. P-type ATPase (P-ATPase) (1 family) 3.A.3 (TCDB)
1.1.09. ABC transporters (6 families) 3.A.1 (TCDB)
1.1.12. General secretory pathway (Sec) (1 family) 3.A.5 (TCDB)
1.1.13. Mitochondrial Carrier (MC) (1 family) 2.A.29 (TCDB)
1.1.14. Major Facilitator Superfamily (MFS) (3 families) 2.A.1 (TCDB)
1.1.15. Resistance-nodulation-cell division (1 family) 2.A.6 (TCDB)
1.1.16. Dicarboxylate/amino acid:Cation Symporter (DAACS) (1 family) 2.A.23 (TCDB)
1.1.17. Monovalent cation/proton antiporter (CPA) (1 family) 2.A.33 (TCDB)
1.1.18. Ligand/cation symporters (5 families)
1.1.19. Ammonia transporter (Amt) (1 family) 1.A.11 (TCDB)
1.1.20. Drug/Metabolite Transporter (DMT) (1 family) 2.A.7 (TCDB)
1.1.21. Single-helix ATPase regulators (2 families)
1.1.22. Voltage-gated channel like (2 families)
1.1.23. Large conductance mechanosensitive ion channel (MscL) (1 family) 1.A.22 (TCDB)
1.1.24. Small conductance mechanosensitive ion channel (MscS) (1 family) 1.A.23 (TCDB)
1.1.25. CorA Metal Ion Transporters (MIT) (1 family) 1.A.35 (TCDB)
1.1.26. Pentameric ligand-gated ion channels (2 families) 1.A.9 (TCDB)
1.1.27. Major Intrinsic Protein (MIP) (1 family) 1.A.8 (TCDB)
1.1.28. Chloride Channel (ClC) (1 family) 2.A.49 (TCDB)
1.1.29. Steryl-sulfate sulfohydrolase (1 family)
1.1.30. Rhomboid proteins (1 family)
1.1.31. T cell receptor transmembrane dimerization domain (1 family)
1.1.32. Outer membrane auxiliary proteins (1 family) 1.B.18 (TCDB)
1.1.33. Disulfide bond oxidoreductase-B (DsbB) (1 family) 5.A.2 (TCDB)
1.1.34. Multi-heme cytochromes (1 family)
1.1.35. Stannin (1 family)
1.1.36. Glycophorin A (1 family)
1.1.37. Inovirus (filamentous phage) major coat protein (2 families)
1.1.38. Pili subunits (1 family)
1.1.39. Pulmonary surfactant-associated protein (1 family)
1.1.40. MAPEG (Eicosanoid and Glutathione metabolism proteins) (1 family)
1.1.41. Magnesium ion transporter-E (MgtE) (1 family) 9.A.19 (TCDB)
1.1.42. Epithelial sodium channel (ENaC) (1 family) 1.A.6 (TCDB)
1.1.43. Cation diffusion facilitator (1 family) 2.A.4 (TCDB)
1.1.44. Peptidase M50 (1 family)
1.1.45. Viral channel proteins (1 family) 1.A.19 (TCDB)
1.1.46. Protein tyrosine kinase (1 family)
1.1.47. Prokaryotic molybdopterin-containing oxidoreductases (1 family) 5.A.3 (TCDB)
1.1.48. Corynebacterial porin B (1 family) 1.B.41 (TCDB)
1.1.49. BNip3 protein family (1 family) 1.A.20 (TCDB)
1.1.50. Integrin transmembrane dimer (1 family)
1.1.51. Immunoglobulin (1 family)
1.1.52. Gap junction-forming connexin (1 family) 1.A.24 (TCDB)
1.1.53. Prokaryotic diacylglycerol kinase (1 family)
1.1.54. SNARE complex (1 family)
1.1.55. Pore-forming haemolysin E (1 family) 1.C.10 (TCDB)
1.1.56. ATP-gated cation channel (1 family) 1.A.7 (TCDB)

Alpha-helical transmembrane (200 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
1.1.01.01. Sensory rhodopsin II, monomer 1h68 Natronomonas pharaonis Archaebac. 1 7 31.6 ± 2.5 12 ± 5 -76.2
1.1.01.01. Archaerhodopsin-2, trimeric 2ei4 Halobacterium sp. Archaebac. 3 21 30.1 ± 0.9 0 ± 1 -158.4
1.1.01.01. Bacteriorhodopsin, monomer 1py6 Halobacterium salinarum Archaebac. 1 7 31.0 ± 2.5 13 ± 6 -75.9
