PDB ID or protein name

All beta monotopic/peripheral superfamilies

2.2.001. Bacterial adhesins (1 family)
2.2.002. Peptidase clan PA (3 families) CL0124 (Pfam)
2.2.003. Peptidase clan AA (2 families) CL0129 (Pfam)
2.2.004. Retinal pigment epithelial membrane protein (1 family) PF03055 (Pfam)
2.2.005. Multicopper oxidase (2 families) CL0026 (Pfam)
2.2.006. Lipocalins (2 families) 8.A.33 (TCDB) CL0116 (Pfam)
2.2.007. Streptavidin-like (3 families)
2.2.008. Thaumatin (1 family) PF00314 (Pfam)
2.2.009. Beta propellers (5 families) CL0186 (Pfam)
2.2.010. High potential iron protein (1 family) PF01355 (Pfam)
2.2.011. C2 domain (1 family) CL0154 (Pfam)
2.2.012. Immunoglobulin-like superfamily (E set) (5 families) CL0159 (Pfam)
2.2.013. Carbohydrate binding domain superfamily (1 family) CL0203 (Pfam)
2.2.014. Galactose-binding domain-like (2 families) CL0202 (Pfam)
2.2.015. Gamma-Crystallin-like superfamily (1 family) CL0333 (Pfam)
2.2.016. Lipoprotein localization factors (1 family) PF07161 (Pfam)
2.2.017. Glycine-rich antifreeze protein (1 family)
2.2.018. Adaptin (1 family) CL0448 (Pfam)
2.2.019. Adsorption protein p2 (1 family) PF09214 (Pfam)
2.2.020. PH domain-like (3 families) CL0266 (Pfam)
2.2.021. Beta-trefoil superfamily (5 families) CL0066 (Pfam)
2.2.022. Hydrophobin (1 family) PF06766 (Pfam)
2.2.023. BamB lipoprotein (1 family) PF01011 (Pfam)
2.2.024. Vitelline membrane outer protein-I (1 family) PF03762 (Pfam)
2.2.025. Superoxide dismutase (1 family) PF00080 (Pfam)
2.2.026. FYVE/PHD zinc finger (1 family) CL0390 (Pfam)
2.2.027. C1 domain (1 family) CL0006 (Pfam)
2.2.028. Invertebrate chitin-binding proteins (2 families) CL0155 (Pfam)
2.2.029. MAC/Perforin (MABP) domain (1 family) 1.C.39 (TCDB) PF10240 (Pfam)
2.2.030. Elafin-like (1 family) PF10511 (Pfam)
2.2.031. Kringle-like (1 family)
2.2.032. Ricin-type beta-trefoil lectin domain (1 family) 1.C.72 (TCDB) PF00652 (Pfam)
2.2.033. Plant lectins/antimicrobial peptides (1 family) PF00187 (Pfam)
2.2.034. Omega conotoxin-like knottin (12 families) CL0083 (Pfam)
2.2.035. Cholesterol-dependent cytolysin (1 family) CL0293 (Pfam)
2.2.036. Lactococcin 972 (1 family) 1.C.37 (TCDB) PF09683 (Pfam)
2.2.037. Copper amine oxidase (1 family) PF01179 (Pfam)
2.2.038. Cloacin translocation domain (1 family) PF03515 (Pfam)
2.2.039. Snake toxin-like (2 families) 1.C.74 (TCDB) CL0117 (Pfam)
2.2.040. Neurotoxin III (1 family) PF08098 (Pfam)
2.2.041. Defensin-like (5 families) CL0075 (Pfam)
2.2.042. Pneumovirus matrix protein (1 family) PF03393 (Pfam)
2.2.043. TRAP-like (1 family) PF01987 (Pfam)
2.2.044. PLAT domain (1 family) CL0321 (Pfam)
2.2.045. Pectate lyase-like (2 families) CL0268 (Pfam)
2.2.046. Insect hemolymph lipoprotein (1 family) PF03260 (Pfam)
2.2.047. Galactose-binding domain (1 family) PF02927 (Pfam)
2.2.048. Molybdenum cofactor biosynthesis protein MoeA (1 family) PF03453 (Pfam)
2.2.049. Glycoside hydrolase, family 61 (1 family) PF03443 (Pfam)
2.2.050. Treponema lipoprotein (1 family) 1.B.45 (TCDB)
2.2.051. Necrosis inducing protein (1 family) PF05630 (Pfam)
2.2.052. Allene oxide cyclase (1 family) PF06351 (Pfam)
2.2.053. Fas apoptotic inhibitory molecule (1 family) PF06905 (Pfam)
2.2.054. Hepatitis C virus non-structural 5a domain (1 family) PF08300 (Pfam)
2.2.055. Aspartic peptidase of Shewanella (1 family) PF08985 (Pfam)
2.2.056. Beta-2-glycoprotein-1 fifth domain (1 family) PF09014 (Pfam)
2.2.057. Beta fructosidase superfamily (1 family) CL0143 (Pfam)
2.2.058. Arrestin-like (1 family) CL0135 (Pfam)
2.2.059. Beta-prisms (1 family)
2.2.060. Matrix protein VP40 (1 family) PF02233 (Pfam)
2.2.061. Fungal allergen 1 (1 family) PF16541 (Pfam)
See list of these PDB codes

All beta monotopic/peripheral (492 proteins)

Family Protein Name PDB ID Species Localization Num. Subunits Num. TM Sec. Structs. Hydrophobic Thickness or Depth (Å) Tilt Angle (°) ΔGtransfer (kcal/mol)
2.2.06.01. Prostaglandin-H2 D-isomerase 2ktd Mus musculus Endoplasm. reticulum 1 0 0.0 ± 1.4 73 ± 14 -2.2
2.2.06.02. Fatty acid-binding protein 2k62 Gallus gallus Eukaryo. plasma 1 0 0.0 ± 2.9 82 ± 13 -2.0
2.2.20.01. Cytohesin-2 1u27 Mus musculus Eukaryo. plasma 1 0 0.5 ± 2.4 53 ± 9 -2.4
2.2.06.01. Beta-lactoglobulin 3nq9 Bos taurus Secreted 1 0 0.5 ± 0.9 89 ± 4 -2.7
2.2.06.02. Fatty acid-binding protein 2 2ftb Ambystoma mexicanum (Axolotl) Eukaryo. plasma 1 0 0.6 ± 2.0 77 ± 20 -1.7
2.2.34.02. Hybrid atracotoxin 2h1z Hadronyche versuta (Blue mountains funnel-web spider) Secreted 1 0 0.6 ± 2.0 82 ± 20 -1.9
2.2.20.01. Pleckstrin homology domain-containing family B member 2 2dhi Mus musculus Eukaryo. plasma 1 0 0.6 ± 1.5 86 ± 14 -2.8
2.2.15.01. Gamma-crystallin F 1m8u Bos taurus Secreted 1 0 0.7 ± 1.2 85 ± 4 -4.9
2.2.26.01. RUN and FYVE domain-containing protein 1 2yw8 Homo sapiens Endosome 1 0 0.7 ± 3.4 48 ± 38 -2.8
2.2.06.02. Prostaglandin-H2 D-isomerase, ligand-bound 3o22 Homo sapiens Endoplasm. reticulum 1 0 0.7 ± 1.2 78 ± 13 -2.4
2.2.34.02. Omega-theraphotoxin-Hh1a 1y29 Haplopelma hainanum (Chinese bird spider) Secreted 1 0 0.7 ± 1.3 83 ± 17 -2.7
2.2.20.01. Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1 3nsu Saccharomyces cerevisiae Eukaryo. plasma 1 0 0.8 ± 1.5 57 ± 12 -4.0
2.2.11.01. Protein kinase C alpha, complex with phosphatidyl serine 1dsy Rattus norvegicus Eukaryo. plasma 1 0 0.9 ± 1.5 18 ± 16 -3.0
2.2.41.01. Oral alpha defensin 1 2k1i Macaca mulatta Secreted 1 0 0.9 ± 3.2 70 ± 15 -2.2
2.2.33.01. Hevein 1q9b Hevea brasiliensis (Para rubber tree) Secreted 1 0 1.0 ± 1.0 90 ± 11 -1.8
2.2.20.01. Pleckstrin homology domain-containing family A member 6 (PLEKHA6) 2d9y Homo sapiens Eukaryo. plasma 1 0 1.0 ± 0.3 67 ± 1 -6.2
2.2.34.01. Conotoxin mr3e 2efz Conus marmoreus Secreted 1 0 1.0 ± 1.3 83 ± 25 -3.2
2.2.07.01. YceI-like protein 3q34 Pseudomonas syringae Bact. Gram-neg inner 2 0 1.0 ± 1.1 89 ± 2 -3.9
2.2.05.01. Azurin I 1rkr Alcaligenes xylosoxidans Bact. Gram-neg inner 1 0 1.0 ± 1.0 43 ± 7 -4.3
2.2.34.01. Omega-conotoxin SVIB 1mvj Conus striatus Secreted 1 0 1.1 ± 2.1 20 ± 24 -2.1
2.2.12.02. Rho GDP-dissociation inhibitor 1, complex with cell division control protein 42 1doa Homo sapiens Eukaryo. plasma 2 0 1.1 ± 1.3 87 ± 4 -3.1
2.2.06.02. Fatty acid binding protein 6, ileal (Gastrotropin) 3elz Danio rerio Eukaryo. plasma 1 0 1.1 ± 0.9 85 ± 6 -2.4
2.2.12.01. Mite group 2 allergen Der f 2 1xwv Dermatophagoides farinae (American house dust mite) Secreted 1 0 1.2 ± 1.4 64 ± 10 -3.1
2.2.06.02. Fatty acid-binding protein 2flj Locusta migratoria (Migratory locust) Eukaryo. plasma 1 0 1.2 ± 1.5 62 ± 10 -3.6
2.2.06.02. Myelin P2 protein 1yiv Equus caballus Eukaryo. plasma 1 0 1.3 ± 1.7 53 ± 11 -4.8
2.2.20.01. PH domain containing retinal protein 1 2d9v Mus musculus Eukaryo. plasma 1 0 1.3 ± 1.3 58 ± 14 -5.1
2.2.34.02. Mu-agatoxin-Aa1a 1eit Agelenopsis aperta Secreted 1 0 1.3 ± 1.5 59 ± 10 -3.1
