PDB ID or protein name

Beta-hairpin peptides superfamilies

3.2.01. Antimicrobial beta-hairpin (8 families)
3.2.02. Ksi and T conotoxins (2 families) 8.B.4 (TCDB)
3.2.03. Hepcidin (1 family) PF06446 (Pfam)
3.2.04. Cyclic trypsin inhibitor (1 family)
3.2.05. Macrocyclic bacteriocins (2 families)
3.2.06. Paralytic peptide (1 family) PF02425 (Pfam)
3.2.07. Tricyclic peptide RP71935 (1 family)
3.2.08. Amyloid beta-sheet peptides (2 families)
3.2.09. Octreotide (1 family)
See list of these PDB codes

Beta-hairpin peptides (35 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
3.2.01.01. Arenicin-2, dimer 2l8x Arenicola marina Secreted 2 0 2.7 ± 1.1 87 ± 4 -4.0
3.2.01.01. Arenicin-2 2jni Arenicola marina Secreted 1 0 2.1 ± 1.1 82 ± 15 -5.2
3.2.01.02. Thanatin 8tfv Podisus maculiventris Secreted 1 0 3.7 ± 1.0 81 ± 4 -5.3
3.2.01.03. Androctonin 1cz6 Androctonus australis (Sahara scorpion) Secreted 1 0 1.5 ± 2.8 89 ± 16 -3.2
3.2.01.04. Gomesin 1kfp Acanthoscurria gomesiana (Tarantula spider) Secreted 1 0 0.5 ± 1.0 75 ± 6 -2.7
3.2.01.05. Polyphemusin-1 1rkk Limulus polyphemus (Atlantic horseshoe crab) Secreted 1 0 3.5 ± 3.7 63 ± 11 -4.0
3.2.01.05. Tachyplesin-1 1wo1 Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 1.6 ± 1.3 90 ± 6 -4.5
3.2.01.06. Retrocyclin-2 2atg Macaca mulatta Secreted 1 0 2.4 ± 0.6 87 ± 9 -5.6
3.2.01.06. Theta-defensin 1 (RTD-1) 1hvz Macaca mulatta Secreted 1 0 0.8 ± 1.0 89 ± 4 -2.9
3.2.01.07. Protegrin-1 1pg1 Sus scrofa Secreted 1 0 2.2 ± 0.4 72 ± 4 -4.2
3.2.01.08. Lactoferricin B, peptide 36-60 1lfc Bos taurus Secreted 1 0 4.6 ± 0.5 90 ± 6 -5.3
3.2.01.08. Lactoferricin B, peptide 38-49 1y58 Bos taurus Secreted 1 0 2.9 ± 1.4 86 ± 18 -3.7
3.2.02.01. T-2-conotoxin MrIA 2ew4 Conus marmoreus Secreted 1 0 2.5 ± 1.5 81 ± 19 -3.0
3.2.02.02. Chi-conotoxin MrIB 1ieo Conus marmoreus Secreted 1 0 2.2 ± 1.1 45 ± 12 -1.9
3.2.03.01. Hepcidin 1m4e Homo sapiens Secreted 1 0 2.4 ± 1.5 89 ± 19 -4.2
3.2.03.01. Maurocalcine 1s6w Scorpio maurus Secreted 1 0 1.8 ± 1.6 89 ± 21 -2.3
3.2.04.01. Cyclic trypsin inhibitor STFI-1 1o8y Helianthus annuus Secreted 1 0 3.4 ± 1.3 83 ± 18 -6.0
3.2.05.01. Microcin J25, peptide 38-58 1q71 Escherichia coli Secreted 1 0 3.3 ± 3.2 75 ± 17 -5.2
3.2.05.01. Microcin J25, peptide 38-58, cleaved after 47 1s7p Escherichia coli Secreted 1 0 4.7 ± 1.2 83 ± 18 -5.7
3.2.05.02. Subtilosin A 1pxq Bacillus subtilis Secreted 1 0 7.6 ± 0.8 86 ± 3 -9.3
3.2.06.01. Plasmatocyte-spreading peptide PSP1 1b5n Pseudoplusia includens Secreted 1 0 3.1 ± 1.2 87 ± 16 -3.7
3.2.06.01. Paralytic peptide 1 1hrl Manduca sexta Secreted 1 0 6.5 ± 0.6 51 ± 6 -6.2
3.2.06.01. Paralytic peptide 1irr Bombyx mori Secreted 1 0 2.2 ± 1.9 74 ± 19 -3.3
3.2.06.01. Paralytic peptide 2 1v28 Manduca sexta Secreted 1 0 2.9 ± 1.4 90 ± 16 -4.9
3.2.06.01. Growth-blocking peptide 2djc Spodoptera litura Secreted 1 0 2.9 ± 2.0 19 ± 14 -3.1
3.2.06.01. Growth-blocking peptide, long form 2eqt Pseudaletia separata (Oriental armyworm) Secreted 1 0 4.1 ± 1.4 59 ± 8 -5.7
3.2.07.01. Siamycin II (tricyclic peptide RP71935) 1rpb Streptomyces sp. Secreted 1 0 4.2 ± 1.3 85 ± 15 -8.3
3.2.08.01. Peptide 35-42, alternate polymorph II 2y3l Homo sapiens Secreted 4 0 2.7 ± 1.4 78 ± 8 -6.0
3.2.08.01. Peptide KLVFFA from amyloid beta, alternate polymorph II 3ow9 Homo sapiens Secreted 12 0 4.1 ± 1.4 88 ± 7 -12.8
3.2.08.01. Amyloid beta A4 protein, peptide 672-711 2lnq Homo sapiens Eukaryo. plasma 8 0 6.3 ± 2.0 88 ± 0 -15.5
3.2.08.01. Peptide 30-35 2y3j Homo sapiens Secreted 4 0 4.0 ± 1.4 86 ± 6 -6.2
3.2.08.01. Peptide 35-42, alternate polymorph I 2y3k Homo sapiens Secreted 2 0 3.4 ± 1.4 89 ± 4 -7.2
3.2.08.02. Major prion protein, peptide 138-143 3nve Mesocricetus auratus (Golden hamster) Eukaryo. plasma 12 0 3.6 ± 0.4 89 ± 3 -9.8
3.2.08.02. Major prion protein, peptide 138-143 3nvf Homo sapiens Eukaryo. plasma 10 0 6.9 ± 0.2 83 ± 2 -9.8
3.2.09.01. Octreotide 1soc Designed proteins Undefined 1 0 8.9 ± 1.8 77 ± 21 -7.7