1.1.01.01. Archaerhodopsin-2 1vgo Halobacterium sp. Archaebac. 1 7 30.8 ± 1.5 9 ± 4 -81.8
1.1.01.01. Bacteriorhodopsin, trimer 1m0l Halobacterium salinarum Archaebac. 3 21 30.0 ± 1.1 0 ± 1 -149.5
1.1.01.01. Sensory rhodopsin II 1h2s Natronomonas pharaonis Archaebac. 4 18 29.5 ± 1.1 0 ± 2 -160.0
1.1.01.01. Sensory Rhodopsin 1xio Anabaena sp. Bact. gram-neg inner 1 7 31.2 ± 2.8 8 ± 6 -71.7
1.1.01.01. Xanthorhodopsin 3ddl Salinibacter ruber Bact. gram-neg inner 1 7 26.0 ± 1.5 14 ± 3 -68.2
1.1.01.01. Halorhodopsin 1e12 Halobacterium salinarum Archaebac. 3 21 30.9 ± 1.8 0 ± 1 -151.6
1.1.01.01. Archaerhodopsin-1 1uaz Halobacterium sp. Archaebac. 1 7 31.7 ± 2.2 6 ± 4 -73.9
1.1.01.02. Mu-opioid receptor model in active state with agonist 2iqo Rattus norvegicus Eukaryo. plasma 1 7 35.3 ± 1.6 1 ± 4 -95.7
1.1.01.02. Beta1-adrenergic receptor 2vt4 Meleagris gallopavo Eukaryo. plasma 1 7 32.7 ± 1.5 6 ± 4 -95.7
1.1.01.02. Mu-opioid receptor model (inactive state) with antagonist 2iql Rattus norvegicus Eukaryo. plasma 1 7 35.0 ± 1.0 9 ± 3 -97.7
1.1.01.02. Rhodopsin 1gzm Bos taurus Eukaryo. plasma 1 7 32.4 ± 1.7 8 ± 3 -91.3
1.1.01.02. Cholecystokinin A receptor fragment 1d6g Homo sapiens Eukaryo. plasma 2 0 8.0 ± 0.8 89 ± 7 -16.1
1.1.01.02. Opsin, complex with C-terminal peptide of Galpha subunit of transducin 3dqb Bos taurus Eukaryo. plasma 1 7 31.5 ± 1.4 6 ± 3 -86.3
1.1.01.02. TM1-TM2 fragment of fungal STE2 receptor 2k9p Saccharomyces cerevisiae Eukaryo. plasma 1 2 31.5 ± 2.0 5 ± 7 -25.7
1.1.01.02. Opsin, retinal-free state 3cap Bos taurus Eukaryo. plasma 1 7 31.4 ± 1.3 6 ± 4 -86.0
1.1.01.02. Beta2-adrenergic receptor 2rh1 Homo sapiens Eukaryo. plasma 1 7 31.4 ± 1.3 8 ± 3 -84.3
1.1.01.02. Rhodopsin, a photobleached state 2i37 Bos taurus Eukaryo. plasma 1 7 31.9 ± 1.4 5 ± 4 -88.6
1.1.01.02. A2A adenosine receptor bound to antagonist ZM241385 3eml Homo sapiens Eukaryo. plasma 1 7 33.2 ± 2.2 8 ± 4 -85.1
1.1.01.02. Rhodopsin, a dimer 2i36 Bos taurus Eukaryo. plasma 2 14 30.5 ± 1.4 0 ± 1 -161.5
1.1.01.02. Melanocortin-4 receptor model (active state) with agonist NDP-MSH 2iqr Homo sapiens Eukaryo. plasma 1 7 34.5 ± 1.5 18 ± 3 -80.2
1.1.01.02. Squid rhodopsin dimer 2z73 Todarodes pacificus Eukaryo. plasma 2 14 33.5 ± 1.1 0 ± 2 -167.5
1.1.01.02. Melanocortin-4 receptor model (inactive state) with antagonist AGRP 2iqv Homo sapiens Eukaryo. plasma 1 7 33.5 ± 1.5 19 ± 3 -75.3
1.1.02.01. Photosynthetic reaction center 1eys Thermochromatium tepidum Bact. gram-neg inner 3 11 30.0 ± 1.5 4 ± 1 -133.8
1.1.02.01. Photosynthetic reaction center 1rzh Rhodobacter sphaeroides Bact. gram-neg inner 3 11 30.0 ± 1.2 5 ± 1 -141.0
1.1.02.01. Photosynthetic reaction center 1dxr Rhodopseudomonas viridis Bact. gram-neg inner 3 11 30.5 ± 1.8 6 ± 1 -138.5
1.1.02.02. Photosystem I 1jb0 Thermosynechococcus elongatus Thylakoid 9 32 32.0 ± 0.8 1 ± 1 -345.1
1.1.02.02. Photosystem I 2o01 Pisum sativum Thylakoid 16 43 27.5 ± 0.5 3 ± 1 -791.8
1.1.02.03. Photosystem II 3bz1 Thermosynechococcus elongatus Thylakoid 34 72 31.2 ± 0.6 0 ± 1 -513.1
