• Type: Transmembrane (3 classes)
• Class: Alpha-helical polytopic (156 superfamilies)
• Superfamily: APC (Amino acid-Polyamine-organoCation) superfamily (14 families) CL0062
• Family: Neurotransmitter: sodium symporter (54 proteins) 2.A.22 (TCDB) PF00209 IPR000175 PDBsum
• Species: Aquifex aeolicus (53 proteins)
• Localization: Bacterial Gram-negative inner membrane (1251 proteins)

2a65 >> Leucine transporter LeuT, outward-facing substrate-bound conformation
Hydrophobic Thickness or Depth	29.8 Å
Tilt Angle	0°
ΔGtransfer	-157.9 kcal/mol
Links to 2a65	PDB Sum, PDB, MSD, MMDB, Encompass
Topology	subunit A (N terminus cytoplasmic side)
Resolution	1.65
Primary PDB represention	2a65
Other PDB entries representing this structure	2q6h (1.85), 2q72 (1.7), 2qb4 (1.9), 2qei (1.85), 2qju (2.9), 3f3c (2.1), 3f3d (2.3), 3f3e (1.8), 3f48 (1.9), 3f4i (1.95), 3f4j (2.15), 3gjc (2.8), 3gjd (2.0), 3gwu (2.14), 3gwv (2.35), 3gww (2.46), 3mpn (2.25), 3mpq (2.25), 3qs5 (2.6), 3qs6 (2.8), 3tu0 (2.99), 3usg (2.5), 3usi (3.11), 3usj (3.5), 3usk (4.5), 3usl (2.71), 3usm (3.01), 3uso (4.5), 3usp (2.1), 4hmk (3.0), 4hod (3.3)
Number of TM secondary structures	24
Membranome
Uniprot	O67854_AQUAE

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Download OPM File: 2a65.pdb

PDB Sum, PDB

Topology in Bacterial Gram-negative inner membrane

	periplasm
	cytoplasmic side

3D view in GLMol | LiteMol | Jmol | iCn3D

Comments: First TMH is broken into two short helices (15-24 and 26-35). Only first helix is included as the TMH.