2.2.05.01. Plastocyanin 2plt Chlamydomonas reinhardtii Thylakoid 1 0 1.3 ± 1.5 21 ± 18 -2.0
2.2.12.01. Mite group 2 allergen Der p 2 1ktj Dermatophagoides pteronyssinussearch Secreted 1 0 1.4 ± 1.3 65 ± 9 -3.2
2.2.05.01. Plantacyanin 1f56 Spinacia oleracea Thylakoid 1 0 1.4 ± 1.5 11 ± 15 -2.0
2.2.58.01. Cone arrestin 1suj Ambystoma tigrinum (Tiger salamander) Eukaryo. plasma 1 0 1.4 ± 0.8 82 ± 12 -4.7
2.2.27.01. Ras association domain-containing protein 5, C1 domain 1rfh Mus musculus Eukaryo. plasma 1 0 1.4 ± 0.9 16 ± 6 -3.7
2.2.20.01. PH domain of TAPP2 1v5p Mus musculus Eukaryo. plasma 1 0 1.4 ± 1.3 61 ± 5 -3.7
2.2.20.01. Oxysterol binding protein-related protein 11 2d9x Homo sapiens Eukaryo. plasma 1 0 1.4 ± 1.7 55 ± 18 -3.1
2.2.11.01. Phosphatidylinositide 3-kinase C2 alpha 2b3r Mus musculus Eukaryo. plasma 2 0 1.4 ± 1.5 88 ± 16 -4.4
2.2.14.01. Retinoschisin 3jd6 Homo sapiens Eukaryo. plasma 8 0 1.4 ± 0.1 90 ± 0 -19.5
2.2.11.01. Synaptotagmin-1, C2A domain (Calcium free) 3f00 Homo sapiens Eukaryo. plasma 1 0 1.4 ± 1.5 29 ± 18 -3.3
2.2.41.01. Neutrophil defensin 3 1dfn Homo sapiens Secreted 2 0 1.4 ± 1.3 87 ± 15 -3.9
2.2.05.01. Azurin iso-2 1cuo Methylomonas sp. Bact. Gram-neg inner 1 0 1.4 ± 1.6 69 ± 15 -4.3
2.2.07.01. Lipocalin BcnA 5ixh Burkholderia cepacia Bact. Gram-neg inner 1 0 1.4 ± 2.6 28 ± 29 -1.7
2.2.33.01. Antimicrobial Peptide AMP-1.1a 2kus Stellaria media Secreted 1 0 1.5 ± 0.9 18 ± 27 -2.7
2.2.11.01. Multiple C2 and transmembrane domain-containing protein 2 (MCTP2) 2ep6 Homo sapiens Eukaryo. plasma 1 0 1.5 ± 1.5 7 ± 15 -3.0
2.2.11.01. Rab3 interacting molecule 2 (RIM2), C2A domain 2bwq Rattus norvegicus Eukaryo. plasma 1 0 1.5 ± 1.6 41 ± 19 -1.8
2.2.32.01. ADP-ribosylating toxin CARDS, full-length 4tlw Mycoplasma pneumoniae Secreted 1 0 1.5 ± 1.4 47 ± 2 -4.8
2.2.26.01. LM-5 FYVE domain 1z2q Leishmania major Endosome 1 0 1.5 ± 1.5 22 ± 19 -3.4
2.2.20.01. Myosin X 3tfm Rattus norvegicus Endosome 1 0 1.5 ± 2.6 81 ± 5 -3.0
2.2.41.01. Reptilian defensin 2b5b Caretta caretta Secreted 1 0 1.5 ± 0.4 73 ± 1 -4.1
2.2.20.01. RAC-gamma serine/threonine-protein kinase 2x18 Homo sapiens Eukaryo. plasma 1 0 1.5 ± 1.1 53 ± 4 -3.8
2.2.41.04. Antimicrobial peptide LCI 2b9k Bacillus subtilis Secreted 1 0 1.6 ± 2.9 89 ± 19 -4.4
2.2.11.01. Synaptotagmin-1, C2B domain (Calcium-bound) 4v11 Homo sapiens Eukaryo. plasma 1 0 1.6 ± 2.3 40 ± 7 -3.2
2.2.02.03. Flavivirin protease NS2B 2wv9 Murray valley encephalitis virus Endoplasm. reticulum 1 0 1.6 ± 2.4 69 ± 8 -4.7
2.2.05.01. Pseudoazurin 1pmy Methylobacterium extorquens Bact. Gram-neg inner 1 0 1.6 ± 1.4 45 ± 13 -4.3
2.2.33.01. Antimicrobial peptide 2 1mmc Amaranthus caudatus (Inca-wheat) Secreted 1 0 1.6 ± 1.2 46 ± 9 -3.9
2.2.03.01. Beta-secretase 1 2wf1 Homo sapiens Eukaryo. plasma 1 0 1.7 ± 1.2 61 ± 6 -4.9
2.2.17.01. 6.5 kDa glycine-rich antifreeze protein 2pne Hypogastrura harveyi Secreted 1 0 1.7 ± 0.2 89 ± 5 -7.7
2.2.11.01. Rabphilin-3A 2k3h Mus musculus Eukaryo. plasma 1 0 1.7 ± 2.1 78 ± 16 -4.1
2.2.34.12. Poneritoxin, omega-PONTX-Ae1a 2nbc Anochetus emarginatus Secreted 1 0 1.7 ± 1.8 72 ± 12 -2.5
2.2.20.01. PH domain of TAPP1 1eaz Homo sapiens Eukaryo. plasma 1 0 1.7 ± 1.6 87 ± 14 -3.0
2.2.20.01. Oxysterol-binding protein-related protein 8 1v88 Homo sapiens Eukaryo. plasma 1 0 1.7 ± 1.2 78 ± 4 -4.6
2.2.34.02. Kappa-hexatoxin-Hv1c 1dl0 Hadronyche versuta (Blue mountains funnel-web spider) Secreted 1 0 1.7 ± 1.3 53 ± 17 -3.1
2.2.34.02. Mu-cyrtautoxin-As1a 2m36 Apomastus schlingeri Secreted 1 0 1.7 ± 1.0 49 ± 35 -3.2
2.2.36.01. Lactococcin 972 2lgn Lactococcus lactis Secreted 1 0 1.7 ± 2.8 56 ± 9 -3.3
2.2.11.01. Synaptotagmin-1, C2B domain (Calcium bound) 1uov Rattus norvegicus Eukaryo. plasma 1 0 1.7 ± 1.8 36 ± 13 -3.7
2.2.20.01. Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 2da0 Homo sapiens Eukaryo. plasma 1 0 1.7 ± 2.5 64 ± 20 -2.5
2.2.34.01. Conotoxin Gm9 1ixt Conus gloriamaris (Glory-of-the-Seas cone) Secreted 1 0 1.7 ± 1.7 85 ± 17 -3.0
2.2.34.05. Tachystatin-B1 2dcv Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 1.8 ± 1.1 5 ± 9 -5.9
2.2.01.01. F18 fimbrial adhesin AC, FedF 4b4q Escherichia coli Secreted 1 0 1.8 ± 2.6 81 ± 20 -3.4
2.2.21.04. Cytolethal distending toxin complex 1sr4 Haemophilus ducreyi Bact. Gram-neg outer 3 0 1.8 ± 1.5 34 ± 7 -5.0
2.2.41.01. Defensin-like peptide 1 1b8w Ornithorhynchus anatinus Secreted 1 0 1.8 ± 0.6 84 ± 2 -4.4
2.2.34.02. Robustoxin 1qdp Atrax robustus Secreted 1 0 1.8 ± 1.9 86 ± 18 -5.0
2.2.11.01. C2 domain of E3 ubiquitin-protein ligase NEDD4-like 2nsq Homo sapiens Eukaryo. plasma 1 0 1.8 ± 1.1 85 ± 5 -3.3
2.2.05.01. Plastocyanin 9pcy Phaseolus vulgaris Thylakoid 1 0 1.8 ± 1.6 18 ± 19 -1.9
2.2.27.01. Kinase supressor of Ras, Ksr 1kbf Mus musculus Eukaryo. plasma 1 0 1.8 ± 1.0 63 ± 11 -5.4
2.2.20.01. Son of sevenless homolog 1 (SOS-1) 1xd4 Homo sapiens Eukaryo. plasma 1 0 1.9 ± 3.0 79 ± 2 -4.5
2.2.20.01. Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1 4a6f Saccharomyces cerevisiae Eukaryo. plasma 1 0 1.9 ± 1.6 62 ± 4 -6.1
2.2.06.02. Intestinal fatty acid binding protein, structure 4 2mo5 Homo sapiens Eukaryo. plasma 1 0 1.9 ± 1.3 59 ± 6 -3.4
2.2.06.01. Complement component C8 gamma chain 1lf7 Homo sapiens Secreted 1 0 1.9 ± 2.2 43 ± 12 -2.6
2.2.34.09. Psi-conotoxin PIIIE 1as5 Conus purpurascens (Purple cone) Secreted 1 0 1.9 ± 1.3 87 ± 11 -3.6
2.2.20.01. Rho guanine nucleotide exchange factor 9, conformation 1 4mt7 Rattus norvegicus Eukaryo. plasma 1 0 1.9 ± 2.6 52 ± 14 -3.9
2.2.16.01. Lipoprotein lppX 2byo Mycobacterium tuberculosis Bact. Gram-pos plas. 1 0 1.9 ± 1.7 80 ± 13 -4.8
2.2.06.01. Retinol binding protein, plasma isoform 1iiu Gallus gallus Secreted 1 0 1.9 ± 1.8 35 ± 17 -4.4
2.2.34.01. Mu-conotoxin GS 1ag7 Conus geographus (Geography cone) Secreted 1 0 1.9 ± 1.0 68 ± 15 -2.6
2.2.06.02. Retinol-binding protein 2 1opb Rattus norvegicus Eukaryo. plasma 1 0 1.9 ± 1.4 25 ± 7 -3.6
2.2.39.01. Erabutoxin b 3ebx Laticauda semifasciata (Black-banded sea krait) Secreted 1 0 1.9 ± 1.4 47 ± 11 -4.3
2.2.34.02. U1-theraphotoxin-Ba1b 2kgh Brachypelma ruhnaui (Mexican golden redrump tarantula) Secreted 1 0 1.9 ± 2.5 83 ± 25 -1.9
2.2.05.01. Plastocyanin 1bxv Synechocystis sp. Thylakoid 1 0 2.0 ± 1.6 36 ± 19 -2.6
2.2.06.01. Neutrophil gelatinase-associated lipocalin 3fw5 Homo sapiens Secreted 1 0 2.0 ± 1.2 45 ± 9 -3.1
2.2.07.01. Lipocalin BcnB 5ixg Burkholderia cepacia Bact. Gram-neg inner 1 0 2.0 ± 1.0 36 ± 5 -3.9
2.2.11.01. Protein kinase C delta 1yrk Homo sapiens Eukaryo. plasma 1 0 2.0 ± 1.6 52 ± 19 -1.8
2.2.20.01. Dynamin-2 2ys1 Homo sapiens Eukaryo. plasma 1 0 2.1 ± 0.4 49 ± 3 -5.3
2.2.34.09. Psi-conotoxin PIIIF 1jlp Conus purpurascens (Purple cone) Secreted 1 0 2.1 ± 1.1 72 ± 30 -3.1
2.2.27.01. C1 domain of protein kinase C alpha 2eli Homo sapiens Eukaryo. plasma 1 0 2.1 ± 0.4 23 ± 4 -7.4