1.1.03.01. Light-harvesting complex LH2 1nkz Rhodopseudomonas acidophila Bact. gram-neg inner 18 18 27.8 ± 0.8 0 ± 0 -246.8
1.1.03.01. Light-harvesting complex LH3 1ijd Rhodopseudomonas acidophila Bact. gram-neg inner 18 18 26.2 ± 0.8 0 ± 0 -205.4
1.1.03.01. Light-harvesting complex 1lgh Rhodospirillum molischianum Bact. gram-neg inner 16 16 28.7 ± 0.9 0 ± 1 -187.3
1.1.03.02. Light-Harvesting Complex II 1rwt Spinacia oleracea Thylakoid 3 9 28.0 ± 1.3 0 ± 1 -198.2
1.1.03.02. Light-Harvesting Complex II 2bhw Pisum sativum Thylakoid 3 9 28.0 ± 1.0 0 ± 1 -160.4
1.1.04.01. Cytochrome bc1, mitochondrial 1bcc Gallus gallus Mitochon. inner 10 24 26.1 ± 1.0 0 ± 1 -203.0
1.1.04.01. Cytochrome b6f 1q90 Chlamydomonas reinhardtii Thylakoid 16 26 32.5 ± 0.9 0 ± 1 -261.7
1.1.04.01. Cytochrome bc1, mitochondrial 1l0l Bos taurus Mitochon. inner 12 26 26.8 ± 0.6 0 ± 0 -241.6
1.1.04.01. Cytochrome bc1, bacterial 2fyn Rhodobacter sphaeroides Bact. gram-neg inner 6 20 27.7 ± 1.2 1 ± 1 -195.3
1.1.04.01. Cytochrome bc1, mitochondrial 1kb9 Saccharomyces cerevisiae Mitochon. inner 10 24 26.0 ± 0.8 0 ± 0 -219.4
1.1.04.01. Cytochrome b6f 2e74 Mastigocladus laminosus Thylakoid 16 26 31.5 ± 0.8 0 ± 1 -291.2
1.1.04.01. Cytochrome bc1, mitochondrial 1pp9 Bos taurus Mitochon. inner 10 26 26.1 ± 0.5 0 ± 5 -208.6
1.1.04.01. Cytochrome b6f 2zt9 Nostoc sp. Thylakoid 16 26 31.0 ± 1.0 0 ± 1 269.6
1.1.04.02. Formate dehydrogenase 1kqf Escherichia coli Bact. gram-neg inner 6 15 32.7 ± 1.1 0 ± 2 -174.0
1.1.04.03. Respiratory Nitrate Reductase 1q16 Escherichia coli Bact. gram-neg inner 2 10 29.5 ± 1.0 0 ± 2 -150.6
1.1.04.04. Fumarate reductase 2bs3 Wolinella succinogenes Bact. gram-neg inner 2 10 30.0 ± 1.0 0 ± 1 -131.9
1.1.04.04. Fumarate reductase 2bs2 Wolinella succinogenes Bact. gram-neg inner 2 10 29.7 ± 0.8 0 ± 1 -128.8
1.1.04.05. Succinate dehydrogenase (mitochondrial respiratory complex II) 1yq3 Gallus gallus Mitochon. inner 2 6 33.5 ± 1.2 6 ± 2 -72.0
1.1.04.05. Fumarate reductase 1kf6 Escherichia coli Bact. gram-neg inner 2 6 30.0 ± 1.8 10 ± 5 -84.5
1.1.04.05. Succinate dehydrogenase 1nek Escherichia coli Bact. gram-neg inner 6 18 32.0 ± 1.0 0 ± 1 -203.1
1.1.04.05. Succinate dehydrogenase (mitochondrial respiratory complex II) 1zoy Sus scrofa Mitochon. inner 2 6 28.0 ± 2.2 12 ± 3 -75.1
1.1.05.01. Mitochondrial cytochrome c oxidase 1v55 Bos taurus Mitochon. inner 20 56 25.4 ± 1.8 0 ± 2 -245.1
1.1.05.01. Bacterial cytochrome c oxidase 1m56 Rhodobacter sphaeroides Bact. gram-neg inner 4 22 30.5 ± 0.7 2 ± 0 -201.7
1.1.05.01. Bacterial cytochrome c oxidase 1qle Paracoccus denitrificans Bact. gram-neg inner 4 22 31.2 ± 1.5 3 ± 1 -208.8
1.1.05.01. Bacterial cytochrome c oxidase 1ehk Thermus thermophilus Bact. gram-neg inner 3 15 30.4 ± 1.3 5 ± 2 -135.6
1.1.05.01. Ubiquinol Oxidase 1fft Escherichia coli Bact. gram-neg inner 3 19 29.0 ± 1.2 3 ± 1 -122.9
1.1.05.01. Bacterial cytochrome c oxidase 1ar1 Paracoccus denitrificans Bact. gram-neg inner 2 14 33.5 ± 2.0 9 ± 2 -129.0
1.1.06.01. F1F0 ATP synthase subunit c 1a91 Escherichia coli Bact. gram-neg inner 1 2 36.5 ± 3.2 22 ± 8 -41.4
1.1.06.01. F1F0 ATP synthase 1c17 Escherichia coli Bact. gram-neg inner 13 28 35.9 ± 0.8 2 ± 0 -211.2
