PDB ID or protein name

Alpha/Beta monotopic/peripheral superfamilies

2.3.01. Transglycosidases (10 families) CL0058 (Pfam)
2.3.02. PLC-like phosphodiesterases (2 families) CL0384 (Pfam)
2.3.03. FMN-linked oxidoreductases (1 family) PF01180 (Pfam)
2.3.04. Amidohydrolase superfamily (1 family) CL0034 (Pfam)
2.3.05. FAD/NAD(P)-binding domain (6 families) CL0063 (Pfam)
2.3.06. Alpha/beta-hydrolases (15 families) CL0028 (Pfam)
2.3.07. Peptidase clan MH/MC/MF (1 family) CL0035 (Pfam)
2.3.08. FabD/lysophospholipase-like (1 family) CL0323 (Pfam)
2.3.09. Flavokinase-like nucleotidyl transferase (1 family) CL0119 (Pfam)
2.3.10. UDP-Glycosyltransferase/glycogen phosphorylase (5 families) CL0113 (Pfam)
2.3.11. Chelatase (1 family) CL0043 (Pfam)
2.3.12. Phosphotyrosine protein phosphatases II (1 family)
2.3.13. Thioredoxin-like (7 families) CL0172 (Pfam)
2.3.14. CRAL/TRIO domain (2 families) PF00650 (Pfam)
2.3.15. HIGH-signature proteins, UspA, and PP-ATPase (2 families) CL0039 (Pfam)
2.3.16. P-loop containing nucleoside triphosphate hydrolases (10 families) CL0023 (Pfam)
2.3.17. Common phosphate binding-site TIM barrel superfamily (2 families) CL0036 (Pfam)
2.3.18. CoA-dependent acyltransferases (2 families) CL0149 (Pfam)
2.3.19. Nucleotide-diphospho-sugar transferases (3 families) CL0110 (Pfam)
2.3.20. CheY-like (1 family) PF01058 (Pfam)
2.3.21. Phosphatase (1 family) CL0031 (Pfam)
2.3.22. Flavoprotein (2 families) CL0042 (Pfam)
2.3.23. Thiolase-like superfamily (1 family) CL0046 (Pfam)
2.3.24. Haloacid dehalogenase-like hydrolase superfamily (2 families) CL0137 (Pfam)
2.3.25. SGNH hydrolase superfamily (1 family) CL0264 (Pfam)
2.3.26. Isocitrate/Isopropylmalate dehydrogenase-like superfamily (1 family) CL0270 (Pfam)
2.3.27. Dihydrofolate reductase-like (1 family) CL0387 (Pfam)
2.3.28. NAD(P)-linked oxidoreductase (1 family)
2.3.29. Putative undecaprenyl diphosphate synthase (1 family) PF01255 (Pfam)
2.3.30. Low molecular weight phosphotyrosine protein phosphatase (1 family) PF01451 (Pfam)
2.3.31. PTS system sorbose subfamily IIB component (1 family) PF03830 (Pfam)
2.3.32. MurD-like peptide ligases (1 family) PF08245 (Pfam)
2.3.33. Glycosyl hydrolase family 85 (1 family) PF03644 (Pfam)
See list of these PDB codes

Alpha/Beta monotopic/peripheral (239 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
1.2.22.01. Fatty acid amide hydrolase 1mt5 Rattus norvegicus Endoplasm. reticulum 2 0 11.1 ± 0.2 89 ± 0 -21.9
2.2.29.01. Multivesicular body subunit 12B 3tow Homo sapiens Endosome 1 0 4.5 ± 2.3 33 ± 22 -5.8
2.3.01.01. Glucosylceramidase 1ogs Homo sapiens Lysosome 1 0 4.2 ± 1.1 89 ± 4 -9.0
2.3.01.01. Glucosylceramidase 2vt0 Pan troglodytes Lysosome 1 0 2.3 ± 1.0 86 ± 5 -7.3
2.3.01.02. Beta-glycosidase 1vff Pyrococcus horikoshii Archaebac. 1 0 3.9 ± 1.6 39 ± 10 -9.7
2.3.01.02. Dhurrinase 1v02 Sorghum bicolor Secreted 2 0 2.4 ± 0.5 89 ± 9 -5.1
2.3.01.02. Beta-glucosidase 6 3gnr Oryza sativa (Rice) Secreted 1 0 4.8 ± 0.2 80 ± 1 -12.4
2.3.01.03. Alpha-amylase A 1wza Halothermothrix orenii Secreted 1 0 1.6 ± 0.4 80 ± 1 -6.7
2.3.01.04. Hyaluronidase 1fcq Apis mellifera Secreted 1 0 1.9 ± 2.7 36 ± 13 -3.7
2.3.01.05. 1,3-beta-glucanosyltransferase GAS2, different conformation 2w62 Saccharomyces cerevisiae Eukaryo. plasma 1 0 2.7 ± 0.5 90 ± 1 -6.1
2.3.01.05. 1,3-beta-glucanosyltransferase GAS2 2w61 Saccharomyces cerevisiae Eukaryo. plasma 1 0 2.4 ± 2.3 60 ± 7 -5.4
2.3.01.06. Endoglycoceramidase II 2osx Rhodococcus sp. Secreted 1 0 7.9 ± 0.4 68 ± 1 -13.4