2.2.60.01. Matrix protein VP40 1es6 Zaire ebolavirus Viral 1 0 2.1 ± 0.5 80 ± 3 -6.7
2.2.27.01. Beta-chimaerin 1xa6 Homo sapiens Eukaryo. plasma 1 0 2.1 ± 1.7 65 ± 7 -5.1
2.2.11.01. Synaptotagmin-13 1wfm Homo sapiens Eukaryo. plasma 1 0 2.2 ± 1.9 88 ± 15 -4.5
2.2.20.01. PH domain of Src-associated adaptor protein 2 homologue 1u5f Mus musculus Eukaryo. plasma 2 0 2.2 ± 2.0 56 ± 12 -4.9
2.2.11.01. Synaptotagmin-7 3n5a Mus musculus Vesicle 1 0 2.2 ± 2.3 30 ± 12 -4.1
2.2.12.03. Immunogenic protein MPT63 1lmi Mycobacterium tuberculosis Secreted 1 0 2.2 ± 1.9 86 ± 7 -4.3
2.2.33.01. Antimicrobial peptide 1b 2lb7 Triticum kiharae (Wheat) Secreted 1 0 2.2 ± 0.7 89 ± 7 -2.5
2.2.41.01. Alpha-defensin 4 1zmm Homo sapiens Secreted 1 0 2.2 ± 1.0 76 ± 10 -5.5
2.2.20.01. PH domain of docking protein 2 2d9w Homo sapiens Eukaryo. plasma 1 0 2.2 ± 1.2 13 ± 17 -3.5
2.2.34.02. Mu-theraphotoxin-Hhn1b 1niy Haplopelma hainanum (Chinese bird spider) Secreted 1 0 2.2 ± 0.7 71 ± 6 -4.6
2.2.34.07. Asteropsin B 2lzx Asteropus sp. Secreted 1 0 2.2 ± 1.7 90 ± 21 -3.3
2.2.11.01. C2 domain of E3 ubiquitin-protein ligase NEDD4, complex with GRB10 3m7f Mus musculus Eukaryo. plasma 2 0 2.2 ± 2.0 76 ± 13 -2.7
2.2.20.01. Fermitin family homolog 2 4f7h Homo sapiens Eukaryo. plasma 1 0 2.2 ± 1.4 72 ± 4 -4.2
2.2.34.01. Conotoxin TVIIA 1eyo Conus tulipa (Fish-hunting cone snail) Secreted 1 0 2.2 ± 0.7 74 ± 9 -4.6
2.2.20.01. Rho guanine nucleotide exchange factor 4 2dx1 Homo sapiens Eukaryo. plasma 1 0 2.2 ± 2.2 80 ± 10 -3.6
2.2.11.01. Protein kinase C eta, C2 domain 2fk9 Homo sapiens Eukaryo. plasma 1 0 2.2 ± 2.1 57 ± 6 -5.0
2.2.12.01. Lymphocyte antigen 86 3mtx Gallus gallus Secreted 1 0 2.3 ± 1.6 69 ± 11 -2.4
2.2.11.01. C2A domain of synaptotagmin-5 5h4y Homo sapiens Vesicle 1 0 2.3 ± 2.3 29 ± 11 -4.5
2.2.12.05. Glucans biosynthesis protein G 1txk Escherichia coli Bact. Gram-neg inner 1 0 2.3 ± 0.7 80 ± 8 -5.1
2.2.20.01. PH domain of muscle M-line assembly protein unc-89 1fho Caenorhabditis elegans Eukaryo. plasma 1 0 2.3 ± 1.2 25 ± 14 -4.3
2.2.20.01. Dual adaptor of phosphotyrosine and 3-phosphoinositides 1fao Homo sapiens Eukaryo. plasma 1 0 2.4 ± 2.0 59 ± 19 -3.9
2.2.11.01. Extended synaptotagmin-2, third C2 domain 2dmg Homo sapiens Eukaryo. plasma 1 0 2.4 ± 1.0 76 ± 5 -4.8
2.2.25.01. Superoxide dismutase [Cu-Zn] 1oal Photobacterium leiognathi Bact. Gram-neg inner 1 0 2.4 ± 0.9 77 ± 2 -6.8
2.2.34.11. Violacin 1 2fqa Viola odorata Secreted 1 0 2.4 ± 3.4 70 ± 46 -4.0
2.2.37.01. Primary amine oxidase, liver isozyme 1tu5 Bos taurus Secreted 2 0 2.4 ± 1.2 89 ± 0 -6.1
2.2.34.02. Delta-amaurobitoxin-Pl1b 1v91 Pireneitega luctuosa (Tangled nest spider) Secreted 1 0 2.4 ± 0.9 35 ± 4 -5.7
2.2.08.01. Osmotin 1pcv Nicotiana tabacum Secreted 1 0 2.4 ± 1.9 82 ± 19 -2.7
2.2.06.02. Prostaglandin-H2 D-isomerase, apo form, mutant 4os0 Homo sapiens Endoplasm. reticulum 1 0 2.4 ± 1.0 77 ± 4 -3.1
2.2.34.02. Neurotoxin Hm-3 2mqu Heriaeus melloteei Secreted 1 0 2.4 ± 0.6 75 ± 11 -7.4
2.2.34.02. Psalmotoxin-1 1lmm Psalmopoeus cambridgei (Trinidad chevron tarantula) Secreted 1 0 2.4 ± 1.6 71 ± 15 -4.4
2.2.06.02. Cellular retinol-binding protein II 1crb Rattus norvegicus Eukaryo. plasma 1 0 2.4 ± 1.7 52 ± 19 -5.3
2.2.11.01. C2 domain of otoferlin 3l9b Rattus norvegicus Vesicle 1 0 2.4 ± 5.2 16 ± 33 -3.4
2.2.11.01. Synaptotagmin-4 1ugk Homo sapiens Eukaryo. plasma 1 0 2.5 ± 1.7 34 ± 11 -3.5
2.2.20.01. Rho GTPase-activating protein 27 3pp2 Homo sapiens Eukaryo. plasma 1 0 2.5 ± 2.2 72 ± 14 -3.4
2.2.41.01. Gallinacin-7 5lcs Gallus gallus Secreted 1 0 2.5 ± 1.4 85 ± 5 -5.6
2.2.34.03. Toxin Ptu1 1i26 Peirates turpis (Assassin bug) Secreted 1 0 2.5 ± 0.9 52 ± 7 -3.6
2.2.20.01. Proto-oncogene vav, complex with Ras-related C3 botulinum toxin substrate 1 3bji Homo sapiens Eukaryo. plasma 2 0 2.5 ± 2.2 72 ± 14 -3.4
2.2.11.01. Synaptotagmin-1 1rsy Rattus norvegicus Eukaryo. plasma 1 0 2.5 ± 1.6 24 ± 17 -4.1
2.2.34.02. omega-Agatoxin 1agg Agelenopsis aperta Secreted 1 0 2.5 ± 1.4 57 ± 17 -5.0
2.2.20.01. FYVE, RhoGEF and PH domain-containing protein 6 1wgq Mus musculus Eukaryo. plasma 1 0 2.5 ± 1.8 68 ± 17 -3.2
2.2.11.01. Rabphilin-3A, C2B domain 2cm5 Rattus norvegicus Eukaryo. plasma 1 0 2.5 ± 2.0 56 ± 14 -4.1
2.2.06.02. Adipocyte lipid-binding protein 1tow Homo sapiens Eukaryo. plasma 1 0 2.5 ± 1.7 51 ± 18 -4.5
2.2.20.01. PH domain of oxysterol-binding protein homolog 3, fused with lysozyme 4iap Saccharomyces cerevisiae Endoplasm. reticulum 1 0 2.5 ± 2.3 81 ± 3 -3.6
2.2.16.01. Lipoprotein LprG 3mh9 Mycobacterium tuberculosis Bact. Gram-pos plas. 1 0 2.5 ± 2.7 47 ± 10 -3.0
2.2.34.02. S64 4b2v Sicarius dolichocephalus Secreted 1 0 2.5 ± 0.5 71 ± 2 -4.3
2.2.27.01. C1 domain of unc-13 homolog A 1y8f Rattus norvegicus Eukaryo. plasma 1 0 2.5 ± 1.9 16 ± 17 -2.9
2.2.39.01. Toxin B 1txa Ophiophagus hannah Secreted 1 0 2.6 ± 1.5 51 ± 16 -5.6
2.2.09.01. Kelch-like protein 7 3ii7 Homo sapiens Undefined 1 0 2.6 ± 1.8 90 ± 16 -6.5
2.2.12.04. AP-2 complex 2vj0 Rattus norvegicus Vesicle 1 0 2.6 ± 2.0 80 ± 11 -4.8
2.2.06.02. Retinoid-binding protein 7 1lpj Homo sapiens Eukaryo. plasma 1 0 2.6 ± 1.1 44 ± 13 -6.0
2.2.45.01. Pertactin autotransporter 1dab Bordetella pertussis Bact. Gram-neg outer 1 0 2.6 ± 1.1 73 ± 6 -5.9
2.2.11.01. Protein kinase C beta 3pfq Rattus norvegicus Eukaryo. plasma 1 0 2.6 ± 0.9 45 ± 5 -3.4
2.2.34.10. Imperatoxin-A 1ie6 Pandinus imperator (Emperor scorpion) Secreted 1 0 2.6 ± 0.8 55 ± 13 -3.1
2.2.52.01. Allene oxide cyclase 2 2brj Arabidopsis thaliana Chloroplast inner 3 0 2.6 ± 0.5 88 ± 5 -9.7
2.2.06.02. Prostaglandin-H2 D-isomerase, apo form 4ors Homo sapiens Endoplasm. reticulum 1 0 2.6 ± 0.8 71 ± 7 -3.7
2.2.34.02. U1-theraphotoxin-Hh1a 1i25 Haplopelma hainanum (Chinese bird spider) Secreted 1 0 2.6 ± 0.2 79 ± 1 -5.1
2.2.39.01. Cardiotoxin-A1 (cytotoxin 1) 2cdx Naja atra Secreted 1 0 2.6 ± 1.4 85 ± 17 -6.9
2.2.12.01. Lymphocyte antigen 96, structure 2 4g8a Homo sapiens Eukaryo. plasma 1 0 2.7 ± 1.3 67 ± 6 -3.8
2.2.10.01. High potential iron protein 1hpi Ectothiorhodospira vacuolata Bact. Gram-neg inner 1 0 2.7 ± 1.0 89 ± 12 -4.4
2.2.27.01. C1 domanin of SH3 and cysteine-rich domain-containing protein 3 2db6 Homo sapiens Eukaryo. plasma 1 0 2.7 ± 0.1 75 ± 0 -4.8
2.2.20.01. Ras-specific guanine nucleotide-releasing factor 2dtc Mus musculus Eukaryo. plasma 1 0 2.7 ± 0.4 64 ± 9 -6.3
2.2.05.01. Azurin 1xb8 Pseudomonas aeruginosa Bact. Gram-neg inner 1 0 2.7 ± 0.6 47 ± 4 -5.2
2.2.41.01. Beta-defensin 3 1kj6 Homo sapiens Secreted 1 0 2.7 ± 1.3 18 ± 18 -5.1
2.2.06.02. Myelin P2 protein 1pmp Bos taurus Eukaryo. plasma 1 0 2.7 ± 1.3 61 ± 13 -6.1
2.2.22.01. Hydrophobin NC2, structure 2 4bwh Neurospora crassa Secreted 1 0 2.7 ± 3.1 85 ± 29 -4.5
2.2.20.01. Rac-alpha serine/threonine kinase 1unq Homo sapiens Eukaryo. plasma 1 0 2.7 ± 2.0 67 ± 18 -3.9
