PDB ID or protein name

All alpha monotopic/peripheral superfamilies

2.1.001. Secretory phospholipase A2 (4 families)
2.1.002. Lipoxygenase (1 family) PF00305 (Pfam)
2.1.003. Phospholipase C/P1 nuclease (1 family) CL0368 (Pfam)
2.1.004. Heme-dependent peroxidases (1 family) PF03098 (Pfam)
2.1.005. Six-hairpin glycosidase superfamily (2 families) CL0059 (Pfam)
2.1.006. Signal peptide binding domain (1 family) PF02978 (Pfam)
2.1.007. Multiheme cytochrome (1 family) CL0317 (Pfam)
2.1.008. Cytochrome c (2 families) CL0318 (Pfam)
2.1.009. Uteroglobin-like (1 family) CL0370 (Pfam)
2.1.010. Glycolipid transfer protein (1 family) PF08718 (Pfam)
2.1.011. Spectrin repeat (1 family) PF00435 (Pfam)
2.1.012. Outer surface protein C (1 family) PF01441 (Pfam)
2.1.013. Crustacean CHH/MIH/GIH neurohormone (1 family) PF01147 (Pfam)
2.1.014. Tetratrico peptide repeat superfamily (3 families) CL0020 (Pfam)
2.1.015. ENTH/VHS domain (3 families) CL0009 (Pfam)
2.1.016. Myelin basic protein (1 family) PF01669 (Pfam)
2.1.017. SHERP (1 family)
2.1.018. Annexins (1 family) 1.A.31 (TCDB) PF00191 (Pfam)
2.1.019. Disulfide-stabilized alpha-hairpin (1 family) PF14861 (Pfam)
2.1.020. GLA-domain (1 family) PF00594 (Pfam)
2.1.021. Retroviral matrix protein (5 families) PF00598 (Pfam)
2.1.022. Alternative oxidase (1 family) PF01786 (Pfam)
2.1.023. Ectatomin (1 family) PF06457 (Pfam)
2.1.024. Saposin (1 family) 1.C.35 (TCDB) PF03489 (Pfam)
2.1.025. Bacteriocin, class II (5 families)
2.1.026. Colicin pore forming domain (1 family) 1.C.1 (TCDB) PF01024 (Pfam)
2.1.027. delta-Endotoxin (1 family) 1.C.2 (TCDB) PF03945 (Pfam)
2.1.028. Heat-stable enterotoxin B (1 family) PF09075 (Pfam)
2.1.029. Alpha-helical (HDL) apolipoproteins (6 families)
2.1.030. Mistic (1 family) 9.B.23 (TCDB) PF11458 (Pfam)
2.1.031. Colicin M (1 family) PF14859 (Pfam)
2.1.032. Synuclein (1 family) 1.C.77 (TCDB) PF01387 (Pfam)
2.1.033. DrrA protein (1 family)
2.1.034. DivIVA protein (1 family) PF05103 (Pfam)
2.1.035. PASCIN (protein kinase C and casein kinase substrate) (1 family) PF00611 (Pfam)
2.1.036. Endoplasmic reticulum oxidoreductin (1 family) PF04137 (Pfam)
2.1.037. DBL (Duffy-binding like) (1 family) CL0195 (Pfam)
2.1.038. Corynebacterial porin B (1 family) 1.B.41 (TCDB) PF11565 (Pfam)
2.1.039. Viral protein R (VPR) family (1 family) 1.A.42 (TCDB) PF00522 (Pfam)
2.1.040. Munc13 (mammalian) homology domain (MHD) (1 family) PF10540 (Pfam)
2.1.041. Phosphatidylinositol 3- and 4-kinase (1 family) PF00454 (Pfam)
2.1.042. Enterocin A immunity protein (1 family) PF08951 (Pfam)
2.1.043. Acanthaporin (1 family)
2.1.044. Glycocin (1 family)
2.1.046. Ferritin-like superfamily (1 family) CL0044 (Pfam)
2.1.047. Globin-like (1 family) CL0090 (Pfam)
2.1.048. Dehydroquinate synthase-like superfamily (1 family) CL0224 (Pfam)
2.1.049. HD/PDEase superfamily (1 family) CL0237 (Pfam)
2.1.050. PhoU-like superfamily (1 family) CL0297 (Pfam)
2.1.051. Protein prenyltransferase (1 family) PF01239 (Pfam)
2.1.052. Insect pheromone/odorant binding proteins (1 family) PF01395 (Pfam)
2.1.053. Pex19 protein family (1 family) PF04614 (Pfam)
2.1.054. Programmed cell death protein 10 family (1 family) PF06840 (Pfam)
2.1.055. Pas factor (1 family) PF09016 (Pfam)
2.1.056. L27 domain (1 family) PF09045 (Pfam)
2.1.057. Adhesion protein FadA (1 family) PF09403 (Pfam)
2.1.058. Death Domain superfamily (1 family) CL0041 (Pfam)
2.1.059. Secretion system effector C (1 family) PF04888 (Pfam)
2.1.060. Sea anemone toxin-like proteins (3 families)
2.1.061. Muramidase (1 family)
2.1.062. Sactibiotics (2 families)
2.1.063. Bacterial lipid A acyltransferase (1 family) PF03279 (Pfam)
2.1.064. Hydrophobic surface binding protein A (1 family) PF12296 (Pfam)
See list of these PDB codes

All alpha monotopic/peripheral (305 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
2.1.22.01. Alternative oxidase 3w54 Trypanosoma brucei Mitochon. inner 2 0 9.7 ± 0.3 89 ± 1 -61.2
2.1.04.01. Prostaglandin H2 synthase-1 1q4g Ovis aries Endoplasm. reticulum 2 0 8.9 ± 0.4 90 ± 1 -43.4
2.1.04.01. Prostaglandin H2 synthase-2 (cyclooxygenase) 1cx2 Mus musculus Endoplasm. reticulum 2 0 9.7 ± 0.4 89 ± 3 -37.4
2.1.04.01. Prostaglandin G/H synthase 2 5f19 Homo sapiens Endoplasm. reticulum 2 0 6.2 ± 1.0 90 ± 1 -33.7
2.1.04.01. Alpha-dioxygenase 1 4hhr Arabidopsis thaliana Endoplasm. reticulum 1 0 10.8 ± 0.1 68 ± 2 -31.4
2.1.05.01. Squalene-hopene cyclase 2sqc Alicyclobacillus acidocaldarius Bact. Gram-pos plas. 2 0 7.4 ± 0.5 90 ± 1 -27.8