2.3.01.07. Chitinase A 1nh6 Serratia marcescens Secreted 1 0 2.7 ± 1.3 80 ± 5 -6.1
2.3.01.07. Chitinase B 1h0i Serratia marcescens Secreted 1 0 3.8 ± 1.4 70 ± 12 -5.2
2.3.01.08. Endoglucanase H 2vi0 Clostridium thermocellum Bact. Gram-pos plas. 1 0 1.5 ± 1.3 36 ± 9 -3.8
2.3.01.09. Arabinogalactan endo-1,4-beta-galactosidase 1hjq Humicola insolens (Soft-rot fungus) Secreted 1 0 1.8 ± 1.4 86 ± 7 -3.7
2.3.01.10. Galactocerebrosidase 3zr5 Mus musculus Lysosome 1 0 5.2 ± 0.6 87 ± 1 -15.3
2.3.02.01. Phospholipase C-beta isoform 3, complex with G-protein subunit alpha Q 3ohm Homo sapiens Eukaryo. plasma 2 0 7.5 ± 2.0 39 ± 5 -6.9
2.3.02.01. Phospholipase C-beta isoform 2 2zkm Homo sapiens Eukaryo. plasma 1 0 2.2 ± 2.9 38 ± 12 -3.6
2.3.02.01. Phospholipase C-delta isoform 1 1djx Rattus norvegicus Eukaryo. plasma 1 0 4.1 ± 0.9 68 ± 5 -7.2
2.3.02.02. Phosphatidylinositol-specific phospholipase C 1gym Bacillus cereus Secreted 1 0 4.9 ± 1.0 67 ± 11 -7.2
2.3.02.02. Phosphatidylinositol-specific phospholipase C 1aod Listeria monocytogenes Secreted 1 0 7.4 ± 1.0 79 ± 10 -9.2
2.3.02.02. Phosphatidylinositol-specific phospholipase C 1t6m Bacillus thuringiensis Secreted 1 0 3.8 ± 1.4 89 ± 13 -4.9
2.3.02.02. Phosphatidylinositol-specific phospholipase C 4f2t Staphylococcus aureus Secreted 1 0 4.3 ± 0.5 65 ± 5 -7.8
2.3.03.01. Dihydroorotate dehydrogenase 1d3h Homo sapiens Mitochon. inner 1 0 3.4 ± 0.8 55 ± 6 -10.1
2.3.03.01. Dihydroorotate dehydrogenase 1f76 Escherichia coli Bact. Gram-neg inner 1 0 3.7 ± 0.8 24 ± 8 -8.7
2.3.03.01. Dihydroorotate dehydrogenase 1uum Rattus norvegicus Mitochon. inner 1 0 6.9 ± 0.4 50 ± 6 -6.3
2.3.03.01. Glycolate oxidase 1gox Spinacia oleracea Peroxisome 4 0 4.1 ± 0.0 90 ± 0 -18.5
2.3.03.01. Dihydroorotate dehydrogenase 3i65 Plasmodium falciparum Mitochon. inner 1 0 5.1 ± 1.0 47 ± 6 -13.6
2.3.04.01. Tyrosine-protein phosphatase CpsB 2wje Streptococcus pneumoniae Bact. Gram-pos plas. 1 0 4.2 ± 2.8 76 ± 26 -4.6
2.3.05.01. Flavoprotein-ubiquinone oxydoreductase 2gmh Sus scrofa Mitochon. inner 1 0 7.2 ± 0.8 38 ± 4 -18.5
2.3.05.02. Sulfide-quinone reductase 3sx6 Acidithiobacillus ferrooxidans Bact. Gram-neg inner 1 0 10.6 ± 0.6 70 ± 8 -7.3
2.3.05.02. Rotenone-insensitive NADH-ubiquinone oxidoreductase, NDI1 4g6h Saccharomyces cerevisiae Mitochon. inner 2 0 4.8 ± 0.0 88 ± 1 -13.9
2.3.05.02. Sulfide-quinone reductase 3h28 Aquifex aeolicus Bact. Gram-neg inner 3 0 2.4 ± 0.1 90 ± 0 -19.4
2.3.05.02. Adrenodoxin reductase of mitochondrial p450 systems, complex with adrenodoxin 1e6e Bos taurus Mitochon. inner 2 0 2.3 ± 1.0 11 ± 2 -4.1
2.3.05.03. Glycerol-3-phosphate dehydrogenase (GlpD) 2qcu Escherichia coli Bact. Gram-neg inner 1 0 4.5 ± 1.5 74 ± 11 -8.4
2.3.05.03. D-amino-acid oxidase 1ve9 Sus scrofa Peroxisome 2 0 1.9 ± 2.5 88 ± 4 -4.8
2.3.05.04. Reticulon-4-interacting protein 1 2vn8 Homo sapiens Mitochon. inner 1 0 4.0 ± 0.0 82 ± 0 -10.2
2.3.05.05. RabGDI protein 3p1w Plasmodium falciparum Eukaryo. plasma 1 0 6.6 ± 1.4 47 ± 3 -6.8
2.3.05.05. Secretory pathway GDP dissociation inhibitor 2bcg Saccharomyces cerevisiae Endoplasm. reticulum 2 0 3.5 ± 1.0 70 ± 6 -8.5
2.3.05.06. Endothelin-converting enzyme 2 2pxx Homo sapiens Golgi 1 0 7.1 ± 1.3 37 ± 8 -8.4
2.3.06.01. Acetylcholinesterase 1ea5 Torpedo californica Eukaryo. plasma 1 0 1.8 ± 1.1 34 ± 5 -4.7
2.3.06.01. Bile-salt activated lipase, conformation 1 1aql Bos taurus Secreted 1 0 5.7 ± 1.1 78 ± 7 -9.6