2.2.14.02. SUN domain-containing protein 2 3unp Homo sapiens Nuclear outer 3 0 2.7 ± 0.1 20 ± 0 -5.3
2.2.45.02. Pectate lyase A 1pe9 Erwinia chrysanthemi Secreted 1 0 2.7 ± 0.4 81 ± 3 -6.4
2.2.11.01. C2 domain of E3 ubiquitin-protein ligase NEDD4 3b7y Homo sapiens Eukaryo. plasma 1 0 2.7 ± 1.5 9 ± 6 -4.1
2.2.34.02. Huwentoxin-1 1qk6 Haplopelma hainanum (Chinese bird spider) Secreted 1 0 2.7 ± 1.5 88 ± 11 -5.1
2.2.20.01. Son of sevenless homolog 1 (two domains) 1dbh Homo sapiens Eukaryo. plasma 1 0 2.7 ± 2.8 28 ± 19 -4.2
2.2.34.11. Kalata-B7 2jwm Oldenlandia affinis Secreted 1 0 2.7 ± 2.2 86 ± 28 -4.8
2.2.39.02. Mambalgin-2 2mfa Dendroaspis polylepis polylepis (Black mamba) Secreted 1 0 2.7 ± 2.5 76 ± 5 -6.4
2.2.34.01. Omega conotoxin TxVII 1f3k Conus textile Secreted 1 0 2.8 ± 1.4 57 ± 18 -4.5
2.2.39.01. alpha-Cobratoxin 1ctx Naja kaouthia Secreted 1 0 2.8 ± 1.7 29 ± 18 -4.6
2.2.05.01. Plastocyanin 1b3i Prochlorothrix hollandica Thylakoid 1 0 2.8 ± 1.4 43 ± 18 -4.4
2.2.20.01. Rho guanine nucleotide exchange factor 9 complex 2dfk Rattus norvegicus Eukaryo. plasma 2 0 2.8 ± 2.7 69 ± 3 -5.0
2.2.14.01. Lactadherin 3bn6 Bos taurus Secreted 1 0 2.8 ± 0.5 11 ± 4 -7.2
2.2.34.07. Asteropsin A 3q8j Asteropus sp. Secreted 1 0 2.8 ± 1.7 75 ± 15 -3.0
2.2.11.01. Synaptotagmin 1, C2A domain 5t0r Mus musculus Vesicle 1 0 2.8 ± 0.8 22 ± 14 -4.2
2.2.34.02. M-theraphotoxin-Gr1a 1lu8 Grammostola rosea (Chilean rose tarantula) Secreted 1 0 2.8 ± 0.9 69 ± 7 -7.2
2.2.41.01. Beta-defensin 8 1e4r Mus musculus Secreted 1 0 2.8 ± 1.1 74 ± 19 -5.5
2.2.35.01. Anthrolysin O 3cqf Bacillus anthracis Secreted 1 0 2.8 ± 1.0 75 ± 1 -5.8
2.2.02.01. Exfoliative toxin B 1qtf Staphylococcus aureus Secreted 1 0 2.8 ± 1.9 81 ± 11 -5.8
2.2.12.02. Rho GDP-dissociation inhibitor 1 1qvy Homo sapiens Eukaryo. plasma 1 0 2.8 ± 1.7 53 ± 19 -5.1
2.2.12.02. Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2 1ds6 Homo sapiens Eukaryo. plasma 2 0 2.8 ± 1.0 82 ± 6 -5.5
2.2.11.01. Synaptotagmin-7 2d8k Homo sapiens Vesicle 1 0 2.8 ± 1.3 27 ± 16 -6.6
2.2.38.01. Colicin E3 1jch Escherichia coli Secreted 4 0 2.8 ± 0.3 89 ± 5 -8.8
2.2.35.01. Streptolysin O 4hsc Streptococcus pyogenes Secreted 1 0 2.8 ± 3.5 15 ± 27 -5.1
2.2.06.02. Intestinal fatty acid binding protein, structure 1 1kzw Homo sapiens Eukaryo. plasma 1 0 2.9 ± 1.3 61 ± 12 -4.1
2.2.41.01. Alpha-defensin cryptdin-4 1tv0 Mus musculus Secreted 1 0 2.9 ± 1.4 67 ± 13 -4.5
2.2.42.01. Matrix protein 2vqp Human respiratory syncytial virus Eukaryo. plasma 1 0 2.9 ± 1.1 86 ± 10 -6.1
2.2.21.02. Fibroblast growth factor 19 1pwa Homo sapiens Secreted 1 0 2.9 ± 1.5 48 ± 21 -4.7
2.2.34.02. Delta-amaurobitoxin-Pl1a 1v90 Pireneitega luctuosa (Tangled nest spider) Secreted 1 0 2.9 ± 0.7 26 ± 14 -4.0
2.2.35.01. Pneumolysin, structure 6 5aof Streptococcus pneumoniae Secreted 1 0 2.9 ± 2.4 33 ± 9 -5.7
2.2.06.02. Fatty acid-binding protein homolog 1 1o8v Echinococcus granulosus Eukaryo. plasma 1 0 2.9 ± 1.0 48 ± 15 -5.8
2.2.11.01. Rabphilin-3A, C2A domain 2chd Rattus norvegicus Eukaryo. plasma 1 0 2.9 ± 1.6 57 ± 19 -2.7
2.2.34.02. Mu-theraphotoxin-Pn3a 5t4r Theraphosidae Secreted 1 0 2.9 ± 0.8 87 ± 5 -4.5
2.2.06.02. Retinol-binding protein 2 2rcq Homo sapiens Eukaryo. plasma 1 0 2.9 ± 1.7 55 ± 6 -5.5
2.2.07.01. Polyisoprenoid-binding protein 1wub Thermus thermophilus Bact. Gram-neg inner 1 0 2.9 ± 1.9 42 ± 13 -4.4
2.2.34.01. Omega conotoxin SO3 1fyg Conus striatus Secreted 1 0 2.9 ± 1.1 76 ± 18 -3.5
2.2.11.01. Protein kinase C epsilon 1gmi Rattus rattus Eukaryo. plasma 1 0 2.9 ± 1.2 46 ± 15 -5.9
2.2.24.01. Vitelline membrane outer protein-I 1vmo Gallus gallus Secreted 1 0 3.0 ± 2.0 51 ± 12 -5.3
2.2.34.02. Omega-hexatoxin-Hv2a 1g9p Hadronyche versuta (Blue mountains funnel-web spider) Secreted 1 0 3.0 ± 1.4 78 ± 5 -4.0
2.2.34.02. Jingzhaotoxin-11 2a2v Chilobrachys guangxiensis (Chinese earth tiger tarantula) Secreted 1 0 3.0 ± 1.8 74 ± 19 -4.6
2.2.07.01. Acidic stress response factor 3hpe Helicobacter pylori Bact. Gram-neg inner 1 0 3.0 ± 0.7 34 ± 8 -6.1
2.2.26.01. Early endosome antigen 1 (EEA1), monomer 1hyi Homo sapiens Endosome 1 0 3.0 ± 2.0 24 ± 17 -3.5
2.2.20.01. Rho guanine nucleotide exchange factor 9, conformation 2 4mt6 Rattus norvegicus Eukaryo. plasma 1 0 3.0 ± 1.9 68 ± 4 -5.1
2.2.20.01. Phosphoinositol 3-phosphate binding protein 1 1upr Homo sapiens Eukaryo. plasma 1 0 3.0 ± 1.4 62 ± 19 -3.6
2.2.20.01. Pleckstrin homology domain-containing family A member 5 (PLEKHA5) 2dkp Homo sapiens Eukaryo. plasma 1 0 3.0 ± 0.9 64 ± 6 -3.9
2.2.11.01. Synaptotagmin-like protein 4 3fdw Homo sapiens Vesicle 1 0 3.0 ± 2.0 71 ± 17 -3.6
2.2.11.01. Synaptotagmin-1 C2A-C2B domains 2r83 Homo sapiens Eukaryo. plasma 1 0 3.0 ± 1.9 89 ± 10 -3.8
2.2.06.02. Intestinal fatty acid binding protein, structure 2 3akm Homo sapiens Eukaryo. plasma 1 0 3.0 ± 1.1 46 ± 8 -4.4
2.2.06.02. Cellular retinol-binding protein II 1kqw Danio rerio Eukaryo. plasma 1 0 3.1 ± 1.3 45 ± 13 -4.9
2.2.34.03. Toxin Ado1 1lmr Agriosphodrus dohrni Secreted 1 0 3.1 ± 1.6 60 ± 19 -4.7
2.2.12.01. Ganglioside GM2 activator, apo-protein 2ag4 Homo sapiens Lysosome 1 0 3.1 ± 1.3 58 ± 12 -5.4
2.2.11.01. Protein kinase C beta, C2 domain 1a25 Rattus norvegicus Eukaryo. plasma 1 0 3.1 ± 1.0 44 ± 18 -2.8
2.2.09.03. Surface layer protein 1l0q Methanosarcina mazei (Methanosarcina frisia) Archaebac. 1 0 3.1 ± 0.9 81 ± 7 -5.1
2.2.06.02. Brain fatty acid binding protein 1fdq Homo sapiens Eukaryo. plasma 1 0 3.1 ± 1.4 51 ± 15 -4.9
2.2.18.01. Subunit mu of AP-2 clatrin adaptor complex, open conformation 2xa7 Rattus norvegicus Vesicle 4 0 3.1 ± 2.2 84 ± 14 -5.9
2.2.41.01. Paneth cell-specific alpha-defensin 1 2mxq Equus caballus Secreted 1 0 3.1 ± 0.6 75 ± 5 -7.2
2.2.11.01. Perforin-1 3nsj Mus musculus Vesicle 1 0 3.1 ± 1.0 34 ± 11 -3.3
2.2.06.02. Der f 13 allergen 2a0a Dermatophagoides farinae (American house dust mite) Secreted 1 0 3.1 ± 1.3 50 ± 6 -3.5
2.2.34.08. Agouti-related protein 1mr0 Homo sapiens Secreted 1 0 3.1 ± 2.0 37 ± 18 -5.6
2.2.06.01. Allergen Bos d 2 1bj7 Bos taurus Secreted 1 0 3.1 ± 1.3 50 ± 6 -3.5
2.2.12.01. Ganglioside GM2 activator 2agc Mus musculus Lysosome 1 0 3.2 ± 1.0 54 ± 12 -5.3
2.2.20.01. PH domain of Src-associated adaptor protein 2 1u5e Mus musculus Eukaryo. plasma 2 0 3.2 ± 2.0 39 ± 13 -4.6
2.2.35.01. Listeriolysin O 4cdb Listeria monocytogenes Secreted 1 0 3.2 ± 0.0 30 ± 0 -6.0
2.2.34.02. Beta-theraphotoxin-Cj1a 2i1t Chilobrachys guangxiensis (Chinese earth tiger tarantula) Secreted 1 0 3.2 ± 0.7 58 ± 6 -5.8
2.2.20.01. Triple functional domain protein 1nty Homo sapiens Eukaryo. plasma 1 0 3.2 ± 2.0 59 ± 16 -3.9
2.2.06.02. Fatty acid-binding protein 9 4a60 Homo sapiens Eukaryo. plasma 1 0 3.2 ± 1.1 38 ± 6 -4.6
2.2.06.01. Outer membrane lipoprotein Blc 1qwd Escherichia coli Bact. Gram-neg outer 1 0 3.2 ± 2.0 80 ± 15 -4.6
2.2.41.01. Pelovaterin 2jr3 Pelodiscus sinensis (Chinese softshell turtle) Secreted 1 0 3.2 ± 2.3 58 ± 5 -3.5