1.1.06.01. ATP synthase of chloroplast 2w5j Spinacia oleracea Thylakoid 14 28 35.5 ± 1.4 0 ± 1 -148.1
1.1.06.01. F-type Sodium ATPase 1yce Ilyobacter tartaricus Bact. gram-neg inner 11 22 37.0 ± 0.8 0 ± 1 -138.3
1.1.06.01. F1F0 ATP synthase 2wie Arthrospira platensis Thylakoid 15 30 31.4 ± 0.5 0 ± 1 -157.3
1.1.06.01. V-type Sodium ATPase 2bl2 Enterococcus hirae Bact. gram-neg inner 10 40 36.7 ± 0.8 0 ± 0 -242.5
1.1.06.01. F1F0 ATP synthase subunit c 1wu0 Bacillus ps3 Bact. gram-pos plas. 1 2 32.6 ± 2.3 39 ± 6 -35.6
1.1.07.01. Particulate Methane Monooxygenase 3chx Methylosinus trichosporium Bact. gram-neg inner 10 30 28.7 ± 1.0 0 ± 1 -214.0
1.1.07.01. Particulate Methane Monooxygenase 1yew Methylococcus capsulatus Bact. gram-neg inner 9 42 25.0 ± 0.9 0 ± 1 -199.2
1.1.08.01. Sodium-potassium pump, E2-Pi state 2zxe Squalus acanthias Eukaryo. plasma 3 13 30.1 ± 1.8 8 ± 2 -115.7
1.1.08.01. Calcium ATPase, E2 state (Ca-free) 2agv Oryctolagus cuniculus Endoplasm. reticulum 1 10 30.1 ± 1.8 18 ± 3 -81.8
1.1.08.01. Calcium ATPase, E1-2Ca state 1su4 Oryctolagus cuniculus Endoplasm. reticulum 1 10 29.0 ± 2.8 23 ± 4 -81.0
1.1.08.01. Calcium ATPase, E2-Pi state 1wpg Oryctolagus cuniculus Endoplasm. reticulum 1 10 30.0 ± 1.5 19 ± 2 -89.9
1.1.08.01. Sodium-potassium pump, E2-Pi state 3b8e Sus scrofa Eukaryo. plasma 3 12 30.0 ± 1.0 12 ± 2 -121.1
1.1.08.01. Calcium ATPase, E1-ATP state 1t5s Oryctolagus cuniculus Endoplasm. reticulum 1 10 27.0 ± 1.2 24 ± 1 -80.4
1.1.08.01. Plasma membrane proton pump, E1-ATP state 3b8c Arabidopsis thaliana Eukaryo. plasma 1 10 27.5 ± 1.8 11 ± 3 -69.4
1.1.08.01. Calcium ATPase, E1P-ADP state 1wpe Oryctolagus cuniculus Endoplasm. reticulum 1 10 30.5 ± 1.0 19 ± 1 -79.1
1.1.08.01. Calcium ATPase, E2-Pi state, alternative conformation 3b9b Oryctolagus cuniculus Endoplasm. reticulum 1 10 28.0 ± 1.5 15 ± 2 -80.4
1.1.09.01. ABC transporter permease HI1471 2nq2 Haemophilus influenzae Bact. gram-neg inner 2 20 31.5 ± 1.4 1 ± 3 -148.2
1.1.09.01. ABC-transporter BtuCD in complex with BtuF 2qi9 Escherichia coli Bact. gram-neg inner 2 22 27.3 ± 1.1 4 ± 2 -140.7
1.1.09.01. ABC transporter BtuCD 1l7v Escherichia coli Bact. gram-neg inner 2 22 29.1 ± 1.0 0 ± 2 -142.8
1.1.09.02. Multidrug ABC transporter SAV1866, closed state 2hyd Staphylococcus aureus Bact. gram-pos plas. 2 12 34.5 ± 2.0 0 ± 2 -135.0
1.1.09.02. Lipid flippase MsbA 3b60 Salmonella typhimurium Bact. gram-neg inner 2 12 32.5 ± 0.9 0 ± 1 -111.8
1.1.09.03. Molybdate transporter ModBC, open state 3d31 Methanosarcina acetivorans Archaebac. 2 12 29.3 ± 1.0 1 ± 2 -112.6
1.1.09.03. Molybdate transporter ModBC, open state 2onk Archaeoglobus fulgidus Archaebac. 2 12 35.0 ± 1.3 0 ± 2 -119.0
1.1.09.04. Maltose transporter MalFGK 2r6g Escherichia coli Bact. gram-neg inner 2 14 29.5 ± 2.0 2 ± 3 -121.9
1.1.09.05. Methionine importer MetNI 3dhw Escherichia coli Bact. gram-neg inner 2 10 23.5 ± 2.0 6 ± 5 -78.4
1.1.09.06. P-glycoprotein 3g5u Mus musculus Eukaryo. plasma 1 12 30.6 ± 1.2 3 ± 2 -120.9
1.1.12.01. Preprotein Translocase SecY 1rh5 Methanococcus jannaschii Archaebac. 3 12 28.5 ± 1.0 10 ± 1 -115.4