2.1.04.01. Fatty acid alpha-oxidase 4kvl Oryza sativa (Rice) Endoplasm. reticulum 1 0 5.5 ± 0.7 90 ± 1 -19.0
2.1.15.03. Clathrin assembly lymphoid myeloid leukemia (CALM) protein 1hfa Rattus norvegicus Eukaryo. plasma 1 0 14.2 ± 2.0 44 ± 14 -17.9
2.1.05.01. Lanosterol synthase 1w6k Homo sapiens Endoplasm. reticulum 1 0 7.6 ± 1.0 77 ± 4 -17.8
2.1.29.02. Apolipoprotein A-II 2ou1 Homo sapiens Secreted 2 0 2.7 ± 1.2 87 ± 2 -17.7
2.1.06.01. Signal recognition 54 kDa protein 3kl4 Sulfolobus solfataricus Vacuole 2 0 9.7 ± 0.5 31 ± 5 -16.4
2.1.32.01. Alpha-synuclein 1xq8 Homo sapiens Eukaryo. plasma 1 0 8.7 ± 1.1 87 ± 4 -15.7
2.1.01.01. Snake phospholipase A2 2i0u Vipera nikolskii Secreted 1 0 5.6 ± 0.9 88 ± 9 -15.2
2.1.01.01. Phospholipase A2 homolog, ammodytin L 3dih Vipera ammodytes ammodytes Secreted 1 0 5.0 ± 0.4 82 ± 5 -14.4
2.1.02.01. Arachidonate 15-lipoxygenase 2p0m Oryctolagus cuniculus Eukaryo. plasma 1 0 8.6 ± 0.1 87 ± 5 -14.3
2.1.10.01. Glycolipid transfer protein Het-c2 3kv0 Podospora anserina Eukaryo. plasma 1 0 8.3 ± 1.3 83 ± 5 -13.6
2.1.01.01. Phospholipase A2, group X 1le6 Homo sapiens Secreted 1 0 7.4 ± 0.9 78 ± 6 -13.2
2.1.01.01. Ammodytin L1 isoform 3ux7 Vipera ammodytes meridionalis Secreted 1 0 2.7 ± 0.3 82 ± 1 -13.2
2.1.01.01. Snake phospholipase A2, group II 1pp2 Crotalus atrox Secreted 1 0 3.7 ± 1.3 80 ± 7 -12.9
2.1.38.01. Anion-specific porin B 2vql Corynebacterium glutamicum Bact. Gram-pos cell wall 1 0 6.2 ± 0.3 83 ± 2 -12.7
2.1.01.01. Snake phospholipase A2, group II, VRV-PL-VIIIa 1zwp Daboia russelli pulchella Secreted 1 0 4.9 ± 1.0 76 ± 7 -12.5
2.1.01.01. Snake phospholipase A2, group II (ecarpholin S) 2qhd Echis carinatus Secreted 1 0 8.1 ± 0.6 79 ± 5 -12.5
2.1.02.01. 9R-lipoxygenase 5ek8 Synechococcus sp. Bact. Gram-neg inner 1 0 4.0 ± 0.7 78 ± 6 -12.2
2.1.47.01. Group 1 truncated hemoglobin glbN 2gkn Mycobacterium tuberculosis Bact. Gram-pos plas. 2 0 4.5 ± 0.4 86 ± 1 -11.9
2.1.02.01. Arachidonate 15-lipoxygenase 5ir4 Pseudomonas aeruginosa Secreted 1 0 4.9 ± 1.8 71 ± 2 -11.8
2.1.01.01. Myotoxin II 2aoz Atropoides nummifer Secreted 1 0 3.4 ± 0.7 80 ± 3 -11.8
2.1.01.01. Snake phospholipase A2, group II, acidic 1bk9 Agkistrodon halys pallas Secreted 1 0 7.3 ± 0.3 87 ± 3 -11.4
2.1.01.01. Snake phospholipase A2, group II, B 1jia Agkistrodon halys pallas Secreted 1 0 3.3 ± 0.5 78 ± 4 -11.2
2.1.01.01. Snake phospholipase A2, ammodytoxin A, group II 3g8g Vipera ammodytes ammodytes Secreted 1 0 4.1 ± 0.9 80 ± 6 -11.0
2.1.29.03. Apolipoprotein C-I, peptide 1-38 1opp Homo sapiens Secreted 1 0 3.6 ± 0.2 87 ± 2 -10.9
2.1.01.01. Snake phospholipase A2, group I 1poa Naja atra Secreted 1 0 4.8 ± 1.0 89 ± 7 -10.7
2.1.01.04. Phospholipase A2 homolog 2wg7 Oryza sativa (Rice) Secreted 1 0 4.0 ± 1.1 77 ± 3 -10.7
2.1.02.01. Linoleate 9/13-lipoxygenase 4g32 Pseudomonas aeruginosa Bact. Gram-neg inner 1 0 5.8 ± 0.9 33 ± 2 -10.7
2.1.10.01. Accelerated-cell-death 11 protein, complex with lipid 4nti Arabidopsis thaliana Eukaryo. plasma 1 0 5.7 ± 0.5 80 ± 2 -10.7
2.1.10.01. Ceramide-1-phosphate transfer protein 4k8n Homo sapiens Eukaryo. plasma 1 0 7.0 ± 1.0 81 ± 4 -10.6
2.1.29.02. Apolipoprotein A-II, different conformation 1l6l Homo sapiens Secreted 2 0 3.9 ± 1.2 65 ± 8 -10.6
2.1.02.01. Arachidonate 15-lipoxygenase 4nre Homo sapiens Eukaryo. plasma 1 0 4.5 ± 1.5 83 ± 2 -10.6
2.1.01.01. Myotoxin 1s8i Agkistrodon contortrix laticinctus Secreted 1 0 4.9 ± 0.7 83 ± 5 -10.6
2.1.01.01. Snake phospholipase A2 homolog bothropstoxin-1, group II 3i03 Bothrops jararacussu Secreted 1 0 2.5 ± 0.5 76 ± 5 -10.6
2.1.01.01. Myotoxin II 1y4l Bothrops asper Secreted 1 0 2.8 ± 0.8 76 ± 7 -10.3
2.1.16.01. Myelin basic protein 2lug Mus musculus Eukaryo. plasma 1 0 5.6 ± 1.5 79 ± 7 -10.3
2.1.01.01. Snake phospholipase A2, group II 1vap Agkistridon piscivorus Secreted 1 0 5.1 ± 0.6 88 ± 5 -10.3
2.1.18.01. Annexin XII 1dm5 Hydra vulgaris Eukaryo. plasma 3 0 2.7 ± 1.0 90 ± 7 -10.2
2.1.01.01. Basic phospholipase A2 PA-11 3v9m Pseudechis australis Secreted 1 0 4.0 ± 0.5 83 ± 2 -10.1
2.1.10.01. Glycolipid transfer protein, conformation 1 1sx6 Homo sapiens Eukaryo. plasma 1 0 4.3 ± 1.1 85 ± 5 -10.1
2.1.53.01. Peroxisomal biogenesis factor 19 2wl8 Homo sapiens Peroxisome 1 0 8.3 ± 0.8 79 ± 14 -9.9
2.1.29.04. Apolipoprotein C-II 1i5j Homo sapiens Secreted 1 0 4.4 ± 2.3 42 ± 3 -9.9
2.1.29.03. Cholesteryl ester transfer inhibitor protein 1eze Papio hamadryas (Hamadryas baboon) Secreted 1 0 4.6 ± 0.2 89 ± 3 -9.9