2.2.39.02. Dendroaspin (mambin) 1drs Dendroaspis jamesoni kaimosae Secreted 1 0 3.3 ± 1.5 87 ± 12 -6.5
2.2.06.02. Cellular retinol-binding protein III 1ggl Homo sapiens Eukaryo. plasma 1 0 3.3 ± 1.9 53 ± 16 -4.9
2.2.27.01. Diacylglycerol kinase delta 1r79 Homo sapiens Eukaryo. plasma 1 0 3.3 ± 1.6 34 ± 19 -4.9
2.2.40.01. Neurotoxin III 1ans Anemonia sulcata Secreted 1 0 3.3 ± 1.4 50 ± 15 -4.7
2.2.11.01. Protein unc-13 homolog A, C2C domain 3kwu Rattus norvegicus Eukaryo. plasma 1 0 3.3 ± 1.9 67 ± 16 -3.6
2.2.06.02. Retinol-binding protein 1 5h9a Homo sapiens Eukaryo. plasma 1 0 3.3 ± 0.9 59 ± 4 -5.7
2.2.06.02. Intestinal fatty acid binding protein, structure 3 2mji Homo sapiens Eukaryo. plasma 1 0 3.3 ± 1.0 57 ± 14 -4.1
2.2.34.01. Kappa-conotoxin PVIIA 1av3 Conus purpurascens (Purple cone) Secreted 1 0 3.4 ± 1.9 77 ± 7 -3.2
2.2.14.01. C2 domain of coagulation factor V 1czs Homo sapiens Eukaryo. plasma 1 0 3.4 ± 1.6 13 ± 15 -6.2
2.2.45.01. Outer membrane protein IcsA autotransporter 3ml3 Shigella flexneri Bact. Gram-neg outer 1 0 3.4 ± 0.5 65 ± 2 -6.2
2.2.11.01. C2 domain of abscisic acid-related protein CAR1 5a50 Arabidopsis thaliana Eukaryo. plasma 1 0 3.4 ± 1.2 79 ± 4 -6.3
2.2.34.02. Kappa-sparatoxin-Hv1b 1emx Heteropoda venatoria (Brown huntsman spider) Secreted 1 0 3.4 ± 0.9 57 ± 8 -4.8
2.2.34.05. Tachystatin-B2 2dcw Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 3.4 ± 0.8 2 ± 6 -10.1
2.2.34.11. Leaf cyclotide 2 2kuk Viola hederacea Secreted 1 0 3.4 ± 1.2 83 ± 20 -5.9
2.2.12.01. Lymphocyte antigen 96 2z64 Mus musculus Eukaryo. plasma 1 0 3.4 ± 1.1 66 ± 4 -7.0
2.2.12.02. Rho GDP-dissociation inhibitor 1, complex with RhoA 1cc0 Homo sapiens Eukaryo. plasma 2 0 3.4 ± 1.8 84 ± 6 -5.5
2.2.11.01. E3 ubiquitin-protein ligase Itchy homolog 2nq3 Homo sapiens Eukaryo. plasma 1 0 3.4 ± 1.9 25 ± 17 -6.7
2.2.04.01. Retinoid isomerohydrolase, conformation 3 4f30 Bos taurus Eukaryo. plasma 1 0 3.4 ± 1.4 61 ± 7 -10.9
2.2.57.01. Levansucrase 1w18 Gluconacetobacter diazotrophicus (Acetobacter diazotrophicus) Secreted 1 0 3.4 ± 1.6 57 ± 3 -7.2
2.2.39.01. Muscarinic m1-toxin1 2vlw Dendroaspis angusticeps (Eastern green mamba) Secreted 1 0 3.4 ± 0.9 82 ± 9 -4.9
2.2.34.02. Hanatoxin 1 1d1h Grammostola rosea (Chilean rose tarantula) Secreted 1 0 3.4 ± 1.7 68 ± 15 -4.2
2.2.34.02. Mu-theraphotoxin-Hhn2a 2jtb Haplopelma hainanum (Chinese bird spider) Secreted 1 0 3.4 ± 1.5 74 ± 12 -4.7
2.2.06.02. Intestinal fatty acid binding protein, structure 1 1icm Rattus norvegicus Eukaryo. plasma 1 0 3.5 ± 1.5 51 ± 18 -4.3
2.2.41.01. Beta-defensin 1 1ijv Homo sapiens Secreted 1 0 3.5 ± 1.9 74 ± 17 -5.4
2.2.06.02. Fatty acid bindin protein, isoform B 5gge Drosophila melanogaster Nuclear inner 1 0 3.5 ± 3.5 52 ± 7 -7.0
2.2.07.02. Factor H binding protein 1ys5 Neisseria meningitidis Bact. Gram-neg outer 1 0 3.5 ± 2.6 84 ± 5 -5.6
2.2.05.01. Amicyanin 1sfd Paracoccus denitrificans Bact. Gram-neg inner 1 0 3.5 ± 0.8 49 ± 10 -4.0
2.2.34.06. Antimicrobial peptide 1 1dkc Phytolacca americana (American pokeweed) Secreted 1 0 3.5 ± 1.2 84 ± 10 -4.1
2.2.61.01. Effector protein PevD1 5xmz Verticillium dahliae Secreted 1 0 3.5 ± 0.8 33 ± 2 -5.6
2.2.21.01. Hisactophilin-1 1hce Dictyostelium discoideum Eukaryo. plasma 1 0 3.5 ± 1.1 60 ± 15 -1.6
2.2.11.01. Protein unc-13 homolog A, C2A domain 2cjs Rattus norvegicus Eukaryo. plasma 1 0 3.5 ± 2.0 47 ± 12 -5.0
2.2.41.01. Neutrophil defensin 1, dimer 3gny Homo sapiens Secreted 2 0 3.5 ± 0.5 84 ± 6 -5.0
2.2.33.01. Antifungal peptide 2 1p9z Eucommia ulmoides (Hardy rubber tree) Secreted 1 0 3.5 ± 2.0 84 ± 18 -2.9
2.2.27.01. Rac GTPase-activating protein 1 4b6d Homo sapiens Eukaryo. plasma 1 0 3.5 ± 0.9 55 ± 4 -5.9
2.2.27.01. C1 domain of protein kinase C gamma 2e73 Homo sapiens Eukaryo. plasma 1 0 3.5 ± 1.3 53 ± 9 -4.7
2.2.34.02. U2-agatoxin-Aop1a 2e2s Allagelena opulenta Secreted 1 0 3.5 ± 0.7 45 ± 14 -5.7
2.2.06.01. Retinol binding protein 1rbp Homo sapiens Secreted 1 0 3.5 ± 0.8 70 ± 6 -5.8
2.2.20.01. Pleckstrin 1pls Homo sapiens Eukaryo. plasma 1 0 3.6 ± 2.0 61 ± 19 -3.8
2.2.41.02. Toxin CgNa 2h9x Condylactis gigantea (Giant Caribbean anemone) Secreted 1 0 3.6 ± 1.6 70 ± 15 -2.7
2.2.20.01. PH domain of GPCR kinase 1 1bak Homo sapiens Eukaryo. plasma 1 0 3.6 ± 0.9 88 ± 2 -6.0
2.2.39.01. Weak tryptophan-containing neurotoxin 2mj0 Naja kaouthia Secreted 1 0 3.6 ± 1.7 57 ± 5 -5.9
2.2.27.01. C1 domain of protein kinase C theta 4fkd Mus musculus Eukaryo. plasma 1 0 3.6 ± 0.4 35 ± 2 -8.0
2.2.12.01. Lymphocyte antigen 96, structure 1 2e56 Homo sapiens Secreted 1 0 3.6 ± 0.7 68 ± 4 -6.7
2.2.41.01. Chimeric beta-defensin 2/3 2lxo Designed proteins Undefined 1 0 3.6 ± 0.8 56 ± 14 -5.6
2.2.41.01. Beta-defensin 7 1e4t Mus musculus Secreted 1 0 3.6 ± 1.4 13 ± 19 -5.2
2.2.23.01. Lipoprotein BamB, conformation 2 3p1l Escherichia coli Bact. Gram-neg outer 1 0 3.6 ± 2.8 89 ± 10 -6.4
2.2.34.02. Omega-theraphotoxin-Gr1a 1koz Grammostola rosea (Chilean rose tarantula) Secreted 1 0 3.6 ± 0.8 68 ± 6 -6.5
2.2.41.01. Spheniscin-2 (bird defensin) 1ut3 Aptenodytes patagonicus Secreted 1 0 3.6 ± 1.6 44 ± 17 -6.2
2.2.34.11. Cycloviolacin-O14 2gj0 Viola odorata Secreted 1 0 3.6 ± 1.5 85 ± 16 -5.4
2.2.34.02. Mu-theraphotoxin-Hhn2b 1nix Haplopelma hainanum (Chinese bird spider) Secreted 1 0 3.6 ± 1.1 64 ± 5 -5.5
2.2.34.02. U1-theraphotoxin-Cj1a 2aap Chilobrachys guangxiensis (Chinese earth tiger tarantula) Secreted 1 0 3.6 ± 0.7 82 ± 5 -4.9
2.2.59.01. Zymogen granule membrane protein 16 3vy7 Homo sapiens Secreted 1 0 3.6 ± 2.1 54 ± 15 -4.6
2.2.41.01. Neutrophil defensin 1 2pm1 Homo sapiens Secreted 1 0 3.6 ± 1.3 85 ± 6 -3.8
2.2.14.01. C2 domain of coagulation factor VIII 4mo3 Sus scrofa Eukaryo. plasma 1 0 3.7 ± 0.6 19 ± 4 -9.7
2.2.41.02. Anthopleurin-A 1ahl Anthopleura xanthogrammica Secreted 1 0 3.7 ± 1.2 86 ± 11 -7.3
2.2.11.01. C2 domain of GTPase activating protein 1 4rj9 Oryza sativa (Rice) Eukaryo. plasma 1 0 3.7 ± 1.4 16 ± 6 -5.6
2.2.14.01. C2 domains of coagulation factor Va 1sdd Bos taurus Eukaryo. plasma 2 0 3.7 ± 2.0 35 ± 8 -8.7
2.2.06.02. Adipocyte lipid-binding protein 1a18 Mus musculus Eukaryo. plasma 1 0 3.7 ± 0.8 47 ± 7 -7.4
2.2.41.05. Crotamine 1z99 Crotalus durissus terrificus Secreted 1 0 3.7 ± 0.8 26 ± 5 -5.6
2.2.41.01. Alpha-defensin 6 1zmq Homo sapiens Secreted 1 0 3.7 ± 1.6 76 ± 18 -3.6
2.2.32.01. ADP-ribosylating toxin CARDS, nicked 4tlv Mycoplasma pneumoniae Secreted 1 0 3.7 ± 1.1 44 ± 10 -4.8
2.2.34.11. Kalata B1, all-D analogue 2jue Designed proteins Undefined 1 0 3.7 ± 1.0 82 ± 17 -5.5
2.2.28.02. Scarabaecin 1iyc Oryctes rhinoceros (Coconut rhinoceros beetle) Secreted 1 0 3.7 ± 2.3 90 ± 23 -5.0
2.2.04.01. Retinoid isomerohydrolase, conformation 2 4f2z Bos taurus Eukaryo. plasma 1 0 3.7 ± 0.9 56 ± 2 -9.2
2.2.44.01. DENN domain-containing and Rab6-interacting proteins 3cwz Mus musculus Golgi 2 0 3.7 ± 1.0 77 ± 2 -5.2
