PDB ID or protein name

1ds6 » Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2

1ds6 » Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2
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Topology in Eukaryotic plasma membrane
Topologyextracellular side
cytoplasmic side
1ds6 » Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2
Depth 2.8 ± 1.0 Å
Tilt Angle 82 ± 6°
ΔGtransfer -5.5 kcal/mol
Links to 1ds6 PDB Sum, PDB, SCOP, MSD, OCA, MMDB
Topology cytoplasmic
Resolution 2.3 Å
Other PDB entries representing this structure none
Number of subunits 2
Experimental Verification for 1ds6 » Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2
The inhibitor is bound to RAC2 protein (Ras-related C3 botulinum toxin substrate 2). RAC2 has S-geranylgeranyl cysteine 189. The geranylgeranyl residue can be buried in the membrane if the C-terminus of RAC2 is extended or unfolded (the C-terminal residues are missing in the crystal structure). The interaction with membrane is weak, since this is the inactive (GDP-bound) state. RAC2 is membrane-associated when activated.
Comments on 1ds6 » Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.