2.1.01.01. Snake phospholipase A2, ammodytoxin C, group II 3g8h Vipera ammodytes ammodytes Secreted 1 0 4.1 ± 1.1 81 ± 8 -9.7
2.1.46.01. Protein yciE 3ogh Escherichia coli Undefined 2 0 4.0 ± 1.0 88 ± 4 -9.7
2.1.02.01. Manganese lipoxygenase 5fno Magnaporthe oryzae Eukaryo. plasma 1 0 4.7 ± 0.7 61 ± 2 -9.7
2.1.01.01. Snake phospholipase A2, group II 1oz6 Echis carinatus Secreted 1 0 5.6 ± 1.0 84 ± 13 -9.6
2.1.37.01. Erythrocyte membrane protein 1 variant 3c64 Plasmodium falciparum Eukaryo. plasma 1 0 5.3 ± 2.5 52 ± 3 -9.6
2.1.24.01. Pulmonary surfactant-associated protein B fragments 2dwf Homo sapiens Secreted 1 0 5.6 ± 1.3 77 ± 4 -9.5
2.1.01.02. Phospholipase A2 1poc Apis mellifera Secreted 1 0 4.0 ± 1.6 60 ± 6 -9.5
2.1.01.01. Snake phospholipase A2, group II, RVV-VD 1vip Vipera russelli Secreted 1 0 4.4 ± 0.8 85 ± 11 -9.5
2.1.21.01. Influenza virus matrix protein M1, structure 2 4pus Influenza virus Viral 2 0 2.3 ± 1.6 81 ± 3 -9.4
2.1.56.01. PALS1-associated tight junction protein 1vf6 Homo sapiens Eukaryo. plasma 2 0 5.8 ± 0.4 53 ± 2 -9.4
2.1.21.02. Matrix protein p10 5hyb Mouse mammary tumor virus Viral 1 0 12.9 ± 10.0 73 ± 10 -9.4
2.1.01.01. Basic phospholipase A2 homolog CTs-R6 4h0s Trimeresurus stejnegeri Secreted 1 0 6.0 ± 1.2 87 ± 4 -9.4
2.1.01.01. Myotoxin 1mc2 Agkistrodon acutus Secreted 1 0 2.4 ± 0.1 80 ± 2 -9.4
2.1.10.01. Glycolipid transfer protein, structure 2 1wbe Bos taurus Eukaryo. plasma 1 0 1.1 ± 2.4 89 ± 8 -9.4
2.1.01.01. Snake phospholipase A2, acidic 2, group I 1p7o Micropechis ikaheka Secreted 1 0 2.6 ± 0.5 90 ± 2 -9.4
2.1.29.03. Apolipoprotein C-I, peptide 61-79 1alf Homo sapiens Secreted 1 0 4.1 ± 0.5 86 ± 3 -9.4
2.1.02.01. 8R-Lipoxygenase, central and C-terminal domains 3fg3 Plexaura homomalla Eukaryo. plasma 1 0 5.0 ± 0.6 86 ± 5 -9.3
2.1.62.02. Subtilosin A 1pxq Bacillus subtilis Secreted 1 0 7.6 ± 0.8 86 ± 3 -9.3
2.1.03.01. Alpha-toxin (PHLC1_CLOPE), open state 1ca1 Clostridium perfringens Secreted 1 0 2.9 ± 1.0 89 ± 4 -9.3
2.1.01.01. Snake phospholipase A2 homolog zhaoermiatoxin, group II 2ph4 Zhaoermia manqshanensis Secreted 1 0 4.8 ± 0.8 86 ± 5 -9.2
2.1.02.01. Linoleate 9/13-lipoxygenase, with N-terminal helix 4g33 Pseudomonas aeruginosa Bact. Gram-neg inner 1 0 4.3 ± 0.0 16 ± 0 -9.1
2.1.24.01. Saposin-like domain of plant aspartic protease 3rfi Solanum tuberosum Secreted 1 0 5.6 ± 3.2 66 ± 3 -9.1
2.1.17.01. Small hydrophilic endoplasmic reticulum-associated protein (Sherp) 2x43 Leishmania major Endoplasm. reticulum 1 0 4.1 ± 0.3 82 ± 2 -9.0
2.1.01.01. Snake phospholipase A2, acidic 2h4c Daboia russellii siamensis Secreted 1 0 5.7 ± 1.1 88 ± 10 -9.0
2.1.01.01. Snake phospholipase A2, group I 1ozy Micropechis ikaheka Secreted 1 0 2.6 ± 1.0 85 ± 5 -9.0
2.1.02.01. 12S-Lipoxygenase 3d3l Homo sapiens Eukaryo. plasma 1 0 5.0 ± 0.6 51 ± 3 -9.0
2.1.18.01. Annexin V 1a8a Rattus norvegicus Eukaryo. plasma 3 0 2.1 ± 1.1 89 ± 10 -8.9
2.1.62.01. Thuricin beta 2la0 Bacillus cereus Secreted 1 0 10.0 ± 2.6 37 ± 7 -8.8
2.1.01.01. Snake phospholipase A2, group II 1jlt Vipera ammodytes meridionalis Secreted 1 0 2.8 ± 1.0 89 ± 7 -8.7
2.1.02.01. Arachidonate 15-lipoxygenase 3rde Sus scrofa Eukaryo. plasma 1 0 6.9 ± 0.4 83 ± 1 -8.7
2.1.01.01. Phospholipase A2, group IB 4p2p Sus scrofa Secreted 1 0 3.3 ± 0.8 89 ± 7 -8.6
2.1.25.04. Acidocin B 2mwr Lactobacillus acidophilus Secreted 1 0 4.9 ± 1.6 76 ± 0 -8.6
2.1.01.01. Snake phospholipase A2, group II, hypotensive 1umv Bothrops jararacussu Secreted 1 0 5.1 ± 0.7 87 ± 4 -8.6
2.1.18.01. Annexin VI 1m9i Homo sapiens Eukaryo. plasma 1 0 2.8 ± 0.3 82 ± 0 -8.5
2.1.01.01. Snake phospholipase A2, group I, isoform 2 1u4j Bungarus caeruleus Secreted 1 0 2.2 ± 0.6 83 ± 4 -8.5
2.1.41.01. Phosphatidylinositol 4-kinase type 2-alpha, structure 1 4hne Homo sapiens Golgi 1 0 7.2 ± 2.4 35 ± 0 -8.5
2.1.24.01. Saposin A (peptide 60-140), conformation in disc 4ddj Homo sapiens Lysosome 1 0 6.4 ± 0.9 89 ± 3 -8.5
2.1.01.01. Snake phospholipase A2, group II, neutral 1bjj Agkistrodon halys pallas Secreted 1 0 2.6 ± 0.7 86 ± 5 -8.4
2.1.03.01. Phospholipase C 1p6d Bacillus cereus Secreted 1 0 2.8 ± 1.0 52 ± 6 -8.4
2.1.15.01. Epsin-1 5ahv Saccharomyces cerevisiae Eukaryo. plasma 2 0 7.5 ± 2.0 20 ± 6 -8.3
2.1.10.01. Glycolipid transfer protein, structure 1 1tfj Bos taurus Eukaryo. plasma 1 0 3.9 ± 1.0 90 ± 5 -8.3