1.1.12.01. Preprotein Translocase SecY 3din Thermotoga maritima Bact. gram-neg inner 3 13 25.5 ± 1.5 12 ± 2 -82.1
1.1.12.01. Preprotein translocase SecY 2zjs Thermus thermophilus Bact. gram-neg inner 2 11 26.5 ± 1.0 10 ± 1 -108.4
1.1.13.01. Mitochondrial ADP/ATP carrier 1ym6 Bos taurus Mitochon. inner 2 7 28.4 ± 1.3 5 ± 3 -62.8
1.1.13.01. Mitochondrial ADP/ATP carrier 1okc Bos taurus Mitochon. inner 1 6 28.0 ± 1.8 5 ± 3 -52.4
1.1.13.03. Multidrug transporter EmrD 2gfp Escherichia coli Bact. gram-neg inner 1 12 31.8 ± 1.0 11 ± 2 -88.5
1.1.14.01. Glycerol-3-Phosphate Transporter 1pw4 Escherichia coli Bact. gram-neg inner 1 12 31.0 ± 1.4 3 ± 3 -107.8
1.1.14.02. Lactose permease, structure at neutral pH 2cfq Escherichia coli Bact. gram-neg inner 1 12 31.9 ± 1.2 5 ± 3 -113.4
1.1.14.02. Lactose Permease, structure at acidic pH 2cfp Escherichia coli Bact. gram-neg inner 1 12 31.4 ± 1.4 5 ± 3 -111.7
1.1.15.01. Multidrug exporter MexB 2v50 Pseudomonas aeruginosa Bact. gram-neg inner 3 36 27.5 ± 0.8 0 ± 1 -189.7
1.1.15.01. Multidrug efflux transporter AcrB 2gif Escherichia coli Bact. gram-neg inner 3 36 27.5 ± 0.8 2 ± 2 -212.8
1.1.15.01. Multidrug efflux transporter AcrB with an additional TM helix 2rdd Escherichia coli Bact. gram-neg inner 6 39 26.5 ± 0.8 0 ± 1 -239.0
1.1.16.01. Proton Glutamate Symport Protein 2nwl Pyrococcus horikoshii Archaebac. 3 39 26.8 ± 0.9 0 ± 1 -251.0
1.1.17.01. Sodium/proton antiporter 1 (NhaA) 1zcd Escherichia coli Bact. gram-neg inner 1 14 27.5 ± 1.0 4 ± 2 -100.1
1.1.18.01. Leucine transporter LeuT 2a65 Aquifex aeolicus Bact. gram-neg inner 2 28 27.0 ± 0.9 0 ± 1 -170.9
1.1.18.02. Nucleobase-cation symporter-1 2jln Mycobacterium liquefaciens Bact. gram-neg inner 1 12 27.9 ± 1.3 20 ± 1 -114.1
1.1.18.03. Sodium/sugar symporter vSGLT 3dh4 Vibrio parahaemolyticus Bact. gram-neg inner 2 30 27.0 ± 1.2 0 ± 1 -204.4
1.1.18.04. Sodium-betaine symporter BetP 2w8a Corinebacterium glutamicum Bact. gram-neg inner 3 39 27.9 ± 0.8 0 ± 1 -246.7
1.1.18.05. Arginine/agmatine antiporter (AdiC) 3h5m Escherichia coli Bact. gram-neg inner 2 26 34.0 ± 1.4 0 ± 1 -157.3
1.1.18.05. ApcT transporter 3gia Methanococcus jannaschii Archaebac. 1 12 30.6 ± 2.0 15 ± 2 -108.8
1.1.18.05. Arginine/agmatine antiporter (AdiC) 3hqk Salmonella enterica Bact. gram-neg inner 2 26 26.9 ± 1.0 1 ± 2 -155.6
1.1.19.01. Ammonia Channel 1u7g Escherichia coli Bact. gram-neg inner 3 33 28.0 ± 1.0 0 ± 1 -164.4
1.1.19.01. Ammonium transporter Amt-1 2b2f Archaeoglobus fulgidus Archaebac. 3 33 27.5 ± 0.6 0 ± 1 -177.8
1.1.19.01. Rh-like protein 3b9w Nitrosomonas europaea Bact. gram-neg inner 3 24 29.0 ± 1.0 0 ± 1 -184.6
1.1.19.01. Rh-like protein 3b9y Nitrosomonas europaea Bact. gram-neg inner 3 33 29.0 ± 1.0 0 ± 1 -184.5
1.1.19.01. Rhesus Glycoprotein RhCG 3hd6 Homo sapiens Eukaryo. plasma 3 36 30.5 ± 1.1 0 ± 1 -189.3
1.1.21.01. Phospholamban 1zll Homo sapiens Endoplasm. reticulum 5 5 31.5 ± 1.2 0 ± 1 -91.1
1.1.21.01. Sarcolipin 1jdm Homo sapiens Endoplasm. reticulum 1 1 28.9 ± 1.8 1 ± 7 -32.1
