PDB ID or protein name

Alpha/Beta monotopic/peripheral superfamilies

2.3.01. Transglycosidases (2 families)
2.3.02. PLC-like phosphodiesterases (2 families)
2.3.03. FMN-linked oxidoreductases (1 family)
2.3.04. NAD(P)-binding Rossmann-fold domains (1 family)
2.3.05. FAD/NAD(P)-binding domain (4 families)
2.3.06. Alpha/beta-hydrolases (10 families)
2.3.07. Caspase-like (1 family)
2.3.08. FabD/lysophospholipase-like (1 family)
2.3.09. Amidase signature (AS) enzymes (1 family)
2.3.10. UDP-Glycosyltransferase/glycogen phosphorylase (3 families)
2.3.11. Chelatase (1 family)
2.3.12. Phosphotyrosine protein phosphatases II (1 family)
2.3.13. Thioredoxin-like (2 families)
2.3.14. CRAL/TRIO domain (2 families)
2.3.15. Adenine nucleotide alpha hydrolases-like (1 family)
2.3.16. P-loop containing nucleoside triphosphate hydrolases (3 families)
2.3.17. ClpP/Crotonase (1 family)
2.3.18. CoA-dependent acyltransferases (1 family)
2.3.19. Nucleotide-diphospho-sugar transferases (1 family)
2.3.20. CheY-like (1 family)

Alpha/Beta monotopic/peripheral (113 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
2.3.01.01. Glucosylceramidase 1ogs Homo sapiens Lysosome 1 0 3.2 ± 1.4 88 ± 7 -4.1
2.3.01.02. Beta-glycosidase 1vff Pyrococcus horikoshii Archaebac. 1 0 3.3 ± 0.7 37 ± 8 -6.5
2.3.02.01. Phospholipase C-delta isoform 1 1djx Rattus norvegicus Eukaryo. plasma 1 0 4.1 ± 1.5 67 ± 11 -3.2
2.3.02.02. Phosphatidylinositol-specific phospholipase C 2ptd Bacillus cereus Secreted 1 0 3.9 ± 1.5 62 ± 17 -6.0
2.3.02.02. Phosphatidylinositol-specific phospholipase C 2plc Listeria monocytogenes Secreted 1 0 7.3 ± 0.9 87 ± 10 -8.4
2.3.02.02. Phosphatidylinositol-specific phospholipase C, ligand-bound 1gym Bacillus cereus Secreted 1 0 4.4 ± 1.6 74 ± 19 -4.3
2.3.02.02. Phosphatidylinositol-specific phospholipase C, ligand-bound 1aod Listeria monocytogenes Secreted 1 0 7.4 ± 1.0 86 ± 10 -8.0
2.3.02.02. Phosphatidylinositol-specific phospholipase C 1t6m Bacillus thuringiensis Secreted 1 0 3.0 ± 1.6 83 ± 17 -1.8
2.3.03.01. Glycolate oxidase 1gox Spinacia oleracea Peroxisome 4 0 3.2 ± 0.6 90 ± 3 -9.5
2.3.03.01. Dihydroorotate dehydrogenase 1f76 Escherichia coli Bact. gram-neg inner 1 0 3.2 ± 1.1 30 ± 13 -6.4
2.3.03.01. Dihydroorotate dehydrogenase 3i65 Plasmodium falciparum Mitochon. inner 1 0 6.5 ± 0.1 52 ± 1 -10.7
2.3.03.01. Dihydroorotate dehydrogenase 1d3h Homo sapiens Mitochon. inner 1 0 3.0 ± 0.8 54 ± 7 -7.0
2.3.03.01. Dihydroorotate dehydrogenase 1uum Rattus norvegicus Mitochon. inner 1 0 10.2 ± 0.6 43 ± 6 -4.5
