1ds6 » Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2
- Type: Monotopic/peripheral (4 classes)
- Class: All beta monotopic/peripheral (60 superfamilies)
- Superfamily: Immunoglobulin-like superfamily (E set) (5 families) CL0159
- Family: RHO protein GDP dissociation inhibitor (5 proteins) PF02115 IPR000406 PDBsum
- Species: Homo sapiens (2659 proteins)
- Localization: Eukaryotic plasma membrane (3316 proteins)
| 1ds6 >> Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2 | |
|---|---|
| Hydrophobic Thickness or Depth | 2.8 Å |
| Tilt Angle | 82° |
| ΔGtransfer | -5.5 kcal/mol |
| Links to 1ds6 | PDB Sum, PDB, MSD, MMDB |
| Topology | cytoplasmic side |
| Resolution | 2.35 |
| Primary PDB represention | 1ds6 |
| Other PDB entries representing this structure | none |
| Number of TM secondary structures | 0 |
| Membranome |  |
| Uniprot | GDIR2_HUMAN, RAC2_HUMAN |
Comments: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
| Verification: Rho GDP-dissociation inhibitor 2, complex with G-protein RAC2 | |
|---|---|
| The inhibitor is bound to RAC2 protein (Ras-related C3 botulinum toxin substrate 2). RAC2 has S-geranylgeranyl cysteine 189. The geranylgeranyl residue can be buried in the membrane if the C-terminus of RAC2 is extended or unfolded (the C-terminal residues are missing in the crystal structure). The interaction with membrane is weak, since this is the inactive (GDP-bound) state. RAC2 is membrane-associated when activated. |