1.1.21.02. Na,K-ATPase regulatory protein FXYD1 (phospholemman) 2jp3 Rattus norvegicus Endoplasm. reticulum 1 1 32.5 ± 1.0 11 ± 6 -31.2
1.1.21.02. Na,K-ATPase regulatory protein FXYD1 (phospholemman) 2jo1 Homo sapiens Endoplasm. reticulum 1 1 30.7 ± 2.8 8 ± 3 -34.8
1.1.22.01. Potassium channel KcsA, full-length, closed 3eff Streptomyces lividans Bact. gram-pos plas. 12 12 31.8 ± 1.4 0 ± 1 -126.3
1.1.22.01. Potassium channel, open state 3e86 Bacillus cereus Bact. gram-pos plas. 4 12 26.0 ± 1.2 0 ± 1 -101.3
1.1.22.01. Potassium channel KvAP, sensor domain 1ors Aeropyrum pernix Archaebac. 1 5 29.1 ± 2.8 24 ± 3 -65.8
1.1.22.01. Potassium channel Kv1.2. 2a79 Rattus norvegicus Eukaryo. plasma 4 28 26.3 ± 0.8 0 ± 1 -200.6
1.1.22.01. Potassium channel KvAP 1orq Aeropyrum pernix Archaebac. 4 12 26.0 ± 1.5 0 ± 2 -94.0
1.1.22.01. Potassium channel Kv1.2., structure in a membrane-like environment 2r9r Rattus norvegicus Eukaryo. plasma 4 28 28.5 ± 0.7 0 ± 1 -286.8
1.1.22.01. Potassium channel KcsA 1r3j Streptomyces lividans Bact. gram-pos plas. 4 12 33.1 ± 1.0 0 ± 2 -119.1
1.1.22.01. Potassium channel KvAP 2a0l Aeropyrum pernix Archaebac. 4 12 27.5 ± 1.1 0 ± 1 -141.4
1.1.22.01. Potassium channel KcsA 1s5h Streptomyces coelicolor Bact. gram-pos plas. 4 12 33.5 ± 1.1 0 ± 2 -125.0
1.1.22.01. Bacterial cyclic nucleotide regulated ion channel 3beh Rhizobium loti Bact. gram-neg inner 4 28 30.2 ± 1.0 0 ± 1 -240.7
1.1.22.01. Potassium channel, closed state 2ahy Bacillus cereus Bact. gram-pos plas. 4 12 29.2 ± 1.1 0 ± 1 -116.4
1.1.22.02. Potassium channel Kirbac3.1 1xl6 Magnetospirillum magnetotacticum Bact. gram-neg inner 4 12 28.3 ± 1.5 0 ± 2 -89.0
1.1.22.02. Potassium channel Kirbac1.1 1p7b Burkholderia pseudomallei Bact. gram-neg inner 4 12 32.0 ± 0.6 0 ± 1 -145.2
1.1.22.02. Kir3.1-prokaryotic Kir channel chimera 2qks Burkholderia xenovorans Bact. gram-neg inner 4 12 34.0 ± 1.8 0 ± 1 -101.2
1.1.23.01. Mechanosensitive channel MscL 2oar Mycobacterium tuberculosis Bact. gram-pos plas. 5 10 35.0 ± 1.2 0 ± 1 -157.5
1.1.24.01. Mechanosensitive channel protein MscS, open state 2vv5 Escherichia coli Bact. gram-neg inner 7 21 25.0 ± 0.5 0 ± 0 -162.9
1.1.24.01. Mechanosensitive channel protein MscS, expanded state 2oau Escherichia coli Bact. gram-neg inner 7 14 23.7 ± 0.8 2 ± 2 -181.6
1.1.25.01. CorA magnesium transporter 2bbj Thermotoga maritima Bact. gram-neg inner 5 10 29.1 ± 1.2 0 ± 2 -103.9
1.1.26.01. Acetylcholine receptor 2bg9 Torpedo marmorata Eukaryo. plasma 5 20 31.0 ± 1.6 3 ± 2 -158.0
1.1.26.02. Ligand gated ion channel, inactive conformation 2vl0 Erwinia chrysanthemi Bact. gram-neg inner 5 20 35.0 ± 0.8 0 ± 1 -156.4
1.1.26.02. Ligand gated ion channel, active conformation 3eam Gloeobacter violaceus Bact. gram-neg inner 5 20 32.5 ± 1.6 0 ± 1 -196.6
1.1.27.01. Aquaglyceroporin 3c02 Plasmodium falciparum Eukaryo. plasma 4 32 31.0 ± 1.6 0 ± 1 -155.3
1.1.27.01. Glycerol uptake facilitator 1ldf Escherichia coli Bact. gram-neg inner 4 32 26.6 ± 0.8 0 ± 0 -167.6
1.1.27.01. Aquaporin-4 2d57 Rattus norvegicus Eukaryo. plasma 4 32 29.8 ± 1.1 0 ± 1 -154.5
1.1.27.01. Aquaporin-0, open state 2b6p Bos taurus Eukaryo. plasma 4 32 28.3 ± 0.9 0 ± 1 -146.5
