PDB ID or protein name

Beta-hairpin peptides superfamilies

3.2.001. Antimicrobial beta-hairpin (10 families)
3.2.002. Beta-hairpin conotoxins (1 family) 8.B.4 (TCDB)
3.2.003. Hepcidin (1 family) PF06446 (Pfam)
3.2.004. Cyclic trypsin inhibitor-like (3 families)
3.2.005. Lasso peptides (3 families)
3.2.006. Paralytic peptide (1 family) PF02425 (Pfam)
3.2.008. Amyloid beta-sheet peptides (2 families)
3.2.009. Cyclic LD peptides (3 families)
3.2.010. Inhibitory peptides derived from seed proalbumin (1 family)
3.2.011. Designed beta-hairpin peptides (1 family)
See list of these PDB codes

Beta-hairpin peptides (89 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
3.2.01.06. Symmetrical θ-defensin, BTD-2 2lye Macaca mulatta Secreted 1 0 0.4 ± 2.9 80 ± 22 -1.5
3.2.10.01. PawS derived peptide 11 2lwq Designed proteins Undefined 1 0 10.1 ± 1.4 55 ± 22 -9.5
3.2.05.02. Microcin J25, peptide 38-58, cleaved after 47 1s7p Escherichia coli Secreted 1 0 4.7 ± 1.2 83 ± 18 -5.7
3.2.05.02. Caulosegnin I 2lx6 Caulobacter segnis Secreted 1 0 2.9 ± 0.8 15 ± 5 -6.0
3.2.10.01. PawS derived peptide 9 2nb5 Designed proteins Undefined 1 0 5.6 ± 1.3 79 ± 14 -6.5
3.2.01.02. Thanatin 8tfv Podisus maculiventris Secreted 1 0 3.7 ± 1.0 81 ± 4 -5.3
3.2.01.10. RCB-1 peptide 2mtm Ricinus communis Secreted 1 0 10.1 ± 3.0 37 ± 37 -8.4
3.2.06.01. Growth-blocking peptide 2djc Spodoptera litura Secreted 1 0 2.9 ± 2.0 19 ± 14 -3.1
3.2.02.02. Chi-conotoxin Ar1248 2m62 Conus araneosus Secreted 1 0 1.9 ± 1.0 78 ± 12 -3.0
3.2.10.01. PawS derived peptide 4 2lws Designed proteins Undefined 1 0 7.5 ± 1.3 37 ± 13 -5.8
3.2.05.02. Microcin J25, peptide 38-58 1q71 Escherichia coli Secreted 1 0 3.3 ± 3.2 75 ± 17 -5.2
3.2.05.02. Lassomycin 2mai Lentzea kentuckyensis Secreted 1 0 3.1 ± 1.0 72 ± 9 -4.7
3.2.01.09. Transthyretin-derived peptide 5hpp Designed proteins Undefined 1 0 2.7 ± 1.6 83 ± 6 -5.2
3.2.01.07. Protegrin-1 1pg1 Sus scrofa Secreted 1 0 2.2 ± 0.4 72 ± 4 -4.2
3.2.05.02. Chaxapeptin 1 2n5c Streptomyces leeuwenhoekii Secreted 1 0 7.2 ± 1.0 82 ± 9 -8.8
3.2.06.01. Growth-blocking peptide, long form 2eqt Pseudaletia separata (Oriental armyworm) Secreted 1 0 4.1 ± 1.4 59 ± 8 -5.7
3.2.02.02. Conopeptide CnVA 3zkt Conus consors (Singed cone) Secreted 1 0 7.9 ± 2.9 88 ± 27 -5.2
3.2.10.01. PawS derived peptide 5 2lwt Designed proteins Undefined 1 0 8.1 ± 2.2 55 ± 21 -5.2
3.2.06.01. Plasmatocyte-spreading peptide PSP1 1b5n Pseudoplusia includens Secreted 1 0 3.1 ± 1.2 87 ± 16 -3.7
3.2.05.02. Xanthomonin I 4nag Xanthomonas gardneri Secreted 1 0 8.7 ± 2.4 81 ± 11 -5.0
3.2.05.02. Sphingopyxin I 5jqf Sphingopyxis alaskensis Undefined 1 0 1.7 ± 1.8 40 ± 16 -3.7
3.2.01.03. Androctonin 1cz6 Androctonus australis (Sahara scorpion) Secreted 1 0 1.5 ± 2.8 89 ± 16 -3.2
3.2.10.01. PawS derived peptide 20 2ndn Zinnia haageana Secreted 1 0 1.8 ± 0.7 83 ± 11 -4.6
3.2.04.01. Cyclic trypsin inhibitor STFI-1 1jbl Helianthus annuus Secreted 1 0 7.2 ± 0.8 72 ± 8 -6.1
3.2.10.01. PawS derived peptide 7 2lwu Designed proteins Undefined 1 0 2.0 ± 1.4 81 ± 10 -3.0