2.1.03.01. Alpha-toxin, different sequence (PHLC2_CLOPE in Uniprot) 1kho Clostridium perfringens Secreted 1 0 3.8 ± 1.0 87 ± 4 -8.2
2.1.61.01. Muramidase Tse3-Tsi3 complex, conformation 2 4luq Pseudomonas aeruginosa Bact. Gram-neg outer 2 0 2.2 ± 1.4 69 ± 5 -8.2
2.1.14.01. Peroxisome targeting signal 1 receptor PEX5 1hxi Trypanosoma brucei Peroxisome 1 0 3.7 ± 1.0 71 ± 5 -8.1
2.1.18.01. Annexin VI 1avc Bos taurus Eukaryo. plasma 1 0 4.4 ± 1.0 83 ± 1 -8.1
2.1.61.01. Muramidase Tse3 4m5e Pseudomonas aeruginosa Bact. Gram-neg outer 1 0 5.2 ± 2.0 65 ± 10 -8.0
2.1.01.01. Snake phospholipase A2 RV-7, group II 1oqs Daboia russellii siamensis Secreted 1 0 2.7 ± 1.1 87 ± 8 -7.9
2.1.08.01. Cytochrome c peroxidase 1nml Marinobacter hydrocarbonoclasticus Bact. Gram-neg inner 1 0 2.2 ± 0.4 83 ± 0 -7.9
2.1.29.03. Apolipoprotein C-I, peptide 33-50 1ale Homo sapiens Secreted 1 0 4.9 ± 1.0 72 ± 4 -7.8
2.1.62.01. Thuricin alpha 2l9x Bacillus cereus Secreted 1 0 7.1 ± 3.2 84 ± 7 -7.8
2.1.01.01. Phospholipase A2 bothropstoxin-2 2oqd Bothrops jararacussu Secreted 1 0 6.0 ± 0.6 85 ± 4 -7.8
2.1.61.01. Muramidase Tse3-Tsi3 complex, conformation 1 4m5f Pseudomonas aeruginosa Bact. Gram-neg outer 2 0 3.4 ± 0.2 84 ± 3 -7.8
2.1.09.01. Major allergen I 1puo Felis catus Secreted 1 0 3.7 ± 0.8 58 ± 6 -7.8
2.1.01.01. Phospholipase A2 homolog, taipoxin beta chain 3vbz Oxyuranus scutellatus scutellatus Secreted 1 0 2.8 ± 0.7 87 ± 2 -7.7
2.1.05.02. Farnesyl diphosphate synthase (Geranyltranstransferase) 1rqj Escherichia coli Bact. Gram-neg inner 1 0 3.3 ± 0.7 87 ± 3 -7.7
2.1.62.01. Thuricin 17 2lbz Bacillus cereus Secreted 1 0 3.4 ± 2.6 88 ± 0 -7.7
2.1.01.03. Phospholipase A2 group XIII 4aup Tuber borchii Secreted 1 0 3.7 ± 0.7 63 ± 6 -7.7
2.1.18.01. Annexin IV 1i4a Bos taurus Eukaryo. plasma 3 0 2.5 ± 1.1 89 ± 3 -7.7
2.1.01.01. Snake phospholipase A2 homolog 1, group II 2ok9 Bothrops pirajai Secreted 1 0 3.5 ± 1.4 76 ± 7 -7.6
2.1.18.01. Annexin IV 2zoc Homo sapiens Eukaryo. plasma 1 0 3.4 ± 1.1 82 ± 7 -7.6
2.1.18.01. Annexin IV 2zhj Rattus norvegicus Eukaryo. plasma 1 0 4.1 ± 1.0 80 ± 1 -7.6
2.1.63.01. Lipid A biosynthesis lauroyl acyltransferase 5kn7 Acinetobacter baumannii Bact. Gram-neg outer 1 0 7.4 ± 1.4 66 ± 0 -7.5
2.1.01.01. Snake phospholipase A2, group I 1s6b Naja sagittifera Secreted 1 0 3.0 ± 1.1 81 ± 10 -7.5
2.1.01.01. Snake phospholipase A2, acidic, group II 1ijl Agkistrodon acutus Secreted 1 0 4.2 ± 1.2 83 ± 12 -7.5
2.1.59.01. AcrH-AopB chaperone-translocator complex 3wxx Aeromonas hydrophila Bact. Gram-neg inner 2 0 3.6 ± 2.2 51 ± 3 -7.4
2.1.01.01. Phospholipase A2, group IB 1g4i Bos taurus Secreted 1 0 1.9 ± 0.5 87 ± 4 -7.4
2.1.02.01. Arachidonate 15-lipoxygenase 5med Synechococcus sp. Bact. Gram-neg inner 1 0 3.3 ± 1.6 75 ± 7 -7.4
2.1.01.01. Myotoxin 1god Bothrops godmani Secreted 1 0 3.0 ± 0.8 80 ± 8 -7.4
2.1.01.01. Snake phospholipase A2 crotoxin basic chain 2, group II 2qog Crotalus durissus terrificus Secreted 1 0 2.1 ± 1.1 84 ± 8 -7.2
2.1.01.01. MTX-II chain A 4k06 Bothrops brazili Secreted 1 0 5.0 ± 1.3 60 ± 11 -7.1
2.1.10.01. Glycolipid transfer protein, conformation 2 1swx Homo sapiens Eukaryo. plasma 1 0 4.6 ± 1.0 87 ± 8 -7.1
2.1.24.01. Saposin C (peptide 311-391) 1sn6 Homo sapiens Lysosome 1 0 4.8 ± 1.1 82 ± 7 -7.1
2.1.01.01. Acidic phospholipase A2 5 4rfp Trimeresurus stejnegeri Secreted 1 0 2.8 ± 0.3 81 ± 3 -7.1
2.1.15.01. Tepsin 5wfb Homo sapiens Golgi 1 0 3.8 ± 1.2 79 ± 5 -7.0
2.1.01.01. Phospholipase A2, group IIA 1n28 Homo sapiens Secreted 1 0 3.6 ± 0.6 88 ± 4 -7.0
2.1.01.01. Snake phospholipase A2, group I, isoform 3 3jql Naja sagittifera Secreted 1 0 6.2 ± 1.0 85 ± 5 -7.0
2.1.12.01. Outer surface protein C 1g5z Borrelia burgdorferi Bact. Gram-neg outer 2 0 3.6 ± 0.6 2 ± 8 -7.0
2.1.13.01. Molt-inhibiting hormone 1j0t Marsupenaeus japonicus Secreted 1 0 4.1 ± 0.4 66 ± 6 -7.0
2.1.25.01. Bacteriocin AS-48 1o82 Enterococcus faecalis Secreted 1 0 4.4 ± 1.1 81 ± 13 -7.0
2.1.27.01. Cry2Aa 1i5p Bacillus thuringiensis Secreted 1 0 3.4 ± 1.2 16 ± 12 -7.0
2.1.03.01. Alpha-toxin (PHLC_CLOP1) 2wxu Clostridium perfringens Secreted 1 0 4.0 ± 0.9 85 ± 5 -7.0
2.1.10.01. Ceramide-1-phosphate transfer protein 4kbr Mus musculus Eukaryo. plasma 1 0 3.5 ± 1.5 77 ± 10 -6.9
2.1.01.01. Phospholipase A2 BnSP-7 1pa0 Bothrops neuwiedi pauloensis Secreted 1 0 2.8 ± 1.0 78 ± 10 -6.9
2.1.63.01. Phosphatidylinositol mannoside acyltransferase PatA 5f34 Mycobacterium smegmatis Bact. Gram-pos plas. 0 0 3.9 ± 0.5 58 ± 1 -6.9