1.1.27.01. Aquaporin-5 3d9s Homo sapiens Eukaryo. plasma 4 32 29.5 ± 1.2 0 ± 1 -160.3
1.1.27.01. Aquaporin AQY1 2w2e Pichia pastoris Eukaryo. plasma 4 32 30.0 ± 0.9 0 ± 1 -148.2
1.1.27.01. Aquaporin-0 2b6o Ovis aries Eukaryo. plasma 4 32 30.5 ± 1.2 0 ± 1 -169.9
1.1.27.01. Aquaporin-1 1h6i Homo sapiens Eukaryo. plasma 4 32 25.0 ± 1.5 0 ± 1 -148.9
1.1.27.01. Aquaporin-1 1j4n Bos taurus Eukaryo. plasma 4 32 29.2 ± 1.2 0 ± 1 -150.9
1.1.27.01. Aquaporin Sopip2 1z98 Spinacia oleracea Eukaryo. plasma 4 32 27.5 ± 1.2 0 ± 1 -140.7
1.1.27.01. Aquaporin Aqpm 2f2b Methanobacterium thermoautotrophicum Archaebac. 4 32 24.0 ± 1.2 0 ± 1 -132.8
1.1.27.01. Aquaporin-0 1ymg Bos taurus Eukaryo. plasma 4 32 29.2 ± 0.9 0 ± 1 -155.3
1.1.27.01. Aquaporin Sopip2, open state 2b5f Spinacia oleracea Eukaryo. plasma 4 32 27.4 ± 1.0 1 ± 1 -144.0
1.1.27.01. Aquaporin-0 1sor Ovis aries Eukaryo. plasma 4 32 29.0 ± 1.0 0 ± 1 -153.8
1.1.27.01. Aquaporin-4 3gd8 Homo sapiens Eukaryo. plasma 4 32 27.9 ± 1.1 0 ± 1 -154.3
1.1.27.01. Aquaporin Z 1rc2 Escherichia coli Bact. gram-neg inner 4 32 27.5 ± 1.5 0 ± 2 -149.6
1.1.28.01. Clc chloride channel 1ots Escherichia coli Bact. gram-neg inner 2 28 23.4 ± 1.6 0 ± 4 -135.2
1.1.28.01. Clc chloride channel 1kpl Salmonella typhimurium Bact. gram-neg inner 2 28 22.7 ± 1.8 0 ± 4 -143.0
1.1.29.01. Steryl-sulfatase 1p49 Homo sapiens Endoplasm. reticulum 1 2 32.0 ± 2.8 20 ± 3 -44.1
1.1.30.01. Protease glpG 2nr9 Haemophilus influenzae Bact. gram-neg inner 1 6 22.6 ± 2.0 15 ± 3 -61.8
1.1.30.01. Protease glpG 2ic8 Escherichia coli Bact. gram-neg inner 1 6 28.4 ± 2.0 17 ± 5 -69.3
1.1.31.01. Zeta-zeta dimer of T cell receptor 2hac Homo sapiens Eukaryo. plasma 2 2 32.5 ± 2.0 4 ± 8 -40.3
1.1.32.01. Outer membrane lipoprotein Wza 2j58 Escherichia coli Bact. gram-neg outer 8 8 31.0 ± 1.0 0 ± 1 -127.9
1.1.33.01. Disulfide bond formation protein B 2zuq Escherichia coli Bact. gram-neg inner 1 4 25.9 ± 2.0 39 ± 5 -48.4
1.1.33.01. Disulfide bond formation protein B 2k74 Escherichia coli Bact. gram-neg inner 1 4 26.0 ± 1.8 26 ± 5 -56.7
1.1.33.01. DsbB - DsbA complex 2hi7 Escherichia coli Bact. gram-neg inner 1 4 23.8 ± 1.5 30 ± 3 -44.1
1.1.33.01. DsbB - DsbA complex 2zup Escherichia coli Bact. gram-neg inner 1 4 21.5 ± 3.2 23 ± 5 -24.4
1.1.34.01. Cytochrome c nitrite reductase complex 2j7a Desulfovibrio vulgaris Bact. gram-neg inner 2 2 32.6 ± 1.0 1 ± 3 -66.5
1.1.35.01. Stannin 1zza Homo sapiens Mitochon. outer 1 1 35.4 ± 2.2 23 ± 12 -27.6
1.1.36.01. Domain of glycophorin A 1afo Homo sapiens Eukaryo. plasma 2 2 31.3 ± 2.2 2 ± 10 -51.5
1.1.37.01. Major coat protein 1ifi Bacteriophage fd Secreted 15 15 30.0 ± 1.5 0 ± 1 -40.1
1.1.37.01. Major coat protein 1ifk Bacteriophage f1 Secreted 15 15 29.0 ± 1.2 0 ± 1 -64.1
1.1.37.02. Major coat protein 1ifp Bacteriophage pf3 Secreted 12 12 32.8 ± 0.2 10 ± 0 -107.0
1.1.37.02. Major coat protein 1hgz Bacteriophage ph75 Secreted 15 15 28.3 ± 0.9 11 ± 0 -55.7
1.1.38.01. Type IV pilin 2pil Neisseria gonorrhoeae Secreted 1 1 28.5 ± 3.5 26 ± 13 -33.1
1.1.39.01. Pulmonary surfactant-associated protein C 1spf Sus scrofa Secreted 1 1 32.8 ± 5.8 21 ± 7 -39.8