2.3.04.01. Corticosteroid 11-beta-dehydrogenase, isozyme 1 1xu7 Homo sapiens Endoplasm. reticulum 2 0 7.8 ± 0.7 87 ± 5 -13.4
2.3.04.01. Corticosteroid 11-beta-dehydrogenase, isozyme 1 3g49 Cavia porcellus Endoplasm. reticulum 2 0 5.3 ± 1.2 89 ± 9 -7.3
2.3.04.01. Corticosteroid 11-beta-dehydrogenase, isozyme 1 1y5m Mus musculus Endoplasm. reticulum 2 0 3.6 ± 0.3 89 ± 3 -14.9
2.3.05.01. Adrenodoxin reductase of mitochondrial p450 systems, complex with adrenodoxin 1e6e Bos taurus Mitochon. inner 2 0 4.2 ± 1.2 33 ± 12 -4.3
2.3.05.02. Glycerol-3-phosphate dehydrogenase (GlpD) 2qcu Escherichia coli Bact. gram-neg inner 1 0 4.6 ± 1.3 77 ± 7 -6.1
2.3.05.02. Protoporphyrinogen oxidase 1sez Nicotiana tabacum Mitochon. inner 1 0 3.7 ± 1.6 49 ± 15 -7.2
2.3.05.02. Monoamine oxidase B 1ojd Homo sapiens Mitochon. outer 2 0 16.2 ± 0.7 80 ± 2 -17.1
2.3.05.02. Alpha-glycerophosphate oxidase (GlpO) 2rgh Streptococcus sp. Bact. gram-pos plas. 1 0 2.9 ± 1.0 70 ± 6 -4.1
2.3.05.02. Monoamine oxidase A 1o5w Rattus norvegicus Mitochon. outer 2 2 33.0 ± 2.5 8 ± 5 -30.5
2.3.05.02. Monoamine oxidase A 2bxs Homo sapiens Mitochon. outer 1 0 9.6 ± 0.9 21 ± 9 -9.3
2.3.05.02. Flavoprotein-ubiquinone oxydoreductase 2gmh Sus scrofa Mitochon. inner 1 0 10.3 ± 1.0 41 ± 3 -18.2
2.3.05.02. Monoamine oxidase A 2z5x Homo sapiens Mitochon. outer 1 1 30.0 ± 2.4 17 ± 5 -27.1
2.3.05.03. Rab GDP dissociation inhibitor alpha 1d5t Bos taurus Eukaryo. plasma 1 0 2.4 ± 1.9 26 ± 12 -2.4
2.3.06.01. Bile-salt activated lipase 1f6w Homo sapiens Secreted 1 0 5.4 ± 1.0 78 ± 10 -4.4
2.3.06.01. Acetylcholinesterase 1ea5 Torpedo californica Eukaryo. plasma 1 0 1.5 ± 0.7 36 ± 9 -3.1
2.3.06.01. Acetylcholinesterase 1n5m Mus musculus Eukaryo. plasma 1 0 3.4 ± 1.0 30 ± 6 -5.0
2.3.06.01. Bile-salt activated lipase, different conformations of loops 1akn Bos taurus Secreted 1 0 5.7 ± 1.7 67 ± 13 -6.6
2.3.06.01. Acetylcholinesterase, complex with Fasciculin II 1f8u Homo sapiens Eukaryo. plasma 2 0 3.3 ± 0.9 66 ± 5 -6.4
2.3.06.01. Butyryl cholinesterase 1p0i Homo sapiens Eukaryo. plasma 1 0 1.8 ± 1.4 40 ± 6 -2.6
2.3.06.01. Bile-salt activated lipase 1aql Bos taurus Secreted 1 0 6.0 ± 1.0 80 ± 8 -9.7
2.3.06.02. Antigen 85a 1sfr Mycobacterium tuberculosis Bact. gram-pos cell wall 1 0 2.6 ± 0.7 23 ± 9 -6.0
2.3.06.02. Antigen 85b 1f0n Mycobacterium tuberculosis Bact. gram-pos cell wall 1 0 2.8 ± 0.9 24 ± 7 -5.3
2.3.06.02. Antigen 85c 1dqz Mycobacterium tuberculosis Bact. gram-pos cell wall 1 0 4.5 ± 0.9 30 ± 6 -5.9
2.3.06.03. Gastric lipase 1hlg Homo sapiens Secreted 1 0 3.4 ± 0.9 6 ± 8 -5.0