2.1.40.01. Protein unc-13 homolog A, MHD domain 3swh Rattus norvegicus Eukaryo. plasma 1 0 6.6 ± 3.0 27 ± 12 -6.8
2.1.58.01. Serine/threonine-protein kinase pelle 1ik7 Drosophila melanogaster Eukaryo. plasma 1 0 1.5 ± 3.7 86 ± 0 -6.8
2.1.03.01. Alpha-toxin (PHLC_CLOP1) , different conformation 1qmd Clostridium perfringens Secreted 1 0 4.8 ± 1.0 80 ± 8 -6.7
2.1.14.01. Peroxisomal targeting signal 1 receptor 1fch Homo sapiens Peroxisome 1 0 6.9 ± 1.2 54 ± 3 -6.7
2.1.57.01. Adhesin FadA 3etw Fusobacterium nucleatum Secreted 1 0 5.0 ± 3.8 47 ± 5 -6.7
2.1.01.01. Snake phospholipase A2-3, group II 1gmz Bothrops pirajai Secreted 1 0 3.8 ± 1.5 88 ± 10 -6.7
2.1.01.01. Snake phospholipase A2, group I, acidic 2 1m8t Ophiophagus hannah Secreted 1 0 4.4 ± 0.8 88 ± 6 -6.6
2.1.15.02. Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) 1dvp Drosophila melanogaster Endosome 2 0 3.0 ± 0.0 89 ± 0 -6.6
2.1.29.01. Apolipoprotein A-I 2a01 Homo sapiens Secreted 1 0 4.8 ± 1.2 63 ± 11 -6.5
2.1.51.01. Protein farnesyltransferase/geranylgeranyltransferase 2h6f Homo sapiens Eukaryo. plasma 2 0 4.5 ± 1.5 87 ± 6 -6.5
2.1.25.02. Enterocin NKR-5-3B 2mp8 Enterococcus faecium Secreted 1 0 4.9 ± 1.9 68 ± 29 -6.4
2.1.02.01. Seed lipoxygenase-1 1yge Glycine max Eukaryo. plasma 1 0 3.0 ± 2.6 68 ± 3 -6.4
2.1.35.01. Protein kinase C and casein kinase substrate 3qni Homo sapiens Eukaryo. plasma 2 0 3.0 ± 0.0 90 ± 0 -6.4
2.1.21.02. Matrix protein p10, myristoylated, structure 2 2mxi Mason-Pfizer monkey virus Viral 1 0 3.8 ± 0.7 58 ± 3 -6.3
2.1.44.01. Bacteriocin glycocin F 2kuy Lactobacillus plantarum Secreted 1 0 5.4 ± 1.2 65 ± 6 -6.2
2.1.18.01. Annexin VIII 1w3w Homo sapiens Eukaryo. plasma 1 0 4.1 ± 1.0 79 ± 9 -6.2
2.1.02.01. Seed lipoxygenase-D 2iuk Glycine max Eukaryo. plasma 1 0 3.7 ± 1.7 85 ± 8 -6.2
2.1.36.01. Endoplasmic reticulum oxidoreductin, a mutant 3m31 Saccharomyces cerevisiae Endoplasm. reticulum 1 0 1.9 ± 1.2 27 ± 9 -6.2
2.1.11.01. Spectrin alpha chain 2spc Drosophila melanogaster Eukaryo. plasma 2 0 4.3 ± 0.8 87 ± 11 -6.2
2.1.07.01. Decaheme cytochrome c MtrF 3pmq Shewanella oneidensis Bact. Gram-neg outer 1 0 3.9 ± 0.9 86 ± 2 -6.2
2.1.01.01. Snake phospholipase A2, acidic, group I 2wq5 Naja naja Secreted 1 0 3.4 ± 0.3 89 ± 6 -6.2
2.1.01.01. Snake phospholipase A2, group I 1ae7 Notechis scutatus scutatus (Mainland tiger snake) Secreted 1 0 4.7 ± 0.6 84 ± 9 -6.2
2.1.14.03. Vesicular transport protein sec17 1qqe Saccharomyces cerevisiae Vacuole 1 0 5.2 ± 6.1 17 ± 15 -6.2
2.1.03.01. Alpha-toxin 1olp Clostridium absonum Secreted 1 0 2.8 ± 1.8 62 ± 11 -6.1
2.1.08.01. Cytochrome c551 1cor Pseudomonas stutzeri Bact. Gram-neg inner 1 0 2.6 ± 1.1 73 ± 12 -6.1
2.1.01.01. Snake phospholipase A2 natratoxin, group I 2osh Naja atra Secreted 1 0 2.6 ± 1.6 83 ± 11 -6.1
2.1.64.01. AFMP4P 5j5k Aspergillus fumigatus Eukaryo. plasma 1 0 3.9 ± 1.9 73 ± 13 -6.1
2.1.41.01. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit 3ml9 Homo sapiens Eukaryo. plasma 1 0 3.0 ± 0.8 83 ± 2 -6.0
2.1.18.01. Annexin IV, monomeric state 1ann Bos taurus Eukaryo. plasma 1 0 2.2 ± 1.0 77 ± 3 -6.0
2.1.14.02. SusD superfamily protein 3myv Bacteroides vulgatus Secreted 1 0 4.0 ± 1.0 64 ± 2 -6.0
2.1.28.01. Heat-stable enterotoxin II 1ehs Escherichia coli Secreted 1 0 1.4 ± 1.1 64 ± 11 -6.0
2.1.03.01. Alpha-toxin (PHLC1_CLOPE), closed state (inactive) 1gyg Clostridium perfringens Secreted 1 0 6.1 ± 2.0 75 ± 6 -5.9
2.1.08.01. Quinohemoprotein alcohol dehydrogenase ADH IIB 1kv9 Pseudomonas putida Bact. Gram-neg outer 1 0 1.7 ± 1.1 77 ± 22 -5.9
2.1.18.01. Annexin 4mdv Schistosoma mansoni Eukaryo. plasma 1 0 3.7 ± 0.8 77 ± 9 -5.9
2.1.01.01. Snake phospholipase A2, group I, acidic 1 1gp7 Ophiophagus hannah Secreted 1 0 4.6 ± 1.0 84 ± 12 -5.8
2.1.01.01. Snake phospholipase A2, isoform 3 2osn Bungarus caeruleus Secreted 1 0 2.4 ± 0.6 84 ± 4 -5.8
2.1.54.01. Programmed cell death protein 10 3ajm Homo sapiens Golgi 2 0 2.7 ± 0.4 86 ± 7 -5.8
2.1.20.01. Prothrombin 1nl2 Bos taurus Eukaryo. plasma 1 0 3.9 ± 3.0 18 ± 24 -5.8
2.1.21.02. Matrix protein p10 2f76 Mason-Pfizer monkey virus Viral 1 0 3.9 ± 1.2 48 ± 5 -5.8
2.1.01.01. Snake phospholipase A2 isoform 5, group I 1y75 Naja sagittifera Secreted 1 0 4.4 ± 0.7 81 ± 10 -5.7
2.1.55.01. Secretion factor PAS 2b8i Vibrio vulnificus Secreted 1 0 5.4 ± 1.5 72 ± 7 -5.7
2.1.18.01. Annexin III 1axn Homo sapiens Eukaryo. plasma 1 0 2.7 ± 0.8 77 ± 11 -5.7
2.1.20.01. Coagulation factor XIV (protein C) in complex with its receptor 1lqv Homo sapiens Eukaryo. plasma 2 0 3.4 ± 3.9 53 ± 14 -5.6