2.3.06.01. Acetylcholinesterase 1n5m Mus musculus Eukaryo. plasma 1 0 3.7 ± 1.3 28 ± 6 -6.1
2.3.06.01. Neuroligin-1, complex with neurexin-1-beta 3biw Rattus norvegicus Eukaryo. plasma 2 0 5.9 ± 1.0 80 ± 3 -8.8
2.3.06.01. Bile-salt activated lipase, structure 1 1f6w Homo sapiens Secreted 1 0 1.8 ± 0.5 81 ± 10 -5.1
2.3.06.01. Acetylcholinesterase, complex with fasciculin-2 1f8u Homo sapiens Eukaryo. plasma 2 0 2.6 ± 1.0 60 ± 9 -7.3
2.3.06.01. Neuroligin-2 3bl8 Mus musculus Eukaryo. plasma 1 0 1.7 ± 1.6 32 ± 5 -4.1
2.3.06.01. Bile-salt activated lipase, structure 2 1jmy Homo sapiens Secreted 1 0 5.0 ± 1.4 85 ± 9 -5.3
2.3.06.01. Bile-salt activated lipase, conformation 2 1akn Bos taurus Secreted 1 0 3.8 ± 1.5 77 ± 15 -6.7
2.3.06.01. Butyryl cholinesterase 1p0i Homo sapiens Eukaryo. plasma 1 0 3.1 ± 0.8 43 ± 10 -6.4
2.3.06.01. Neuroligin-1, complex with human neurexin-1-alpha 3b3q Mus musculus Eukaryo. plasma 2 0 1.8 ± 1.0 81 ± 1 -3.6
2.3.06.01. Neuroligin-4, X-linked, complex with neurexin 1-beta 2xb6 Homo sapiens Eukaryo. plasma 2 0 1.9 ± 3.0 84 ± 11 -3.3
2.3.06.01. Acetylcholinesterase 1qon Drosophila melanogaster Eukaryo. plasma 1 0 5.5 ± 1.6 4 ± 13 -5.0
2.3.06.01. Acetylcholinesterase 4ey4 Homo sapiens Eukaryo. plasma 1 0 3.2 ± 0.5 33 ± 2 -8.4
2.3.06.01. Bile-salt activated lipase, conformation 3 2bce Bos taurus Secreted 1 0 5.3 ± 0.8 74 ± 6 -7.0
2.3.06.02. MPT51/MPB51 antigen 1r88 Mycobacterium tuberculosis Bact. Gram-pos cell wall 1 0 1.8 ± 1.0 28 ± 26 -3.9
2.3.06.02. Antigen 85b 1f0n Mycobacterium tuberculosis Bact. Gram-pos cell wall 1 0 3.7 ± 0.9 33 ± 7 -7.4
2.3.06.02. Antigen 85c 1va5 Mycobacterium tuberculosis Bact. Gram-pos cell wall 1 0 4.2 ± 0.2 34 ± 3 -8.2
2.3.06.02. Antigen 85a 1sfr Mycobacterium tuberculosis Bact. Gram-pos cell wall 1 0 2.8 ± 0.8 27 ± 9 -7.5
2.3.06.03. Gastric lipase, closed state 1hlg Homo sapiens Secreted 1 0 3.2 ± 1.4 6 ± 12 -5.6
2.3.06.03. Gastric lipase, open (active) state 1k8q Canis lupus familiaris Secreted 1 0 7.2 ± 0.5 78 ± 6 -12.6
2.3.06.04. Palmitoyl protein thioesterase 1 1eh5 Bos taurus Lysosome 1 0 5.3 ± 0.9 59 ± 6 -8.1
2.3.06.04. Acyl transferase LuxD 1tht Vibrio harveyi Bact. Gram-neg inner 1 0 3.3 ± 1.3 85 ± 4 -6.1
2.3.06.04. Palmitoyl protein thioesterase 2 1pja Homo sapiens Lysosome 1 0 3.7 ± 1.6 60 ± 15 -4.6
2.3.06.04. Palmitoyl-protein thioesterase 1 3gro Homo sapiens Lysosome 1 0 3.6 ± 0.1 55 ± 3 -6.8
2.3.06.05. Carboxylesterase 2 1auo Pseudomonas fluorescens Bact. Gram-neg inner 1 0 1.7 ± 3.0 33 ± 21 -3.4
2.3.06.05. Carboxylesterase 3cn9 Pseudomonas aeruginosa Bact. Gram-neg inner 1 0 3.5 ± 2.1 11 ± 32 -4.1
2.3.06.05. Thermostable Esterase 3doh Thermotoga maritima Bact. Gram-neg inner 1 0 4.0 ± 2.0 84 ± 13 -4.4
2.3.06.05. Copper inducible hydrolase YahD 3og9 Lactococcus lactis Bact. Gram-pos plas. 1 0 1.4 ± 1.1 33 ± 10 -4.0
2.3.06.05. Acyl-protein thioesterase 1 1fj2 Homo sapiens Eukaryo. plasma 1 0 9.6 ± 2.0 64 ± 14 -4.7
2.3.06.05. Carboxylesterase 2h1i Bacillus cereus Bact. Gram-pos plas. 1 0 2.3 ± 1.8 32 ± 31 -3.6
2.3.06.06. Lipase B, circular permutation 3icv Candida antarctica Secreted 2 0 8.3 ± 0.8 83 ± 7 -11.3
2.3.06.06. Triacylglycerol lipase, open (active) state 1ein Humicola lanuginosa Secreted 1 0 8.1 ± 0.8 63 ± 4 -14.5
2.3.06.06. Triacylglycerol lipase 1lgy Rhizopus niveus Secreted 1 0 1.9 ± 1.8 33 ± 16 -4.8
2.3.06.06. Triacylglycerol lipase, closed (inactive) state 1dt5 Humicola lanuginosa Secreted 1 0 5.1 ± 0.9 79 ± 13 -5.9