3.2.06.01. Paralytic peptide 1irr Bombyx mori Secreted 1 0 2.2 ± 1.9 74 ± 19 -3.3
3.2.05.02. Xanthomonin II 2mfv Xanthomonas gardneri Secreted 1 0 4.1 ± 0.9 38 ± 6 -4.4
3.2.10.01. PawS derived peptide 22 2ndl Designed proteins Undefined 1 0 8.6 ± 2.1 64 ± 9 -5.3
3.2.01.04. Gomesin 1kfp Acanthoscurria gomesiana (Tarantula spider) Secreted 1 0 0.5 ± 1.0 75 ± 6 -2.7
3.2.10.01. PawS derived peptide 21 2ndm Zinnia haageana Secreted 1 0 1.9 ± 1.2 83 ± 16 -3.7
3.2.04.02. Bowman-Birk type proteinase inhibitor peptide 1gm2 Macrotyloma axillare Secreted 1 0 2.0 ± 1.9 59 ± 14 -3.5
3.2.05.02. Microcin J25, redesigned, version 1 2mmt Designed proteins Undefined 1 0 3.0 ± 0.9 90 ± 5 -5.2
3.2.05.01. Siamycin II (tricyclic peptide RP71935) 1rpb Streptomyces sp. Secreted 1 0 4.2 ± 1.3 85 ± 15 -8.3
3.2.01.01. Arenicin-1 2jsb Arenicola marina Secreted 1 0 2.4 ± 2.1 80 ± 11 -5.2
3.2.11.01. Peptide NC_cEE_D1 5kx2 Designed proteins Undefined 1 0 4.9 ± 1.9 70 ± 14 -4.6
3.2.01.05. Polyphemusin-1 1rkk Limulus polyphemus (Atlantic horseshoe crab) Secreted 1 0 3.5 ± 3.7 63 ± 11 -4.0
3.2.05.02. LP2006 5jpl Nocardiopsis alba Secreted 1 0 3.6 ± 1.7 59 ± 12 -4.2
3.2.04.03. Peptide leucine arginine 2m3n Lithobates pipiens Secreted 1 0 4.7 ± 0.6 83 ± 5 -5.7
3.2.05.02. Microcin J25, redesigned, version 2 2mmw Designed proteins Undefined 1 0 2.6 ± 3.5 90 ± 4 -3.7
3.2.09.02. Gramicidin S 1tk2 Bacillus brevis Secreted 1 0 8.5 ± 1.7 86 ± 21 -8.6
3.2.03.01. Hepcidin, structure 1 3h0t Homo sapiens Secreted 1 0 4.7 ± 0.6 82 ± 9 -7.0
3.2.11.01. Anti-inflammatory peptide 5vav Designed proteins Undefined 1 0 7.7 ± 0.8 63 ± 12 -9.0
3.2.03.01. Maurocalcine 1s6w Scorpio maurus Secreted 1 0 1.8 ± 1.6 89 ± 21 -2.3
3.2.01.07. Protegrin-5 2nc7 Sus scrofa Secreted 1 0 2.3 ± 1.2 87 ± 6 -2.4
3.2.05.02. Astexin-3 2m8f Asticcacaulis excentricus Secreted 1 0 6.2 ± 1.1 64 ± 28 -5.9
3.2.05.02. Astexin-4 2n6u Asticcacaulis excentricus Secreted 1 0 2.8 ± 1.1 41 ± 21 -3.8
3.2.06.01. Growth-blocking peptide 2dj9 Mamestra brassicae Secreted 1 0 2.2 ± 0.7 31 ± 4 -6.2
3.2.01.05. Tachyplesin-1 2rtv Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 4.2 ± 0.4 88 ± 3 -6.8
3.2.01.01. Arenicin-3 5y0i Arenicola marina Secreted 1 0 3.0 ± 1.6 83 ± 5 -3.9
3.2.01.01. Arenicin-2 2jni Arenicola marina Secreted 1 0 2.1 ± 1.1 82 ± 15 -5.2
3.2.01.09. Cyclic beta-hairpin peptide 2m7i Designed proteins Secreted 1 0 2.0 ± 0.5 84 ± 8 -4.1
3.2.05.03. Bicyclic peptide BI-32169 3njw Streptomyces sp. Secreted 1 0 6.1 ± 0.3 86 ± 3 -9.9
3.2.01.09. Chignolin 5awl Designed proteins Undefined 1 0 2.6 ± 2.1 77 ± 28 -2.8
3.2.02.02. T-2-conotoxin MrIA 2ew4 Conus marmoreus Secreted 1 0 2.5 ± 1.5 81 ± 19 -3.0
3.2.01.08. Lactoferricin B, peptide 10-19 1y5c Bos taurus Secreted 1 0 2.2 ± 1.2 54 ± 11 -3.4
3.2.09.01. Octreotide 1soc Designed proteins Undefined 1 0 8.9 ± 1.8 77 ± 21 -7.7
3.2.01.08. Lactoferricin B, peptide 36-60 1lfc Bos taurus Secreted 1 0 4.6 ± 0.5 90 ± 6 -5.3