2.1.02.01. Seed lipoxygenase-3 1rrh Glycine max Eukaryo. plasma 1 0 3.8 ± 1.3 84 ± 7 -5.6
2.1.08.02. Cytochrome c4 1m70 Pseudomonas stutzeri Bact. Gram-neg inner 1 0 5.4 ± 0.8 67 ± 14 -5.6
2.1.29.05. Apolipoprotein C-III 2jq3 Homo sapiens Secreted 1 0 2.9 ± 1.4 85 ± 0 -5.6
2.1.18.01. Annexin I 1hm6 Sus scrofa Vesicle 1 0 2.1 ± 0.9 88 ± 7 -5.6
2.1.01.03. Prokaryotic phospholipase A2 1kp4 Streptomyces violaceoruber Secreted 1 0 2.4 ± 1.3 42 ± 13 -5.6
2.1.01.01. Snake phospholipase A2 homolog 2, group II 2q2j Bothrops pirajai Secreted 1 0 1.9 ± 1.2 89 ± 9 -5.6
2.1.21.01. Influenza virus matrix protein M1, structure 1 1aa7 Influenza virus Viral 2 0 2.6 ± 0.8 89 ± 4 -5.6
2.1.51.01. Protein farnesyltransferase/geranylgeranyltransferase 1jcr Rattus norvegicus Eukaryo. plasma 2 0 3.2 ± 2.3 56 ± 5 -5.6
2.1.14.01. Peroxisomal targeting signal 1 receptor, complex with sterol carrier protein 2 2c0l Homo sapiens Peroxisome 2 0 3.1 ± 2.5 85 ± 35 -5.5
2.1.41.01. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform 3hhm Homo sapiens Eukaryo. plasma 2 0 1.3 ± 0.5 78 ± 1 -5.5
2.1.47.01. Group 2 truncated hemoglobin glbO 2qrw Mycobacterium tuberculosis Bact. Gram-pos plas. 1 0 4.5 ± 1.0 52 ± 3 -5.5
2.1.31.01. Colicin-M 3da4 Escherichia coli Bact. Gram-neg inner 1 0 2.5 ± 0.9 49 ± 11 -5.5
2.1.60.03. Pseudecin, conformation 1 2ddb Pseudechis porphyriacus Secreted 1 0 4.8 ± 0.7 90 ± 3 -5.4
2.1.08.01. Cytochrome c551 451c Pseudomonas aeruginosa Bact. Gram-neg inner 1 0 1.4 ± 0.9 85 ± 10 -5.4
2.1.34.01. Septium site-determining protein DivIVA 2wuj Bacillus subtilis Bact. Gram-pos plas. 2 0 4.0 ± 1.8 2 ± 18 -5.4
2.1.01.01. Snake phospholipase A2, group I, KPA2 1g2x Bungarus caeruleus Secreted 1 0 3.8 ± 1.5 84 ± 10 -5.4
2.1.35.01. Protein kinase C and casein kinase substrate 3lll Mus musculus Vesicle 2 0 1.9 ± 0.4 88 ± 1 -5.4
2.1.24.01. NK-lysin 1nkl Sus scrofa Secreted 1 0 2.8 ± 1.5 37 ± 12 -5.4
2.1.18.01. Annexin V 1hvf Homo sapiens Eukaryo. plasma 1 0 2.3 ± 1.5 79 ± 10 -5.4
2.1.10.01. Accelerated-cell-death 11 apo-protein 4nt1 Arabidopsis thaliana Eukaryo. plasma 1 0 2.6 ± 2.0 85 ± 7 -5.4
2.1.15.01. Epsin-1 1h0a Rattus norvegicus Eukaryo. plasma 1 0 3.2 ± 1.1 39 ± 19 -5.3
2.1.41.01. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, delta isoform 2wxf Mus musculus Eukaryo. plasma 1 0 2.3 ± 1.8 89 ± 3 -5.3
2.1.25.03. Enterocin 7A 2m5z Enterococcus faecalis Secreted 0 0 4.4 ± 0.3 57 ± 3 -5.3
2.1.01.01. Myotoxin II 1xxs Bothrops moojeni Secreted 1 0 4.5 ± 1.2 76 ± 10 -5.3
2.1.49.01. cGMP-specific 3',5'-cyclic phosphodiesterase 1rkp Homo sapiens Eukaryo. plasma 1 0 5.0 ± 1.6 61 ± 11 -5.2
2.1.20.01. Coagulation factor X, GLA domain 1iod Bos taurus Secreted 1 0 3.3 ± 0.9 25 ± 15 -5.2
2.1.60.03. Natrin-1 1xx5 Naja atra Secreted 1 0 2.6 ± 2.4 60 ± 49 -5.2
2.1.01.01. Phospholipase A2 isoform 4 1yxh Naja sagittifera Secreted 1 0 1.7 ± 0.5 81 ± 2 -5.2
2.1.30.01. Membrane-integrating protein mistic, mstX 1ygm Bacillus subtilis Bact. Gram-pos plas. 1 0 2.6 ± 1.8 31 ± 6 -5.2
2.1.23.01. Ectatomin 1eci Ectatomma tuberculatum Secreted 2 0 5.3 ± 1.8 58 ± 15 -5.2
2.1.60.03. Cysteine-rich venom protein 1rc9 Trimeresurus stejnegeri Secreted 1 0 3.9 ± 0.7 73 ± 5 -5.1
2.1.41.01. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, more complete 4ezk Homo sapiens Eukaryo. plasma 1 0 3.6 ± 0.6 81 ± 2 -5.1
2.1.11.01. Alpha-actinin-2 1hci Homo sapiens Eukaryo. plasma 2 0 0.4 ± 0.7 90 ± 12 -5.1
2.1.18.01. Annexin V 1yii Gallus gallus Eukaryo. plasma 1 0 3.1 ± 0.7 79 ± 7 -5.1
2.1.01.01. Snake phospholipase A2, group I, isoform 1 1tc8 Bungarus caeruleus Secreted 1 0 3.1 ± 1.4 89 ± 11 -5.0
2.1.33.01. DrrA protein, PtdIns(4) binding domain 3n6o Legionella pneumophila Vacuole 1 0 5.1 ± 1.4 56 ± 10 -4.9
2.1.44.01. Bacteriocin ASM1 2mvi Lactobacillus plantarum Secreted 1 0 5.3 ± 1.4 33 ± 5 -4.9
2.1.07.01. Nonaheme cytochrome c 1duw Desulfovibrio desulfuricans Bact. Gram-neg inner 1 0 5.1 ± 0.4 87 ± 10 -4.9
2.1.20.01. Coagulation factor VIIa 1dan Homo sapiens Eukaryo. plasma 4 0 4.2 ± 6.0 25 ± 26 -4.9
2.1.43.01. Acanthaporin 2lrd Acanthamoeba culbertsoni Secreted 1 0 4.8 ± 3.0 56 ± 26 -4.9
2.1.29.01. Apolipoprotein E 2l7b Homo sapiens Secreted 1 0 2.5 ± 1.0 73 ± 8 -4.9
2.1.33.01. DrrA protein, PtdIns(4) binding domain, from different strain 3l0m Legionella pneumophila Vacuole 1 0 3.7 ± 4.2 44 ± 7 -4.8