2.3.06.06. Lipase 1, open (active) state 1lpp Candida rugosa Secreted 1 0 10.0 ± 0.4 83 ± 1 -28.0
2.3.06.06. Triacylglycerol lipase 3g7n Penicillium expansum Secreted 1 0 3.8 ± 1.1 81 ± 14 -9.0
2.3.06.06. Lipase 2 1gz7 Candida rugosa Secreted 1 0 4.8 ± 1.3 87 ± 10 -8.5
2.3.06.06. Lipase 1, closed (inactive) state 1trh Candida rugosa Secreted 1 0 4.9 ± 1.3 85 ± 7 -7.4
2.3.06.06. Lipase LipA 2qua Serratia marcescens Secreted 1 0 8.9 ± 0.2 59 ± 0 -37.5
2.3.06.06. Lipase 2 3o0d Yarrowia lipolytica Secreted 1 0 6.8 ± 2.4 79 ± 26 -9.4
2.3.06.06. Type-B carboxylesterase/lipase 1cle Candida cylindracea Secreted 1 0 10.2 ± 0.0 83 ± 0 -24.7
2.3.06.06. Lipase B, open state 1lbs Candida antarctica Secreted 1 0 3.7 ± 1.0 76 ± 6 -12.7
2.3.06.06. Lipase 2ory Photbacterium lipolyticum Secreted 1 0 6.3 ± 1.1 62 ± 10 -12.0
2.3.06.06. Triacylglycerol lipase, closed (inactive) state 3tgl Rhizomucor miehei Secreted 1 0 2.7 ± 1.1 39 ± 7 -5.8
2.3.06.06. Lipase 2 1thg Geotrichum candidum Secreted 1 0 6.4 ± 1.7 23 ± 14 -4.7
2.3.06.06. Triacylglycerol lipase, open (active) state 4tgl Rhizomucor miehei Secreted 1 0 8.8 ± 0.9 64 ± 11 -18.2
2.3.06.07. Lipase, open (active) state 1ex9 Pseudomonas aeruginosa Secreted 1 0 11.0 ± 1.0 52 ± 5 -30.0
2.3.06.07. Tentative lipase 2zyr Archaeoglobus fulgidus Secreted 1 0 3.0 ± 1.0 57 ± 8 -7.5
2.3.06.07. Lipase 1cvl Pseudomonas glumae Secreted 1 0 9.9 ± 1.0 53 ± 9 -8.7
2.3.06.07. Lipase L1 1ku0 Bacillus stearothermophilus Secreted 1 0 4.0 ± 0.6 23 ± 9 -8.9
2.3.06.07. Lipase L1, different isoform 1ji3 Bacillus stearothermophilus Secreted 1 0 3.5 ± 1.7 22 ± 10 -8.0
2.3.06.07. Thermostable lipase 2dsn Geobacillus zalihae Secreted 1 0 4.9 ± 0.9 32 ± 3 -7.7
2.3.06.07. Triacylglycerol lipase 2w22 Geobacillus thermocatenulatus Secreted 1 0 5.6 ± 0.0 86 ± 0 -22.4
2.3.06.07. Lipase, complex with foldase 2es4 Pseudomonas glumae Secreted 2 0 8.5 ± 0.0 65 ± 2 -7.2
2.3.06.07. Lipase A 1isp Bacillus subtilis Secreted 1 0 1.9 ± 0.8 59 ± 12 -5.2
2.3.06.07. PHB depolymerase PhaZ7 2x5x Pseudomonas lemoignei Secreted 1 0 4.1 ± 3.0 54 ± 41 -5.6
2.3.06.07. Lipase 1qge Pseudomonas glumae Secreted 1 0 3.7 ± 0.9 24 ± 3 -7.7
2.3.06.07. Lipase 5lip Burkholderia cepacia Secreted 1 0 9.0 ± 1.0 46 ± 2 -30.6
2.3.06.07. Lipase 2z8x Pseudomonas sp. MIS 38 Secreted 1 0 6.8 ± 1.7 74 ± 6 -8.2
2.3.06.08. Pancreatic lipase-related protein 2 1w52 Equus caballus Secreted 1 0 4.8 ± 0.2 83 ± 0 -12.7
2.3.06.08. Pancreatic lipase-related protein 1 2ppl Homo sapiens Secreted 1 0 7.1 ± 0.9 79 ± 6 -10.2
2.3.06.08. Pancreatic lipase 1hpl Equus caballus Secreted 1 0 3.8 ± 0.3 80 ± 5 -8.1
2.3.06.08. Pancreatic lipase 1gpl Cavia porcellus Secreted 1 0 5.8 ± 1.0 86 ± 9 -7.8
2.3.06.08. Pancreatic lipase 1bu8 Rattus norvegicus Secreted 1 0 3.5 ± 1.3 87 ± 10 -6.1
2.3.06.08. Pancreatic lipase, complex with colipase from Pig 1n8s Homo sapiens Secreted 2 0 7.6 ± 0.6 45 ± 4 -10.8
2.3.06.08. Pancreatic lipase-related protein 2 2oxe Homo sapiens Secreted 1 0 10.2 ± 1.1 88 ± 8 -10.1
2.3.06.08. Pancreatic lipase, complex with colipase from Pig 1lpb Homo sapiens Secreted 2 0 9.2 ± 0.4 89 ± 2 -24.2
2.3.06.08. Pancreatic lipase, complex with colipase from Pig 1lpa Homo sapiens Secreted 2 0 11.3 ± 0.1 82 ± 1 -24.5
2.3.06.08. Pancreatic lipase-related protein 1 1rp1 Canis lupus familiaris Secreted 1 0 6.3 ± 1.0 79 ± 4 -7.5
2.3.06.08. Pancreatic lipase, complex with colipase 1eth Sus scrofa Secreted 2 0 13.6 ± 0.2 90 ± 3 -13.3