2.2.26.01. FYVE domain of Vps27 protein 1vfy Saccharomyces cerevisiae Vacuole 1 0 3.7 ± 1.8 24 ± 19 -4.2
2.2.05.02. Mavicyanin 1ws8 Cucurbita pepo Undefined 1 0 3.7 ± 0.5 31 ± 8 -6.5
2.2.11.01. Extended synaptotagmin-2, two first C2 domains 4npk Homo sapiens Eukaryo. plasma 1 0 3.8 ± 2.8 56 ± 9 -4.5
2.2.03.01. Saccharopepsin 1fq5 Saccharomyces cerevisiae Vacuole 1 0 3.8 ± 0.8 84 ± 6 -8.1
2.2.21.03. Interleukin-36 receptor antagonist protein 1md6 Mus musculus Secreted 1 0 3.8 ± 0.4 40 ± 3 -6.5
2.2.20.01. PH domain of 3-phosphoinositide-dependent protein kinase 1 1w1g Homo sapiens Eukaryo. plasma 1 0 3.8 ± 1.8 20 ± 18 -4.8
2.2.11.01. Synaptotagmin-1, C2A domain (Calcium bound) 1byn Rattus norvegicus Eukaryo. plasma 1 0 3.8 ± 1.6 32 ± 19 -4.7
2.2.06.02. Epidermal fatty acid binding protein 4lkt Homo sapiens Eukaryo. plasma 1 0 3.8 ± 1.2 39 ± 7 -6.7
2.2.20.01. Rac-beta serine/threonine protein kinase 1p6s Homo sapiens Eukaryo. plasma 1 0 3.8 ± 1.8 83 ± 11 -5.7
2.2.34.02. Toxin GsMTx2 1lup Grammostola rosea (Chilean rose tarantula) Secreted 1 0 3.8 ± 1.1 90 ± 8 -4.8
2.2.39.01. Cytotoxin 4 4om5 Naja atra Secreted 1 0 3.8 ± 0.6 75 ± 3 -11.1
2.2.26.01. Rabphilin-3A 1zbd Rattus norvegicus Eukaryo. plasma 2 0 3.8 ± 1.8 68 ± 15 -4.0
2.2.20.01. PH domain of fermitin family homolog 3 5l81 Mus musculus Eukaryo. plasma 1 0 3.8 ± 2.2 59 ± 7 -4.2
2.2.34.06. Peptide jS1 2n5q Jasminum sambac Secreted 1 0 3.8 ± 1.2 71 ± 15 -6.1
2.2.11.01. Perforin 3w57 Psetta maxima Secreted 1 0 3.8 ± 1.2 38 ± 5 -7.8
2.2.34.08. Agouti-signaling protein 1y7j Homo sapiens Secreted 1 0 3.8 ± 1.6 62 ± 7 -6.9
2.2.45.01. Pertactin, complex with phage tail protein 2iou Bordetella bronchiseptica Bact. Gram-neg outer 4 0 3.9 ± 1.2 82 ± 2 -8.2
2.2.22.01. Hydrophobin NC2, structure 1 4aog Neurospora crassa Secreted 1 0 3.9 ± 1.7 85 ± 7 -4.6
2.2.11.01. C2 domain of abscisic acid-related protein CAR4 5a52 Arabidopsis thaliana Eukaryo. plasma 2 0 3.9 ± 0.7 82 ± 11 -6.6
2.2.34.06. Gurmarin 1c4e Gymnema sylvestre Secreted 1 0 3.9 ± 2.6 75 ± 16 -4.8
2.2.34.11. Circulin A 1bh4 Chassalia parviflora Secreted 1 0 3.9 ± 1.2 60 ± 18 -6.6
2.2.06.01. Extracellular fatty acid-binding protein 2kt4 Coturnix coturnix japonica (Japanese quail) Secreted 1 0 3.9 ± 2.9 61 ± 8 -3.4
2.2.34.05. Tachystatin-A2 1cix Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 3.9 ± 2.9 65 ± 14 -4.7
2.2.41.02. Toxin APETx1 1wqk Anthopleura elegantissima (Sea anemone) Secreted 1 0 4.0 ± 1.4 32 ± 18 -7.3
2.2.34.01. Conotoxin muOxi-GVIIJ 2n8h Conus geographus (Geography cone) Secreted 1 0 4.0 ± 1.0 43 ± 5 -4.1
2.2.11.01. Synaptotagmin-3 3hn8 Rattus norvegicus Eukaryo. plasma 1 0 4.0 ± 3.1 74 ± 19 -4.0
2.2.41.01. Beta-defensin 106 2lwl Homo sapiens Secreted 1 0 4.0 ± 1.5 70 ± 9 -6.4
2.2.34.02. Omega-agatoxin-4A 1oav Agelenopsis aperta Secreted 1 0 4.0 ± 1.1 75 ± 14 -4.0
2.2.27.01. C1 domain of protein kinase C delta 2yuu Homo sapiens Nuclear outer 1 0 4.0 ± 0.9 77 ± 20 -6.5
2.2.12.02. Rho GDP-dissociation inhibitor 1, complex with G-protein RAC2 1hh4 Homo sapiens Eukaryo. plasma 2 0 4.0 ± 0.6 88 ± 6 -7.2
2.2.34.11. Vodo peptide N 2aks Viola odorata Secreted 1 0 4.0 ± 1.4 89 ± 22 -6.7
2.2.55.01. Shewanella peptidase 3nji Shewanella oneidensis Undefined 2 0 4.0 ± 0.9 81 ± 7 -5.6
2.2.39.01. Muscarinic m1-toxin1, sequence version 3neq Dendroaspis angusticeps (Eastern green mamba) Secreted 1 0 4.0 ± 0.8 65 ± 5 -7.0
2.2.20.01. PH domain of Src-associated adaptor 55 protein 1u5d Homo sapiens Eukaryo. plasma 2 0 4.0 ± 1.8 68 ± 18 -6.4
2.2.35.01. Intermedilysin - CD59 receptor complex, trapped toxin 5imy Streptococcus intermedius Secreted 2 0 4.1 ± 1.6 63 ± 7 -7.5
2.2.34.11. Kalata-B5 2kux Oldenlandia affinis Secreted 1 0 4.1 ± 1.0 61 ± 25 -6.6
2.2.06.02. Myelin P2 protein 2wut Homo sapiens Eukaryo. plasma 1 0 4.1 ± 0.5 47 ± 7 -3.4
2.2.34.11. Cycloviolacin O1 1df6 Viola odorata Secreted 1 0 4.1 ± 1.2 63 ± 19 -5.9
2.2.34.06. Tripatide 2mfs Trichocereus pachanoi Thylakoid 1 0 4.1 ± 0.8 81 ± 6 -7.6
2.2.35.01. Pneumolysin, structure 4 5aod Streptococcus pneumoniae Secreted 1 0 4.1 ± 1.6 26 ± 4 -6.1
2.2.22.01. Hydrophobin II 1r2m Hypocrea jecorina Secreted 1 0 4.1 ± 1.0 16 ± 15 -6.6
2.2.34.02. Phrixotoxin 1 1v7f Paraphysa scrofa Secreted 1 0 4.1 ± 1.2 90 ± 16 -6.8
2.2.06.01. Retinol binding protein 1aqb Sus scrofa Secreted 1 0 4.1 ± 1.1 75 ± 14 -4.4
2.2.14.01. Coagulation factor VIII, EM-based structure 3j2q Homo sapiens Eukaryo. plasma 2 0 4.1 ± 1.2 76 ± 3 -8.5
2.2.20.01. Dynamin-1 1dyn Homo sapiens Eukaryo. plasma 2 0 4.1 ± 1.2 88 ± 15 -9.7
2.2.02.01. Serine protease HTRA1 3nzi Homo sapiens Secreted 6 0 4.2 ± 0.7 90 ± 0 -11.8
2.2.34.11. Varv peptide F 3e4h Viola arvensis Secreted 1 0 4.2 ± 3.0 87 ± 43 -5.6
2.2.56.01. Beta-2-glycoprotein 1 3op8 Homo sapiens Secreted 1 0 4.2 ± 1.8 47 ± 10 -6.1
2.2.11.01. E3 ubiquitin-protein ligase SMURF2 2jqz Homo sapiens Eukaryo. plasma 1 0 4.2 ± 1.8 23 ± 17 -5.6
2.2.07.03. Streptavidin 1mm9 Streptomyces avidinii Secreted 1 0 4.2 ± 1.6 56 ± 3 -8.4
2.2.39.01. Ancestral Mamba toxin 1 5mg9 Dendroaspis angusticeps (Eastern green mamba) Secreted 1 0 4.2 ± 1.2 49 ± 6 -8.0
2.2.41.01. Alpha-defensin 5 1zmp Homo sapiens Secreted 1 0 4.2 ± 1.6 84 ± 14 -2.8
2.2.53.01. Fas apoptotic inhibitory molecule 1 3mx7 Homo sapiens Eukaryo. plasma 1 0 4.2 ± 1.4 16 ± 13 -7.1
2.2.05.01. Amicyanin 1id2 Paracoccus versutus Bact. Gram-neg inner 1 0 4.2 ± 1.3 52 ± 8 -4.9
2.2.07.01. Protein yceI 1y0g Escherichia coli Bact. Gram-neg inner 1 0 4.2 ± 1.5 24 ± 16 -2.1
2.2.20.01. SET binding factor 1 1v5u Mus musculus Eukaryo. plasma 1 0 4.2 ± 1.5 59 ± 10 -5.3
2.2.39.01. Cardiotoxin V4II 1cdt Naja mossambica mossambica Secreted 2 0 4.2 ± 1.0 46 ± 14 -6.9
2.2.06.02. Fatty acid-binding protein, epidermal 4azp Mus musculus Eukaryo. plasma 1 0 4.2 ± 2.4 57 ± 11 -5.5
2.2.12.01. Ganglioside GM2 activator 1tjj Homo sapiens Lysosome 1 0 4.2 ± 0.3 57 ± 4 -8.3
2.2.34.07. Asteropsin F 2n2g Asteropus sp. Secreted 1 0 4.3 ± 1.7 60 ± 11 -3.4
2.2.26.01. FYVE domain of protein 27 1x4u Homo sapiens Vesicle 1 0 4.3 ± 1.9 38 ± 19 -6.9
2.2.46.01. Low molecular mass 30 kDa lipoprotein 19G1 4iy8 Bombyx mori Secreted 1 0 4.3 ± 1.2 31 ± 8 -4.2
2.2.26.01. FYVE domain of protein 19 1wfk Mus musculus Vesicle 1 0 4.3 ± 1.8 17 ± 16 -5.5
2.2.06.01. Retinol binding protein 1kt6 Bos taurus Secreted 1 0 4.3 ± 1.7 74 ± 12 -4.7
2.2.35.01. Pneumolysin, structure 2 5cr6 Streptococcus pneumoniae Secreted 1 0 4.3 ± 1.9 24 ± 3 -6.4
2.2.06.02. Muscle fatty acid binding protein 1hmt Homo sapiens Eukaryo. plasma 1 0 4.3 ± 1.6 49 ± 12 -5.0
2.2.34.02. Voltage sensor toxin VSTx1 1s6x Grammostola rosea (Chilean rose tarantula) Secreted 1 0 4.4 ± 1.4 79 ± 13 -6.3
2.2.13.01. Cellulosomal scaffoldin 2xbt Bacteroides cellulosolvens Secreted 1 0 4.4 ± 0.3 84 ± 14 -5.8