3.2.09.03. Tyrocidine A 4m6e Bacillus brevis Secreted 1 0 6.8 ± 0.9 56 ± 8 -9.0
3.2.05.02. Astexin-1, structure 1 2lti Asticcacaulis excentricus Secreted 1 0 2.4 ± 1.0 85 ± 9 -3.6
3.2.01.09. Peptide PG-990 2n7o Designed proteins Undefined 1 0 7.9 ± 1.6 68 ± 21 -5.6
3.2.01.08. Lactoferricin B, peptide 38-49 1y58 Bos taurus Secreted 1 0 2.9 ± 1.4 86 ± 18 -3.7
3.2.01.07. Protegrin-2 2muh Sus scrofa Secreted 1 0 2.1 ± 3.3 88 ± 2 -3.2
3.2.02.02. Chi-conotoxin MrIB 1ieo Conus marmoreus Secreted 1 0 2.2 ± 1.1 45 ± 12 -1.9
3.2.01.09. Peptidomimetic TWLKKRRWKKAK-D-Pro-P 2m7j Designed proteins Undefined 1 0 1.0 ± 1.7 75 ± 37 -2.7
3.2.03.01. Hepcidin, structure 2 1m4f Homo sapiens Secreted 1 0 5.9 ± 1.2 76 ± 18 -6.4
3.2.01.07. Cys-free protegrin analogue 2mq2 Designed proteins Secreted 1 0 1.3 ± 1.1 61 ± 19 -3.5
3.2.05.02. Astexin-1, structure 2 2m37 Asticcacaulis excentricus Secreted 1 0 3.2 ± 1.1 83 ± 13 -5.1
3.2.01.09. Peptide PG-989 2n7n Designed proteins Undefined 1 0 6.1 ± 1.4 83 ± 7 -5.5
3.2.01.06. Theta-defensin 1 (RTD-1) 1hvz Macaca mulatta Secreted 1 0 0.8 ± 1.0 89 ± 4 -2.9
3.2.05.02. Caulonodin 2mlj Caulobacter sp. Secreted 1 0 2.4 ± 1.7 87 ± 15 -5.0
3.2.06.01. Paralytic peptide 1 1hrl Manduca sexta Secreted 1 0 6.5 ± 0.6 51 ± 6 -6.2
3.2.10.01. PawS derived peptide 6 2lwv Designed proteins Undefined 1 0 6.8 ± 1.1 69 ± 16 -7.3
3.2.04.01. Cyclic trypsin inhibitor STFI-1, permutant 1o8y Helianthus annuus Secreted 1 0 3.4 ± 1.3 83 ± 18 -6.0
3.2.01.01. Alvinellacin 2llr Alvinella pompejana Secreted 1 0 1.6 ± 1.4 90 ± 5 -2.6
3.2.05.01. Sviceucin 2ls1 Streptomyces sviceus Secreted 1 0 2.6 ± 1.3 78 ± 5 -7.0
3.2.10.01. PawS derived peptide 10 2nb6 Designed proteins Undefined 1 0 9.9 ± 2.0 48 ± 30 -9.1
3.2.01.06. Retrocyclin-2 (HTD-2) 2atg Macaca mulatta Secreted 1 0 2.4 ± 0.6 87 ± 9 -5.6
3.2.06.01. Paralytic peptide 2 1v28 Manduca sexta Secreted 1 0 2.9 ± 1.4 90 ± 16 -4.9
3.2.08.01. Peptide 35-42, alternate polymorph I 2y3k Homo sapiens Secreted 2 0 3.4 ± 1.4 89 ± 4 -7.2
3.2.08.01. A macrocyclic beta-sheet peptide 4q8d Designed proteins Undefined 2 2 20.8 ± 0.4 10 ± 3 -6.6
3.2.01.01. Arenicin-2, dimer 2l8x Arenicola marina Secreted 2 0 2.7 ± 1.1 87 ± 4 -4.0
3.2.01.07. Protegrin-3, dimer 2mz6 Sus scrofa Secreted 2 0 0.4 ± 2.1 89 ± 2 -2.3
3.2.08.01. Amyloid beta A4 protein, peptide 688-707 5hoy Homo sapiens Eukaryo. plasma 3 0 6.0 ± 1.0 89 ± 0 -5.7
3.2.08.01. Peptide 30-35 2y3j Homo sapiens Secreted 4 0 4.0 ± 1.4 86 ± 6 -6.2
3.2.08.01. Peptide 35-42, alternate polymorph II 2y3l Homo sapiens Secreted 4 0 2.7 ± 1.4 78 ± 8 -6.0
3.2.08.01. Amyloid beta A4 protein, peptide 672-711 2lnq Homo sapiens Eukaryo. plasma 8 0 6.3 ± 2.0 88 ± 0 -15.5
3.2.08.02. Major prion protein, peptide 138-143 3nvf Homo sapiens Eukaryo. plasma 10 0 6.9 ± 0.2 83 ± 2 -9.8
3.2.08.02. Major prion protein, peptide 138-143 3nve Mesocricetus auratus (Golden hamster) Eukaryo. plasma 12 0 3.6 ± 0.4 89 ± 3 -9.8
3.2.08.01. Peptide KLVFFA from amyloid beta, alternate polymorph II 3ow9 Homo sapiens Secreted 12 0 4.1 ± 1.4 88 ± 7 -12.8