2.3.06.09. Cutinase 1 3gbs Aspergillus oryzae Secreted 1 0 11.2 ± 0.5 55 ± 5 -12.6
2.3.06.09. Cutinase 1 3dcn Colletotrichum gloeosporioides Secreted 1 0 5.7 ± 1.2 44 ± 8 -10.1
2.3.06.09. Cutinase-like protein 2czq Cryptococcus sp. Secreted 1 0 4.9 ± 1.3 54 ± 16 -9.0
2.3.06.09. Lysin B from mycobacteriophage 3hc7 Mycobacterium phage D29 Bact. Gram-pos plas. 1 0 6.6 ± 2.0 50 ± 12 -7.0
2.3.06.09. Cutinase 1 1oxm Fusarium solani Secreted 1 0 6.8 ± 1.1 36 ± 15 -9.1
2.3.06.09. Mycobacterial lipase 3aja Mycobacterium smegmatis Secreted 1 0 6.0 ± 1.0 28 ± 10 -6.7
2.3.06.10. Lipase 1jfr Streptomyces exfoliatus Secreted 1 0 5.0 ± 1.3 60 ± 10 -6.4
2.3.06.10. Lipase 2fx5 Pseudomonas mendocina Secreted 1 0 5.5 ± 1.0 50 ± 5 -8.4
2.3.06.10. vitellogenin 3d59 Dendroaspis polylepis polylepis (Black mamba) Endosome 1 0 5.5 ± 1.2 87 ± 10 -13.6
2.3.06.11. Monoglyceride lipase MGLL, closed ligand-bound conformation 3pe6 Homo sapiens Eukaryo. plasma 1 0 0.9 ± 3.0 54 ± 28 -2.7
2.3.06.11. Monoglyceride lipase MGLL, open ligand-free conformation 3jw8 Homo sapiens Eukaryo. plasma 1 0 8.1 ± 1.3 11 ± 9 -11.3
2.3.06.12. Esterase LipW 3qh4 Mycobacterium marinum Bact. Gram-pos plas. 1 0 2.4 ± 1.2 76 ± 32 -5.0
2.3.06.12. Carboxylesterase (EstA) 1jji Archaeoglobus fulgidus Archaebac. 1 0 2.8 ± 1.0 56 ± 22 -4.8
2.3.06.12. Gibberellin receptor GID1 3ebl Oryza sativa (Rice) Nuclear inner 1 0 5.2 ± 1.5 59 ± 14 -9.1
2.3.06.12. Gibberellin receptor GID1A 2zsh Arabidopsis thaliana Nuclear inner 1 0 2.6 ± 1.2 89 ± 6 -5.0
2.3.06.12. Heroin esterase 1lzk Rhodococcus sp. Bact. Gram-pos plas. 1 0 1.5 ± 1.5 69 ± 9 -4.0
2.3.06.12. Carboxylesterase 2hm7 Alicyclobacillus acidocaldarius Bact. Gram-pos plas. 1 0 5.8 ± 1.7 70 ± 5 -7.7
2.3.06.13. Protein Ndr1 2xmr Homo sapiens Eukaryo. plasma 1 0 8.2 ± 2.6 50 ± 10 -8.8
2.3.06.13. Protein NDRG2 2qmq Mus musculus Eukaryo. plasma 1 0 8.3 ± 2.2 43 ± 14 -9.6
2.3.06.14. Esterase LipA 3h2g Xanthomonas oryzae Secreted 1 0 5.1 ± 1.7 87 ± 8 -4.9
2.3.06.14. Lipase A, closed state 3guu Candida antarctica Secreted 1 0 4.4 ± 1.0 80 ± 2 -10.9
2.3.06.15. Polyneuridine-aldehyde esterase 2wfm Rauvolfia serpentina (Serpentwood) Endoplasm. reticulum 1 0 2.5 ± 1.7 88 ± 3 -4.6
2.3.07.01. Endoglucanase 1vho Thermotoga maritima Undefined 1 0 5.4 ± 0.2 89 ± 1 -7.0
2.3.08.01. Cytosolic phospholipase A2, group IVA 1cjy Homo sapiens Nuclear outer 1 0 5.8 ± 1.0 70 ± 9 -9.9
2.3.08.01. Patatin 1oxw Solanum cardiophyllum Secreted 1 0 3.9 ± 2.0 28 ± 11 -6.5
2.3.09.01. Cytidylyltransferase, second membrane-anchoring helix 1pei Rattus norvegicus Eukaryo. plasma 1 0 4.9 ± 1.0 83 ± 11 -8.2
2.3.09.01. Cytidylyltransferase 3hl4 Rattus norvegicus Eukaryo. plasma 2 0 2.7 ± 4.0 74 ± 8 -3.2
2.3.09.01. Cytidylyltransferase, first membrane-anchoring helix 1peh Rattus norvegicus Eukaryo. plasma 1 0 3.2 ± 0.6 90 ± 2 -5.0
2.3.10.01. Glycosyltransferase GtfA 1pn3 Amycolatopsis orientalis (Nocardia orientalis) Undefined 1 0 7.2 ± 1.0 80 ± 5 -7.7
2.3.10.01. Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase 3s2u Pseudomonas aeruginosa Bact. Gram-neg inner 1 0 6.8 ± 0.9 60 ± 2 -8.3
2.3.10.01. Peptidoglycan biosynthesis glycosyltransferase MurG 1f0k Escherichia coli Bact. Gram-neg inner 1 0 5.3 ± 1.2 55 ± 7 -8.6
2.3.10.01. Peptidoglycan biosynthesis glycosyltransferase MurG 1nlm Escherichia coli Bact. Gram-neg inner 1 0 4.8 ± 1.1 50 ± 7 -7.5
2.3.10.02. Beta-1,2-glucuronosyltrnansferase GumK 2q6v Xanthomonas campestris Bact. Gram-neg inner 1 0 5.2 ± 1.0 61 ± 8 -9.5