1.1.40.01. Lekotriene C4 synthase 2uuh Homo sapiens Endoplasm. reticulum 3 12 26.3 ± 1.2 0 ± 1 -58.2
1.1.40.01. Microsomal glutathione S-transferase 1 2h8a Rattus norvegicus Endoplasm. reticulum 3 12 29.5 ± 1.7 0 ± 1 -72.2
1.1.40.01. FLAP protein (5-lipoxygenase activator) 2q7r Homo sapiens Endoplasm. reticulum 3 12 22.5 ± 4.7 0 ± 2 -81.4
1.1.40.01. Microsomal prostaglandin E synthase 1 3dww Homo sapiens Endoplasm. reticulum 3 12 33.4 ± 1.8 1 ± 3 -113.3
1.1.41.01. Magnesium ion transporter-E (MgtE) 2yvx Thermus thermophilus Bact. gram-neg inner 2 10 32.0 ± 1.5 0 ± 2 -95.5
1.1.42.01. Acid-sensing ion channel 2qts Gallus gallus Eukaryo. plasma 3 6 37.5 ± 2.2 13 ± 2 -76.9
1.1.43.01. Ferrous-iron efflux pump fieF 2qfi Escherichia coli Bact. gram-neg inner 2 12 41.2 ± 2.5 0 ± 3 -36.3
1.1.43.01. Ferrous-iron efflux pump fieF 3h90 Escherichia coli Bact. gram-neg inner 2 12 30.0 ± 1.3 0 ± 3 -117.5
1.1.44.01. Site-2 protease (S2P) metalloprotease 3b4r Methanococcus jannaschii Archaebac. 1 6 26.4 ± 2.0 26 ± 4 -84.6
1.1.45.01. M2 transmembrane domain tetramer, open state, ligand-free 3bkd Influenza virus Viral 4 4 24.8 ± 1.4 1 ± 3 -69.3
1.1.45.01. M2 transmembrane domain tetramer, open state, complex with amantadine 3c9j Influenza virus Viral 4 4 25.0 ± 1.0 7 ± 4 -76.5
1.1.45.01. M2 transmembrane domain tetramer, closed state 2rlf Influenza virus Viral 4 4 31.4 ± 1.8 4 ± 7 -79.3
1.1.46.01. Receptor tyrosine kinase EphA1 2k1k Homo sapiens Eukaryo. plasma 2 2 28.4 ± 1.2 0 ± 3 -51.4
1.1.46.01. Receptor tyrosine kinase EphA2 2k9y Homo sapiens Eukaryo. plasma 2 2 36.5 ± 1.5 0 ± 5 -52.8
1.1.46.01. Transmembrane domain of growth factor receptor (EGF) ErbB2 2jwa Homo sapiens Eukaryo. plasma 2 2 33.5 ± 2.2 0 ± 5 -60.5
1.1.47.01. Polysulfide reductase 2vpz Thermus thermophilus Bact. gram-neg inner 2 16 27.3 ± 1.1 0 ± 1 -130.1
1.1.48.01. Anion-specific porin B 2vql Corinebacterium glutamicum Bact. gram-neg outer 1 0 6.2 ± 1.0 85 ± 3 -11.4
1.1.49.01. BNip3 transmembrane domain dimer 2ka1 Homo sapiens Mitochon. outer 2 2 34.0 ± 3.0 11 ± 11 -49.7
1.1.49.01. BNip3 transmembrane domain dimer 2j5d Homo sapiens Mitochon. outer 2 2 28.5 ± 2.0 11 ± 6 -42.4
1.1.50.01. Integrin alphaIIb-beta3 transmembrane complex 2k9j Homo sapiens Eukaryo. plasma 2 2 38.3 ± 2.2 6 ± 11 -71.7
1.1.51.01. Human CD4 2klu Homo sapiens Eukaryo. plasma 1 1 33.9 ± 3.8 12 ± 14 -34.9
1.1.52.01. Connexin 26 gap junction channel (beta-2 protein) 2zw3 Spodoptera frugiperda Eukaryo. plasma 6 24 32.5 ± 1.3 0 ± 1 -170.5
1.1.53.01. Diacylglycerol kinase (DAGK) 2kdc Escherichia coli Bact. gram-neg inner 3 9 33.5 ± 0.0 0 ± 1 -77.1
1.1.54.01. SNARE complex (syntaxin 1A, SNAP-25 and synaptobrevin 2) 3hd7 Rattus norvegicus Eukaryo. plasma 2 2 27.2 ± 2.0 2 ± 7 -41.9
1.1.55.01. Pore-forming haemolysin E (HlyE) 2wcd Escherichia coli Secreted 12 36 31.0 ± 0.5 0 ± 1 -203.1
1.1.56.01. ATP-gated P2X4 ion channel in the closed state 3h9v Danio rerio Eukaryo. plasma 3 6 25.5 ± 1.3 0 ± 2 -67.7
1.2.18.01. Lipid A deacylase LpxR 3fid Salmonella typhimurium Bact. gram-neg outer 1 12 27.4 ± 3.0 13 ± 6 -61.5