2.3.06.03. Gastric lipase, open (active) state 1k8q Canis familiaris Secreted 1 0 6.3 ± 0.7 80 ± 4 -10.8
2.3.06.04. Palmitoyl protein thioesterase 1 1eh5 Bos taurus Lysosome 1 0 4.6 ± 1.9 52 ± 12 -5.1
2.3.06.04. Palmitoyl protein thioesterase 2 1pja Homo sapiens Lysosome 1 0 3.9 ± 1.4 49 ± 13 -2.8
2.3.06.05. Lipase 1jfr Streptomyces exfoliatus Secreted 1 0 5.0 ± 0.7 57 ± 9 -5.1
2.3.06.05. Lipase 2fx5 Pseudomonas mendocina Secreted 1 0 5.2 ± 1.0 50 ± 8 -4.8
2.3.06.06. Triacylglycerol lipase 1lgy Rhizopus niveus Secreted 1 0 2.2 ± 2.0 28 ± 10 -3.5
2.3.06.06. Triacylglycerol lipase, closed (inactive) state 1tib Humicola lanuginosa Secreted 1 0 1.9 ± 0.8 42 ± 8 -3.3
2.3.06.06. Lipase 1, open (active) state 1lpp Candida rugosa Secreted 1 0 9.1 ± 0.4 84 ± 1 -30.6
2.3.06.06. Triacylglycerol lipase, closed (inactive) state 1dt5 Humicola lanuginosa Secreted 1 0 2.9 ± 1.4 84 ± 15 -4.8
2.3.06.06. Lipase 2 1gz7 Candida rugosa Secreted 1 0 3.1 ± 1.0 81 ± 5 -7.7
2.3.06.06. Lipase LipA 2qua Serratia marcescens Secreted 1 0 7.9 ± 0.3 58 ± 1 -47.2
2.3.06.06. Type-B carboxylesterase/lipase 1cle Candida cylindracea Secreted 1 0 9.6 ± 0.2 84 ± 0 -28.0
2.3.06.06. Lipase 1, closed (inactive) state 1trh Candida rugosa Secreted 1 0 3.0 ± 0.9 80 ± 5 -7.8
2.3.06.06. Triacylglycerol lipase 1lbs Candida antarctica Secreted 1 0 11.5 ± 0.9 82 ± 11 -16.9
2.3.06.06. Triacylglycerol lipase, closed (inactive) state 2veo Candida antarctica Secreted 1 0 4.1 ± 1.0 75 ± 6 -6.5
2.3.06.06. Triacylglycerol lipase, closed (inactive) state 3tgl Rhizomucor miehei Secreted 1 0 4.5 ± 1.5 28 ± 13 -4.1
2.3.06.06. Triacylglycerol lipase, open (active) state 4tgl Rhizomucor miehei Secreted 1 0 4.9 ± 0.6 55 ± 5 -14.0
2.3.06.06. Lipase 2 1thg Geotrichum candidum Secreted 1 0 5.3 ± 2.0 48 ± 18 -4.5
2.3.06.06. Triacylglycerol lipase, open (active) state 1ein Humicola lanuginosa Secreted 1 0 9.5 ± 1.0 71 ± 12 -13.5
2.3.06.07. Lipase 1cvl Chromobacterium viscosum Secreted 1 0 3.2 ± 1.4 72 ± 9 -7.5
2.3.06.07. Lipase L1 1ku0 Bacillus stearothermophilus Secreted 1 0 4.9 ± 1.4 20 ± 11 -6.5
2.3.06.07. Thermostable lipase 2dsn Geobacillus zalihae Secreted 1 0 5.4 ± 0.9 28 ± 10 -6.6
2.3.06.07. Lipase L1, different isoform 1ji3 Bacillus stearothermophilus Secreted 1 0 5.0 ± 1.6 21 ± 8 -6.5
2.3.06.07. Triacylglycerol lipase 2w22 Geobacillus thermocatenulatus Secreted 1 0 4.5 ± 0.1 89 ± 1 -18.0
2.3.06.07. Lipase A 1isp Bacillus subtilis Secreted 1 0 1.8 ± 1.1 47 ± 10 -2.6
2.3.06.07. Lipase 1qge Pseudomonas glumae Secreted 1 0 6.7 ± 1.8 67 ± 15 -5.8
2.3.06.07. Lipase 2ory Photbacterium lipolyticum Secreted 1 0 6.2 ± 1.0 59 ± 4 -8.1