2.3.10.03. Heptosyltransferase WaaC 2h1h Escherichia coli Bact. Gram-neg inner 1 0 5.0 ± 1.1 67 ± 5 -9.1
2.3.10.03. LPS heptosyltransferase II 1psw Escherichia coli Bact. Gram-neg inner 1 0 3.1 ± 1.1 58 ± 8 -5.6
2.3.10.04. Teichoic acid biosynthesis protein F 3l7l Staphylococcus epidermidis Bact. Gram-pos plas. 1 0 6.9 ± 2.0 35 ± 15 -10.8
2.3.10.05. 3-Deoxy-D-manno-octulosonic-acid transferase, WaaA 2xci Aquifex aeolicus Bact. Gram-neg outer 1 0 8.3 ± 1.5 72 ± 1 -20.3
2.3.11.01. Ferrochelatase 1hrk Homo sapiens Mitochon. inner 2 0 2.7 ± 0.1 90 ± 0 -9.9
2.3.11.01. Ferrochelatase, mitochondrial 1lbq Saccharomyces cerevisiae Mitochon. inner 2 0 5.3 ± 0.5 90 ± 3 -6.9
2.3.12.01. Myotubularin-related protein 2 1zvr Homo sapiens Eukaryo. plasma 1 0 3.1 ± 0.4 89 ± 8 -5.0
2.3.13.01. Microsomal prostaglandin E synthase 2 1z9h Macaca fascicularis Golgi 2 0 4.8 ± 0.5 90 ± 4 -15.7
2.3.13.02. Phosducin/Transducin beta-gamma complex, conformation 1 1a0r Bos taurus Eukaryo. plasma 3 0 2.3 ± 1.0 50 ± 4 -7.4
2.3.13.02. Phosducin/Transducin beta-gamma complex, conformation 2 2trc Rattus norvegicus Eukaryo. plasma 3 0 2.2 ± 1.0 62 ± 10 -4.9
2.3.13.02. Phosducin/Transducin beta-gamma complex, conformation 3 1b9x Rattus norvegicus Eukaryo. plasma 3 0 1.0 ± 1.6 49 ± 12 -3.9
2.3.13.03. Thiol-disulfide interchange protein DsbA 1u3a Escherichia coli Bact. Gram-neg inner 1 0 2.2 ± 1.4 86 ± 8 -4.2
2.3.13.04. Glutathione peroxidase-like protein 2vup Trypanosoma brucei Undefined 1 0 3.0 ± 1.7 84 ± 7 -4.1
2.3.13.05. Putative peroxiredoxin Rv2238c/MT2298 1xvw Mycobacterium tuberculosis Undefined 1 0 4.6 ± 1.0 20 ± 5 -7.0
2.3.13.06. Glutathione transferase GST1-4 3g7j Anopheles dirus Undefined 2 0 3.1 ± 0.3 88 ± 1 -7.6
2.3.13.06. Stringent starvation protein A 3mdk Pseudomonas putida Undefined 2 0 4.8 ± 0.1 89 ± 0 -5.5
2.3.13.07. Chloride intracellular channel protein 1 1rk4 Homo sapiens Nuclear outer 1 0 3.0 ± 1.0 40 ± 5 -5.5
2.3.14.01. Phosphatidylinositol transfer protein PDR16 4fmm Saccharomyces cerevisiae Endoplasm. reticulum 1 0 9.9 ± 2.6 78 ± 19 -13.9
2.3.14.01. Retinaldehyde-binding protein 1, closed state 3hx3 Homo sapiens Eukaryo. plasma 1 0 1.2 ± 2.9 77 ± 32 -4.8
2.3.14.01. Alpha-tocopherol transfer protein, open state 1oiz Homo sapiens Golgi 1 0 8.1 ± 1.0 64 ± 10 -17.6
2.3.14.01. Alpha-tocopherol transfer protein, open state 3w68 Mus musculus Golgi 1 0 6.0 ± 0.6 70 ± 2 -13.8
2.3.14.01. Yeast Sec14 Homolog Sfh1 (YKL091C) 3b7n Saccharomyces cerevisiae Nuclear outer 1 0 2.9 ± 1.5 65 ± 18 -5.8
2.3.14.01. SEC14-like protein 2 (supernatant factor protein) 1o6u Homo sapiens Eukaryo. plasma 1 0 3.6 ± 1.4 62 ± 14 -4.9
2.3.14.01. Retinaldehyde-binding protein 1, closed state, more complete structure 3hy5 Homo sapiens Eukaryo. plasma 1 0 2.0 ± 3.9 55 ± 17 -4.5
2.3.14.01. Phosphatidylinositol transfer protein sec14p 1aua Saccharomyces cerevisiae Golgi 1 0 8.8 ± 1.1 75 ± 10 -14.3
2.3.14.01. Neurofibromin 2d4q Homo sapiens Eukaryo. plasma 1 0 1.6 ± 2.0 34 ± 19 -3.3
2.3.14.01. Alpha-tocopherol transfer protein, closed state with ligand 1r5l Homo sapiens Golgi 1 0 4.3 ± 1.0 77 ± 9 -11.8
2.3.14.02. Uncharacterized protein 2q3l Shewanella loihica Bact. Gram-neg inner 1 0 6.0 ± 0.5 64 ± 4 -12.6
2.3.15.01. Electron transfer flavoprotein 1efp Paracoccus denitrificans Bact. Gram-neg inner 2 0 4.3 ± 1.1 90 ± 13 -4.8
2.3.15.01. Electron transfer flavoprotein 1efv Homo sapiens Mitochon. inner 2 0 4.6 ± 1.3 79 ± 12 -4.6