2.2.35.01. Perfringolysin 1pfo Clostridium perfringens Secreted 1 0 4.4 ± 2.0 38 ± 12 -6.7
2.2.34.01. Omega-conotoxin GVIA 2cco Conus geographus (Geography cone) Secreted 1 0 4.4 ± 0.9 62 ± 7 -3.1
2.2.34.02. Huwentoxin-4 1mb6 Haplopelma hainanum (Chinese bird spider) Secreted 1 0 4.4 ± 0.8 70 ± 12 -5.8
2.2.34.11. Kalata-B12 2kvx Oldenlandia affinis Secreted 1 0 4.4 ± 1.2 68 ± 27 -5.6
2.2.02.03. Serine protease/helicase NS3 2whx Dengue virus Endoplasm. reticulum 2 0 4.4 ± 2.3 68 ± 9 -5.6
2.2.30.01. Elafin, complex with elastase from Pig 1fle Homo sapiens Secreted 2 0 4.4 ± 2.0 52 ± 11 -6.3
2.2.34.11. Tricyclon-A 1yp8 Viola arvensis Secreted 1 0 4.4 ± 1.7 71 ± 19 -4.7
2.2.34.02. Beta-theraphotoxin-Ps1a 5we3 Paraphysa scrofa Secreted 1 0 4.4 ± 3.2 86 ± 5 -5.4
2.2.41.02. Sea anemone toxin IA 1atx Anemonia sulcata Secreted 1 0 4.5 ± 1.7 63 ± 12 -6.1
2.2.20.01. T-lymphoma invasion and metastasis-inducing protein 1, with G-protein RAC2 1foe Mus musculus Eukaryo. plasma 2 0 4.5 ± 1.1 64 ± 7 -6.7
2.2.03.02. Retropepsin 2q63 Human immunodeficiency virus type 1 Eukaryo. plasma 2 0 4.5 ± 0.4 89 ± 4 -10.4
2.2.11.01. C2 domain of E3 ubiquitin-protein ligase SMURF1 3pyc Homo sapiens Eukaryo. plasma 1 0 4.5 ± 2.1 23 ± 17 -5.7
2.2.28.01. Tachycitin 1dqc Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 4.5 ± 0.8 78 ± 8 -5.6
2.2.35.01. Pneumolysin, structure 5 5aoe Streptococcus pneumoniae Secreted 1 0 4.5 ± 2.6 36 ± 16 -5.1
2.2.34.07. Asteropsin E 2m3j Asteropus sp. Secreted 1 0 4.5 ± 1.1 65 ± 7 -3.6
2.2.14.01. Coagulation factor VIII 2r7e Homo sapiens Eukaryo. plasma 2 0 4.5 ± 3.0 39 ± 6 -11.5
2.2.06.02. Fatty acid-binding protein 1ftp Schistocerca gregaria Eukaryo. plasma 1 0 4.5 ± 1.0 53 ± 11 -5.2
2.2.06.01. Apolipoprotein D 2hzq Homo sapiens Secreted 1 0 4.5 ± 0.9 69 ± 5 -7.8
2.2.34.02. Kappa-theraphotoxin-Scg1a 1la4 Stromatopelma calceatum griseipes Secreted 1 0 4.6 ± 0.4 80 ± 5 -5.9
2.2.11.01. Synaptotagmin-17 2enp Homo sapiens Eukaryo. plasma 1 0 4.6 ± 1.5 6 ± 14 -4.9
2.2.09.02. Diisopropyl-fluorophosphatase 3o4p Loligo vulgaris (Common European squid) Undefined 1 0 4.6 ± 1.3 82 ± 5 -6.6
2.2.34.11. Kalata B2, segment 71-98 (repeat 1) 1pt4 Oldenlandia affinis Secreted 1 0 4.6 ± 1.2 83 ± 14 -9.2
2.2.39.01. Beta-cardiotoxin 3plc Ophiophagus hannah Secreted 1 0 4.6 ± 1.1 73 ± 4 -6.7
2.2.35.01. Pneumolysin, structure 1 4qqq Streptococcus pneumoniae Secreted 1 0 4.6 ± 3.7 27 ± 7 -6.8
2.2.34.01. Omega-conotoxin MVIIA 1mvi Conus magus Secreted 1 0 4.7 ± 1.9 68 ± 14 -4.0
2.2.20.01. Collagen type IV alpha-3-binding protein 2rsg Homo sapiens Golgi 1 0 4.7 ± 0.9 60 ± 8 -7.0
2.2.34.07. Asteropsin D 2lzy Asteropus sp. Secreted 1 0 4.7 ± 1.5 49 ± 29 -3.0
2.2.41.01. Alpha-defensin corticostatin-related peptide RK-1 1ews Oryctolagus cuniculus Secreted 1 0 4.7 ± 1.1 18 ± 17 -4.4
2.2.48.01. Hypothetical molybdopterin biosynthesis MoeA protein 1uz5 Pyrococcus horikoshii Undefined 1 0 4.7 ± 1.7 79 ± 2 -5.0
2.2.35.01. Pneumolysin, structure 3 5cr8 Streptococcus pneumoniae Secreted 1 0 4.7 ± 1.2 37 ± 6 -9.3
2.2.27.01. RAF-1 proto-oncogene serine/threonine-protein kinase 1faq Homo sapiens Eukaryo. plasma 1 0 4.8 ± 1.1 30 ± 14 -7.3
2.2.06.02. Muscle fatty acid binding protein 1bwy Bos taurus Eukaryo. plasma 1 0 4.8 ± 1.3 71 ± 12 -6.6
2.2.27.01. C1 domain of protein kinase C gamma 1tbn Rattus rattus Eukaryo. plasma 1 0 4.8 ± 1.6 42 ± 19 -3.7
2.2.14.01. C2 domain of coagulation factor VIII 1d7p Homo sapiens Eukaryo. plasma 1 0 4.8 ± 2.0 28 ± 10 -8.8
2.2.34.11. Palicourein 1r1f Palicourea condensata Secreted 1 0 4.8 ± 1.4 70 ± 19 -5.0
2.2.34.02. Protoxin-II 5o0u Thrixopelma pruriens Secreted 1 0 4.8 ± 3.8 60 ± 2 -8.5
2.2.14.01. Coagulation factor VIII, light chain 3j2s Homo sapiens Eukaryo. plasma 1 0 4.8 ± 1.0 34 ± 15 -6.1
2.2.12.01. Ganglioside GM2 activator, different conformation 1pub Homo sapiens Lysosome 1 0 4.9 ± 0.7 50 ± 8 -7.3
2.2.41.02. Toxin APETx2 1wxn Anthopleura elegantissima (Sea anemone) Secreted 1 0 4.9 ± 1.7 33 ± 18 -5.5
2.2.34.11. Leaf cyclotide 1 1za8 Viola hederacea Secreted 1 0 4.9 ± 1.3 48 ± 24 -8.5
2.2.54.01. Non-structural protein 5A 3fqm Hepatitis C virus Endoplasm. reticulum 1 0 4.9 ± 1.1 77 ± 7 -7.5
2.2.23.01. Lipoprotein BamB, conformation 3 3q7o Escherichia coli Bact. Gram-neg outer 1 0 4.9 ± 1.5 69 ± 3 -6.9
2.2.02.02. Hepatitis C virus NS3 protease 2o8m Hepatitis C virus Endoplasm. reticulum 4 0 5.0 ± 1.3 72 ± 8 -9.0
2.2.34.02. beta-TRTX-Pre1a toxin 5i1x Psalmopoeus cambridgei (Trinidad chevron tarantula) Secreted 1 0 5.0 ± 1.6 52 ± 12 -6.3
2.2.39.01. Bucandin 1f94 Bungarus candidus (Malayan krait) Secreted 1 0 5.0 ± 1.3 61 ± 6 -4.9
2.2.35.01. Pneumolysin, structure 7 4zgh Streptococcus pneumoniae Secreted 1 0 5.0 ± 2.5 24 ± 25 -4.9
2.2.34.11. Circulin B 2eri Chassalia parviflora Secreted 1 0 5.0 ± 1.0 69 ± 20 -8.4
2.2.23.01. Lipoprotein BamB, conformation 1 3prw Escherichia coli Bact. Gram-neg outer 1 0 5.1 ± 1.2 81 ± 7 -8.5
2.2.06.02. Fatty acid-binding protein Sm14 1vyf Schistosoma mansoni Eukaryo. plasma 1 0 5.1 ± 1.2 42 ± 18 -5.2
2.2.34.11. Cycloviolacin-O2 2kcg Viola odorata Secreted 1 0 5.1 ± 2.9 58 ± 36 -6.8
2.2.20.01. PH domain of pleckstrin homology domain-containing family A member 3 2mdx Homo sapiens Eukaryo. plasma 1 0 5.1 ± 1.1 11 ± 19 -4.1
2.2.39.01. Cytotoxin-1 1rl5 Naja naja oxiana Secreted 1 0 5.2 ± 2.0 51 ± 16 -5.7
2.2.41.01. Beta-defensin 2 1fd3 Homo sapiens Secreted 1 0 5.2 ± 1.2 80 ± 12 -9.1
2.2.09.05. Peroxisomal targeting signal 2 receptor, comnplex with Pex21p and thiolase 3w15 Saccharomyces cerevisiae Peroxisome 3 0 5.2 ± 1.6 84 ± 7 -5.8
2.2.34.02. ACTX-HI:OB4219 1kqi Hadronyche infensa Secreted 1 0 5.2 ± 1.2 72 ± 15 -8.2
2.2.34.11. Kalata B1, segment 93-120 1nb1 Oldenlandia affinis Secreted 1 0 5.3 ± 1.4 81 ± 18 -5.5
2.2.35.01. Intermedilysin 1s3r Streptococcus intermedius Secreted 1 0 5.3 ± 2.0 61 ± 16 -5.6
2.2.27.01. RAS guanyl-releasing protein 1 4l9m Homo sapiens Eukaryo. plasma 1 0 5.3 ± 1.3 24 ± 3 -7.8
2.2.22.01. Hydrophobin I 2gvm Hypocrea jecorina Secreted 1 0 5.3 ± 1.1 27 ± 18 -8.7
2.2.34.02. Beta-theraphotoxin-Tp1a 2m9l Thrixopelma pruriens Secreted 1 0 5.4 ± 0.7 73 ± 3 -6.6
2.2.12.01. Niemann-Pick type C2 protein 3web Camponotus japonicus Secreted 1 0 5.4 ± 0.3 73 ± 4 -7.6
2.2.50.01. Lipoprotein TP0453, intermediate conformation 3k8j Treponema pallidum Bact. Gram-neg outer 1 0 5.4 ± 1.4 33 ± 6 -9.9
2.2.39.01. Muscarinic m1-toxin1, chimeric sequence 3fev Dendroaspis angusticeps (Eastern green mamba) Secreted 1 0 5.5 ± 1.5 76 ± 8 -6.3
2.2.11.01. Extended synaptotagmin-2, SMP-C2A-C2B domains 4p42 Homo sapiens Eukaryo. plasma 1 0 5.5 ± 2.8 67 ± 6 -3.3
2.2.34.11. Kalata-B8 2b38 Oldenlandia affinis Secreted 1 0 5.5 ± 1.0 88 ± 12 -5.6
2.2.34.02. Beta-hexatoxin-Mg1a 2gx1 Macrothele gigas (Spider) Secreted 1 0 5.6 ± 2.6 51 ± 9 -4.6
2.2.35.01. Suilysin 3hvn Streptococcus suis Secreted 1 0 5.6 ± 1.1 5 ± 4 -6.4