2.1.42.01. Lactococcin-A immunity protein 5lfi Lactococcus lactis Secreted 1 0 2.7 ± 1.4 40 ± 9 -4.8
2.1.31.01. Colicin M, alternative orientation 2xmx Escherichia coli Secreted 1 0 2.4 ± 2.3 82 ± 4 -4.8
2.1.02.01. Seed lipoxygenase-B 2iuj Glycine max Eukaryo. plasma 1 0 1.7 ± 3.0 51 ± 15 -4.8
2.1.36.01. Endoplasmic reticulum oxidoreductin 1rp4 Saccharomyces cerevisiae Endoplasm. reticulum 1 0 2.0 ± 1.8 16 ± 9 -4.7
2.1.41.01. Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform 1e7u Sus scrofa Eukaryo. plasma 1 0 2.5 ± 0.9 85 ± 3 -4.7
2.1.41.01. Phosphatidylinositol 3-kinase catalytic subunit type 3 3ls8 Homo sapiens Eukaryo. plasma 1 0 2.7 ± 2.2 75 ± 9 -4.7
2.1.08.01. Cytochrome c552 1a8c Nitrosomonas europaea Bact. Gram-neg inner 1 0 2.7 ± 1.0 80 ± 11 -4.7
1.2.38.02. Lysozyme 3hde Enterobacteria phage p21 Secreted 1 0 1.8 ± 1.4 55 ± 10 -4.7
2.1.61.01. Muramidase Tse3-Tsi3 complex, conformation 3 3wa5 Pseudomonas aeruginosa Bact. Gram-neg outer 2 0 4.5 ± 1.4 84 ± 7 -4.6
2.1.25.02. Carnocyclin A 2kjf Carnobacterium maltaromaticum Secreted 1 0 2.1 ± 1.1 61 ± 12 -4.6
2.1.60.03. Pseudecin, conformation 2 2epf Pseudechis porphyriacus Secreted 1 0 5.4 ± 1.1 86 ± 1 -4.6
2.1.01.01. Phospholipase A2 homolog 1ppa Agkistridon piscivorus Secreted 1 0 1.2 ± 0.9 85 ± 8 -4.5
2.1.33.01. DrrA protein, PtdIns(4) binding domain, complex with PtdIns(4) 4mxp Legionella pneumophila Vacuole 1 0 2.8 ± 2.6 59 ± 12 -4.5
2.1.42.01. Immunity protein for enterocin A (Entl) 2bl7 Enterococcus faecium Secreted 1 0 3.3 ± 1.0 89 ± 3 -4.5
2.1.24.01. Saposin-like protein Ac-SLP-1 3s64 Ancylostoma caninum Secreted 1 0 4.2 ± 2.2 53 ± 16 -4.5
2.1.20.01. Osteocalcin 1q8h Sus scrofa Secreted 1 0 2.3 ± 1.7 81 ± 17 -4.4
2.1.60.01. Aurelin 2lg4 Aurelia aurita Secreted 1 0 2.0 ± 0.9 50 ± 6 -4.4
2.1.20.01. Coagulation factor IX, GLA domain 1nl0 Homo sapiens Secreted 1 0 4.1 ± 0.9 38 ± 13 -4.4
2.1.52.01. Pheromone binding protein 1ow4 Rhyparobia maderae (Madeira cockroach) Secreted 1 0 4.4 ± 0.8 30 ± 16 -4.4
2.1.18.01. Annexin 24 1dk5 Capsicum annuum Eukaryo. plasma 1 0 3.5 ± 1.3 76 ± 18 -4.4
2.1.19.01. Nigellin 2nb2 Nigella sativa Secreted 1 0 4.7 ± 2.2 69 ± 12 -4.4
2.1.64.01. Envelope glycoprotein, ligand-binding domain 1 5e7x Talaromyces marneffei Eukaryo. plasma 1 0 2.7 ± 2.2 55 ± 13 -4.4
2.1.60.02. Potassium channel blocking domain of matrix metalloproteinase-23 2k72 Rattus norvegicus Eukaryo. plasma 1 0 2.1 ± 2.3 77 ± 22 -4.4
2.1.48.01. Glycerol dehydrogenase 1kq3 Thermotoga maritima Undefined 1 0 2.5 ± 1.8 80 ± 5 -4.3
2.1.08.01. Cytochrome c2 1cxa Rhodobacter sphaeroides Bact. Gram-neg inner 1 0 2.0 ± 1.2 88 ± 13 -4.3
2.1.42.01. Putative carnobacteriocin-B2 immunity protein 1tdp Carnobacterium maltaromaticum Secreted 1 0 4.4 ± 0.5 90 ± 9 -4.3
2.1.50.01. Phosphate transport system protein phoU homolog 2 1sum Thermotoga maritima Bact. Gram-neg inner 1 0 4.9 ± 2.1 68 ± 4 -4.3
2.1.29.01. Apolipoprotein A-I 2lem Mus musculus Secreted 1 0 2.7 ± 1.7 79 ± 2 -4.3
2.1.60.03. Pseudechetoxin 2dda Pseudechis australis Secreted 1 0 4.5 ± 2.8 89 ± 7 -4.3
2.1.44.01. Sublancin-168 2mij Bacillus subtilis Secreted 1 0 4.0 ± 5.0 83 ± 0 -4.2
2.1.27.01. Cry3Bb1 1ji6 Bacillus thuringiensis Secreted 1 0 3.8 ± 1.6 64 ± 6 -4.2
2.1.24.01. Saposin A (peptide 60-140) 2dob Homo sapiens Lysosome 1 0 2.0 ± 2.5 70 ± 29 -4.2
2.1.29.01. Apolipoprotein E 1ya9 Mus musculus Secreted 1 0 1.6 ± 1.4 85 ± 11 -4.1
2.1.29.06. Perilipin-3 1szi Mus musculus Endosome 1 0 2.4 ± 2.3 61 ± 6 -4.1
2.1.29.01. Apolipoprotein A-I, alternative structure of C-terminal domain 3r2p Homo sapiens Secreted 2 0 1.7 ± 1.6 87 ± 3 -4.1
2.1.15.02. ADP-ribosylation factor-binding protein GGA2 1mhq Homo sapiens Golgi 1 0 4.2 ± 1.2 74 ± 5 -4.1
2.1.39.01. Viral protein R, full length 1m8l Human immunodeficiency virus type 1 Eukaryo. plasma 1 0 4.7 ± 2.8 64 ± 36 -4.0
2.1.25.05. Lacticin Q 2n8p Lactococcus lactis Secreted 1 0 3.5 ± 0.8 80 ± 6 -4.0
2.1.01.01. Phospholipase A2 2not Notechis scutatus scutatus (Mainland tiger snake) Secreted 1 0 2.6 ± 1.5 73 ± 8 -3.9
2.1.20.01. Coagulation factor IX 1pfx Sus scrofa Eukaryo. plasma 2 0 1.9 ± 6.0 84 ± 10 -3.9
2.1.01.01. Phospholipase A2, beta bungarotoxin A1 chain, complex with bungarotoxin 1bun Bungarus multicinctus Secreted 2 0 1.7 ± 0.9 79 ± 3 -3.8
2.1.19.01. Antifungal peptide 2l2r Echinochloa crus-galli Secreted 1 0 3.4 ± 1.5 50 ± 8 -3.8
2.1.18.01. Annexin II 1w7b Homo sapiens Eukaryo. plasma 1 0 2.4 ± 1.2 87 ± 18 -3.8
2.1.25.03. Enterocin 7B 2m60 Enterococcus faecalis Secreted 1 0 3.2 ± 1.6 53 ± 15 -3.8