2.3.15.02. FAD synthase 2wsi Saccharomyces cerevisiae Mitochon. inner 1 0 3.3 ± 1.7 65 ± 17 -4.0
2.3.16.01. Shikimate kinase 1e6c Erwinia chrysanthemi Bact. Gram-neg inner 2 0 2.6 ± 1.8 90 ± 12 -5.8
2.3.16.01. Shikimate kinase 1via Campylobacter jejuni Bact. Gram-neg inner 2 0 3.9 ± 1.4 89 ± 11 -5.0
2.3.16.02. Translocation ATPase SecA 1tf5 Bacillus subtilis Bact. Gram-pos plas. 1 0 2.5 ± 1.1 64 ± 5 -7.0
2.3.16.03. Transducin 1got Bos taurus Eukaryo. plasma 3 0 4.9 ± 1.2 61 ± 8 -7.0
2.3.16.04. Dynamin-like protein 2j69 Nostoc punctiforme Bact. Gram-neg inner 1 0 4.0 ± 7.0 15 ± 10 -5.5
2.3.16.04. EH domain-containing protein 2 2qpt Mus musculus Endosome 2 0 4.5 ± 2.1 20 ± 14 -7.8
2.3.16.05. ATPase Get3, complex with Get1 cytosolic domain 3sja Saccharomyces cerevisiae Endoplasm. reticulum 4 0 6.4 ± 1.6 89 ± 45 -8.1
2.3.16.05. ATPase Get3, homodimer 3a36 Saccharomyces cerevisiae Endoplasm. reticulum 2 0 5.6 ± 3.0 66 ± 10 -6.6
2.3.16.06. ADP-ribosylation factor-like protein 2, complex with human PDEdelta 1ksg Mus musculus Eukaryo. plasma 1 0 6.9 ± 1.7 77 ± 15 -5.7
2.3.16.06. ADP-ribosylation factor-like protein 1 2x77 Leishmania major Eukaryo. plasma 1 0 1.6 ± 1.4 80 ± 5 -3.6
2.3.16.06. ADP-ribosylation factor-like protein 5A 1z6y Homo sapiens Eukaryo. plasma 1 0 1.5 ± 1.9 66 ± 15 -4.0
2.3.16.06. ADP-ribosylation factor 1 (ARF1) 2k5u Saccharomyces cerevisiae Golgi 1 0 2.9 ± 1.6 24 ± 18 -5.5
2.3.16.06. ADP-ribosylation factor 1 (ARF1), different conformation 2ksq Saccharomyces cerevisiae Golgi 1 0 4.7 ± 0.1 62 ± 0 -10.4
2.3.16.06. ADP-ribosylation factor-like protein 1 1moz Saccharomyces cerevisiae Golgi 2 0 0.7 ± 1.1 90 ± 6 -4.3
2.3.16.06. ADP-ribosylation factor-like protein 3 1fzq Mus musculus Golgi 1 0 3.3 ± 1.1 73 ± 9 -5.8
2.3.16.06. ADP-ribosylation factor-like protein 8A 2h18 Homo sapiens Endosome 1 0 1.2 ± 3.6 58 ± 28 -2.6
2.3.16.07. Ras-related protein Rab-7a 1vg8 Rattus norvegicus Endosome 1 0 1.7 ± 0.5 74 ± 3 -5.3
2.3.16.07. Ras-related protein Rab-9A 1wms Homo sapiens Eukaryo. plasma 1 0 1.9 ± 0.8 48 ± 7 -5.0
2.3.16.07. GTP-binding protein Rheb 1xtq Homo sapiens Eukaryo. plasma 1 0 2.6 ± 0.6 76 ± 20 -5.1
2.3.16.07. Ras-related C3 botulinum toxin substrate 1 2p2l Homo sapiens Eukaryo. plasma 1 0 3.2 ± 0.8 58 ± 2 -5.2
2.3.16.08. Interferon-inducible GTPase 1 1tpz Mus musculus Endoplasm. reticulum 1 0 2.5 ± 2.0 37 ± 7 -5.0
2.3.16.09. GTP-binding protein YjiA 1nij Escherichia coli Bact. Gram-neg inner 1 0 3.4 ± 0.1 41 ± 1 -6.7
2.3.16.10. Tetraacyldisaccharide 4-kinase 4ehx Aquifex aeolicus Bact. Gram-neg inner 1 0 8.0 ± 1.1 69 ± 3 -13.9
2.3.16.10. Tetraacyldisaccharide 4-kinase, complex with ADP/ATP 4ehy Aquifex aeolicus Bact. Gram-neg inner 1 0 7.9 ± 0.9 71 ± 4 -12.1
2.3.17.01. Phospho-2-dehydro-3-deoxyheptonate aldolase 1of8 Saccharomyces cerevisiae Undefined 2 0 7.2 ± 0.4 80 ± 6 -9.3
2.3.17.02. Dihydropteroate synthase 1tx2 Bacillus anthracis Bact. Gram-pos plas. 2 0 2.5 ± 0.3 90 ± 2 -7.7
2.3.17.02. Folic acid synthesis protein FOL1 2bmb Saccharomyces cerevisiae Mitochon. inner 1 0 2.0 ± 0.6 31 ± 2 -5.8
2.3.18.01. Carnitine O-acetyltransferase 1ndb Mus musculus Mitochon. inner 1 0 3.0 ± 0.9 85 ± 6 -7.6
2.3.18.01. Carnitine O-octanoyltransferase 1nm8 Homo sapiens Mitochon. inner 1 0 1.7 ± 3.0 67 ± 15 -5.3
2.3.18.01. Choline O-acetyltransferase 2fy2 Homo sapiens Eukaryo. plasma 1 0 1.5 ± 2.2 87 ± 17 -5.2
2.3.18.01. Carnitine O-acetyltransferase, complex with substrate 2h3u Mus musculus Mitochon. inner 1 0 3.0 ± 1.0 87 ± 3 -5.9