2.2.41.02. Antihypertensive protein BDS-1 1bds Anemonia sulcata Secreted 1 0 5.6 ± 0.8 83 ± 9 -9.6
2.2.51.01. 25 kDa protein elicitor 3gnz Pythium aphanidermatum Secreted 1 0 5.7 ± 2.5 77 ± 13 -5.1
2.2.20.01. PH domain of GPCR kinase 2 2bcj Bos taurus Eukaryo. plasma 3 0 5.7 ± 1.5 85 ± 5 -10.4
2.2.34.02. Spiderine-1a, 108-165 2n86 Oxyopes takobius (Lynx spider) Secreted 1 0 5.8 ± 3.7 57 ± 6 -5.7
2.2.08.01. Osmotin-like protein 1aun Nicotiana tabacum Secreted 1 0 5.8 ± 1.0 85 ± 11 -6.7
2.2.35.01. Intermedilysin - CD59 receptor complex, disulfide-locked mutant 4bik Streptococcus intermedius Secreted 1 0 5.9 ± 3.1 28 ± 43 -6.4
2.2.04.01. 9-cis-epoxycarotenoid dioxygenase 1, chloroplastic 3npe Zea mays Thylakoid 1 0 6.0 ± 0.1 30 ± 5 -11.1
2.2.41.01. Beta-defensin 12 1bnb Bos taurus Secreted 1 0 6.0 ± 1.6 88 ± 15 -10.8
2.2.12.04. ADP-ribosylation factor-binding protein GGA1 1om9 Homo sapiens Golgi 2 0 6.1 ± 1.0 76 ± 21 -5.1
2.2.04.01. Lignostilbene-alpha,beta-dioxygenase (retinal-forming oxygenase) 2biw Synechocystis sp. Bact. Gram-neg inner 1 0 6.1 ± 0.9 39 ± 9 -12.9
2.2.03.01. Plasmepsin-2 1lf2 Plasmodium falciparum Vacuole 1 0 6.2 ± 0.4 76 ± 3 -11.0
2.2.27.01. C1 domain of protein kinase C theta 2enn Homo sapiens Eukaryo. plasma 1 0 6.2 ± 1.9 89 ± 3 -7.5
2.2.39.02. Mambalgin-1 5dz5 Dendroaspis polylepis polylepis (Black mamba) Secreted 1 0 6.2 ± 0.1 69 ± 1 -5.6
2.2.39.01. Cardiotoxin-A5 1kxi Naja atra Secreted 1 0 6.3 ± 1.1 69 ± 15 -10.5
2.2.34.02. U5-theraphotoxin-Hh1a 1qk7 Haplopelma hainanum (Chinese bird spider) Secreted 1 0 6.3 ± 0.5 47 ± 2 -5.2
2.2.30.01. Nawaprin 1udk Naja nigricollis Secreted 1 0 6.3 ± 1.0 81 ± 8 -7.3
2.2.11.01. Cytosolic phospholipase A2, group IVA 1rlw Homo sapiens Eukaryo. plasma 1 0 6.4 ± 1.9 57 ± 17 -7.8
2.2.41.02. Anthopleurin-B 1apf Anthopleura xanthogrammica Secreted 1 0 6.4 ± 1.3 78 ± 19 -7.1
2.2.06.01. Epididymal-specific lipocalin-5 1epb Rattus norvegicus Secreted 1 0 6.4 ± 1.1 74 ± 4 -3.8
2.2.34.02. Kappa-theraphotoxin-Pg1a 2wh9 Chilobrachys guangxiensis (Chinese earth tiger tarantula) Secreted 1 0 6.4 ± 1.0 57 ± 6 -9.2
2.2.39.01. Cardiotoxin VI 1ug4 Naja atra Secreted 1 0 6.4 ± 0.9 62 ± 4 -12.2
2.2.41.03. Big defensin 2rng Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 0 6.5 ± 2.3 21 ± 4 -7.5
2.2.34.01. Delta conotoxin TxVIA 1fu3 Conus textile Secreted 1 0 6.5 ± 1.8 25 ± 18 -8.3
2.2.34.11. Melanocortin agonist based on kalata-B1 2lur Designed proteins Undefined 1 0 6.5 ± 1.0 74 ± 21 -6.7
2.2.12.04. ADP-ribosylation factor binding protein Gga3 domain 1p4u Homo sapiens Golgi 1 0 6.5 ± 1.1 71 ± 11 -6.5
2.2.06.02. Cellular retinoic acid-binding protein 1 1cbr Bos taurus Eukaryo. plasma 1 0 6.5 ± 1.1 45 ± 11 -5.4
2.2.34.01. Delta conotoxin EVIA 1g1z Conus ermineus Secreted 1 0 6.5 ± 1.9 72 ± 18 -8.7
2.2.27.01. C1 domain of protein kinase C delta 1ptr Mus musculus Eukaryo. plasma 1 0 6.6 ± 1.5 19 ± 8 -5.9
2.2.39.01. Cytotoxin 1 ( Cardiotoxin gamma) 1tgx Naja mossambica pallida Secreted 1 0 6.7 ± 1.0 59 ± 12 -10.0
2.2.34.06. Inhibitor cystine knot peptide MCh-1 2m2q Momordica charantia Secreted 1 0 6.9 ± 0.7 74 ± 7 -6.3
2.2.34.11. Cycloviolacin O1 1vb8 Viola hederacea Secreted 1 0 6.9 ± 1.0 88 ± 17 -9.7
2.2.50.01. Lipoprotein TP0453, closed conformation 3k8g Treponema pallidum Bact. Gram-neg outer 1 0 6.9 ± 2.8 46 ± 7 -8.5
2.2.03.01. Cathepsin D 1lyb Homo sapiens Lysosome 2 0 7.0 ± 0.6 87 ± 5 -11.2
2.2.06.02. Cellular retinoic acid-binding protein 2 1cbs Homo sapiens Nuclear outer 1 0 7.1 ± 1.9 41 ± 13 -5.9
2.2.39.01. Cardiotoxin III (cytotoxin 3) 1h0j Naja atra Secreted 1 0 7.1 ± 0.9 59 ± 7 -11.3
2.2.47.01. Glycoside hydrolase family 9 protein 1wzx Clostridium thermocellum Bact. Gram-pos plas. 1 0 7.4 ± 2.0 77 ± 6 -4.1
2.2.02.01. Mitochondrial serine protease HtrA2 1lcy Homo sapiens Mitochon. inner 1 0 7.4 ± 1.8 67 ± 14 -5.1
2.2.34.06. Ginsentide 2ml7 Panax ginseng Secreted 1 0 7.6 ± 1.1 54 ± 8 -7.7
2.2.43.01. Hypothetical protein SpyM3_0169 1pg6 Streptococcus pyogenes Undefined 1 0 7.6 ± 1.5 57 ± 6 -7.2
2.2.04.01. Retinoid isomerohydrolase, conformation 1 3fsn Bos taurus Eukaryo. plasma 1 0 7.8 ± 1.0 73 ± 10 -10.3
2.2.39.01. Cardiotoxin II (cytotoxin II) 1ffj Naja naja oxiana Secreted 1 0 7.9 ± 0.8 56 ± 5 -13.7
2.2.21.05. Kunitz-type proteinase inhibitor BbCI 2gzb Bauhinia bauhinioides Secreted 1 0 7.9 ± 0.3 28 ± 3 -9.3
2.2.34.07. Asteropsin G 2n3p Asteropus sp. Secreted 1 0 8.0 ± 1.4 37 ± 17 -5.3
2.2.41.01. Gallinacin-2 2lg5 Gallus gallus Secreted 1 0 8.0 ± 1.2 62 ± 6 -8.2
2.2.12.01. Epididymal secretory protein E1 1nep Bos taurus Secreted 1 0 8.0 ± 1.4 73 ± 14 -4.6
2.2.41.02. Sea anemone neurotoxin-1 1shi Stoichactis helianthus Secreted 1 0 8.0 ± 1.0 87 ± 17 -5.9
2.2.34.02. Atracotoxin-hvI 1vtx Hadronyche versuta (Blue mountains funnel-web spider) Secreted 1 0 8.3 ± 1.0 89 ± 10 -9.4
2.2.35.01. Intermedilysin - CD59 receptor complex 5imt Streptococcus intermedius Secreted 4 0 8.3 ± 0.9 10 ± 26 -9.7
2.2.02.02. HCV serine protease NS3 3p8n Hepatitis C virus Endoplasm. reticulum 2 0 8.7 ± 1.7 56 ± 8 -9.9
2.2.19.01. Adsorption protein p2 1n7v Bacteriophage prd1 Viral 1 0 8.7 ± 0.4 81 ± 1 -8.6
2.2.50.01. Lipoprotein TP0453, open conformation 3k8i Treponema pallidum Bact. Gram-neg outer 1 0 8.9 ± 2.4 38 ± 2 -12.0
2.2.03.01. Plasmepsin IV 1qs8 Plasmodium vivax Vacuole 1 0 9.1 ± 1.5 75 ± 5 -8.9
2.2.41.01. Defensin-like peptide 2/4 1d6b Ornithorhynchus anatinus Secreted 1 0 9.2 ± 0.7 73 ± 2 -11.0
2.2.09.04. Nucleoporin NUP120 3f7f Saccharomyces cerevisiae Nuclear inner 1 0 9.3 ± 2.1 66 ± 5 -11.0
2.2.03.01. Phytepsin 1qdm Hordeum vulgare Vacuole 1 0 9.9 ± 1.1 88 ± 10 -10.4
2.2.34.01. Mu-O conotoxin MrVIB 1rmk Conus marmoreus Secreted 1 0 10.1 ± 1.3 62 ± 19 -10.7
2.2.31.01. Collagen-binding type II domain of seminal plasma protein PDC-109 1h8p Bos taurus Secreted 2 0 10.5 ± 0.9 87 ± 7 -16.6
2.2.34.04. Albumin 1 subunit B (Pab1) 1p8b Pisum sativum Secreted 1 0 11.1 ± 0.9 40 ± 13 -8.2
2.2.34.04. Leginsulin 1ju8 Glycine max Secreted 1 0 11.3 ± 1.6 21 ± 17 -8.6
2.2.20.01. Spectrin beta chain 1btn Mus musculus Eukaryo. plasma 1 0 13.7 ± 1.6 57 ± 19 -17.3
2.2.20.02. Disabled homolog 1 1nu2 Mus musculus Eukaryo. plasma 1 0 14.8 ± 1.1 46 ± 12 -17.6
2.2.20.01. Cytohesin-3 (Grp1) 1fhx Mus musculus Eukaryo. plasma 1 0 15.0 ± 1.2 18 ± 15 -16.4
2.2.26.01. Early endosome antigen 1 (EEA1), model of dimer with lipids 1joc Homo sapiens Endosome 2 0 15.0 ± 0.4 2 ± 11 -34.0
2.2.20.01. PH domain of phospholipase C delta 1 1mai Rattus norvegicus Eukaryo. plasma 1 0 15.0 ± 1.8 22 ± 14 -17.8
2.2.20.01. PH domain of tyrosine-protein kinase BTK 1bwn Homo sapiens Eukaryo. plasma 2 0 15.3 ± 0.5 90 ± 10 -33.3
2.2.20.03. Radixin 1gc6 Mus musculus Eukaryo. plasma 1 0 15.4 ± 1.8 17 ± 12 -17.9
2.2.41.03. Big defensin, segment 43-72 2rq2 Tachypleus tridentatus (Japanese horseshoe crab) Secreted 1 1 25.6 ± 4.4 18 ± 2 -13.5