2.3.06.07. Lipase 5lip Burkholderia cepacia Secreted 1 0 11.4 ± 1.0 44 ± 8 -38.2
2.3.06.07. Lipase 2z8x Pseudomonas sp. MIS 38 Secreted 1 0 3.0 ± 1.2 64 ± 5 -5.8
2.3.06.07. Lipase, open (active) state 1ex9 Pseudomonas aeruginosa Secreted 1 0 11.1 ± 0.5 53 ± 4 -37.0
2.3.06.08. Pnacreatic lipase-related protein 2 1w52 Equus caballus Secreted 1 0 4.9 ± 0.4 85 ± 1 -9.6
2.3.06.08. Pancreatic lipase 1hpl Equus caballus Secreted 1 0 3.3 ± 0.6 79 ± 5 -6.0
2.3.06.08. Pancreatic lipase, complex with colipase from Pig 1lpb Homo sapiens Secreted 2 0 10.3 ± 1.0 87 ± 5 -26.2
2.3.06.08. Pancreatic lipase-related protein 1 2ppl Homo sapiens Secreted 1 0 7.6 ± 1.0 80 ± 5 -7.7
2.3.06.08. Pancreatic lipase, complex with colipase 1eth Sus scrofa Secreted 2 0 13.4 ± 0.5 87 ± 5 -15.2
2.3.06.08. Pancreatic lipase 1gpl Cavia porcellus Secreted 1 0 5.5 ± 1.2 87 ± 13 -5.2
2.3.06.08. Pancreatic lipase 1bu8 Rattus norvegicus Secreted 1 0 4.5 ± 1.3 84 ± 9 -7.4
2.3.06.08. Pancreatic lipase, complex with colipase from Pig 1n8s Homo sapiens Secreted 2 0 11.4 ± 1.3 61 ± 6 -13.9
2.3.06.08. Pancreatic lipase, complex with colipase from Pig 1lpa Homo sapiens Secreted 2 0 8.7 ± 1.4 89 ± 7 -22.1
2.3.06.09. Cutinase 1oxm Fusarium solani Secreted 1 0 7.4 ± 1.3 36 ± 7 -10.4
2.3.06.10. Plasma platelet activating factor acetylhydrolase 3d59 Homo sapiens Eukaryo. plasma 1 0 6.7 ± 0.1 89 ± 2 -16.2
2.3.07.01. Apopain (caspase-3) 1nme Homo sapiens Eukaryo. plasma 4 0 3.1 ± 1.6 73 ± 18 -2.7
2.3.08.01. Patatin 1oxw Solanum cardiophyllum Secreted 1 0 4.3 ± 1.8 26 ± 10 -6.5
2.3.08.01. Cytosolic phospholipase A2, group IVA 1cjy Homo sapiens Nuclear outer 1 0 5.7 ± 1.4 68 ± 19 -9.8
2.3.09.01. Fatty acid amine hydrolase 1mt5 Rattus norvegicus Endoplasm. reticulum 2 0 10.0 ± 0.3 89 ± 2 -30.8
2.3.10.01. Peptidoglycan biosynthesis glycosyltransferase MurG 1f0k Escherichia coli Bact. gram-neg inner 1 0 4.2 ± 1.4 53 ± 5 -6.9
2.3.10.01. Peptidoglycan biosynthesis glycosyltransferase MurG 1nlm Escherichia coli Bact. gram-neg inner 1 0 4.5 ± 1.0 55 ± 5 -7.5
2.3.10.02. Beta-1,2-glucuronosyltrnansferase GumK 2q6v Xanthomonas campestris Bact. gram-neg inner 1 0 5.6 ± 1.0 56 ± 4 -7.7
2.3.10.03. Heptosyltransferase WaaC 2h1h Escherichia coli Bact. gram-neg inner 1 0 2.4 ± 1.8 61 ± 14 -4.8
2.3.10.03. LPS heptosyltransferase II 1psw Escherichia coli Bact. gram-neg inner 1 0 2.5 ± 1.0 67 ± 6 -1.4
2.3.11.01. Ferrochelatase 1hrk Homo sapiens Mitochon. inner 2 0 7.2 ± 0.1 86 ± 0 -9.2
2.3.12.01. Myotubularin-related protein 2 1zvr Homo sapiens Eukaryo. plasma 1 0 2.9 ± 1.0 88 ± 8 -2.3