2.1.02.01. Arachidonate 5-lipoxygenase 3o8y Homo sapiens Eukaryo. plasma 1 0 2.1 ± 1.0 89 ± 4 -3.8
2.1.60.01. Potassium channel toxin ShK 1roo Stoichactis helianthus Secreted 1 0 1.2 ± 1.2 46 ± 8 -3.7
2.1.18.01. Annexin GH1 1n00 Gossypium hirsutum Eukaryo. plasma 1 0 1.5 ± 2.0 70 ± 17 -3.7
2.1.24.01. Saposin-like protein 5 2jsa Caenorhabditis elegans Secreted 1 0 1.8 ± 2.2 47 ± 0 -3.7
2.1.42.01. Bacteriocin 2fu2 Streptococcus pyogenes Secreted 1 0 1.6 ± 1.1 77 ± 16 -3.7
2.1.21.04. Matrix protein p19 1a6s Rous sarcoma virus Viral 1 0 3.1 ± 2.7 89 ± 14 -3.6
2.1.01.01. Phospholipase A2, group IB 3elo Homo sapiens Secreted 1 0 0.4 ± 1.5 52 ± 16 -3.5
2.1.18.01. Annexin A2 4x9p Bos taurus Vesicle 1 0 2.7 ± 2.4 81 ± 12 -3.5
2.1.24.01. Saposin-like protein Na-SLP-1 3s63 Necator americanus Secreted 1 0 2.2 ± 1.6 74 ± 10 -3.5
2.1.21.03. Matrix protein p15 1mn8 Moloney murine leukemia virus Endosome 1 0 1.5 ± 1.8 65 ± 24 -3.5
2.1.08.01. Cytochrome c6 1f1f Arthrospira maxima Thylakoid 1 0 4.8 ± 1.6 80 ± 15 -3.5
2.1.19.01. Antimicrobial peptide Tk-Amp-X2 2m6a Hordeum vulgare Secreted 1 0 1.2 ± 1.0 65 ± 7 -3.4
2.1.24.01. Saposin D (peptide 405-486) 2rb3 Homo sapiens Secreted 1 0 2.2 ± 1.7 88 ± 10 -3.4
2.1.18.01. Annexin D1 1ycn Arabidopsis thaliana Eukaryo. plasma 1 0 2.3 ± 1.1 78 ± 14 -3.4
2.1.21.02. Matrix protein p10, myristoylated, structure 1 2lpy Mason-Pfizer monkey virus Viral 1 0 3.2 ± 0.5 8 ± 6 -3.4
2.1.19.01. Ribosome-inactivating protein luffin P1 2l37 Luffa aegyptiaca Secreted 1 0 1.3 ± 0.9 80 ± 7 -3.3
2.1.08.01. Cytochrome c2 1co6 Rhodopseudomonas viridis Bact. Gram-neg inner 1 0 1.4 ± 0.7 78 ± 10 -3.3
2.1.08.01. Mono-heme c-type cytochrome ScyA 1kx7 Shewanella putrefaciens Bact. Gram-neg inner 1 0 1.8 ± 1.1 72 ± 12 -3.2
2.1.24.01. Saposin B (peptide 195-273), structure 2 4v2o Homo sapiens Lysosome 2 0 1.5 ± 1.0 51 ± 4 -3.2
2.1.02.01. 8R-Lipoxygenase, complete structure 3dy5 Plexaura homomalla Eukaryo. plasma 1 0 2.3 ± 1.5 88 ± 10 -3.2
2.1.37.01. Erythrocyte membrane protein 1 2xu0 Plasmodium falciparum Eukaryo. plasma 1 0 3.3 ± 6.0 75 ± 45 -3.2
2.1.26.01. Colicin A channel-forming domain 1col Escherichia coli Secreted 1 0 1.8 ± 1.0 43 ± 11 -3.2
2.1.42.01. Mundticin KS immunity protein 2zrr Enterococcus mundtii Secreted 1 0 1.6 ± 1.5 72 ± 9 -3.2
2.1.20.01. Osteocalcin 4mzz Bos taurus Secreted 1 0 1.8 ± 1.1 43 ± 8 -3.0
2.1.60.01. Potassium channel toxin Bgk 1bgk Bunodosoma granulifera Secreted 1 0 1.8 ± 1.7 19 ± 27 -2.9
2.1.08.01. Cytochrome c6 1ls9 Cladophora glomerata Thylakoid 1 0 4.1 ± 1.0 70 ± 14 -2.9
2.1.64.01. Envelope glycoprotein, ligand-binding domain 2 5fb7 Talaromyces marneffei Eukaryo. plasma 1 0 3.2 ± 2.5 64 ± 10 -2.9
2.1.60.03. Cysteine-rich secretory protein 2 2a05 Mus musculus Secreted 1 0 1.4 ± 1.8 52 ± 133 -2.8
2.1.29.03. Apolipoprotein C-I, peptide 27-83 1ioj Homo sapiens Secreted 1 0 0.6 ± 1.8 80 ± 16 -2.8
2.1.41.01. Phosphatidylinositol 4-kinase type 2-alpha, structure 2 4pla Homo sapiens Golgi 1 0 1.0 ± 1.7 49 ± 3 -2.8
2.1.19.01. Kappa-buthitoxin-Tt2b 2li3 Tityus trivittatus Secreted 1 0 0.8 ± 0.7 40 ± 6 -2.7
2.1.01.01. Basic phospholipase A2 homolog 1 3t0r Bothrops moojeni Secreted 1 0 3.7 ± 1.6 86 ± 12 -2.6
2.1.25.05. Aureocin A53 2n8o Staphylococcus aureus Secreted 1 0 0.8 ± 0.4 78 ± 6 -2.6
2.1.08.01. Mitochondrial cytochrome c 1hrc Equus caballus Mitochon. inner 1 0 2.1 ± 1.0 80 ± 16 -2.6
2.1.21.05. Matrix protein p15 1hek Equine infectious anemia virus Endosome 1 0 1.0 ± 2.8 76 ± 21 -2.6
2.1.02.01. Arachidonate 5-lipoxygenase, complex with arachidonic acid 3v99 Homo sapiens Eukaryo. plasma 1 0 3.0 ± 2.3 88 ± 9 -2.5
2.1.60.03. Cysteine-rich secretory protein 2 2cq7 Homo sapiens Secreted 1 0 0.7 ± 1.1 68 ± 5 -2.5
2.1.60.02. Lasiocepsin 2mbd Lasioglossum laticeps Secreted 1 0 0.6 ± 1.3 47 ± 15 -2.5
2.1.24.01. Saposin B (peptide 195-273), structure 1 1n69 Homo sapiens Lysosome 2 0 1.2 ± 1.0 58 ± 6 -2.4
2.1.24.01. Pore-forming peptide ameobapore A 1of9 Entamoeba histolytica Undefined 1 0 1.5 ± 1.0 13 ± 18 -2.3
1.2.38.03. Endo-type membrane-bound lytic murein transglycosylase A 2y8p Escherichia coli Bact. Gram-neg outer 1 0 0.0 ± 3.6 86 ± 15 -2.2
2.1.42.01. PapB 2ip6 Pediococcus pentosaceus Secreted 1 0 0.6 ± 2.6 72 ± 23 -2.2
2.1.26.01. Colicin-E1 2i88 Escherichia coli Secreted 1 0 1.1 ± 3.3 58 ± 37 -1.7
2.1.08.01. Cytochrome c6 1c6s Thermosynechococcus elongatus Thylakoid 1 0 0.4 ± 1.7 89 ± 16 -1.3