2.3.18.01. Choline O-acetyltransferase 1q6x Rattus norvegicus Eukaryo. plasma 1 0 3.6 ± 0.6 75 ± 6 -8.5
2.3.18.01. Carnitine O-palmitoyltransferase 1, liver isoform, N-terminal domain 2le3 Homo sapiens Mitochon. outer 1 0 3.9 ± 3.7 80 ± 3 -9.3
2.3.18.01. Choline O-acetyltransferase, different conformation 1t1u Rattus norvegicus Eukaryo. plasma 1 0 2.1 ± 1.7 73 ± 15 -6.8
2.3.18.01. Carnitine O-palmitoyltransferase 2 2h4t Rattus norvegicus Mitochon. inner 1 0 4.0 ± 1.2 67 ± 10 -9.4
2.3.18.02. Phthiocerol/phthiodiolone dimycocerosyl transferase 1q9j Mycobacterium tuberculosis Bact. Gram-pos cell wall 1 0 6.7 ± 2.2 25 ± 6 -5.2
2.3.19.01. Alpha-toxin 2vk9 Clostridium novyi Secreted 1 0 3.2 ± 1.0 80 ± 2 -5.2
2.3.19.01. Toxin B 2bvl Clostridium difficile Secreted 1 0 2.0 ± 1.1 24 ± 14 -4.2
2.3.19.01. Cytotoxin L 2vkh Clostridium sordellii Secreted 1 0 1.4 ± 2.0 51 ± 17 -4.5
2.3.19.02. Histo-blood group ABO system transferase 2rj6 Homo sapiens Golgi 1 0 2.1 ± 1.3 77 ± 3 -7.1
2.3.19.03. Galactofuranosyl transferase GlfT2 4fix Mycobacterium tuberculosis Bact. Gram-pos plas. 4 0 3.6 ± 0.0 90 ± 0 -24.8
2.3.20.01. Hydrophilic domain of respiratory complex I 3i9v Thermus thermophilus Bact. Gram-neg inner 8 0 5.1 ± 14.0 34 ± 10 -11.6
2.3.21.01. Protein-tyrosine phosphatase, mitochondrial 1 3rgq Mus musculus Mitochon. inner 1 0 1.7 ± 0.7 54 ± 7 -4.9
2.3.22.01. Uncharacterized protein 1rtt Pseudomonas aeruginosa Undefined 1 0 3.1 ± 2.5 70 ± 22 -4.1
2.3.22.02. NrdI protein 2x2o Bacillus cereus Undefined 1 0 3.6 ± 0.5 77 ± 4 -4.6
2.3.22.02. NrdI protein 2xod Bacillus anthracis Undefined 1 0 4.1 ± 0.4 72 ± 3 -4.8
2.3.23.01. Beta-Ketoacyl synthase/Acyl transferase 1tqy Streptomyces coelicolor Bact. Gram-pos plas. 2 0 1.4 ± 0.2 83 ± 1 -4.9
2.3.24.01. Phosphonoacetaldehyde hydrolase 1rdf Bacillus cereus Undefined 1 0 4.3 ± 0.9 68 ± 4 -5.1
2.3.24.01. Phosphatase YidA 1rkq Escherichia coli Undefined 1 0 2.5 ± 1.3 79 ± 9 -4.1
2.3.24.02. Phosphoglycolate phosphatase 1l6r Thermoplasma acidophilum Undefined 1 0 3.6 ± 0.5 86 ± 3 -7.5
2.3.24.02. Predicted hydrolase 3mpo Lactobacillus brevis Undefined 1 0 3.6 ± 0.0 83 ± 7 -5.7
2.3.24.02. Hydrolase 3n1u Legionella pneumophila Undefined 4 0 5.6 ± 0.6 90 ± 1 -10.8
2.3.25.01. Putative platelet activating factor 2hsj Streptococcus pneumoniae Undefined 2 0 7.9 ± 0.7 89 ± 4 -8.5
2.3.26.01. Phosphate acyltransferase 1u7n Enterococcus faecalis Bact. Gram-pos plas. 2 0 6.1 ± 1.5 78 ± 13 -6.1
2.3.27.01. Dihydrofolate reductase 3nzb Pneumocystis carinii Undefined 1 0 3.9 ± 1.9 72 ± 10 -5.9
2.3.28.01. Aldo-keto reductase family 1 member C1 1qwk Caenorhabditis elegans Undefined 1 0 2.8 ± 1.0 66 ± 3 -6.3
2.3.28.01. Aldo-keto reductase family 1 member C21 3fjn Mus musculus Undefined 1 0 2.8 ± 1.0 56 ± 3 -5.2
2.3.29.01. Undecaprenyl pyrophosphate synthase 2d2r Helicobacter pylori Bact. Gram-neg inner 2 0 1.3 ± 0.9 78 ± 1 -4.5
2.3.30.01. Putative acid phosphatase Wzb 2wja Escherichia coli Bact. Gram-neg inner 1 0 2.5 ± 1.3 10 ± 8 -4.0
2.3.31.01. Sorbose-specific phosphotransferase enzyme IIB component 1nrz Klebsiella pneumoniae Bact. Gram-neg inner 1 0 2.1 ± 0.7 83 ± 3 -4.5
2.3.32.01. UDP-N-acetylmuramate--L-alanine ligase 1p31 Haemophilus influenzae Bact. Gram-neg inner 1 0 4.4 ± 1.8 29 ± 14 -4.6
2.3.33.01. Endo-beta-N-acetylglucosaminidase 2vtf Arthrobacter protophormiae Secreted 1 0 4.1 ± 0.7 52 ± 2 -6.5
2.4.10.01. Synapsin I 1auv Bos taurus Vesicle 1 0 1.9 ± 1.1 86 ± 11 -5.2