2.3.13.01. Microsomal prostaglandin E synthase 2 1z9h Macaca fascicularis Golgi 2 0 4.4 ± 0.4 90 ± 5 -13.1
2.3.13.02. Phosducin/Transducin beta-gamma complex, conformation 3 1b9x Rattus norvegicus Eukaryo. plasma 3 0 1.6 ± 1.6 52 ± 5 -1.4
2.3.13.02. Phosducin/Transducin beta-gamma complex, conformation 1 1a0r Bos taurus Eukaryo. plasma 3 0 2.7 ± 1.7 45 ± 12 -3.7
2.3.13.02. Phosducin/Transducin beta-gamma complex, conformation 2 2trc Rattus norvegicus Eukaryo. plasma 3 0 4.4 ± 1.0 64 ± 4 -2.9
2.3.14.01. Yeast Sec14 Homolog Sfh1 (YKL091C) 3b7n Saccharomyces cerevisiae Nuclear outer 1 0 4.7 ± 1.0 72 ± 8 -3.4
2.3.14.01. SEC14-like protein 2 (supernatant factor protein) 1o6u Homo sapiens Eukaryo. plasma 1 0 3.2 ± 1.3 61 ± 11 -3.5
2.3.14.01. Neurofibromin 2d4q Homo sapiens Eukaryo. plasma 1 0 1.7 ± 2.0 29 ± 8 -1.6
2.3.14.01. Alpha-tocopherol transfer protein, closed state with ligand 1r5l Homo sapiens Golgi 1 0 4.0 ± 0.5 74 ± 9 -14.6
2.3.14.01. Alpha-tocopherol transfer protein, open state with detergent 1oiz Homo sapiens Golgi 1 0 8.4 ± 0.9 63 ± 6 -20.7
2.3.14.01. Phosphatidylinositol transfer protein sec14p 1aua Saccharomyces cerevisiae Golgi 1 0 7.8 ± 0.3 63 ± 5 -14.0
2.3.14.02. Uncharacterized protein 2q3l Shewanella loihica Bact. gram-neg inner 1 0 6.5 ± 0.4 69 ± 4 -11.3
2.3.15.01. Electron transfer flavoprotein 1efv Homo sapiens Mitochon. inner 2 0 2.9 ± 1.0 82 ± 10 -3.1
2.3.15.01. Electron transfer flavoprotein 1efp Paracoccus denitrificans Bact. gram-neg inner 2 0 3.8 ± 2.0 81 ± 18 -4.7
2.3.16.01. Shikimate kinase 1e6c Erwinia chrysanthemi Bact. gram-neg inner 2 0 2.8 ± 0.9 89 ± 10 -5.3
2.3.16.01. Shikimate kinase 1via Campylobacter jejuni Bact. gram-neg inner 2 0 3.1 ± 1.0 85 ± 12 -3.0
2.3.16.02. Translocation ATPase SecA 1tf5 Bacillus subtilis Bact. gram-pos plas. 1 0 2.4 ± 1.8 65 ± 5 -2.6
2.3.16.03. Transducin 1got Bos taurus Eukaryo. plasma 3 0 10.3 ± 1.0 62 ± 6 -12.7
2.3.17.01. Membrane protease specific for a stomatin homolog 2deo Pyrococcus horikoshii Archaebac. 1 0 4.2 ± 1.1 80 ± 6 -5.4
2.3.18.01. Carnitine O-palmitoyltransferase 2 2h4t Rattus norvegicus Mitochon. inner 1 0 3.6 ± 1.0 76 ± 12 -8.6
2.3.19.01. Toxin B 2bvl Clostridium difficile Secreted 1 0 6.9 ± 2.0 32 ± 20 -2.4
2.3.19.01. Cytotoxin L 2vkh Clostridium sordellii Secreted 1 0 2.4 ± 1.0 47 ± 13 -3.8
2.3.19.01. Alpha-toxin 2vk9 Clostridium novyi Secreted 1 0 4.4 ± 2.0 64 ± 15 -4.7
2.3.20.01. Hydrophilic domain of respiratory complex I 3i9v Thermus thermophilus Bact. gram-neg inner 8 0 5.1 ± 2.0 49 ± 10 -9.7
2.4.10.01. Synapsin I 1auv Bos taurus Vesicle 1 0 2.5 ± 1.1 88 ± 7 -4.4